Abstract
Giriş: Magnezyum oksit (MgO) fonksiyonel kabızlık için standart bir tedavidir. Ancak bu ilaç, plazma magnezyum (Mg) düzeyleri ve diğer elektrolitlerdeki olası değişiklikler açısından kapsamlı bir şekilde değerlendirilmemiştir. Bu retrospektif çalışma, fonksiyonel kabızlığı olan çocuklarda oral MgO tedavisi sonrası serum magnezyumunun diğer bazı elektrolit düzeyleriyle birlikte etkilerini değerlendirmeyi amaçladı.
Yöntem: Yerel etik kurul onayı alındıktan sonra 2014-2018 yılları arasında farklı şehirlerdeki iki farklı Çocuk Cerrahisi polikliniğine başvuran hastaların arşivleri değerlendirildi. Hastaların demografik bulguları kaydedildi. Kronik kabızlığın tanısı için Roma-III sınıflandırma kriterleri kullanıldı. Tam fizik muayene sonrasında kronik beslenme sorunları dışında olası organik nedenler yoksa serum elektrolit düzeyleri elde edilerek değerlendirildi. Bulgular istatistiksel olarak değerlendirildi ve literatürle tartışıldı.
Sonuç: Konstipasyon grubunda magnezyum değeri kontrol grubuna göre anlamlı derecede yüksekti (p<0,05). Genelleştirilmiş doğrusal model (GLM) sonuçlarında kalsiyum, potasyum ve sodyum düzeylerinin serum magnezyum düzeylerine etkisi anlamlıydı (p<0,05). Kabızlık grubunda kalsiyum ve potasyum düzeylerinin serum magnezyumu üzerindeki etkisi istatistiksel olarak anlamlıydı (p<0.05). Kontrol grubunda ise sadece klor düzeyinin serum magnezyumu üzerindeki etkisi istatistiksel olarak anlamlıydı (p<0.05).
Sonuç: MgO kabızlık için değerli bir tedavi yöntemidir. Ancak özellikle doz ayarlaması dikkate alınarak hastaların elektrolit dengesizliğinin önlenmesi için yan etkiler açısından yakın takip edilmesi gerekmektedir.
Keywords
References
- 1. Leung AK, Hon KL. Paediatrics: how to manage functional constipation. Drugs in context. 2021;10.
- 2. Bharucha AE, Lacy BE. Mechanisms, evaluation, and management of chronic constipation. Gastroenterology. 2020;158(5):1232-49. e3.
- 3. Joinson C, Grzeda MT, von Gontard A, Heron J. Psychosocial risks for constipation and soiling in primary school children. Eur Child Adolesc Psychiatry. 2019;28(2):203-10.
- 4. Bharucha AE, Wald A, editors. Chronic constipation. Mayo Clin Proc; 2019: Elsevier.
- 5. van Summeren JJ, Klunder JW, Holtman GA, Kollen BJ, Berger MY, Dekker JH. Parent-child agreement on health-related quality of life in children with functional constipation in primary care. J Pediatr Gastroenterol Nutr. 2018;67(6):726.
- 6. Rajindrajith S, Devanarayana NM, Perera BJC, Benninga MA. Childhood constipation as an emerging public health problem. World J Gastroenterol. 2016;22(30):6864.
- 7. Shin JE, Jung H-K, Lee TH, Jo Y, Lee H, Song KH, et al. Guidelines for the diagnosis and treatment of chronic functional constipation in Korea. J Neurogastroenterol Motil. 2016;22(3):383.
- 8. Koppen IJ, Lammers LA, Benninga MA, Tabbers MM. Management of functional constipation in children: therapy in practice. Pediatr Drugs. 2015;17(5):349-60.
- 9. Bharucha AE, Pemberton JH, Locke GR. American Gastroenterological Association technical review on constipation. Gastroenterology. 2013;144(1):218-38.
- 10. Paknejad MS, Motaharifard MS, Barimani S, Kabiri P, Karimi M. Traditional, complementary and alternative medicine in children constipation: a systematic review. DARU. 2019;27(2):811-26.
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- 15. Chang SH, Park KY, Kang SK, Kang KS, Na SY, Yang HR, et al. Prevalence, clinical characteristics, and management of functional constipation at pediatric gastroenterology clinics. J Korean Med Sci. 2013;28(9):1356.
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- 18. Guerrera MP, Volpe SL, Mao JJ. Therapeutic uses of magnesium. Am Fam Physician. 2009;80(2):157-62.
- 19. Tatsuki M, Miyazawa R, Tomomasa T, Ishige T, Nakazawa T, Arakawa H. Serum magnesium concentration in children with functional constipation treated with magnesium oxide. World J Gastroenterol: WJG. 2011;17(6):779.
- 20. Fiorentini D, Cappadone C, Farruggia G, Prata C. Magnesium: biochemistry, nutrition, detection, and social impact of diseases linked to its deficiency. Nutrients. 2021;13(4):1136.
- 21. Dupont C, Hébert G. Magnesium Sulfate-Rich Natural Mineral Waters in the Treatment of Functional Constipation–A Review. Nutrients. 2020;12(7):2052.
- 22. Yamaguchi H, Shimada H, Yoshita K, Tsubata Y, Ikarashi K, Morioka T, et al. Severe hypermagnesemia induced by magnesium oxide ingestion: a case series. CEN case rep. 2019;8(1):31-7.
- 23. Pouteau E, Kabir-Ahmadi M, Noah L, Mazur A, Dye L, Hellhammer J, et al. Superiority of magnesium and vitamin B6 over magnesium alone on severe stress in healthy adults with low magnesemia: A randomized, single-blind clinical trial. PloS one. 2018;13(12):e0208454.
- 24. Escobedo-Monge MF, Barrado E, Parodi-Román J, Escobedo-Monge MA, Marcos-Temprano M, Marugán-Miguelsanz JM. Magnesium Status and Calcium/Magnesium Ratios in a Series of Cystic Fibrosis Patients. Nutrients. 2022;14(9):1793.
- 25. Taylor SN. Calcium, Magnesium, Phosphorus, and Vitamin D. World Rev Nutr Diet. 2021;122:122-39.
- 26. Rosanoff A, Dai Q, Shapses SA. Essential nutrient interactions: does low or suboptimal magnesium status interact with vitamin D and/or calcium status? Adv Nutr. 2016;7(1):25-43.
- 27. Wabo TMC, Wu X, Sun C, Boah M, Nkondjock VRN, Cheruiyot JK, et al. Association of dietary calcium, magnesium, sodium, and potassium intake and hypertension: a study on an 8-year dietary intake data from the National Health and Nutrition Examination Survey. Nutr Res Pract.2022;16(1):74-93.
- 28. Pickering RT, Bradlee ML, Singer MR, Moore LL. Higher intakes of potassium and magnesium, but not lower sodium, reduce cardiovascular risk in the Framingham Offspring Study. Nutrients. 2021;13(1):269.
- 29. Pun PH, Middleton JP. Dialysate potassium, dialysate magnesium, and hemodialysis risk. J Am Soc Nephrol. 2017;28(12):3441-51.
- 30. Wones RG, Deck CC, Stadler B, Roark S, Hogg E, Frohman LA. Lack of effect of drinking water chlorine on lipid and thyroid metabolism in healthy humans. Environ health perspect. 1993;99:375-81.
Abstract
Background: Magnesium oxide (MgO) is a standard treatment for functional constipation. However, this medication has not been evaluated extensively for possible alterations of plasma magnesium (Mg) levels and other electrolytes. This retrospective study aimed to appraise the effects of serum magnesium with some other electrolyte levels after oral MgO treatment in children with functional constipation.
Methodology: After the approval of the local ethical committee, archives of the patients who had been admitted to two different Pediatric Surgery outpatient clinics in different cities between 2014-2018 were evaluated. The demographic findings of the patients were recorded. For the diagnosis of chronic constipation, Rome-III classification criteria were used. After complete physical examinations, if there were no possible organic reasons other than chronic dietary problems, serum electrolyte levels were obtained and evaluated. Findings were evaluated statistically and discussed with the literature.
Result: The magnesium value was significantly higher in the constipation group (p<0.05) compared to the control group. In generalized linear models (GLM) results, the effects of calcium, potassium, and sodium levels on serum magnesium levels were significant (p<0.05). The effect of calcium and potassium levels on serum magnesium was statistically significant in the constipation group (p<0.05). In the control group, only the effect of chlorine level on serum magnesium was statistically significant (p<0.05).
Conclusion: MgO is a valuable treatment for constipation. However, especially by taking into account the dose adjustment, close follow-up of the patients for side effects is necessary to prevent patients from electrolyte imbalance.
Keywords
References
- 1. Leung AK, Hon KL. Paediatrics: how to manage functional constipation. Drugs in context. 2021;10.
- 2. Bharucha AE, Lacy BE. Mechanisms, evaluation, and management of chronic constipation. Gastroenterology. 2020;158(5):1232-49. e3.
- 3. Joinson C, Grzeda MT, von Gontard A, Heron J. Psychosocial risks for constipation and soiling in primary school children. Eur Child Adolesc Psychiatry. 2019;28(2):203-10.
- 4. Bharucha AE, Wald A, editors. Chronic constipation. Mayo Clin Proc; 2019: Elsevier.
- 5. van Summeren JJ, Klunder JW, Holtman GA, Kollen BJ, Berger MY, Dekker JH. Parent-child agreement on health-related quality of life in children with functional constipation in primary care. J Pediatr Gastroenterol Nutr. 2018;67(6):726.
- 6. Rajindrajith S, Devanarayana NM, Perera BJC, Benninga MA. Childhood constipation as an emerging public health problem. World J Gastroenterol. 2016;22(30):6864.
- 7. Shin JE, Jung H-K, Lee TH, Jo Y, Lee H, Song KH, et al. Guidelines for the diagnosis and treatment of chronic functional constipation in Korea. J Neurogastroenterol Motil. 2016;22(3):383.
- 8. Koppen IJ, Lammers LA, Benninga MA, Tabbers MM. Management of functional constipation in children: therapy in practice. Pediatr Drugs. 2015;17(5):349-60.
- 9. Bharucha AE, Pemberton JH, Locke GR. American Gastroenterological Association technical review on constipation. Gastroenterology. 2013;144(1):218-38.
- 10. Paknejad MS, Motaharifard MS, Barimani S, Kabiri P, Karimi M. Traditional, complementary and alternative medicine in children constipation: a systematic review. DARU. 2019;27(2):811-26.
- 11. Gordon M, MacDonald JK, Parker CE, Akobeng AK, Thomas AG. Osmotic and stimulant laxatives for the management of childhood constipation. Cochrane Database Syst Rev. 2016(8).
- 12. Gröber U. Micronutrients: Metabolic tuning-prevention-therapy. Drug Metabolism and Drug Interactions. 2009;24(2-4):331. 13. Mori H, Tack J, Suzuki H. Magnesium Oxide in Constipation. Nutrients 2021, 13, 421; 2021.
- 14. Mori H, Suzuki H, Hirai Y, Okuzawa A, Kayashima A, Kubosawa Y, et al. Clinical features of hypermagnesemia in patients with functional constipation taking daily magnesium oxide. J Clin Biochem Nutr. 2019;65(1):76-81.
- 15. Chang SH, Park KY, Kang SK, Kang KS, Na SY, Yang HR, et al. Prevalence, clinical characteristics, and management of functional constipation at pediatric gastroenterology clinics. J Korean Med Sci. 2013;28(9):1356.
- 16. Benninga MA, Voskuijl WP, Taminiau J. Childhood constipation: is there new light in the tunnel? J Pediatr Gastroenterol Nutr. 2004;39(5):448-64.
- 17. Felt B, Wise CG, Olson A, Kochhar P, Marcus S, Coran A. Guideline for the management of pediatric idiopathic constipation and soiling. Arch Pediatr Adolesc Med. 1999;153(4):380-5.
- 18. Guerrera MP, Volpe SL, Mao JJ. Therapeutic uses of magnesium. Am Fam Physician. 2009;80(2):157-62.
- 19. Tatsuki M, Miyazawa R, Tomomasa T, Ishige T, Nakazawa T, Arakawa H. Serum magnesium concentration in children with functional constipation treated with magnesium oxide. World J Gastroenterol: WJG. 2011;17(6):779.
- 20. Fiorentini D, Cappadone C, Farruggia G, Prata C. Magnesium: biochemistry, nutrition, detection, and social impact of diseases linked to its deficiency. Nutrients. 2021;13(4):1136.
- 21. Dupont C, Hébert G. Magnesium Sulfate-Rich Natural Mineral Waters in the Treatment of Functional Constipation–A Review. Nutrients. 2020;12(7):2052.
- 22. Yamaguchi H, Shimada H, Yoshita K, Tsubata Y, Ikarashi K, Morioka T, et al. Severe hypermagnesemia induced by magnesium oxide ingestion: a case series. CEN case rep. 2019;8(1):31-7.
- 23. Pouteau E, Kabir-Ahmadi M, Noah L, Mazur A, Dye L, Hellhammer J, et al. Superiority of magnesium and vitamin B6 over magnesium alone on severe stress in healthy adults with low magnesemia: A randomized, single-blind clinical trial. PloS one. 2018;13(12):e0208454.
- 24. Escobedo-Monge MF, Barrado E, Parodi-Román J, Escobedo-Monge MA, Marcos-Temprano M, Marugán-Miguelsanz JM. Magnesium Status and Calcium/Magnesium Ratios in a Series of Cystic Fibrosis Patients. Nutrients. 2022;14(9):1793.
- 25. Taylor SN. Calcium, Magnesium, Phosphorus, and Vitamin D. World Rev Nutr Diet. 2021;122:122-39.
- 26. Rosanoff A, Dai Q, Shapses SA. Essential nutrient interactions: does low or suboptimal magnesium status interact with vitamin D and/or calcium status? Adv Nutr. 2016;7(1):25-43.
- 27. Wabo TMC, Wu X, Sun C, Boah M, Nkondjock VRN, Cheruiyot JK, et al. Association of dietary calcium, magnesium, sodium, and potassium intake and hypertension: a study on an 8-year dietary intake data from the National Health and Nutrition Examination Survey. Nutr Res Pract.2022;16(1):74-93.
- 28. Pickering RT, Bradlee ML, Singer MR, Moore LL. Higher intakes of potassium and magnesium, but not lower sodium, reduce cardiovascular risk in the Framingham Offspring Study. Nutrients. 2021;13(1):269.
- 29. Pun PH, Middleton JP. Dialysate potassium, dialysate magnesium, and hemodialysis risk. J Am Soc Nephrol. 2017;28(12):3441-51.
- 30. Wones RG, Deck CC, Stadler B, Roark S, Hogg E, Frohman LA. Lack of effect of drinking water chlorine on lipid and thyroid metabolism in healthy humans. Environ health perspect. 1993;99:375-81.
Details
| Primary Language | English |
|---|---|
| Subjects | Pediatric Surgery, Pediatric Gastroenterology |
| Journal Section | Original Articles |
| Authors | |
| Early Pub Date | March 31, 2024 |
| Publication Date | March 31, 2024 |
| Submission Date | November 1, 2023 |
| Acceptance Date | February 16, 2024 |
| Published in Issue | Year 2024 Volume: 12 Issue: 1 |
