Research Article
Year 2020,
Volume: 11 Issue: 1, 1 - 6, 30.01.2020
Abstract
References
- Ahmetov, I.I., Mozhayskaya, I.A., Flavell, D.M., et al. (2006). PPARalpha gene variation and physical performance in Russian athletes. Eur J Appl Physiol, 97(1), 103–108.
- Ahmetov, I.I., Williams, A.G., Popov, D.V., et al. (2009). The combined impact of metabolic gene polymorphisms on elite endurance athlete status and related phenotypes. Hum Genet, 126(6), 751–761.
- Akçamli, D., Sipahi, S., Yüksel, I., et al. (2018). Futbolcularda Peroksizom Proliferatör – Aktive Reseptör Alfa rs4253778 Polimorfizm Dağılımının Belirlenmesi. Eurasian Research in Sport Science, 3(2), 75-79.
- Braissant, O., Foufelle, F., Scotto, C., Dauca, M., Wahli, W. (1996). Differential expression of peroxisome proliferator-activated receptors (PPARs): tissue distribution of PPAR-alpha, -beta, and -gamma in the adult rat. Endocrinology, 137, 354–366.
- Corak, A., Kapıcı, S., Sercan, C., Akkoç, O., Ulucan, K. (2017). A pilot study for determination of anxiety related SLC6A4 promoter "S" and "L" alleles in healthy Turkish athletes. Cellular and Molecular Biology, 63(5), 29-31.
- Desvergne, B., Wahli, W. (1999). Peroxisome proliferator-activated receptors: nuclear control of metabolism. Endocr Rev, 20(5), 649–88.
- Eroğlu, O., Zileli, R., Nalbant, M.A., Ulucan, K. (2018). Prevalence of alpha actinin-3 gene (ACTN3) R577X and angiotensin converting enzyme (ACE) insertion / deletion gene polymorphisms in national and amateur Turkish athletes. Cell Mol Biol (Noisy le Grand), 64 (5), 24-28.
- Eynon, N., Meckel, Y., Sagiv, M., et al. (2010). Do PPARGC1A and PPARalpha polymorphisms influence sprint or endurance phenotypes? Scand J Med Sci Sports, 20(1), e145–e150.
- Flavell, D.M., Jamshidi, Y., Hawe, E., et al. (2002). Peroxisome proliferator-activated receptor alpha gene variants influence progression of coronary atherosclerosis and risk of coronary artery disease. Circulation, 105(12), 1440–1445.
- Ginevičienė, V., Pranckevičienė, E., Milašius, K., Kučinskas, V. (2010). Relating fitness phenotypes to genotypes in Lithuanian elite athletes. Acta Med Litu, 17(1–2), 1–10.
- Jamshidi, Y., Montgomery, H.E., Hense, H.W., et al. (2002). Peroxisome proliferator-activated receptor alpha gene regulates left ventricular growth in response to exercise and hypertension. Circulation, 105(8), 950–955.
- Leone, T.C., Weinheimer, C.J., Kelly, D.P. (1999). A critical role for the peroxisome proliferator-activated receptor alpha (PPARalpha) in the cellular fasting response: the PPARalpha-null mouse as a model of fatty acid oxidation disorders. Proc Natl Acad Sci U S A, 96: 7473–7478.
- Maciejewska, A., Sawczuk, M., Cieszczyk, P. (2011). Variation in the PPAR-alpha gene in Polish rowers. J Sci Med Sport,14(1), 58–64.
- Proia, P., Bianco, A., Schiera, G., et al. (2014). PPARα Gene Variants as Predicted Performance-Enhancing Polymorphisms in Professional Italian Soccer Players. Open Access Journal of Sports Medicine, 5, 273–278.
- Ulucan, K., Bayyurt, G.M., Konuk, M., Güney, A.I. (2014). Effect of alpha-actinin-3 gene on Turkish trained and untrained middle school children’s sprinting performance: a pilot study. Biological Rhythm Research, 45(4), 509- 514.
Peroxisome Proliferator-Activated Receptor Alpha (PPARα) rs4253778 Polymorphism in a Turkish Soccer Player Cohort
Abstract
Peroxisome proliferator-activated receptor alpha gene (PPARA) is one of the important gene determining athletes endurance capacity. The product of the gene functions in the regulation of lipid metabolism, in mostly heart and skeletal system, and maintaining glucose homeostasis and biogenesis in mitochondria. In this study, we aimed to determine the allelic distribution of PPARArs4253778 polymorphism in a Turkish soccer player cohort. For this purpose, we enrolled 22 professional soccer players and 68 sedentary controls for the study. Buccal cells were used for DNA sources, and real- time PCR methodology was followed for genotyping. GG genotypes were superior in both groups, and this was statistically significant when we compare the genotypes between groups. When we consider the alleles, G allele was found more frequently in players, and in controls. When we compare two groups, we determine a statistically significant difference, indicating the effect of G allele in soccer physiology. Our findings suggest that PPARArs4253778 polymorphism is an effective genetic factor in soccer physiology, and should be considered as an important genetic biomarker in sports genetics.
Keywords
References
- Ahmetov, I.I., Mozhayskaya, I.A., Flavell, D.M., et al. (2006). PPARalpha gene variation and physical performance in Russian athletes. Eur J Appl Physiol, 97(1), 103–108.
- Ahmetov, I.I., Williams, A.G., Popov, D.V., et al. (2009). The combined impact of metabolic gene polymorphisms on elite endurance athlete status and related phenotypes. Hum Genet, 126(6), 751–761.
- Akçamli, D., Sipahi, S., Yüksel, I., et al. (2018). Futbolcularda Peroksizom Proliferatör – Aktive Reseptör Alfa rs4253778 Polimorfizm Dağılımının Belirlenmesi. Eurasian Research in Sport Science, 3(2), 75-79.
- Braissant, O., Foufelle, F., Scotto, C., Dauca, M., Wahli, W. (1996). Differential expression of peroxisome proliferator-activated receptors (PPARs): tissue distribution of PPAR-alpha, -beta, and -gamma in the adult rat. Endocrinology, 137, 354–366.
- Corak, A., Kapıcı, S., Sercan, C., Akkoç, O., Ulucan, K. (2017). A pilot study for determination of anxiety related SLC6A4 promoter "S" and "L" alleles in healthy Turkish athletes. Cellular and Molecular Biology, 63(5), 29-31.
- Desvergne, B., Wahli, W. (1999). Peroxisome proliferator-activated receptors: nuclear control of metabolism. Endocr Rev, 20(5), 649–88.
- Eroğlu, O., Zileli, R., Nalbant, M.A., Ulucan, K. (2018). Prevalence of alpha actinin-3 gene (ACTN3) R577X and angiotensin converting enzyme (ACE) insertion / deletion gene polymorphisms in national and amateur Turkish athletes. Cell Mol Biol (Noisy le Grand), 64 (5), 24-28.
- Eynon, N., Meckel, Y., Sagiv, M., et al. (2010). Do PPARGC1A and PPARalpha polymorphisms influence sprint or endurance phenotypes? Scand J Med Sci Sports, 20(1), e145–e150.
- Flavell, D.M., Jamshidi, Y., Hawe, E., et al. (2002). Peroxisome proliferator-activated receptor alpha gene variants influence progression of coronary atherosclerosis and risk of coronary artery disease. Circulation, 105(12), 1440–1445.
- Ginevičienė, V., Pranckevičienė, E., Milašius, K., Kučinskas, V. (2010). Relating fitness phenotypes to genotypes in Lithuanian elite athletes. Acta Med Litu, 17(1–2), 1–10.
- Jamshidi, Y., Montgomery, H.E., Hense, H.W., et al. (2002). Peroxisome proliferator-activated receptor alpha gene regulates left ventricular growth in response to exercise and hypertension. Circulation, 105(8), 950–955.
- Leone, T.C., Weinheimer, C.J., Kelly, D.P. (1999). A critical role for the peroxisome proliferator-activated receptor alpha (PPARalpha) in the cellular fasting response: the PPARalpha-null mouse as a model of fatty acid oxidation disorders. Proc Natl Acad Sci U S A, 96: 7473–7478.
- Maciejewska, A., Sawczuk, M., Cieszczyk, P. (2011). Variation in the PPAR-alpha gene in Polish rowers. J Sci Med Sport,14(1), 58–64.
- Proia, P., Bianco, A., Schiera, G., et al. (2014). PPARα Gene Variants as Predicted Performance-Enhancing Polymorphisms in Professional Italian Soccer Players. Open Access Journal of Sports Medicine, 5, 273–278.
- Ulucan, K., Bayyurt, G.M., Konuk, M., Güney, A.I. (2014). Effect of alpha-actinin-3 gene on Turkish trained and untrained middle school children’s sprinting performance: a pilot study. Biological Rhythm Research, 45(4), 509- 514.
There are 15 citations in total.
Details
| Primary Language | English |
|---|---|
| Subjects | Sports Medicine |
| Journal Section | SPORT AND HEALTH |
| Authors | |
| Publication Date | January 30, 2020 |
| Published in Issue | Year 2020 Volume: 11 Issue: 1 |
