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Year 2020, Volume: 11 Issue: 2, 1 - 4, 29.05.2020

Abstract

References

  • Chamberlain, C. S., Crowley, E., Hirohito, Kobayashi. (2011). Quantification of Collagen Organization and Extracellular Matrix Factors within the Healing Ligament. Microsc Microanal., 17(5), 779–787.
  • Chen, B., Xin-Yu, Z., Dong-Cai, H., Jha, R.K. and Liao-Bin, C. (2016). COL1A1 rs1800012 Polymorphism Associated with Anterior Cruciate Ligament Injuries: A Meta-Analysis. Remedy Open Access - Clinical Rheumatology, 30 Dec, Volume 1, Article 1035.
  • Collins, M., Posthumus, M., Schwellnus, M. (2010). The COL1A1 gene and acute soft tissue ruptures. Br. J. Sports Med., 44, 1063-1064.
  • Erduran, M., Altinisik, J., Meric, G., Ates, O., Ulusal, A.E. and Akseki, D. (2014). Is Sp1 binding site polymorphism within COL1A1 gene associated with tennis elbow? Gene, 537, 308-311.
  • Ficek, K., Cieszczyk, P., Kaczmarczyk, M., et al. (2013). Gene variants within the COL1A1 gene are associated with reduced anterior cruciate ligament injury in professional soccer players. J Sci Med Sport, 16, 396–400.
  • Marini, J.C. and Blissett, A.R. (2013). New genes in bone development: what’s new in osteogenesis imperfecta. The Journal of clinical endocrinology and metabolism, 98, 3095-3103.
  • Nordin, M., Lorenz, T., Campello, M. (2001). Basic Biomechanics of the Musculoskeletal System. Lippincott Williams and Wilkins; Biomechanics of tendons and ligament; electronic book chapter 4, pp.102-125.
  • Khoschnau, S., Melhus, H., Jacobson, A. (2008). Type I collagen alpha1 Sp1 polymorphism and the risk of cruciate ligament ruptures or shoulder dislocations. Am J Sports Med, 36(12), 2432–2436.
  • Posthumus, M., September, A.V., Keegan, M., et al. (2009). Genetic risk factors for anterior cruciate ligament ruptures: COL1A1 gene variant. Br J Sports Med, 43(5), 352–356.
  • Stepien-Slodkowska, M., Ficek, K., Eider, J., et al. (2013). The 1245 G/T polymorphisms in the collagen type I alpha 1 (col1a1) gene in polish skiers with anterior cruciate ligament injury. Biol Sport, 30(1), 57–60.
  • Ulucan, K., Yalcin, S., Akbas, B., Uyumaz, F., Konuk, M. (2014). Analysis of Solute Carrier Family 6 Member 4 Gene promoter polymorphism in young Turkish basketball players. The journal of Neurobehavioral Sciences, 1(2), 37-40.
  • Ulucan, K. (2016). Literature Review of Turkish Sportsmen in Terms of ACTN3 R577X Polymorphism. Clinical and Experimental Health Sciences, 6(1), 44-47.
  • Wang, C., Li, H., Chen, K., Wu, B., Liu, H. (2017). Association of polymorphisms rs1800012 in COL1A1 with sports-related tendon and ligament injuries: a meta-analysis. Oncotarget, 8, 27627–27634.

Collagen type I alpha 1 (COL1A1) rs1800012 polymorphism in cyclists

Year 2020, Volume: 11 Issue: 2, 1 - 4, 29.05.2020

Abstract

Purpose: We suggested that polymorphic differences affect the performance of cyclists. In this study we designed the experiment to identify collagen type I alpha 1 (COL1A1) rs1800012 polymorphism in cyclists. 

Methods: We isolated genomic DNA from buccal epithelial cells of 38 cyclists. We followed COL1A1 rs1800012 single nucleotide polymorphism genotyping technology protocol. We reported allele frequencies for rs1800012 gene variants of cyclists in our kohort. 

Results: Our results indicated the differences of the distribution of COL1A1 rs1800012 SNP between cyclists. The numbers and percentages of CC, AC and AA genotypes for rs1800012 polymorphism that we obtained were 24 (63%), 13 (34%) and 1 (3%), respectively. The distributions of C and A alleles were counted as 61 (80%) and 15 (20%).

Conclusions: There was difference in the genotype and also allele distribution between cyclists. Carriers of a C allele as compared to carriers of the allele A are more prone to cyclism. Larger homogenous cohorts may help clarify the association between COL1A1 rs1800012 polymorphism and physical performance.

References

  • Chamberlain, C. S., Crowley, E., Hirohito, Kobayashi. (2011). Quantification of Collagen Organization and Extracellular Matrix Factors within the Healing Ligament. Microsc Microanal., 17(5), 779–787.
  • Chen, B., Xin-Yu, Z., Dong-Cai, H., Jha, R.K. and Liao-Bin, C. (2016). COL1A1 rs1800012 Polymorphism Associated with Anterior Cruciate Ligament Injuries: A Meta-Analysis. Remedy Open Access - Clinical Rheumatology, 30 Dec, Volume 1, Article 1035.
  • Collins, M., Posthumus, M., Schwellnus, M. (2010). The COL1A1 gene and acute soft tissue ruptures. Br. J. Sports Med., 44, 1063-1064.
  • Erduran, M., Altinisik, J., Meric, G., Ates, O., Ulusal, A.E. and Akseki, D. (2014). Is Sp1 binding site polymorphism within COL1A1 gene associated with tennis elbow? Gene, 537, 308-311.
  • Ficek, K., Cieszczyk, P., Kaczmarczyk, M., et al. (2013). Gene variants within the COL1A1 gene are associated with reduced anterior cruciate ligament injury in professional soccer players. J Sci Med Sport, 16, 396–400.
  • Marini, J.C. and Blissett, A.R. (2013). New genes in bone development: what’s new in osteogenesis imperfecta. The Journal of clinical endocrinology and metabolism, 98, 3095-3103.
  • Nordin, M., Lorenz, T., Campello, M. (2001). Basic Biomechanics of the Musculoskeletal System. Lippincott Williams and Wilkins; Biomechanics of tendons and ligament; electronic book chapter 4, pp.102-125.
  • Khoschnau, S., Melhus, H., Jacobson, A. (2008). Type I collagen alpha1 Sp1 polymorphism and the risk of cruciate ligament ruptures or shoulder dislocations. Am J Sports Med, 36(12), 2432–2436.
  • Posthumus, M., September, A.V., Keegan, M., et al. (2009). Genetic risk factors for anterior cruciate ligament ruptures: COL1A1 gene variant. Br J Sports Med, 43(5), 352–356.
  • Stepien-Slodkowska, M., Ficek, K., Eider, J., et al. (2013). The 1245 G/T polymorphisms in the collagen type I alpha 1 (col1a1) gene in polish skiers with anterior cruciate ligament injury. Biol Sport, 30(1), 57–60.
  • Ulucan, K., Yalcin, S., Akbas, B., Uyumaz, F., Konuk, M. (2014). Analysis of Solute Carrier Family 6 Member 4 Gene promoter polymorphism in young Turkish basketball players. The journal of Neurobehavioral Sciences, 1(2), 37-40.
  • Ulucan, K. (2016). Literature Review of Turkish Sportsmen in Terms of ACTN3 R577X Polymorphism. Clinical and Experimental Health Sciences, 6(1), 44-47.
  • Wang, C., Li, H., Chen, K., Wu, B., Liu, H. (2017). Association of polymorphisms rs1800012 in COL1A1 with sports-related tendon and ligament injuries: a meta-analysis. Oncotarget, 8, 27627–27634.
There are 13 citations in total.

Details

Primary Language English
Subjects Sports Medicine
Journal Section SPORT AND HEALTH
Authors

Beste Tacal Aslan 0000-0001-5271-7917

Başak Funda Eken This is me

Tugba Kaman

Canan Sercan This is me 0000-0002-2218-2234

Korkut Ulucan 0000-0002-1304-9386

Publication Date May 29, 2020
Published in Issue Year 2020 Volume: 11 Issue: 2

Cite

APA Tacal Aslan, B., Funda Eken, B., Kaman, T., Sercan, C., et al. (2020). Collagen type I alpha 1 (COL1A1) rs1800012 polymorphism in cyclists. Pamukkale Journal of Sport Sciences, 11(2), 1-4.