Bronşektazide Sistemik İnflamasyon Belirteci; Nötrofil Jelatinaz İlişkili Lipokalin-2

Songül Özyurt; Neslihan Özçelik; Bilge Yılmaz Kara; Medeni Arpa; Yavuz Metin; Nurgül Orhan; Aziz Gümüş

doi:10.22312/sdusbed.658668

Research Article

Bronşektazide Sistemik İnflamasyon Belirteci; Nötrofil Jelatinaz İlişkili Lipokalin-2

Year 2020, Volume: 11 Issue: 2, 186 - 190, 15.06.2020

Songül Özyurt Neslihan Özçelik Bilge Yılmaz Kara Medeni Arpa Yavuz Metin Nurgül Orhan Aziz Gümüş

Abstract

Giriş ve Amaç: Bronşektazili hastalarda kanda inflamatuar mediatörlerin artmış olduğunun gösterilmesi sistemik inflamasyonun patogenezde önemli bir rol aldığını düşündürmektedir. Çalışmamızın amacı; bronşektazi hastalarında bir inflamasyon belirteci olan Nötrofil Jelatinaz İlişkili Lipokalin-2’nin (NGAL) inflamasyonla ilişkisinin araştırılmasıdır.

Materyal ve Metod: Akut enfeksiyon semptom ve bulguları olmayan 50 bronşektazi tanılı hasta çalışmaya alındı. Romatolojik hastalık, malignite, böbrek yetmezliği, karaciğer yetmezliği ve kalp yetmezliği gibi sistemik ve kronik hastalığı olanlar çalışma dışı bırakıldı. Benzer yaş ve cinsiyet özelliğine sahip 30 sağlıklı kontrol grubu oluşturuldu. Bronşektazili hastalardan ve kontrol grubundan periferik venöz kan örneği alınarak NGAL düzeyi ölçüldü. Aynı zamanda tüm hastalara yüksek rezolüsyonlu bilgisayarlı tomografi (YRBT) çekimi yapılarak bronşektazi dağılımı ve yaygınlığı tespit edildi. Ayrıca hastalara eş zamanlı basit spirometrik ölçüm yapıldı.

Bulgular: Hastaların yaş ortalaması 58±13 idi ve 27 (%54)’si kadınlardan oluşmakta idi. Sağlıklı kontrol grubunun yaş ortalaması 59±15 idi. Bronşektazili hastaların solunum fonksiyon testlerinde; ortalama FEV1(%): 69±28 ve ortalama FEV1/FVC (%): 74±10 olarak tespit edildi. Serum NGAL düzeyi bronşektazili grupta kontrol grubuna göre anlamlı orandayüksek bulundu (Sırasıyla 74.2±24.5 ve 53.3±15.9 (p<0.001)). YRBT ile tespit edilen bronşektazi ve eşlik eden diğer radyolojik bulguların yaygınlığı ile serum NGAL düzeyleri arasında anlamlı bir ilişki tespit edilmedi. Ayrıca spirometrik akciğer volüm ölçümleri ile serum NGAL düzeyleri arasında ilişki saptanmadı.

Sonuç: Bronşektazili hastalarda NGAL’in anlamlı olarak yüksek düzeylerde saptanması, hem bronşektazinin sistemik bir hastalık olduğu bilgisini güçlendirmekte hem de bu hastalarda yeni bir sistemik inflamasyon belirteci olarak kullanılabileceğini düşündürmektedir.

Keywords

Bronşektazi, Nötrofil Jelatinaz İlişkili Lipokalin-2, İnflamasyon

References

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2. Chalmers JD, Moffitt KL, Suarez-Cuartin G, Sibila O, Finch S, Furrie E, et al. Neutrophil elastase activity is associated with exacerbations and lung function decline in bronchiectasis. American journal of respiratory and critical care medicine. 2017;195(10):1384-93.
3. Jasper AE, McIver WJ, Sapey E, Walton GM. Understanding the role of neutrophils in chronic inflammatory airway disease. F1000Research. 2019;8.
4. Schäfer J, Griese M, Chandrasekaran R, Chotirmall SH, Hartl D. Pathogenesis, imaging and clinical characteristics of CF and non-CF bronchiectasis. BMC pulmonary medicine. 2018;18(1):79.
5. Bao GH, Ho CT, Barasch J. The Ligands of Neutrophil Gelatinase-Associated Lipocalin. RSC Adv. 2015;5(126):104363-74.
6. Chakraborty S, Kaur S, Guha S, Batra SK. The multifaceted roles of neutrophil gelatinase associated lipocalin (NGAL) in inflammation and cancer. Biochimica et Biophysica Acta (BBA)-Reviews on Cancer. 2012;1826(1):129-69.
7. Weycker D, Hansen GL, Seifer FD. Prevalence and incidence of noncystic fibrosis bronchiectasis among US adults in 2013. Chronic respiratory disease. 2017;14(4):377-84.
8. Suarez-Cuartin G, Chalmers JD, Sibila O. Diagnostic challenges of bronchiectasis. Respiratory medicine. 2016;116:70-7.
9. Altenburg J, Wortel K, van der Werf TS, Boersma WG. Dutch Teaching Hospital. Netherlands Journal of Medicine. 2015;73(4):147-54.
10. Wilson C, Jones P, O'leary C, Hansell D, Dowling R, Cole P, et al. Systemic markers of inflammation in stable bronchiectasis. European Respiratory Journal. 1998;12(4):820-4.
11. Saleh AD, Chalmers JD, De Soyza A, Fardon TC, Koustas SO, Scott J, et al. The heterogeneity of systemic inflammation in bronchiectasis. Respiratory medicine. 2017;127:33-9.
12. Singh A, Bhalla AS, Jana M. Bronchiectasis revisited: imaging-based pattern approach to diagnosis. Current problems in diagnostic radiology. 2019;48(1):53-60.
13. Bhalla M, Turcios N, Aponte V, Jenkins M, Leitman B, McCauley D, et al. Cystic fibrosis: scoring system with thin-section CT. Radiology. 1991;179(3):783-8.
14. Ooi GC, Khong PL, Chan-Yeung M, Ho JC, Chan PK, Lee JC, et al. High-resolution CT quantification of bronchiectasis: clinical and functional correlation. Radiology. 2002;225(3):663-72.
15. Soni SS, Cruz D, Bobek I, Chionh CY, Nalesso F, Lentini P, et al. NGAL: a biomarker of acute kidney injury and other systemic conditions. International urology and nephrology. 2010;42(1):141-50.
16. Abella V, Scotece M, Conde J, Gómez R, Lois A, Pino J, et al. The potential of lipocalin-2/NGAL as biomarker for inflammatory and metabolic diseases. Biomarkers. 2015;20(8):565-71.
17. Bauvois B, Susin SA. Revisiting neutrophil gelatinase-associated lipocalin (NGAL) in cancer: Saint or sinner? Cancers. 2018;10(9):336.
18. Altekin E, Kenesarı Y. NGAL as a potential diagnostic biomarker. Turk Klinik Biyokimya Derg. 2013;11(1):37-41.
19. Kim JW, Hong DY, Lee KR, Kim SY, Baek KJ, Park SO. Usefulness of plasma neutrophil gelatinase-associated lipocalin concentration for predicting the severity and mortality of patients with community-acquired pneumonia. Clinica Chimica Acta. 2016;462:140-5.
20. Hong DY, Kim JW, Paik JH, Jung HM, Baek KJ, Park SO, et al. Value of plasma neutrophil gelatinase-associated lipocalin in predicting the mortality of patients with sepsis at the emergency department. Clinica Chimica Acta. 2016;452:177-81.
21. Li C, Zhang Z, Peng Y, Gao H, Wang Y, Zhao J, et al. Plasma neutrophil gelatinase-associated lipocalin levels are associated with the presence and severity of coronary heart disease. PloS one. 2019;14(8).
22. Gümüs A, Ozkaya S, Ozyurt S, Cınarka H, Kirbas A, Sahin U, et al. A novel biomarker in the diagnosis of parapneumonic effusion: neutrophil gelatinase-associated lipocalin. Multidisciplinary respiratory medicine. 2014;9(1):49.
23. Ozyurt S, Karatas M, Arpa M, Kara BY, Duman H, Memoglu M, et al. Neutrophil gelatinase-associated lipocalin as a potential biomarker for pulmonary thromboembolism. Turkish Journal of Biochemistry.
24. Gumus A, Cinarka H, Hazıroglu M, Karatas M, Ozyurt S. Neutrophil Gelatinase-Associated Lipocalin: A New Biomarker for COPD Acute Exacerbation. J Lung Pulm Respir Res. 2014;1(2):00008.
25. Arsava BE, Cöplü L. Does airway colonization cause systemic inflammation in bronchiectasis? Tuberk Toraks. 2011;59(4):340-7.
26. Coban H, Gungen AC. Is There a Correlation between New Scoring Systems and Systemic Inflammation in Stable Bronchiectasis? Canadian respiratory journal. 2017;2017.

Year 2020, Volume: 11 Issue: 2, 186 - 190, 15.06.2020

Songül Özyurt Neslihan Özçelik Bilge Yılmaz Kara Medeni Arpa Yavuz Metin Nurgül Orhan Aziz Gümüş

Abstract

References

1. Magis-Escurra C, Reijers MH. Bronchiectasis. BMJ Clin Evid. 2015;2015.
2. Chalmers JD, Moffitt KL, Suarez-Cuartin G, Sibila O, Finch S, Furrie E, et al. Neutrophil elastase activity is associated with exacerbations and lung function decline in bronchiectasis. American journal of respiratory and critical care medicine. 2017;195(10):1384-93.
3. Jasper AE, McIver WJ, Sapey E, Walton GM. Understanding the role of neutrophils in chronic inflammatory airway disease. F1000Research. 2019;8.
4. Schäfer J, Griese M, Chandrasekaran R, Chotirmall SH, Hartl D. Pathogenesis, imaging and clinical characteristics of CF and non-CF bronchiectasis. BMC pulmonary medicine. 2018;18(1):79.
5. Bao GH, Ho CT, Barasch J. The Ligands of Neutrophil Gelatinase-Associated Lipocalin. RSC Adv. 2015;5(126):104363-74.
6. Chakraborty S, Kaur S, Guha S, Batra SK. The multifaceted roles of neutrophil gelatinase associated lipocalin (NGAL) in inflammation and cancer. Biochimica et Biophysica Acta (BBA)-Reviews on Cancer. 2012;1826(1):129-69.
7. Weycker D, Hansen GL, Seifer FD. Prevalence and incidence of noncystic fibrosis bronchiectasis among US adults in 2013. Chronic respiratory disease. 2017;14(4):377-84.
8. Suarez-Cuartin G, Chalmers JD, Sibila O. Diagnostic challenges of bronchiectasis. Respiratory medicine. 2016;116:70-7.
9. Altenburg J, Wortel K, van der Werf TS, Boersma WG. Dutch Teaching Hospital. Netherlands Journal of Medicine. 2015;73(4):147-54.
10. Wilson C, Jones P, O'leary C, Hansell D, Dowling R, Cole P, et al. Systemic markers of inflammation in stable bronchiectasis. European Respiratory Journal. 1998;12(4):820-4.
11. Saleh AD, Chalmers JD, De Soyza A, Fardon TC, Koustas SO, Scott J, et al. The heterogeneity of systemic inflammation in bronchiectasis. Respiratory medicine. 2017;127:33-9.
12. Singh A, Bhalla AS, Jana M. Bronchiectasis revisited: imaging-based pattern approach to diagnosis. Current problems in diagnostic radiology. 2019;48(1):53-60.
13. Bhalla M, Turcios N, Aponte V, Jenkins M, Leitman B, McCauley D, et al. Cystic fibrosis: scoring system with thin-section CT. Radiology. 1991;179(3):783-8.
14. Ooi GC, Khong PL, Chan-Yeung M, Ho JC, Chan PK, Lee JC, et al. High-resolution CT quantification of bronchiectasis: clinical and functional correlation. Radiology. 2002;225(3):663-72.
15. Soni SS, Cruz D, Bobek I, Chionh CY, Nalesso F, Lentini P, et al. NGAL: a biomarker of acute kidney injury and other systemic conditions. International urology and nephrology. 2010;42(1):141-50.
16. Abella V, Scotece M, Conde J, Gómez R, Lois A, Pino J, et al. The potential of lipocalin-2/NGAL as biomarker for inflammatory and metabolic diseases. Biomarkers. 2015;20(8):565-71.
17. Bauvois B, Susin SA. Revisiting neutrophil gelatinase-associated lipocalin (NGAL) in cancer: Saint or sinner? Cancers. 2018;10(9):336.
18. Altekin E, Kenesarı Y. NGAL as a potential diagnostic biomarker. Turk Klinik Biyokimya Derg. 2013;11(1):37-41.
19. Kim JW, Hong DY, Lee KR, Kim SY, Baek KJ, Park SO. Usefulness of plasma neutrophil gelatinase-associated lipocalin concentration for predicting the severity and mortality of patients with community-acquired pneumonia. Clinica Chimica Acta. 2016;462:140-5.
20. Hong DY, Kim JW, Paik JH, Jung HM, Baek KJ, Park SO, et al. Value of plasma neutrophil gelatinase-associated lipocalin in predicting the mortality of patients with sepsis at the emergency department. Clinica Chimica Acta. 2016;452:177-81.
21. Li C, Zhang Z, Peng Y, Gao H, Wang Y, Zhao J, et al. Plasma neutrophil gelatinase-associated lipocalin levels are associated with the presence and severity of coronary heart disease. PloS one. 2019;14(8).
22. Gümüs A, Ozkaya S, Ozyurt S, Cınarka H, Kirbas A, Sahin U, et al. A novel biomarker in the diagnosis of parapneumonic effusion: neutrophil gelatinase-associated lipocalin. Multidisciplinary respiratory medicine. 2014;9(1):49.
23. Ozyurt S, Karatas M, Arpa M, Kara BY, Duman H, Memoglu M, et al. Neutrophil gelatinase-associated lipocalin as a potential biomarker for pulmonary thromboembolism. Turkish Journal of Biochemistry.
24. Gumus A, Cinarka H, Hazıroglu M, Karatas M, Ozyurt S. Neutrophil Gelatinase-Associated Lipocalin: A New Biomarker for COPD Acute Exacerbation. J Lung Pulm Respir Res. 2014;1(2):00008.
25. Arsava BE, Cöplü L. Does airway colonization cause systemic inflammation in bronchiectasis? Tuberk Toraks. 2011;59(4):340-7.
26. Coban H, Gungen AC. Is There a Correlation between New Scoring Systems and Systemic Inflammation in Stable Bronchiectasis? Canadian respiratory journal. 2017;2017.

There are 26 citations in total.

Details

Primary Language	Turkish
Subjects	Health Care Administration
Journal Section	Original Article
Authors	Songül Özyurt 0000-0002-9768-1425 Neslihan Özçelik 0000-0002-4672-6179 Bilge Yılmaz Kara 0000-0003-2690-4932 Medeni Arpa 0000-0001-8321-4829 Yavuz Metin 0000-0002-5238-8911 Nurgül Orhan 0000-0001-8286-8986 Aziz Gümüş 0000-0001-5396-5402
Publication Date	June 15, 2020
Submission Date	December 13, 2019
Published in Issue	Year 2020 Volume: 11 Issue: 2

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Vancouver	Özyurt S, Özçelik N, Yılmaz Kara B, Arpa M, Metin Y, Orhan N, Gümüş A. Bronşektazide Sistemik İnflamasyon Belirteci; Nötrofil Jelatinaz İlişkili Lipokalin-2. Süleyman Demirel Üniversitesi Sağlık Bilimleri Dergisi. 2020;11(2):186-90.

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SDÜ Sağlık Bilimleri Dergisi, makalenin gönderilmesi ve yayınlanması dahil olmak üzere hiçbir aşamada herhangi bir ücret talep etmemektedir. Dergimiz, bilimsel araştırmaları okuyucuya ücretsiz sunmanın bilginin küresel paylaşımını artıracağı ilkesini benimseyerek, içeriğine anında açık erişim sağlamaktadır.