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Alkol Bağımlığında Glukoz Düzeyi Değerlendirmesi Önemli midir?

Year 2012, Volume: 19 Issue: 2, 51 - 54, 30.06.2012

Abdullah Akpınar Osman Şalış

Abstract

Amaç: Bu çalışmada alkol bağımlılığı hastalarındaki açlık glukoz düzeyini ve glukoz düzeyi ile alkol kullanım süresi arasındaki ilişkiyi saptamak amaçlamaktadır.
Gereç ve Yöntem: Bu çalışmada Ocak 2009 ve Mayıs 2010 tarihleri arasında Samsun Ruh Sağlığı ve Hastalıkları Hastanesi'nde alkol bağımlılığı ile yatarak tedavi gören hastaların dosyaları geriye dönük incelenmiştir. Madde kötüye kullanımı veya bağımlısı olan olgular çalışmanın dışında tutulmuştur.
Bulgular: Çalışmaya dahil edilen 124 hastanın yaş ortalaması 46.0±9.5 yıl idi ve tüm hastaların cinsiyeti erkekti. Hastaların glukoz düzeyleri 50-362 mg/dl aralığında idi. Hipoglisemi 5 (% 4.0), Normoglisemi 89 (% 71.8) Hiperglisemi (Glukoz ≥ 110 mg/dl) 30 (% 24.2)'du ve Glukoz düzeyi ≥126 mg/dl olanlar 20 (% 16.1) olarak saptandı. Tedavi öncesi açlık glukoz düzeyi ile alkol kullanım süresi (yıl) arasında doğru orantılı (r:0.2) bir bağlantı saptandı ve bu ilişki istatistiksel açıdan anlamlı idi (p:0.036).
Sonuç: Klinisyen alkol bağımlılığında glukoz seviyesini dikkatle değerlendirmelidir. Alkol bağımlısı hastalarda glukoz düzeyi ile alkol kullanım süresi arasında pozitif bağlantı mevcuttur.

Keywords

Alkol baðýmlýlýðý biyokimya glukoz

References

  • Phillips GB, Safrit HF. Induction of glucose intolerance with alcohol. JAMA 1971; 217:1513-9.
  • Greenhouse L, Lardinois CK. Alcohol-Associated Diabetes Mellitus, A Review of the Impact of Alcohol Consumption on Carbohydrate Metabolism. Arch Fam Med 1996; (5):229-33.
  • Sjoberg RJ, Kidd GS. Pancreatic diabetes mellitus. Diabetes Care 1989; 12:715-24.
  • Nealon WH, Townsend CM Jr, Thompson JC. The time course of beta cell dysfunction in chronic ethanol- induced pancreatitis: a prospective analysis. Surgery 1988; 104:1074-9.
  • Yki-Jarvinen H, Nikkila EA. Ethanol decreases glucoseutilization in healthy man. J Clin Endocrinol Metab 1985; 61:941-5.
  • Bunout D, Petermann M, Bravo M, et al. Glucose turnover rate and peripheral insulin sensitivity in alcoholic patients without liver damage. Ann Nutr Metab 1989; 33:31-8.
  • T ü r k c a n A . A l k o l ü n B i y o l o j i k E t k i l e r i , Farmakolojisi,Emilimi, Daðýlýmý, Metabolizmasý ve Organ Sistemleri Üzerine Etkileri. Turkiye Klinikleri Psikiyatri Dergisi 2010; 3(3):30-6.
  • Standards of Medical Care in Diabetes. American Diabetes Association. Diabetes Care 2005; 28(1):4- 36.
  • Kallas P, Sellers E: Blood glucose in intoxicated chronic alcoholics. Can Med Assoc J 1975; 112:590-2.
  • Madison L. Ethanol-induced hypoglycemia, In Levine R, Luft R (Eds): Advances in Metabolic Disorders, Vol 3. New York, NY, Academic Press, 1968; 85-109.
  • Marinella MA. Alcoholic ketoacidosis presenting with extreme hypoglycemia. Am J Emerg Med 1997;15(3):280-1.
  • Marks V. Alcohol and carbohydrate metabolism. Clin Endocrinol Metab 1978; 7:333-49.
  • Arky RA. Hypoglycemia associated with liverdisease and alcohol. Endocrinol Metab Clin North Am 1989; 18:75-80.
  • Feingold KR, Siperstein MO: Normalization of fasting blood glucose levels in insulin-requiring diabetes: The role of ethanol abstention. Diabetes Care 1983; 6:186.
  • Holbrook TL, Barrett-Connor E, Wingard DL. Aprospective population-based study of alcohol use and non insulin-dependent diabetes mellitus. Am J Epidemiol 1990;132:902-9.
  • Balkau B, Eschwege E, Fontbonne A, Claude JR, Warnet JM. Cardiovascular and alcohol-related deaths in abnormal glucose tolerant and diabetic subjects. Diabetologia 1992; 35:39-44.
  • Lu WT, Chen KW, Lin JD, Huang HS, Lee CR, Huang RS. Ketoacidosis with hyperglycemia in heavy drinkers: a report of 12 cases. Changgeng Yi Xue Za Zhi 1997;20(1):34-8.
  • Lelevich SV. Functional state of glucose metabolism in rat liver under chronic alcohol intoxication. Biomed Khim 2009; 55(6):727-33.
  • Xue R, Zhang S, Deng C, Dong L, Liu T, Wang J et al. Simultaneous determination of blood glucose and isoleucine levels in rats after chronic alcohol exposure by microwave-assisted derivatization and isotope dilution gas chromatography/mass spectrometry. Rapid Commun Mass Spectom 2008; 22(2):245-52.
  • Zhang J, Sun X, Tang L.. Effects of chronic alcohol intake on serum glucose and insulin of rats. Wei Sheng Yan Jiu 2002; 31(2):88-90.
  • Eren I, Erdi O, Ozcankaya R. Relationship between blood glucose control and psychiatric disorders in type II diabetic patients. Türk Psikiyatri Dergisi 2003;14(3):184-91.
  • Ruhland B, Walker L, Wollitzer AO, Peterson CM. Ethanol influences class I and class II MHC antigen expression on human fetal islet-like cell clusters. Alcohol Clin Exp Res 1991;15:745-7.
  • Yüncü Z, Yýldýz U, Kesebir S, Altýntoprak E, Coþkunol H. Alkol Kullaným Bozukluðu Olan Olgularýn Sosyal Destek Sistemlerinin Deðerlendirilmesi. Baðýmlýlýk Dergisi 2005; 6(3):129-135.

Year 2012, Volume: 19 Issue: 2, 51 - 54, 30.06.2012

Abdullah Akpınar Osman Şalış

Abstract

References

  • Phillips GB, Safrit HF. Induction of glucose intolerance with alcohol. JAMA 1971; 217:1513-9.
  • Greenhouse L, Lardinois CK. Alcohol-Associated Diabetes Mellitus, A Review of the Impact of Alcohol Consumption on Carbohydrate Metabolism. Arch Fam Med 1996; (5):229-33.
  • Sjoberg RJ, Kidd GS. Pancreatic diabetes mellitus. Diabetes Care 1989; 12:715-24.
  • Nealon WH, Townsend CM Jr, Thompson JC. The time course of beta cell dysfunction in chronic ethanol- induced pancreatitis: a prospective analysis. Surgery 1988; 104:1074-9.
  • Yki-Jarvinen H, Nikkila EA. Ethanol decreases glucoseutilization in healthy man. J Clin Endocrinol Metab 1985; 61:941-5.
  • Bunout D, Petermann M, Bravo M, et al. Glucose turnover rate and peripheral insulin sensitivity in alcoholic patients without liver damage. Ann Nutr Metab 1989; 33:31-8.
  • T ü r k c a n A . A l k o l ü n B i y o l o j i k E t k i l e r i , Farmakolojisi,Emilimi, Daðýlýmý, Metabolizmasý ve Organ Sistemleri Üzerine Etkileri. Turkiye Klinikleri Psikiyatri Dergisi 2010; 3(3):30-6.
  • Standards of Medical Care in Diabetes. American Diabetes Association. Diabetes Care 2005; 28(1):4- 36.
  • Kallas P, Sellers E: Blood glucose in intoxicated chronic alcoholics. Can Med Assoc J 1975; 112:590-2.
  • Madison L. Ethanol-induced hypoglycemia, In Levine R, Luft R (Eds): Advances in Metabolic Disorders, Vol 3. New York, NY, Academic Press, 1968; 85-109.
  • Marinella MA. Alcoholic ketoacidosis presenting with extreme hypoglycemia. Am J Emerg Med 1997;15(3):280-1.
  • Marks V. Alcohol and carbohydrate metabolism. Clin Endocrinol Metab 1978; 7:333-49.
  • Arky RA. Hypoglycemia associated with liverdisease and alcohol. Endocrinol Metab Clin North Am 1989; 18:75-80.
  • Feingold KR, Siperstein MO: Normalization of fasting blood glucose levels in insulin-requiring diabetes: The role of ethanol abstention. Diabetes Care 1983; 6:186.
  • Holbrook TL, Barrett-Connor E, Wingard DL. Aprospective population-based study of alcohol use and non insulin-dependent diabetes mellitus. Am J Epidemiol 1990;132:902-9.
  • Balkau B, Eschwege E, Fontbonne A, Claude JR, Warnet JM. Cardiovascular and alcohol-related deaths in abnormal glucose tolerant and diabetic subjects. Diabetologia 1992; 35:39-44.
  • Lu WT, Chen KW, Lin JD, Huang HS, Lee CR, Huang RS. Ketoacidosis with hyperglycemia in heavy drinkers: a report of 12 cases. Changgeng Yi Xue Za Zhi 1997;20(1):34-8.
  • Lelevich SV. Functional state of glucose metabolism in rat liver under chronic alcohol intoxication. Biomed Khim 2009; 55(6):727-33.
  • Xue R, Zhang S, Deng C, Dong L, Liu T, Wang J et al. Simultaneous determination of blood glucose and isoleucine levels in rats after chronic alcohol exposure by microwave-assisted derivatization and isotope dilution gas chromatography/mass spectrometry. Rapid Commun Mass Spectom 2008; 22(2):245-52.
  • Zhang J, Sun X, Tang L.. Effects of chronic alcohol intake on serum glucose and insulin of rats. Wei Sheng Yan Jiu 2002; 31(2):88-90.
  • Eren I, Erdi O, Ozcankaya R. Relationship between blood glucose control and psychiatric disorders in type II diabetic patients. Türk Psikiyatri Dergisi 2003;14(3):184-91.
  • Ruhland B, Walker L, Wollitzer AO, Peterson CM. Ethanol influences class I and class II MHC antigen expression on human fetal islet-like cell clusters. Alcohol Clin Exp Res 1991;15:745-7.
  • Yüncü Z, Yýldýz U, Kesebir S, Altýntoprak E, Coþkunol H. Alkol Kullaným Bozukluðu Olan Olgularýn Sosyal Destek Sistemlerinin Deðerlendirilmesi. Baðýmlýlýk Dergisi 2005; 6(3):129-135.
There are 23 citations in total.

Details

Primary Language Turkish
Journal Section Araştırma Makaleleri
Authors

Abdullah Akpınar

Osman Şalış This is me

Publication Date June 30, 2012
Submission Date December 12, 2011
Published in Issue Year 2012 Volume: 19 Issue: 2

Cite

Vancouver Akpınar A, Şalış O. Alkol Bağımlığında Glukoz Düzeyi Değerlendirmesi Önemli midir?. Med J SDU. 2012;19(2):51-4.

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