Research Article
Çok Düşük Doğum Ağırlıklı Preterm Bebeklerde Retinol Metabolizması Değişkenlerinin Prematüre Retinopatisi İle İlişkisi
Abstract
Amaç: Retinol fetusta birçok organın gelişimi için gereklidir. Bu nedenle retinol eksikliği teratojenik etkilere neden olabilir. Bu çalışmada çok düşük doğum ağırlıklı bebeklerde retinol, retinol bağlayıcı protein (RBP) ve plasental retinol transfer hızı düzeyleri ile prematüre retinopatisi (ROP) arasındaki ilişkiyi araştırmayı amaçladık.
Gereç ve Yöntemler: Çalışma ocak-aralık 2020 tarihleri arasında prospektif kohort olarak yürütüldü. Çalışmaya ≤ 30 hafta ve ≤ 1500 gr doğan bebekler dahil edildi. Major anomalileri olan anne ve bebekler dahil edilmedi. Retinol ve RBP seviyeleri umblikal kord ve anne kanında çalışıldı. Plasental retinol transfer oranını hesaplandı. Retinol, RBP ve plasental transfer oranının karşılaştırması herhangi bir evre ROP (+) ve ROP (-) grupları arasında yapıldı. ROP tedavisi gerektiren hastalarda retinol, RBP durumu ve plasenta transfer oranının etkileri araştırıldı.
Bulgular: Toplam 30 hastanın ROP incelemeleri tamamlandı. ROP olan ve olmayanların umblikal kord ve maternal retinol seviyeleri arasında istatistiksel olarak anlamlı bir fark görülmezken, plasental retinol transfer hızı ROP (+) grubunda anlamlı olarak daha düşüktü. Plasental retinol transfer hızı ile ROP evresi arasında negatif korelasyon vardı. ROP olanların alt grup analizinde, tedaviye ihtiyaç duyanların plasental retinol transfer oranının ROP olmayanlara göre daha düşük olduğu bulundu.
Sonuç: Plasental retinol transfer hızı, prematüre bebeklerde tedavi gerektiren ROP için bir prediktif faktör olarak kullanılabilir. Ancak daha geniş katılımlı çalışmalara ihtiyaç vardır.
Keywords
Supporting Institution
Atatürk Üniversitesi Bilimsel Araştırma Projeleri Fonu
Project Number
TSA-2020-8818
References
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- 5) Morriss-Kay GM, Ward SJ. Retinoids and mammalian development. Int Rev Cytol. 1999; 188:73-131. doi:10.1016/s0074-7696(08)61566-1.
- 6) Zhang BY, Zhang T, Lin LM, Wang F, Xin RL, Gu X, et al. Correlation between birth defects and dietary nutrition status in a high incidence area of China. Biomed Environ Sci. 2008; 21(1):37–44. doi: 10.1016/S0895-3988(08)60005
- 7) Lammer EJ, Chen DT, Hoar RM, Agnish ND, Benke PJ, Braun JT, Curry CJ, Fernhoff PM, Grix AW Jr, Lott IT, et al. Retinoic acid embryopathy. N Engl J Med. 1985; 3;313(14):837-41. doi: 10.1056/NEJM198510033131401.
- 8) Bastos Maia S, Rolland Souza AS, Costa Caminha MF, Lins da Silva S, Callou Cruz RSBL, Carvalho Dos Santos C, et al. Vitamin A and Pregnancy: A Narrative Review. Nutrients. 2019: 22;11(3):681. doi: 10.3390/nu11030681.
- 9) Marceau G, Gallot D, Lemery D, Sapin V. Metabolism of retinol during mammalian placental and embryonic development. Vitam Horm. 2007: 75:97-115. https://doi.org/ 10.1016/S0083-6729(06)75004-X.
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- 11) Thoene M, Haskett H, Furtado J, Thompson M, Van Ormer M, Hanson C, et al. Effect of Maternal Retinol Status at Time of Term Delivery on Retinol Placental Concentration, Intrauterine Transfer Rate, and Newborn Retinol Status. Biomedicines. 2020: 8(9):321. doi:10.3390/biomedicines8090321.
- 12) Quadro L, Hamberger L, Gottesman ME, Colantuoni V, Ramakrishnan R, Blaner WS. Transplacental delivery of retinoid: the role of retinol-binding protein and lipoprotein retinyl ester. Am J Physiol Endocrinol Metab. 2004: 286(5):E844-51. doi: 10.1152/ajpendo.00556.2003.
- 13) Brandt RB, Mueller DG, Schroeder JR, Guyer KE, Kirkpatrick BV, Hutcher NE et. Serum vitamin A in premature and term neonates. J Pediatr 1978: 92:101e4. doi: 10.1016/s0022-3476(78)80086-9.
- 14) Mactier H. Vitamin A for preterm infants; where are we now? Semin Fetal Neonatal Med. 2013 ;18(3):166-171. doi: 10.1016/j.siny.2013.01.004.
- 15) Pal S, Iruela-Arispe ML, Harvey VS, et al. Retinoic acid selectively inhibits the vascular permeabilizing effect of VPF/VEGF, an early step in the angiogenic cascade. Microvasc Res. 2000; 60:112-20.
- 16) Darlow BA, Graham PJ, Rojas-Reyes MX. Vitamin A supplementation to prevent mortality and short- and long-term morbidity in very low birth weight infants. Cochrane Database Syst Rev. 2016: 22;2016(8):CD000501. doi: 10.1002/14651858.CD000501
- 17) Sun H, Cheng R, Wang Z. Early Vıtamın A Supplementatıon Improves The Outcome Of Retınopathy Of Prematurıty In Extremely Preterm Infants. Retina. 2020; 40(6):1176-1184. doi:10.1097/IAE.0000000000002543.
- 18) Arun Özer E, Sivaslı Gül Ö, Men G, Talay E, Sütçüoğlu S, Kanık A, Türkoğlu E, Kahramaner Z, Coşar H, Erdemir A, Yaprak I. Retinopathy of Prematurity in Very Low Birth Weight Infants: Effects of Serum Vitamin A and Clinical Parameters. Turk J Ophthalmol 2011; 41:309-313.
- 19) Inder TE, Graham PJ, Winterbourn CC, Austin NC, Darlow BA. Plasma vitamin A levels in the very low birthweight infant e relationship to respiratory outcome. Early Hum Dev 1998; 52:155e68. https://doi.org/ 10.1016/s0378-3782(98)00026-7
- 20) Chen HJ, Hsu CH, Chiang BL. Serum retinol levels and neonatal outcomes in preterm infants. J Formos Med Assoc. 2017: 116(8):626-633. doi: 10.1016/j.jfma.2017.04.019.
Year 2021,
Volume: 11 Issue: 3, 654 - 660, 22.09.2021
Abstract
Project Number
TSA-2020-8818
References
- 1) Bas AY, Demirel N, Koc E, Ulubas Isik D, Hirfanoglu İM, Tunc T; TR-ROP Study Group. Incidence, risk factors and severity of retinopathy of prematurity in Turkey (TR-ROP study): a prospective, multicentre study in 69 neonatal intensive care units. Br J Ophthalmol. 2018; 102(12):1711-1716. doi: 10.1136/bjophthalmol-2017-311789.
- 2) Sun Y, Hellström A, Smith Lois EH. Retinopathy of prematurity. In: Martin RJ, Fanaroff AA, Walsh MC, (eds). Fanaroff and Martin’s neonatal perinatal medicine- diseases of the fetus and newborn. Philadelphia: Elsevier; 2015;.p.1767-74.
- 3) Agrawal G, Dutta S, Prasad R, Dogra MR. Fetal oxidative stress, micronutrient deficiency and risk of retinopathy of prematurity: a nested case-control study. Eur J Pediatr. 2021 Jan 7. doi: 10.1007/s00431-020-03896-x.
- 4) Section on Ophthalmology, American Academy of Pediatrics; American Academy of Ophthalmology; American Association for Pediatric Ophthalmology and Strabismus. Screening examination of premature infants for retinopathy of prematurity. Pediatrics 2013; 131: 189-95.
- 5) Morriss-Kay GM, Ward SJ. Retinoids and mammalian development. Int Rev Cytol. 1999; 188:73-131. doi:10.1016/s0074-7696(08)61566-1.
- 6) Zhang BY, Zhang T, Lin LM, Wang F, Xin RL, Gu X, et al. Correlation between birth defects and dietary nutrition status in a high incidence area of China. Biomed Environ Sci. 2008; 21(1):37–44. doi: 10.1016/S0895-3988(08)60005
- 7) Lammer EJ, Chen DT, Hoar RM, Agnish ND, Benke PJ, Braun JT, Curry CJ, Fernhoff PM, Grix AW Jr, Lott IT, et al. Retinoic acid embryopathy. N Engl J Med. 1985; 3;313(14):837-41. doi: 10.1056/NEJM198510033131401.
- 8) Bastos Maia S, Rolland Souza AS, Costa Caminha MF, Lins da Silva S, Callou Cruz RSBL, Carvalho Dos Santos C, et al. Vitamin A and Pregnancy: A Narrative Review. Nutrients. 2019: 22;11(3):681. doi: 10.3390/nu11030681.
- 9) Marceau G, Gallot D, Lemery D, Sapin V. Metabolism of retinol during mammalian placental and embryonic development. Vitam Horm. 2007: 75:97-115. https://doi.org/ 10.1016/S0083-6729(06)75004-X.
- 10) Koç E, Baş AY, Özdek Ş, Ovalı F, Başmak H. Turkish Neonatal and Turkish Ophthalmology Societies consensus guideline on the retinopathy of prematurity. Turk Pediatri Ars. 2018; 25;53(Suppl 1):S151-S160. doi: 10.5152/TurkPediatriArs.2018.01815.
- 11) Thoene M, Haskett H, Furtado J, Thompson M, Van Ormer M, Hanson C, et al. Effect of Maternal Retinol Status at Time of Term Delivery on Retinol Placental Concentration, Intrauterine Transfer Rate, and Newborn Retinol Status. Biomedicines. 2020: 8(9):321. doi:10.3390/biomedicines8090321.
- 12) Quadro L, Hamberger L, Gottesman ME, Colantuoni V, Ramakrishnan R, Blaner WS. Transplacental delivery of retinoid: the role of retinol-binding protein and lipoprotein retinyl ester. Am J Physiol Endocrinol Metab. 2004: 286(5):E844-51. doi: 10.1152/ajpendo.00556.2003.
- 13) Brandt RB, Mueller DG, Schroeder JR, Guyer KE, Kirkpatrick BV, Hutcher NE et. Serum vitamin A in premature and term neonates. J Pediatr 1978: 92:101e4. doi: 10.1016/s0022-3476(78)80086-9.
- 14) Mactier H. Vitamin A for preterm infants; where are we now? Semin Fetal Neonatal Med. 2013 ;18(3):166-171. doi: 10.1016/j.siny.2013.01.004.
- 15) Pal S, Iruela-Arispe ML, Harvey VS, et al. Retinoic acid selectively inhibits the vascular permeabilizing effect of VPF/VEGF, an early step in the angiogenic cascade. Microvasc Res. 2000; 60:112-20.
- 16) Darlow BA, Graham PJ, Rojas-Reyes MX. Vitamin A supplementation to prevent mortality and short- and long-term morbidity in very low birth weight infants. Cochrane Database Syst Rev. 2016: 22;2016(8):CD000501. doi: 10.1002/14651858.CD000501
- 17) Sun H, Cheng R, Wang Z. Early Vıtamın A Supplementatıon Improves The Outcome Of Retınopathy Of Prematurıty In Extremely Preterm Infants. Retina. 2020; 40(6):1176-1184. doi:10.1097/IAE.0000000000002543.
- 18) Arun Özer E, Sivaslı Gül Ö, Men G, Talay E, Sütçüoğlu S, Kanık A, Türkoğlu E, Kahramaner Z, Coşar H, Erdemir A, Yaprak I. Retinopathy of Prematurity in Very Low Birth Weight Infants: Effects of Serum Vitamin A and Clinical Parameters. Turk J Ophthalmol 2011; 41:309-313.
- 19) Inder TE, Graham PJ, Winterbourn CC, Austin NC, Darlow BA. Plasma vitamin A levels in the very low birthweight infant e relationship to respiratory outcome. Early Hum Dev 1998; 52:155e68. https://doi.org/ 10.1016/s0378-3782(98)00026-7
- 20) Chen HJ, Hsu CH, Chiang BL. Serum retinol levels and neonatal outcomes in preterm infants. J Formos Med Assoc. 2017: 116(8):626-633. doi: 10.1016/j.jfma.2017.04.019.
There are 20 citations in total.
Details
| Primary Language | Turkish |
|---|---|
| Subjects | Health Care Administration |
| Journal Section | Articles |
| Authors | |
| Project Number | TSA-2020-8818 |
| Publication Date | September 22, 2021 |
| Submission Date | April 13, 2021 |
| Published in Issue | Year 2021 Volume: 11 Issue: 3 |
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