Abstract
Objective: There are few studies investigating the impact of the COVID-19 pandemic on patients using omalizumab. In this study, it was aimed to investigate the effects of the COVID-19 pandemic on our patients who have been treating with omalizumab.
Material and Methods: From two centers, a total of 20 patients participated in the study. A questionnaire, consisting of 45 questions prepared by our department, and a visual analogue scale (0: minimum, 10: maximum) were applied face-to-face to the patients.
Results: It was observed that six patients (30%) did not continue their omalizumab treatment during the pandemic period. While 90% (n=18) of the patients were wearing masks, 85% (n=17) stated that they paid attention to social distance. In our study, the frequency of COVID-19 infection in patients using omalizumab was 10% (n=2). With the pandemic, while our patients’ working-study habits were affected negatively (n=10, 50%), their appetite increased (n=8, 40%), and it was noted that there have been changes in their sleep patterns (n=8, 40%).
Conclusion: The COVID-19 pandemic has significantly affected our patients’ treatments and follow-ups. Our results support the argument that the use of omalizumab does not increase the risk of SARS-CoV-2 infection.
Keywords
References
- Del Rio C, Malani PN. COVID-19—new insights on a rapidly changing epidemic. JAMA 2020;323:1339-40.
- World Health Organization. WHO Director-General’s opening remarks at the media briefing on COVID-19 - 11 March 2020. Available from:https://www.who.int/dg/speeches/detail/who-director-general-s-opening-remarks-at-the-mediabriefing-on-covid-19—11-march-2020. Accessed March 15, 2020.
- Lu X, Zhang L, Du H, Zhang J, Li YY, Qu J, et al. SARS-CoV-2 infection in children. N Engl J Med 2020;382:1663-5.
- Stokes J, Casale BT, Anti-IgE therapy, Available at: www.UpToDateInc.com/card, Accessed Apr 24, 2020.
- Buhl R. Anti-IgE antibodies for the treatment of asthma. Curr Opin Pulm Med 2005;11:27-34.
- Denman S, Ford K, Toolan J, Mistry A, Corps C, Wood P, et al. Home self-administration of omalizumab for chronic spontaneous urticaria. Br J Dermatol 2016;175:1405-7.
- Novartis receives European Commission approval for self-administration of Xolair across all indications. Available from: https://www.novartis.com/news/ media-releases/novartis-receives-european-commission-approval-self-administr ation-xolair-across-all-indications. Accessed March 15, 2020.
- Rogliani P, Calzetta L, Matera MG, Laitano R, Ritondo BL, Hanania NA, et al. Severe Asthma and Biological Therapy: When, Which, and for Whom. Pulm Ther 2020;6:47-66.
- Agache I, Rocha C, Beltran J, Song Y, Posso M, Solà I, et al. Efficacy and safety of treatment with biologicals (benralizumab, dupilumab, and omalizumab) for severe allergic asthma: A systematic review for the EAACI Guidelines - recommendations on the use of biologicals in severe asthma. Allergy 2020;75:1043-57.
- Lugogo N, Domingo C, Chanez P, Leigh R, Gilson M, Price RG, et al. Long-term efficacy and safety of mepolizumab in patients with severe eosinophilic asthma: a multi-center, open-label, phase IIIb study. Clin Ther 2016;38:2058–2070.
- Leru PM, Anton VF. Real-Life Benefit of Omalizumab in Improving Control of Bronchial Asthma During COVID-19 Pandemic. Cureus 2021;17;13:e17268.
- Global Initiative for Asthma. 2019 GINA Report, Global Strategy for Asthma Management and Prevention 2019. Available from: https://ginasthma.org. Accessed March 15, 2020.
- Shaker M, Oppenheimer J, Wallace D, Lang DM, Rambasek T, et al. Optimizing Value in the Evaluation of Chronic Spontaneous Urticaria: A Cost-Effectiveness Analysis. J Allergy Clin Immunol Pract 2020;8:2360-2369.e1.
- Tarbox JA, Gutta RC, Radojicic C, Lang DM. Utility of routine laboratory testing in the management of chronic urticaria/angioedema. Ann Allergy Asthma Immunol 2011;107:239-43.
- Moulin D, Donzé O, Talabot-Ayer D, Mézin F, Palmer G, Gabay C. Interleukin (IL)-33 induces the release of pro-inflammatory mediators by mast cells. Cytokine 2007;40:216-25.
- Liu S, Zhi Y, Ying S. COVID-19, and Asthma: Reflection During the Pandemic. Clin Rev Allergy Immunol 2020;59:78-88.
- The American Academy of Allergy, Asthma & Immunology (AAAAI). Available from: https://www.aaaai.org/ask-the-expert/covid. Accessed March 31, 2020.
- American College of Allergy, Asthma and Immunology. Available from: https://acaai.org/news/important-information-about-covid-19- those-asthma. Accessed March 31, 2020.
- British Thoracic Society. Available from:https://www.brit-thoracic.org.uk/about-us/covid-19- information-for-the-respiratory-community/. Accessed March 31, 2020.
- Centers for Disease Control and Prevention (CDC). COVID-19: People who are at higher risk - people with asthma. Available from: https://www.cdc.gov/coronavirus/2019-ncov/specific-groups/asthma.html. Accessed January 05, 2020.
- Self-administration of Xolair prefilled syringe (PFS) for asthma during the COVID-19 pandemic. Available from: https://www.gene.com/ medical-professionals/medicines/Xolair. Accessed April 23, 2020.
- King C, Cox F, Sloan A, McCrea P, Edgar JD, Conlon N. Rapid transition to home omalizumab treatment for chronic spontaneous urticaria during the COVID-19 pandemic: A patient perspective. World Allergy Organ J 2021;14:100587.
- Timmermann H, Mailänder C. Home Self-Administration of Biologics - A German Survey among Omalizumab-Treated Patients with Severe Asthma and their Treating Physicians. Pneumologie 2020;74:103-11.
- Klimek L, Pfaar O, Worm M, Eiwegger T, Hagemann J, Ollert M, et al. Use of biologicals in allergic and type-2 inflammatory diseases during the current COVID-19 pandemic: Position paper of Ärzteverband Deutscher Allergologen (AeDA)A, Deutsche Gesellschaft für Allergologie und Klinische Immunologie (DGAKI)B, Gesellschaft für Pädiatrische Allergologie und Umweltmedizin (GPA)C, Österreichische Gesellschaft für Allergologie und Immunologie (ÖGAI)D, Luxemburgische Gesellschaft für Allergologie und Immunologie (LGAI)E, Österreichische Gesellschaft für Pneumologie (ÖGP)F in co-operation with the German, Austrian, and Swiss ARIA groupsG, and the European Academy of Allergy and Clinical Immunology (EAACI)H. Allergol Select 2020;7;4:53-68.
- Deolmi M, Pisani F. Psychological and psychiatric impact of COVID-19 pandemic among children and adolescents. Acta Biomed 2020;10;91:e2020149.
- Ding X, Yao J. Peer Education Intervention on Adolescents’ Anxiety, Depression, and Sleep Disorder during the COVID-19 Pandemic. Psychiatr Danub 2020;32:527-35.
- Shanahan L, Copeland WE, Angold A, Bondy CL, Costello EJ. Sleep problems predict and are predicted by generalized anxiety/depression and oppositional defiant disorder. J Am Acad Child Adolesc Psychiatry 2014; 53:550-8.
- López-Moreno M, López MTI, Miguel M, Garcés-Rimón M. Physical and Psychological Effects Related to Food Habits and Lifestyle Changes Derived from Covid-19 Home Confinement in the Spanish Population. Nutrients 2020;12:3445.
- Cekic S, Karali Z, Cicek F, Canitez Y, Sapan N. The Impact of the COVID-19 Pandemic in Adolescents with Asthma. J Korean Med Sci 2021;36:e339.
- Radu MC, Schnakovszky C, Herghelegiu E, Ciubotariu VA, Cristea I. The Impact of the COVID-19 Pandemic on the Quality of Educational Process: A Student Survey. Int J Environ Res Public Health 2020;17:7770.
- Gopal R, Singh V, Aggarwal A. Impact of online classes on the satisfaction and performance of students during the pandemic period of COVID 19. Educ Inf Technol (Dordr) 2021;26:6923-47.
Abstract
Amaç: Omalizumab kullanan hastalarda COVİD-19 pandemisinin etkisini araştıran az sayıda çalışma bulunmaktadır. Bu çalışmada, omalizumab tedavisi alan hastalarımızda COVİD-19 pandemisinin etkilerinin araştırılması amaçlandı.
Gereç ve Yöntemler: Çalışmaya iki merkezden toplam 20 hasta katıldı. Hastalara tarafımızca hazırlanan 45 sorudan oluşan anket ve görsel analog skala (0: minimum, 10: maksimum) yüz yüze uygulandı.
Bulgular: Altı hastanın (%30) pandemi döneminde omalizumab tedavisine devam etmediği görüldü. Hastaların %90’ı (n=18) maske takıyorken, %85’i (n=17) sosyal mesafeye dikkat ettiğini belirtti. Çalışmamızda omalizumab kullanan hastalarda COVİD-19 enfeksiyon sıklığı %10 (n=2)’di. Pandemi ile hastalarımızın ders çalışma alışkanlıkları olumsuz etkilenirken (n=10, %50), iştahlarının arttığı (n=8, %40) ve uyku düzeninde değişiklikler (n=8, %40) olduğu tespit edildi.
Sonuç: COVİD-19 pandemisi hastalarımızın tedavi ve takiplerini önemli ölçüde etkilemiştir. Sonuçlarımız, omalizumab kullanımının COVİD-19 enfeksiyonu riskini artırmadığı görüşünü desteklemektedir.
Keywords
References
- Del Rio C, Malani PN. COVID-19—new insights on a rapidly changing epidemic. JAMA 2020;323:1339-40.
- World Health Organization. WHO Director-General’s opening remarks at the media briefing on COVID-19 - 11 March 2020. Available from:https://www.who.int/dg/speeches/detail/who-director-general-s-opening-remarks-at-the-mediabriefing-on-covid-19—11-march-2020. Accessed March 15, 2020.
- Lu X, Zhang L, Du H, Zhang J, Li YY, Qu J, et al. SARS-CoV-2 infection in children. N Engl J Med 2020;382:1663-5.
- Stokes J, Casale BT, Anti-IgE therapy, Available at: www.UpToDateInc.com/card, Accessed Apr 24, 2020.
- Buhl R. Anti-IgE antibodies for the treatment of asthma. Curr Opin Pulm Med 2005;11:27-34.
- Denman S, Ford K, Toolan J, Mistry A, Corps C, Wood P, et al. Home self-administration of omalizumab for chronic spontaneous urticaria. Br J Dermatol 2016;175:1405-7.
- Novartis receives European Commission approval for self-administration of Xolair across all indications. Available from: https://www.novartis.com/news/ media-releases/novartis-receives-european-commission-approval-self-administr ation-xolair-across-all-indications. Accessed March 15, 2020.
- Rogliani P, Calzetta L, Matera MG, Laitano R, Ritondo BL, Hanania NA, et al. Severe Asthma and Biological Therapy: When, Which, and for Whom. Pulm Ther 2020;6:47-66.
- Agache I, Rocha C, Beltran J, Song Y, Posso M, Solà I, et al. Efficacy and safety of treatment with biologicals (benralizumab, dupilumab, and omalizumab) for severe allergic asthma: A systematic review for the EAACI Guidelines - recommendations on the use of biologicals in severe asthma. Allergy 2020;75:1043-57.
- Lugogo N, Domingo C, Chanez P, Leigh R, Gilson M, Price RG, et al. Long-term efficacy and safety of mepolizumab in patients with severe eosinophilic asthma: a multi-center, open-label, phase IIIb study. Clin Ther 2016;38:2058–2070.
- Leru PM, Anton VF. Real-Life Benefit of Omalizumab in Improving Control of Bronchial Asthma During COVID-19 Pandemic. Cureus 2021;17;13:e17268.
- Global Initiative for Asthma. 2019 GINA Report, Global Strategy for Asthma Management and Prevention 2019. Available from: https://ginasthma.org. Accessed March 15, 2020.
- Shaker M, Oppenheimer J, Wallace D, Lang DM, Rambasek T, et al. Optimizing Value in the Evaluation of Chronic Spontaneous Urticaria: A Cost-Effectiveness Analysis. J Allergy Clin Immunol Pract 2020;8:2360-2369.e1.
- Tarbox JA, Gutta RC, Radojicic C, Lang DM. Utility of routine laboratory testing in the management of chronic urticaria/angioedema. Ann Allergy Asthma Immunol 2011;107:239-43.
- Moulin D, Donzé O, Talabot-Ayer D, Mézin F, Palmer G, Gabay C. Interleukin (IL)-33 induces the release of pro-inflammatory mediators by mast cells. Cytokine 2007;40:216-25.
- Liu S, Zhi Y, Ying S. COVID-19, and Asthma: Reflection During the Pandemic. Clin Rev Allergy Immunol 2020;59:78-88.
- The American Academy of Allergy, Asthma & Immunology (AAAAI). Available from: https://www.aaaai.org/ask-the-expert/covid. Accessed March 31, 2020.
- American College of Allergy, Asthma and Immunology. Available from: https://acaai.org/news/important-information-about-covid-19- those-asthma. Accessed March 31, 2020.
- British Thoracic Society. Available from:https://www.brit-thoracic.org.uk/about-us/covid-19- information-for-the-respiratory-community/. Accessed March 31, 2020.
- Centers for Disease Control and Prevention (CDC). COVID-19: People who are at higher risk - people with asthma. Available from: https://www.cdc.gov/coronavirus/2019-ncov/specific-groups/asthma.html. Accessed January 05, 2020.
- Self-administration of Xolair prefilled syringe (PFS) for asthma during the COVID-19 pandemic. Available from: https://www.gene.com/ medical-professionals/medicines/Xolair. Accessed April 23, 2020.
- King C, Cox F, Sloan A, McCrea P, Edgar JD, Conlon N. Rapid transition to home omalizumab treatment for chronic spontaneous urticaria during the COVID-19 pandemic: A patient perspective. World Allergy Organ J 2021;14:100587.
- Timmermann H, Mailänder C. Home Self-Administration of Biologics - A German Survey among Omalizumab-Treated Patients with Severe Asthma and their Treating Physicians. Pneumologie 2020;74:103-11.
- Klimek L, Pfaar O, Worm M, Eiwegger T, Hagemann J, Ollert M, et al. Use of biologicals in allergic and type-2 inflammatory diseases during the current COVID-19 pandemic: Position paper of Ärzteverband Deutscher Allergologen (AeDA)A, Deutsche Gesellschaft für Allergologie und Klinische Immunologie (DGAKI)B, Gesellschaft für Pädiatrische Allergologie und Umweltmedizin (GPA)C, Österreichische Gesellschaft für Allergologie und Immunologie (ÖGAI)D, Luxemburgische Gesellschaft für Allergologie und Immunologie (LGAI)E, Österreichische Gesellschaft für Pneumologie (ÖGP)F in co-operation with the German, Austrian, and Swiss ARIA groupsG, and the European Academy of Allergy and Clinical Immunology (EAACI)H. Allergol Select 2020;7;4:53-68.
- Deolmi M, Pisani F. Psychological and psychiatric impact of COVID-19 pandemic among children and adolescents. Acta Biomed 2020;10;91:e2020149.
- Ding X, Yao J. Peer Education Intervention on Adolescents’ Anxiety, Depression, and Sleep Disorder during the COVID-19 Pandemic. Psychiatr Danub 2020;32:527-35.
- Shanahan L, Copeland WE, Angold A, Bondy CL, Costello EJ. Sleep problems predict and are predicted by generalized anxiety/depression and oppositional defiant disorder. J Am Acad Child Adolesc Psychiatry 2014; 53:550-8.
- López-Moreno M, López MTI, Miguel M, Garcés-Rimón M. Physical and Psychological Effects Related to Food Habits and Lifestyle Changes Derived from Covid-19 Home Confinement in the Spanish Population. Nutrients 2020;12:3445.
- Cekic S, Karali Z, Cicek F, Canitez Y, Sapan N. The Impact of the COVID-19 Pandemic in Adolescents with Asthma. J Korean Med Sci 2021;36:e339.
- Radu MC, Schnakovszky C, Herghelegiu E, Ciubotariu VA, Cristea I. The Impact of the COVID-19 Pandemic on the Quality of Educational Process: A Student Survey. Int J Environ Res Public Health 2020;17:7770.
- Gopal R, Singh V, Aggarwal A. Impact of online classes on the satisfaction and performance of students during the pandemic period of COVID 19. Educ Inf Technol (Dordr) 2021;26:6923-47.
Details
| Primary Language | English |
|---|---|
| Subjects | Internal Diseases |
| Journal Section | ORIGINAL ARTICLES |
| Authors | |
| Publication Date | March 22, 2023 |
| Submission Date | May 13, 2022 |
| Published in Issue | Year 2023 Volume: 17 Issue: 2 |
The publication language of Turkish Journal of Pediatric Disease is English.
Manuscripts submitted to the Turkish Journal of Pediatric Disease will go through a double-blind peer-review process. Each submission will be reviewed by at least two external, independent peer reviewers who are experts in the field, in order to ensure an unbiased evaluation process. The editorial board will invite an external and independent editor to manage the evaluation processes of manuscripts submitted by editors or by the editorial board members of the journal. The Editor in Chief is the final authority in the decision-making process for all submissions. Articles accepted for publication in the Turkish Journal of Pediatrics are put in the order of publication, with at least 10 original articles in each issue, taking into account the acceptance dates. If the articles sent to the reviewers for evaluation are assessed as a senior for publication by the reviewers, the section editor and the editor considering all aspects (originality, high scientific quality and citation potential), it receives publication priority in addition to the articles assigned for the next issue.
The aim of the Turkish Journal of Pediatrics is to publish high-quality original research articles that will contribute to the international literature in the field of general pediatric health and diseases and its sub-branches. It also publishes editorial opinions, letters to the editor, reviews, case reports, book reviews, comments on previously published articles, meeting and conference proceedings, announcements, and biography. In addition to the field of child health and diseases, the journal also includes articles prepared in fields such as surgery, dentistry, public health, nutrition and dietetics, social services, human genetics, basic sciences, psychology, psychiatry, educational sciences, sociology and nursing, provided that they are related to this field. can be published.