Case Report
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Short course of conventional dose oral prednisone therapy in immune thrombocytopenic purpura associated with parvovirus B19 infection

Year 2016, Volume: 7 Issue: 4, 117 - 119, 28.11.2016

Abstract

Childhood immune thrombocytopenic purpura (ITP) is usually benign and a self-limited disorder. Often there is a preceding
viral like illness or vaccination. Human parvovirus B-19 (HPV) has also been detected in blood or bone marrow samples of
some patients with acute ITP. Treatment of ITP due to HPV is controversial. We report a case presented with macroscopic
hematuria and diagnosed as acute ITP due to HPV, and treated with short course conventional dose oral prednisone
successfully. This treatment seems to be safe and effective and may be an alternative treatment option to IVIG therapy in
patients with HPV associated with ITP

References

  • Bolton-Maggs PHB. Idiopathic thrombocytopenic purpura. Arch Dis Child 2000; 83: 220-2.
  • Yenicesu I, Yetkin S, Ozyurek E, Aslan D. Virus-associated immune thrombocytopenic purpura in childhood. Ped Hematol Oncol 2002; 19: 433-7.
  • Heegaard ED, Rosthoj S, Petersen BL, Nielsen S, Karup Pedersen F, Hornsleth A. Role of parvovirus B19 infection in childhood idiopathic thrombocytopenic purpura. Acta Paediatr 1999; 88: 614-7. M
  • Murray JC, Kelly PK, Wayne RH, Hogrefe WR, McClain KL. Childhood idiopathic thrombocytopenic purpura: association with human parvovirus B19 infection. Am J Pediatr Hematol Oncol 1994; 16: 314-9.
  • Oeda E, Shinohara K, Inoue H, Nomiyam J. Parvovirus B19 infection causing severe peripheral blood thrombocytopenia and persistent viremia. Am J Hematol 1994; 45: 274-5.
  • Skinnider LF, McSheffrey BJ, Sheridan D, Deneer H. Congenital spherocytic hemolytic anemia in a family presenting with transient red cell aplasia from parvovirus B19 infection. Am J Hematol 1998; 58: 341-2.
  • Pont J, Puchhammer-Stöckl E, Chott A, et al. Recurrent granulocytic aplasia as clinical presentation of a persistent parvovirus B19 infection. Br J Haematol 1992; 80: 160-5.
  • Ozawa K, Ayub J, Kajigaya S, Shimada T, Young N. The gene encoding the nonstructural protein of B19 [human] parvovirus may be lethal in transfected cells. J Virol 1988; 62: 2884-9.
  • Hsiao C-C. Epstein-Barr virus associated with immune thrombocytopenic purpura in childhood: a retrospective study. Child Health 2000; 78: 118

Parvovirüs B19 enfeksiyonunda görülen immün trombositopenik purpurada kısa süreli konvansiyonel doz oral prednizon tedavisi

Year 2016, Volume: 7 Issue: 4, 117 - 119, 28.11.2016

Abstract

Çocukluk çağı immün trombositopenik purpura (İTP) genellikle benign ve kendini sınırlayan bir hastalıktır. Genellikle viral
bir hastalık ya da aşılama sonrası oluşur. Akut ITP olan bazı hastaların kan veya kemik iliği örneklerinde İnsan parvovirüs B-19
(HPV) tespit edilmiştir. HPV nedeniyle İTP tedavisi tartışmalıdır. Bu yazıda makroskopik hematüri ve HPV’ye bağlı akut İTP
tanılı olgunun kısa süreli konvansiyonel doz oral prednizon ile başarılı tedavisini sunduk. Güvenli ve etkili olan bu tedavi, HPV
ilişkili İTP hastalarında İVİG tedavisine alternatif bir seçenek olabilir.

References

  • Bolton-Maggs PHB. Idiopathic thrombocytopenic purpura. Arch Dis Child 2000; 83: 220-2.
  • Yenicesu I, Yetkin S, Ozyurek E, Aslan D. Virus-associated immune thrombocytopenic purpura in childhood. Ped Hematol Oncol 2002; 19: 433-7.
  • Heegaard ED, Rosthoj S, Petersen BL, Nielsen S, Karup Pedersen F, Hornsleth A. Role of parvovirus B19 infection in childhood idiopathic thrombocytopenic purpura. Acta Paediatr 1999; 88: 614-7. M
  • Murray JC, Kelly PK, Wayne RH, Hogrefe WR, McClain KL. Childhood idiopathic thrombocytopenic purpura: association with human parvovirus B19 infection. Am J Pediatr Hematol Oncol 1994; 16: 314-9.
  • Oeda E, Shinohara K, Inoue H, Nomiyam J. Parvovirus B19 infection causing severe peripheral blood thrombocytopenia and persistent viremia. Am J Hematol 1994; 45: 274-5.
  • Skinnider LF, McSheffrey BJ, Sheridan D, Deneer H. Congenital spherocytic hemolytic anemia in a family presenting with transient red cell aplasia from parvovirus B19 infection. Am J Hematol 1998; 58: 341-2.
  • Pont J, Puchhammer-Stöckl E, Chott A, et al. Recurrent granulocytic aplasia as clinical presentation of a persistent parvovirus B19 infection. Br J Haematol 1992; 80: 160-5.
  • Ozawa K, Ayub J, Kajigaya S, Shimada T, Young N. The gene encoding the nonstructural protein of B19 [human] parvovirus may be lethal in transfected cells. J Virol 1988; 62: 2884-9.
  • Hsiao C-C. Epstein-Barr virus associated with immune thrombocytopenic purpura in childhood: a retrospective study. Child Health 2000; 78: 118
There are 9 citations in total.

Details

Subjects Health Care Administration
Journal Section Case Report
Authors

Serkan Tursun

Neşe Yaralı This is me

Publication Date November 28, 2016
Published in Issue Year 2016 Volume: 7 Issue: 4

Cite

APA Tursun, S., & Yaralı, N. (2016). Parvovirüs B19 enfeksiyonunda görülen immün trombositopenik purpurada kısa süreli konvansiyonel doz oral prednizon tedavisi. Turkish Journal of Clinics and Laboratory, 7(4), 117-119.
AMA Tursun S, Yaralı N. Parvovirüs B19 enfeksiyonunda görülen immün trombositopenik purpurada kısa süreli konvansiyonel doz oral prednizon tedavisi. TJCL. November 2016;7(4):117-119.
Chicago Tursun, Serkan, and Neşe Yaralı. “Parvovirüs B19 Enfeksiyonunda görülen immün Trombositopenik Purpurada kısa süreli Konvansiyonel Doz Oral Prednizon Tedavisi”. Turkish Journal of Clinics and Laboratory 7, no. 4 (November 2016): 117-19.
EndNote Tursun S, Yaralı N (November 1, 2016) Parvovirüs B19 enfeksiyonunda görülen immün trombositopenik purpurada kısa süreli konvansiyonel doz oral prednizon tedavisi. Turkish Journal of Clinics and Laboratory 7 4 117–119.
IEEE S. Tursun and N. Yaralı, “Parvovirüs B19 enfeksiyonunda görülen immün trombositopenik purpurada kısa süreli konvansiyonel doz oral prednizon tedavisi”, TJCL, vol. 7, no. 4, pp. 117–119, 2016.
ISNAD Tursun, Serkan - Yaralı, Neşe. “Parvovirüs B19 Enfeksiyonunda görülen immün Trombositopenik Purpurada kısa süreli Konvansiyonel Doz Oral Prednizon Tedavisi”. Turkish Journal of Clinics and Laboratory 7/4 (November 2016), 117-119.
JAMA Tursun S, Yaralı N. Parvovirüs B19 enfeksiyonunda görülen immün trombositopenik purpurada kısa süreli konvansiyonel doz oral prednizon tedavisi. TJCL. 2016;7:117–119.
MLA Tursun, Serkan and Neşe Yaralı. “Parvovirüs B19 Enfeksiyonunda görülen immün Trombositopenik Purpurada kısa süreli Konvansiyonel Doz Oral Prednizon Tedavisi”. Turkish Journal of Clinics and Laboratory, vol. 7, no. 4, 2016, pp. 117-9.
Vancouver Tursun S, Yaralı N. Parvovirüs B19 enfeksiyonunda görülen immün trombositopenik purpurada kısa süreli konvansiyonel doz oral prednizon tedavisi. TJCL. 2016;7(4):117-9.


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