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Çocuk ve adölesanlarda vücut kitle indeksi ortalama trombosit hacmini etkiler mi?

Year 2019, Volume: 10 Issue: 2, 247 - 250, 12.06.2019
https://doi.org/10.18663/tjcl.522291

Abstract

Amaç: Çocukluk çağındaki
obezite ile ortalama platelet volümünün (MPV) ilişkisini araştıran çalışmalar
daha çok adölesan dönemi içermektedir. Daha küçük yaştaki çocuklardaki
obezitenin MPV’ye etkisi ve yaşa göre zayıf hastalarda MPV değişiklikleri
tanımlanmamıştır.

Bu çalışmanın birinci sonlanım noktası obez, yaşa göre normal ve
düşük VKİ’ne sahip çocuk ve adölesanlarda MPV değerlerinin incelenmesidir.

Gereç ve Yöntemler: Üç yıllık hastane verilerinden
yararlanılarak çocuk endokrinoloji polikliniğine başvuran hastaların dosyaları
retrospektif incelendi. Hastalar vücut kitle indekslerine göre obes, normal ve
zayıf olarak gruplara ayrıldı. Grupların MPV değerleri kıyaslandı.

Bulgular: Çalışmaya
dahil olan 261 çocuğun yaş ortalamaları 11,2± 3,7 (min:1,0, max:17,8) olup
%37,9 ‘u (n=99)  obez, %27,6’sı (n=72)
yaşa göre zayıf, %34,5 ‘i (n=90) ise normal ağırlıkta (kontrol grubu) bulundu.
Tüm hastaların hemoglobin ve MPV değerleri normal aralıkta olup obez ve kontrol
gruplarında yaşa göre zayıf gruba göre yüksek bulundu.
Ayrıca insülin
direnci olan/ olmayanlar arasında da MPV değerleri arasına istatistiksel olarak
anlamlı bir fark tespit edilemedi.









Sonuç: Çalışmamızda
literatürden farklı olarak MPV değerinin zayıf çocuklarda normal kiloda ve obez
olanlara göre düşük, ancak hepsinde de normal aralıkta olduğunu saptadık.
İnsülin direncinin MPV değerlerine etkisi olmadığını gösterdik. MPV
değerlerinin klinik uygulamalarda yeri ile ilgili daha çok çalışmaya ihtiyaç
vardır.

References

  • 1. Thompson CB, Eaton KA, Princiotta SM, Rushin CA, Valeri CR. Size dependent platelet subpopulations: relationship of platelet volume to ultrastructure, enzymatic activity, and function. Br J Haematol 1982; 50: 509-19.
  • 2. Chu SG, Becker RC, Berger PB et al. Mean platelet volume as a predictor of cardiovascular risk: a systematic review and meta-analysis. J Thromb Haemost 2010; 8: 148-56.
  • 3. Venkatesh V, Kumar R, Varma DK, Bhatia P, Yadav J, Dayal D. Changes in platelet morphology indices in relation to duration of disease and glycemic control in children with type 1 diabetes mellitus. J Diabetes Complications 2018; 32: 833-38.
  • 4. Dursun A, Ozsoylu S, Akyildiz BN. Neutrophil-to-lymphocyte ratio and mean platelet volume can be useful markers to predict sepsis in children. ak J Med Sci 2018; 34: 918-22.
  • 5. Çelik SF, Çelik E. The neutrophil-to-lymphocyte ratio and mean platelet volume can be associated with severity of valvular involvement in patients with acute rheumatic carditis. Cardiovasc J Afr 2018; 23; 29: 296-300.
  • 6. Özkan EA, Khosroshahi HE, Serin Hİ et al. The evaluation of carotid intima-media thickness and mean platelet volume values and correlation with cardiac functions in obese children. Int J Clin Exp Med 2015; 15; 8: 22557-63
  • 7. Arslan N, Makay B, Hızlı S et al. Assessment of atherosclerosis in obese adolescents: positive correlation of mean platelet volume and carotid intima media thickness. J Paediatr Child Health 2013; 49: 963-68.
  • 8. Arslan N, Makay B. Mean platelet volume in obese adolescents with nonalcoholic fatty liver disease. J Pediatr Endocrinol Metab 2010; 23: 807-13.
  • 9. Marshall WA, Tanner JM. Variations in pattern of pubertal changes in girls. Arch Dis Child 1969; 44: 291-303.
  • 10. Marshall WA, Tanner JM. Variations in the pattern of pubertal changes in boys. Arch Dis Child 1970; 45: 13-23.
  • 11. Kurtoğlu S, Hatipoğlu N, Mazıcıoğlu M, Kendirici M, Keskin M, Kondolot M.Insulin resistance in obese children and adolescents: HOMA-IR cut-off levels in the prepubertal and pubertal periods. J Clin Res Pediatr Endocrinol 2010; 2: 100-6.
  • 12. Oświęcimska J, Malczyk Ż, Szymlak A, et al. Changes in Platelet Count and Size Indices in Adolescent Patients With Anorexia Nervosa. Clin Appl Thromb Hemost 2017; 23: 562-566.

Does body mass index affect mean platelet volume in childhood and adolescence?

Year 2019, Volume: 10 Issue: 2, 247 - 250, 12.06.2019
https://doi.org/10.18663/tjcl.522291

Abstract

Aim: Studies
concerning relationship between obesity in childhood and mean platelet volume
(MPV) are limited to adolescence period. Affect of obesity on MPV in younger
children and changes in MPV levels in underweight has not been established. We aimed to
evaluate MPV levels in obese, normal weight and underweight children.

Material
and Methods:
Three year-old period of medical records of patients attending pediatric
endocrinology are examined retrospectively. Patients are categorized as obese,
normal and underweight for age, according to body mass indexes. MPV levels are
compared between groups.

Results: We detected that MPV
levels were low in underweight children when compared with obese and normal
weight group, which was not compatible with literature. However all levels were
within normal limits.







Conclusion:
We established that insulin resistance does not affect MPV levels. More studies
are needed concerning the use of MPV level in clinical practise.

References

  • 1. Thompson CB, Eaton KA, Princiotta SM, Rushin CA, Valeri CR. Size dependent platelet subpopulations: relationship of platelet volume to ultrastructure, enzymatic activity, and function. Br J Haematol 1982; 50: 509-19.
  • 2. Chu SG, Becker RC, Berger PB et al. Mean platelet volume as a predictor of cardiovascular risk: a systematic review and meta-analysis. J Thromb Haemost 2010; 8: 148-56.
  • 3. Venkatesh V, Kumar R, Varma DK, Bhatia P, Yadav J, Dayal D. Changes in platelet morphology indices in relation to duration of disease and glycemic control in children with type 1 diabetes mellitus. J Diabetes Complications 2018; 32: 833-38.
  • 4. Dursun A, Ozsoylu S, Akyildiz BN. Neutrophil-to-lymphocyte ratio and mean platelet volume can be useful markers to predict sepsis in children. ak J Med Sci 2018; 34: 918-22.
  • 5. Çelik SF, Çelik E. The neutrophil-to-lymphocyte ratio and mean platelet volume can be associated with severity of valvular involvement in patients with acute rheumatic carditis. Cardiovasc J Afr 2018; 23; 29: 296-300.
  • 6. Özkan EA, Khosroshahi HE, Serin Hİ et al. The evaluation of carotid intima-media thickness and mean platelet volume values and correlation with cardiac functions in obese children. Int J Clin Exp Med 2015; 15; 8: 22557-63
  • 7. Arslan N, Makay B, Hızlı S et al. Assessment of atherosclerosis in obese adolescents: positive correlation of mean platelet volume and carotid intima media thickness. J Paediatr Child Health 2013; 49: 963-68.
  • 8. Arslan N, Makay B. Mean platelet volume in obese adolescents with nonalcoholic fatty liver disease. J Pediatr Endocrinol Metab 2010; 23: 807-13.
  • 9. Marshall WA, Tanner JM. Variations in pattern of pubertal changes in girls. Arch Dis Child 1969; 44: 291-303.
  • 10. Marshall WA, Tanner JM. Variations in the pattern of pubertal changes in boys. Arch Dis Child 1970; 45: 13-23.
  • 11. Kurtoğlu S, Hatipoğlu N, Mazıcıoğlu M, Kendirici M, Keskin M, Kondolot M.Insulin resistance in obese children and adolescents: HOMA-IR cut-off levels in the prepubertal and pubertal periods. J Clin Res Pediatr Endocrinol 2010; 2: 100-6.
  • 12. Oświęcimska J, Malczyk Ż, Szymlak A, et al. Changes in Platelet Count and Size Indices in Adolescent Patients With Anorexia Nervosa. Clin Appl Thromb Hemost 2017; 23: 562-566.
There are 12 citations in total.

Details

Primary Language Turkish
Subjects Health Care Administration
Journal Section Orıgınal Artıcle
Authors

Neslihan Karakurt 0000-0001-5487-9485

Havva Nur Peltek Kendirci

Publication Date June 12, 2019
Published in Issue Year 2019 Volume: 10 Issue: 2

Cite

APA Karakurt, N., & Peltek Kendirci, H. N. (2019). Çocuk ve adölesanlarda vücut kitle indeksi ortalama trombosit hacmini etkiler mi?. Turkish Journal of Clinics and Laboratory, 10(2), 247-250. https://doi.org/10.18663/tjcl.522291
AMA Karakurt N, Peltek Kendirci HN. Çocuk ve adölesanlarda vücut kitle indeksi ortalama trombosit hacmini etkiler mi?. TJCL. June 2019;10(2):247-250. doi:10.18663/tjcl.522291
Chicago Karakurt, Neslihan, and Havva Nur Peltek Kendirci. “Çocuk Ve adölesanlarda vücut Kitle Indeksi Ortalama Trombosit Hacmini Etkiler Mi?”. Turkish Journal of Clinics and Laboratory 10, no. 2 (June 2019): 247-50. https://doi.org/10.18663/tjcl.522291.
EndNote Karakurt N, Peltek Kendirci HN (June 1, 2019) Çocuk ve adölesanlarda vücut kitle indeksi ortalama trombosit hacmini etkiler mi?. Turkish Journal of Clinics and Laboratory 10 2 247–250.
IEEE N. Karakurt and H. N. Peltek Kendirci, “Çocuk ve adölesanlarda vücut kitle indeksi ortalama trombosit hacmini etkiler mi?”, TJCL, vol. 10, no. 2, pp. 247–250, 2019, doi: 10.18663/tjcl.522291.
ISNAD Karakurt, Neslihan - Peltek Kendirci, Havva Nur. “Çocuk Ve adölesanlarda vücut Kitle Indeksi Ortalama Trombosit Hacmini Etkiler Mi?”. Turkish Journal of Clinics and Laboratory 10/2 (June 2019), 247-250. https://doi.org/10.18663/tjcl.522291.
JAMA Karakurt N, Peltek Kendirci HN. Çocuk ve adölesanlarda vücut kitle indeksi ortalama trombosit hacmini etkiler mi?. TJCL. 2019;10:247–250.
MLA Karakurt, Neslihan and Havva Nur Peltek Kendirci. “Çocuk Ve adölesanlarda vücut Kitle Indeksi Ortalama Trombosit Hacmini Etkiler Mi?”. Turkish Journal of Clinics and Laboratory, vol. 10, no. 2, 2019, pp. 247-50, doi:10.18663/tjcl.522291.
Vancouver Karakurt N, Peltek Kendirci HN. Çocuk ve adölesanlarda vücut kitle indeksi ortalama trombosit hacmini etkiler mi?. TJCL. 2019;10(2):247-50.


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