Abstract
References
- Nieman LK. Cushing’s syndrome: update on signs, symptoms and biochemical screening. Eur J Endocrinol. 2015 Oct;173(4):M33-8. doi: 10.1530/EJE-15-0464.
- Richa CG, Saad KJ, Halabi GH, Gharios EM, Nasr FL, Merheb MT. Case-series of paraneoplastic Cushing syndrome in small-cell lung cancer. Endocrinol Diabetes Metab Case Rep. 2018 Mar 8;2018:18-0004. doi: 10.1530/EDM-18-0004.
- Vrkljan M, Vizner B, Zawawi A, Bekic M, Gorecan M, Grbac I. Ectopic ACTH secretion and Cushing’s syndrome. Acta Clin Croat. 2015 Dec;54(4):536-40.
- Jensen RT. Harrison’s Principles of Internal Medicine. 15th ed. New York: McGraw-Hill; 2001:596-7.
- Avcı N, Kurt E, Kazak E, Alkış N, Çubukçu E, Ölmez ÖF, Deligönül A, Evrensel T. Ectopic ACTH Syndrome in a patient with small cell lung cancer: A case report. Journal of Uludağ University Faculty of Medicine. 2013;39(3):193-5.
- Terzolo M, Reimondo G, Alì A, Bovio S, Daffara F, Paccotti P, Angeli A. Ectopic ACTH syndrome: molecular bases and clinical heterogeneity. Ann Oncol. 2001;12 Suppl 2:S83-7. doi: 10.1093/annonc/12.suppl_2.s83.
- Davi’ MV, Cosaro E, Piacentini S, Reimondo G, Albiger N, Arnaldi G, Faggiano A, Mantovani G, Fazio N, Piovesan A, Arvat E, Grimaldi F, Canu L, Mannelli M, Ambrogio AG, Pecori Giraldi F, Martini C, Lania A, Albertelli M, Ferone D, Zatelli MC, Campana D, Colao A, Scaroni C, Terzolo M, De Marinis L, Cingarlini S, Micciolo R, Francia G. Prognostic factors in ectopic Cushing’s syndrome due to neuroendocrine tumors: a multicenter study. Eur J Endocrinol. 2017 Apr;176(4):453-61. doi: 10.1530/EJE-16-0809.
Abstract
The most common cause of adrenocorticotropic hormone (ACTH)-dependent Cushing’s syndrome is a benign ACTH-producing pituitary tumour or, less frequently, ectopic ACTH production from non-pituitary tumours. Ectopic ACTH syndrome occurs more commonly in men and usually presents after 40 years. It is most commonly associated with small cell lung cancer. Although this syndrome is associated with severe hypercortisolemia, some findings of Cushing’s syndrome, such as central obesity, may not be observed due to underlying malignant diseases. In these cases, rapid metabolic disruption, anorexia, myopathy, glucose intolerance, hypokalemic alkalosis, and hyperpigmentation accompany the patients’ clinical condition. In the current case report, we aimed to emphasize that ectopic ACTH syndrome should be kept in mind in the differential diagnosis, especially in the presence of hypokalemia accompanying hypertension and proximal muscle weakness, if the patient also has progressive weight loss.
References
- Nieman LK. Cushing’s syndrome: update on signs, symptoms and biochemical screening. Eur J Endocrinol. 2015 Oct;173(4):M33-8. doi: 10.1530/EJE-15-0464.
- Richa CG, Saad KJ, Halabi GH, Gharios EM, Nasr FL, Merheb MT. Case-series of paraneoplastic Cushing syndrome in small-cell lung cancer. Endocrinol Diabetes Metab Case Rep. 2018 Mar 8;2018:18-0004. doi: 10.1530/EDM-18-0004.
- Vrkljan M, Vizner B, Zawawi A, Bekic M, Gorecan M, Grbac I. Ectopic ACTH secretion and Cushing’s syndrome. Acta Clin Croat. 2015 Dec;54(4):536-40.
- Jensen RT. Harrison’s Principles of Internal Medicine. 15th ed. New York: McGraw-Hill; 2001:596-7.
- Avcı N, Kurt E, Kazak E, Alkış N, Çubukçu E, Ölmez ÖF, Deligönül A, Evrensel T. Ectopic ACTH Syndrome in a patient with small cell lung cancer: A case report. Journal of Uludağ University Faculty of Medicine. 2013;39(3):193-5.
- Terzolo M, Reimondo G, Alì A, Bovio S, Daffara F, Paccotti P, Angeli A. Ectopic ACTH syndrome: molecular bases and clinical heterogeneity. Ann Oncol. 2001;12 Suppl 2:S83-7. doi: 10.1093/annonc/12.suppl_2.s83.
- Davi’ MV, Cosaro E, Piacentini S, Reimondo G, Albiger N, Arnaldi G, Faggiano A, Mantovani G, Fazio N, Piovesan A, Arvat E, Grimaldi F, Canu L, Mannelli M, Ambrogio AG, Pecori Giraldi F, Martini C, Lania A, Albertelli M, Ferone D, Zatelli MC, Campana D, Colao A, Scaroni C, Terzolo M, De Marinis L, Cingarlini S, Micciolo R, Francia G. Prognostic factors in ectopic Cushing’s syndrome due to neuroendocrine tumors: a multicenter study. Eur J Endocrinol. 2017 Apr;176(4):453-61. doi: 10.1530/EJE-16-0809.
Details
| Primary Language | English |
|---|---|
| Subjects | Internal Diseases |
| Journal Section | Case Reports |
| Authors | |
| Publication Date | April 1, 2022 |
| Submission Date | February 23, 2022 |
| Acceptance Date | March 9, 2022 |
| Published in Issue | Year 2022 Volume: 4 - Supplement 1 |
