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Resveratrol, Oxinflammation and Epilepsy

Year 2022, Volume: 2 Issue: 1, 71 - 87, 28.01.2022

Zeynep Kasap Acungil Elif Azize Özşahin Delibaş

Abstract

Resveratrol a natural polyphenol that is over-synthesized in some plant species, especially in stress situations, is frequently cited for its antioxidant, anti-inflammatory, neuroprotective, cardioprotective, antiviral and antibacterial properties. Prooxidant-antioxidant balance in the body is of great importance for maintaining a healthy life. The imbalance between the production of reactive oxygen species (ROS) and antioxidant activity can disrupt the redox-dependent homeostatic signal, causing inflammation processes to begin. Excessive production of ROS in the brain, which is susceptible to oxidative stress, is referred to as a common underlying factor for the etiology of a number of neurodegenerative diseases, including epilepsy. Another notable feature of resveratrol is that it can cross the blood-brain barrier, regulate redox pathways and the Sirtuin system, thereby modulating gene transcription in the brain to control inflammation and apoptosis. Although there is some evidence that inflammation and oxidative stress may play a role in the etiology of epilepsy, which is a chronic, neurological disorder, its pathogenesis has not been fully elucidated. In this review, it is discussed that resveratrol, which is capable of exhibiting neuroprotective actions, acts as an anticonvulsant agent and may be an effective agent in reducing damage to neural tissue and even preventing seizure development in auxiliary antiepileptic therapy.

Keywords

Epilepsy Inflammation Oxidative Stress Oxinflammation Resveratrol

References

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Resveratrol, Oksenflamasyon ve Epilepsi

Year 2022, Volume: 2 Issue: 1, 71 - 87, 28.01.2022

Zeynep Kasap Acungil Elif Azize Özşahin Delibaş

Abstract

Bazı bitki türlerinin özellikle stres durumlarında sentezini artırdığı doğal bir polifenol olan Resveratrol (RVS), antioksidan, antiinflamatuar, nöroprotektif, kardiyoprotektif, antiviral ve antibakteriyel özellikleri ile sıkça gündeme gelmektedir. Vücutta prooksidan-antioksidan dengesi, sağlıklı bir yaşam sürdürülebilmesi için büyük önem taşımaktadır. Reaktif oksijen türlerinin (ROS) üretimi ile antioksidan aktivite arasındaki dengesizlik redoksa bağımlı homeostatik sinyali bozarak inflamasyon süreçlerinin başlamasına neden olabilir. Oksidatif strese yatkın olan beyindeki aşırı ROS üretimi, epilepsi de dahil bir dizi nörodejeneratif hastalığın etiyolojisi için ortak bir altta yatan faktör olarak anılır. RVS’ün kayda değer özelliklerinden bir diğeri de, kan-beyin bariyerini geçebilmesi, redoks yollarını ve Sirtuin sistemini düzenleyebilmesi, böylelikle beyinde gen transkripsiyonunu modüle ederek inflamasyonu ve apoptozu kontrol edebilmesidir. Bugüne kadar kronik, nörolojik bir bozukluk olan epilepsi etyolojisinde, inflamasyon ve oksidatif stresin rolü olabileceğine dair bazı kanıtlar olsa da, patogenezi tam olarak aydınlatılamamıştır. Bu derlemede, nöroprotektif eylemler sergileyebilme yeteneğindeki RVS’ün bir antikonvülzan ajan gibi davrandığı, nöral dokudaki hasarı azaltmada ve hatta yardımcı antiepileptik tedavide nöbet gelişimini önlemede etkili bir ajan olabileceği tartışılmaktadır.

Keywords

Epilepsi İnflamasyon Oksidatif Stres Oksİnflamasyon Resveratrol

References

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  • Referans7. Pallàs M, Ortuño-Sahagún D, Andrés-Benito P, Ponce-Regalado DM, Rojas-Mayorquín AE. Resveratrol in epilepsy: preventive or treatment opportunities? Frontiers in Bioscience. 2014;19(1):1057–1064.
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  • Referans10. Çıracı E, Kalafat T. Effects of Resveratrol on Cardiovascular Diseases. Bes Diy Der. 2021;49(1):91–9.
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  • Referans19. Sies H, Jones DP. Reactive oxygen species (ROS) as pleiotropic physiological signalling agents. Nat Rev Mol Cell Biol. 2020;21:363–383.
  • Referans20. Dodson, M. Redmann, N.S. Rajasekaran, V. Darley-Usmar, J. Zhang. KEAP1-NRF2 signalling and autophagy in protection against oxidative and reductive proteotoxicity. Biochem J. 2015;469:347–355.
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  • Referans24. Packer L, Cadenas E. Oxidants and antioxidants revisited. New concepts of oxidative stress. Free Radical Research. 2007;41(9):951–952.
  • Referans25. Forman HJ, Davies KJA, Ursini F. How do nutritional antioxidants really work: nucleophilic tone and para-hormesis versus free radical scavenging in vivo Free Radic Biol Med. 2014;66:24–35.
  • Referans26. Roberts RA, Laskin DL, Smith CV, Robertson FM et al. Nitrative and oxidative stress in toxicology and disease. Toxicol Sci. 2009;112:4–16.
  • Referans27. Dalton TP, Shertzer HG, Puga A. Regulation of gene expression by reactive oxygen. Ann Rev Pharmacol Toxicol. 1999;39:67–101.
  • Referans28. Scandalios JG. Genomic responses to oxidative stress. In: Meyers RA, ed. Encyclopedia of Molecular Cell Biology and Molecular Medicine. Vol 5. 2nd ed. Weinheim, Germany:Wiley-VCH;2004:p489–512.
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There are 89 citations in total.

Details

Primary Language Turkish
Subjects Health Care Administration
Journal Section Derlemeler
Authors

Zeynep Kasap Acungil 0000-0003-0475-7628

Elif Azize Özşahin Delibaş 0000-0002-4195-0884

Publication Date January 28, 2022
Submission Date December 17, 2021
Published in Issue Year 2022 Volume: 2 Issue: 1

Cite

Vancouver Kasap Acungil Z, Özşahin Delibaş EA. Resveratrol, Oksenflamasyon ve Epilepsi. TOGÜ Sağlık Bilimleri Dergisi. 2022;2(1):71-87.
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