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Extracellular Matrix Structure and Tasks

Year 2018, Volume: 23 Issue: 1, 295 - 310, 24.04.2018
https://doi.org/10.17482/uumfd.327376

Abstract

The extracellular matrix (ECM) is a complex
structure located between and supporting cells within mammalian tissues. The
ECM is secreted by cells in contact or contact. Extracellular matrix (ECM) is
traditionally classified as glycosphingolipids and fibrous proteins. In
glycosphingolipids, they are divided into two groups: non-sulfated proteins
(hyaluronic acid) and sulfated proteins (chondroitin sulfate, keratin sulphate
I and II, heparin, heparan sulfate and dermatan sulphate). Fibrous proteins are
classified as structural proteins (collagen, elastin) and adhesion proteins
(fibronectin, laminin, tenascin, vitronectin, integrin).This work deals with the
structure of the extracellular matrix molecule affecting cell growth and
differentiation, affecting cell growth and differentiation, water and minerals
affecting the growth factor, and the proteins involved in this structure.

References

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  • Handel, T.M., Johnson, Z., Crown, S.E., Lau, E.K., Proudfoot, A.E., (2005) Regulation of Protein Function by Glycosaminoglycans-as Exemplified by Chemokines. Annual Review of Biochemistry, 74, 385-410. doi: 10.1146/annurev.biochem.72.121801.161747
  • Hynes, R.O., (2002) Integrins: Bidirectional, Allosteric Signaling Machines. Cell, 110, 673-687. doi.org/10.1016/S0092-8674(02)00971-6
  • Järveläinen, H., Sainio, A., Koulu, M., Wight, T.N., Penttienen, R., (2009) Extracellular Matrix Molecules: Potential Targets in Pharmacotherapy. Pharmacological Reviews, 61(2), 198-223. doi: 10.1124/pr.109.001289
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EKSTRASELÜLER MATRİS YAPISI VE GÖREVLERİ

Year 2018, Volume: 23 Issue: 1, 295 - 310, 24.04.2018
https://doi.org/10.17482/uumfd.327376

Abstract

Ekstrasellüler
matriks (ECM), memeli dokuları içindeki hücrelerin arasında bulunan ve onları
destekleyen bir kompleks yapıdır. ECM içinde bulunduğu veya temas halindeki
hücreler tarafından salgılanmaktadır. Ekstrasellüler matriks (ECM), geleneksel
olarak glikoaminglikanlar ve fibröz proteinler olarak sınıflandırılırlar.
Glikoaminglikanlarda kendi içlerinde sülfatlanmamış proteinler (Hyalüronik
asit) ve sülfatlanmış proteinler (kondroitin sülfat, keratan sülfat I ve II,
heparin, heparan sülfat ve dermatan sülfat) olmak üzere ikiye ayrılır. Fibröz
proteinler ise yapısal proteinler (kollajen, elastin) ve yapıştırıcı (adhezyon)
proteinler (Fibronektin, laminin, tenaskin, vitronektin, integrin) olarak
sınıflandırılır. 
Yapılan
bu çalışma ile hücrelerin yapısı ve hareketini etkileyen, hücre gelişme ve
farklılaşmasını etkileyen, su ve mineral tutan, büyüme faktörünü etkileyen ekstrasellüler
matris molekülünün yapısı ve bu yapıda bulunan proteinlerin görevlerinden
bahsedilmiştir.

References

  • Akgün, I., Öğüt, T., (2002) Oral Glukozamin ve Kondroitin Sülfatın Osteoartrit Tedavideki Yeri. Türk Ortopedi ve Travmatoloji Birliği Derneği Dergisi, 1(2), 66-70.
  • Alovskaya, A., Alekseeva, T., Phillips, J.B., King, V., Brown, R., (2007) Fibronectin, collagen, fibrin-components of extracellular matrix for nerve regeneration. Topics in Tissue Engineering, 3, 1-26.
  • Ata, R., Antonescu, C.N., (2017) Integrins and Cell Metabolism: an Intimate Relationship Impacting Cancer. International Journal of Molecular Sciences, 18(189), 1-31. doi:10.3390/ijms18010189
  • Aviezer, D., Safran, M., Yayon, A., (1999) Heparin Differentially Regulates the Interaction of Fibroblast Growth Factor-4 with FGF Receptors 1 And 2. Biochemical and Biophysical Research Communications, 263(3), 621-626. doi: 10.1006/bbrc.1999.1434
  • Barczyk, M., Carracedo, S., Gullberg, D., 2010. Integrins. Cell Tissue Research, 339, 269-280. doi: 10.1007/s00441-009-0834-6.
  • Bayram, C., 2012. Hücre ve Doku Mühendisliği Araştırma Grubu. Nanoteknoloji ve Nanotıp Bilim Dergisi (N@nobülten), 18-27.
  • Bosman, F., ve Stamenkovic, I., (2003) Functional Structure and Composition of the Extracellular Matrix. Journal of Pathology, 200(4), 423-428. doi: 10.1002/path.1437
  • Campbell I.D., Humphries, M.J., (2011) Integrin Structure, Activation, and Interactions. Cold Spring Harbor Perspectives in Biology, 3, 1-14. doi: 10.1101/cshperspect.a004994
  • Cantor, J.O., Shteyngart, B, Cerreta, J.M., Lıu, M, Armand, G., Turıno, G.M., (2000) The Effect of Hyaluronan on Elastic Fiber Injury in Vitro and Elastaseinduced Airspace Enlargement in Vivo. Experimental Biology and Medicine, 225(1), 65– 71.
  • Chiquet-Ehrismann, R., (1990) What distinguishes tenascin from fibronectin? FASEB Journal, 4(9), 2598-2604.
  • Çavdar, Z., (2008) Kolon ve Rektum Kanserlerinde Endostatin’in Matriks Metalloproteinaz-2 Üzerine Gösterdiği Etkinin Araştırılması. Dokuz Eylül Üniversitesi, Sağlık Bilimleri Enstitüsü, Biyokimya Anabilim Dalı, Doktora Tezi, 144s., İzmir.
  • De Medeiros Matsushita M., Da Silva, L.F., Dos Santos, M.A., Fernezlian, S., Schrumpf, J.A., Roughley, P., Hiemstra, P.S., Saldiva, P.H., Mauad, T., Dolhnikoff, M., (2005) Airway Proteoglycans are Differentially Altered in Fatal Asthma. The Journal of Pathology, 207(1), 102-110. doi: 10.1002/path.1818
  • Debelle, L., Tamburro, A.M., (1999) Elastin: Molecular Description And Function. The International Journal of Biochemistry & Cell Biology, 31(2), 261-272. doi.org/10.1016/S1357-2725(98)00098-3
  • Frantz, C., Stewart, K.M., Weaver, V.M., (2010) The Extracellular Matrix at a Glance. Journal of Cell Science, 123(24), 4195-4200. doi: 10.1242/jcs.023820
  • Funderburgh, J.L., (2000) Keratan sulfate: structure, biosynthesis and function. Glycobiology, 10, 951-958. doi.org/10.1093/glycob/10.10.951
  • Funderburgh, J.L., (2002) Keratan Sulfate Biosynthesis. IUBMB Life, 54,187–194. doi: 10.1080/15216540214932
  • Gerdin, B., Hällgren, R., (1997) Dynamic Role of Hyaluronan (HYA) in Connective Tissue Activation and Inflammation. Journal of Internal Medicine, 242(1), 49–55. doi: 10.1046/j.1365-2796.1997.00173.x
  • Gill, S., Wight, T.N., Frevert, C.W., (2010) Proteoglycans: Key Regulators of Pulmonary Inflammation and the Innate Immune Response to Lung Infection. Anat Rec (Hoboken), 293(6), 968-981. doi: 10.1002/ar.21094
  • Green, W.F., Konnaris, K., Woolcock, A.J., 1993. Effect of Salbutamol, Fenoterol, and Sodium Cromoglycate on the Release of Heparin from Sensitized Human Lung Fragments Challenged with Dermatophagoides Pteronyssinus Allergen. American Journal of Respiratory Cell and Molecular Biology, 8(5), 518-521. doi: 10.1165/ajrcmb/8.5.518
  • Gullberg, D., (2003) I domains in integrins. vol 1. Landes Bioscience, Georgetown, Texas. pp 1–185. doi:10.1007/978-94-017-9153-3
  • Gümüşderelioğlu, M., Maviş, B., Karakeçili, A., Kahraman, A.S., Çakmak, S., Tığlı, S., Demirtaş, T., Aday, S., 2007. Doku Mühendisliğinde Nanoteknoloji. Bilim ve Teknik Dergisi, Yeni Ufuklara Eki, Ekim Sayısı.
  • Gürbüz, Y., Aydın, Ö., Almaç, A., (2006) Tenascin Expression Patterns Of Salivary Gland Tumors: An Immunhistochemical And Comparative Study. KBB-Forum Dergisi, 5(1), 35-40.
  • Handel, T.M., Johnson, Z., Crown, S.E., Lau, E.K., Proudfoot, A.E., (2005) Regulation of Protein Function by Glycosaminoglycans-as Exemplified by Chemokines. Annual Review of Biochemistry, 74, 385-410. doi: 10.1146/annurev.biochem.72.121801.161747
  • Hynes, R.O., (2002) Integrins: Bidirectional, Allosteric Signaling Machines. Cell, 110, 673-687. doi.org/10.1016/S0092-8674(02)00971-6
  • Järveläinen, H., Sainio, A., Koulu, M., Wight, T.N., Penttienen, R., (2009) Extracellular Matrix Molecules: Potential Targets in Pharmacotherapy. Pharmacological Reviews, 61(2), 198-223. doi: 10.1124/pr.109.001289
  • Johansson, S., Svineng, G., Wennerberg, K., Armulik, A., Lohikangas, L., (1997) Fibronectin-Integrin Interactions. Frontiers in Bioscience 2, 126-146.
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There are 73 citations in total.

Details

Primary Language Turkish
Subjects Engineering
Journal Section Survey Articles
Authors

İbrahim Üçgül

Sultan Aras

Ufuk Elibüyük

Publication Date April 24, 2018
Submission Date July 8, 2017
Acceptance Date March 22, 2018
Published in Issue Year 2018 Volume: 23 Issue: 1

Cite

APA Üçgül, İ., Aras, S., & Elibüyük, U. (2018). EKSTRASELÜLER MATRİS YAPISI VE GÖREVLERİ. Uludağ Üniversitesi Mühendislik Fakültesi Dergisi, 23(1), 295-310. https://doi.org/10.17482/uumfd.327376
AMA Üçgül İ, Aras S, Elibüyük U. EKSTRASELÜLER MATRİS YAPISI VE GÖREVLERİ. UUJFE. April 2018;23(1):295-310. doi:10.17482/uumfd.327376
Chicago Üçgül, İbrahim, Sultan Aras, and Ufuk Elibüyük. “EKSTRASELÜLER MATRİS YAPISI VE GÖREVLERİ”. Uludağ Üniversitesi Mühendislik Fakültesi Dergisi 23, no. 1 (April 2018): 295-310. https://doi.org/10.17482/uumfd.327376.
EndNote Üçgül İ, Aras S, Elibüyük U (April 1, 2018) EKSTRASELÜLER MATRİS YAPISI VE GÖREVLERİ. Uludağ Üniversitesi Mühendislik Fakültesi Dergisi 23 1 295–310.
IEEE İ. Üçgül, S. Aras, and U. Elibüyük, “EKSTRASELÜLER MATRİS YAPISI VE GÖREVLERİ”, UUJFE, vol. 23, no. 1, pp. 295–310, 2018, doi: 10.17482/uumfd.327376.
ISNAD Üçgül, İbrahim et al. “EKSTRASELÜLER MATRİS YAPISI VE GÖREVLERİ”. Uludağ Üniversitesi Mühendislik Fakültesi Dergisi 23/1 (April 2018), 295-310. https://doi.org/10.17482/uumfd.327376.
JAMA Üçgül İ, Aras S, Elibüyük U. EKSTRASELÜLER MATRİS YAPISI VE GÖREVLERİ. UUJFE. 2018;23:295–310.
MLA Üçgül, İbrahim et al. “EKSTRASELÜLER MATRİS YAPISI VE GÖREVLERİ”. Uludağ Üniversitesi Mühendislik Fakültesi Dergisi, vol. 23, no. 1, 2018, pp. 295-10, doi:10.17482/uumfd.327376.
Vancouver Üçgül İ, Aras S, Elibüyük U. EKSTRASELÜLER MATRİS YAPISI VE GÖREVLERİ. UUJFE. 2018;23(1):295-310.

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