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Immunotherapy and Radiotherapy Combination

Year 2020, Volume: 46 Issue: 2, 225 - 235, 01.08.2020
https://doi.org/10.32708/uutfd.710919

Abstract

Immunotherapy is a treatment proven to be effective in terms of response, duration of response and survival in many types of cancer by strengthening the immune system. The response rates are 20%, and new treatments that produce synergistic effect with immunotherapy are needed in resistant patients. Antigenic stimulation released from tumor cells with radiotherapy can complement immunotherapy by making the tumor more easily recognized by the immune system. The systemic effect of radiotherapy on metastases other than the irradiated target is defined as “abscopal” effect and the main purpose of immuno-radiotherapy is to evoke the “abscopal” effect. The significant contribution of immuno-radiotherapy to response and survival has been shown primarily in malignant melanoma and lung cancers, and is seen as a promising treatment method in other solit tumors as well.

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İmmunoterapi ve Radyoterapi Kombinasyonu

Year 2020, Volume: 46 Issue: 2, 225 - 235, 01.08.2020
https://doi.org/10.32708/uutfd.710919

Abstract

İmmunoterapi, bağışıklık sisteminin güçlendirilmesi ile birçok kanser türünde yanıt, yanıt süresi ve sağkalım açısından etkinliği kanıtlanmış bir tedavidir. Yanıt oranları %20 olup dirençli hastalarda immunoterapi ile sinerjik etki yaratan yeni tedavilere gereksinim vardır. Radyoterapi ile tümör hücrelerinden salınan antijenik uyarı tümörün bağışıklık sistemi tarafından daha kolay tanınmasını sağlayarak immunoterapinin tamamlayıcısı olabilir. Radyoterapinin, ışınlanan hedef dışındaki metastazlar üzerindeki sistemik etkisi “abscopal” etki olarak tanımlanmış olup immuno-radyoterapinin temel amacı “abscopal” etkiyi uyandırmaktır. İmmuno-radyoterapinin yanıt ve sağkalıma anlamlı katkısı öncelikle malign melanom ve akciğer kanserlerinde gösterilmiş olup diğer solid tümörlerde de gelecek vaat eden önemli bir tedavi yöntemi olarak görülmektedir.

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There are 101 citations in total.

Details

Primary Language Turkish
Subjects Oncology and Carcinogenesis
Journal Section Review Articles
Authors

Süreyya Sarıhan 0000-0003-4816-5798

Publication Date August 1, 2020
Acceptance Date June 17, 2020
Published in Issue Year 2020 Volume: 46 Issue: 2

Cite

APA Sarıhan, S. (2020). İmmunoterapi ve Radyoterapi Kombinasyonu. Uludağ Üniversitesi Tıp Fakültesi Dergisi, 46(2), 225-235. https://doi.org/10.32708/uutfd.710919
AMA Sarıhan S. İmmunoterapi ve Radyoterapi Kombinasyonu. Uludağ Tıp Derg. August 2020;46(2):225-235. doi:10.32708/uutfd.710919
Chicago Sarıhan, Süreyya. “İmmunoterapi Ve Radyoterapi Kombinasyonu”. Uludağ Üniversitesi Tıp Fakültesi Dergisi 46, no. 2 (August 2020): 225-35. https://doi.org/10.32708/uutfd.710919.
EndNote Sarıhan S (August 1, 2020) İmmunoterapi ve Radyoterapi Kombinasyonu. Uludağ Üniversitesi Tıp Fakültesi Dergisi 46 2 225–235.
IEEE S. Sarıhan, “İmmunoterapi ve Radyoterapi Kombinasyonu”, Uludağ Tıp Derg, vol. 46, no. 2, pp. 225–235, 2020, doi: 10.32708/uutfd.710919.
ISNAD Sarıhan, Süreyya. “İmmunoterapi Ve Radyoterapi Kombinasyonu”. Uludağ Üniversitesi Tıp Fakültesi Dergisi 46/2 (August 2020), 225-235. https://doi.org/10.32708/uutfd.710919.
JAMA Sarıhan S. İmmunoterapi ve Radyoterapi Kombinasyonu. Uludağ Tıp Derg. 2020;46:225–235.
MLA Sarıhan, Süreyya. “İmmunoterapi Ve Radyoterapi Kombinasyonu”. Uludağ Üniversitesi Tıp Fakültesi Dergisi, vol. 46, no. 2, 2020, pp. 225-3, doi:10.32708/uutfd.710919.
Vancouver Sarıhan S. İmmunoterapi ve Radyoterapi Kombinasyonu. Uludağ Tıp Derg. 2020;46(2):225-3.

ISSN: 1300-414X, e-ISSN: 2645-9027

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