Yıl 2018, Cilt 3, Sayı 2, Sayfalar 102 - 107 2018-08-30

Evaluation of mean platelet volume and platelet count in patients with schizophrenia
Şizofreni hastalarında ortalama trombosit hacminin değerlendirilmesi

Memduha Aydin [1] , Bilge Cetin Ilhan [2] , Tuba Serife Elmas [3] , Yusuf Cokunlu [4] , Ibrahim Eren [5]

16 30

Introduction: Compared to the general population, cardiovascular diseases are more common in schizophrenia patients and the mortality rate is higher than the general population. One of the explanations for increased cardiovascular events in patients with schizophrenia is the increase in platelet activity. Platelets are essential for progression of atherosclerotic lesions, plaque destabilization, and thrombus formation. Mean platelet volume (MPV) is a measure of platelet size and a good marker of platelet function and activation, which increases in cardiovascular diseases. MPV is routinely reported during complete blood count analysis. The aim of the present study was to evaluate MPV values of patients with schizophrenia.

Methods: In this retrospective study, hospital-records of the patients who were consecutively admitted to psychiatry inpatient clinic between January 2015 and January 2017 with the diagnosis of schizophrenia were reviewed. Healthy subjects with no personal history of psychiatric disorder were included as a control group. 

Results: A total of 100 (59 female, 41 male) schizophrenic patients who had been consecutively admitted to the psychiatry inpatient clinic and 37 (20 female, 17 male) healthy controls were included in this retrospective study. There were no significant differences between the patient group and control group in the terms of age (mean age patient group vs control group: 37.72 vs 35.03, p=0.081) and sex (p=0.603). Body mass index (BMI) was found to be significantly different between groups, higher in the patient group (p=0.001). The MPV was found to be significantly higher in patient group compared with the control group (MPV, patient group vs control group: 10.34 fL vs 9.97 fL, p=0.041). Platelet count (PC) was significantly lower in the patient group (PC, patient group vs control group: 234.36 vs 267.38, p=0.008) There was no correlation between MPV and BMI (p=0.354, r=0.10), and duration of illness (p=0.530, r=0.06). 

Conclusions: As a result, increased MPV and decreased PC were found in a group of schizophrenic patient in this study. Since increased MPV and decreased PC are evaluated as risk factors for cardiovascular diseases in the general population, they can also be considered as a predictor of risk factors for cardiovascular diseases that are more frequently encountered in schizophrenia.

Giriş: Şizofreni hastalarında genel popülasyona kıyasla kardiyovasküler hastalıklara daha sık rastlanmaktadır, mortalite oranı genel popülasyona göre daha yüksektir. Şizofreni hastalarında artmış kardiyovasküler olayların açıklamalarından biri de trombosit aktivitesinin artmasıdır. Trombositler aterosklerotik lezyonların progresyonu, plak destabilizasyonu ve tromboz oluşumu için gereklidir. Ortalama trombosit hacmi (MPV), trombosit büyüklüğünün ve kardiyovasküler hastalıklarda artan platelet fonksiyonunun ve aktivasyonunun iyi bir göstergesidir. Tam kan sayımı analizi sırasında MPV rutin olarak bakılmaktadır. Bu çalışmanın amacı şizofreni hastalarının MPV değerlerini değerlendirmektir.

Yöntem: Bu retrospektif çalışmada psikiyatri kliniğine Ocak 2015 – Ocak 2017  tarihleri arasında  ardışık olarak başvurmuş olan şizofreni  hastalarının hastane dosya kayıtları incelendi. Kişisel psikiyatrik öyküsü olmayan sağlıklı bireyler kontrol grubu olarak alındı.

Bulgular: Psikiyatri polikliniğine ardışık olarak başvuran toplam 100 (59 kadın, 41erkek) şizofreni hastası  ve 37 (20 kadın, 17 erkek) sağlıklı kontrol bu retrospektif çalışmaya alındı. Hasta grubu ve sağlıklı kontrol grubu arasında yaş (hasta grubu ve kontrol grubu ortalama yaş, sırasıyla 37,72 ve 35,03, p=0,081) ve cinsiyet bakımından anlamlı bir fark yoktu (p=0,603). Vücut kitle indexi (VKİ) hasta grubunda daha yüksek olmasıyla gruplar arasında anlamlı fark bulunmuştur (p=0,001). MPV kontrol grubuna kıyasla hasta grubunda anlamlı yüksek bulundu (hasta grubu ile kontrol grubu MPV sırayla; 10,34 fL ve 9,97 fL, p=0,041).  Platelet sayısı (PC) hasta grubunda anlamlı düşük bulundu (hasta grubu ile kontrol grubu platelet sayısı sırayla: 234,36 ve 267,38, p=0,008). MPV ve VKİ arasında herhangi bir ilişki bulunmadı (p=0,354, r=0,10), MPV ile  hastalık süresi arasında herhangi bir ilişki bulunmadı (p=0,530, r=0,06).

Sonuç: Sonuç olarak, bu çalışmada bir grup şizofreni hastasında artmış MPV ve azalmış PC bulundu. Artmış MPV ve azalmış PC, genel popülasyonda kardiyovasküler hastalıklar için risk faktörü olarak değerlendirildiğinden, şizofrenide daha sık karşılaşılan kardiyovasküler hastalıklar için risk faktörlerinin bir göstergesi olarak da düşünülebilir.

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Birincil Dil en
Konular Sağlık Bilimleri
Yayımlanma Tarihi Aug 2018
Dergi Bölümü Araştırma Makalesi (Original Article)
Yazarlar

Orcid: 0000-0001-7679-6568
Yazar: Memduha Aydin (Sorumlu Yazar)
Kurum: Selcuk University, Faculty of Medicine, Department of Psychiatry, Konya
Ülke: Turkey


Orcid: 0000-0002-5941-8394
Yazar: Bilge Cetin Ilhan
Kurum: Konya Training and Research Hospital, Department of Psychiatry, Konya
Ülke: Turkey


Orcid: 0000-0003-0325-8616
Yazar: Tuba Serife Elmas
Kurum: Konya Training and Research Hospital, Department of Psychiatry, Konya
Ülke: Turkey


Orcid: 0000-0002-6170-8614
Yazar: Yusuf Cokunlu
Kurum: Konya Training and Research Hospital, Department of Psychiatry, Konya
Ülke: Turkey


Orcid: 0000-0003-1626-7810
Yazar: Ibrahim Eren
Kurum: Konya Training and Research Hospital, Department of Psychiatry, Konya
Ülke: Turkey


Bibtex @araştırma makalesi { fppc401101, journal = {FAMILY PRACTICE AND PALLIATIVE CARE}, issn = {2458-8865}, eissn = {2459-1505}, address = {SERNEV}, year = {2018}, volume = {3}, pages = {102 - 107}, doi = {10.22391/fppc.401101}, title = {Evaluation of mean platelet volume and platelet count in patients with schizophrenia}, key = {cite}, author = {Cokunlu, Yusuf and Elmas, Tuba Serife and Aydin, Memduha and Eren, Ibrahim and Cetin Ilhan, Bilge} }
APA Aydin, M , Cetin Ilhan, B , Elmas, T , Cokunlu, Y , Eren, I . (2018). Evaluation of mean platelet volume and platelet count in patients with schizophrenia. FAMILY PRACTICE AND PALLIATIVE CARE, 3 (2), 102-107. DOI: 10.22391/fppc.401101
MLA Aydin, M , Cetin Ilhan, B , Elmas, T , Cokunlu, Y , Eren, I . "Evaluation of mean platelet volume and platelet count in patients with schizophrenia". FAMILY PRACTICE AND PALLIATIVE CARE 3 (2018): 102-107 <http://www.fppc.com.tr/issue/39137/401101>
Chicago Aydin, M , Cetin Ilhan, B , Elmas, T , Cokunlu, Y , Eren, I . "Evaluation of mean platelet volume and platelet count in patients with schizophrenia". FAMILY PRACTICE AND PALLIATIVE CARE 3 (2018): 102-107
RIS TY - JOUR T1 - Evaluation of mean platelet volume and platelet count in patients with schizophrenia AU - Memduha Aydin , Bilge Cetin Ilhan , Tuba Serife Elmas , Yusuf Cokunlu , Ibrahim Eren Y1 - 2018 PY - 2018 N1 - doi: 10.22391/fppc.401101 DO - 10.22391/fppc.401101 T2 - FAMILY PRACTICE AND PALLIATIVE CARE JF - Journal JO - JOR SP - 102 EP - 107 VL - 3 IS - 2 SN - 2458-8865-2459-1505 M3 - doi: 10.22391/fppc.401101 UR - http://dx.doi.org/10.22391/fppc.401101 Y2 - 2018 ER -
EndNote %0 FAMILY PRACTICE AND PALLIATIVE CARE Evaluation of mean platelet volume and platelet count in patients with schizophrenia %A Memduha Aydin , Bilge Cetin Ilhan , Tuba Serife Elmas , Yusuf Cokunlu , Ibrahim Eren %T Evaluation of mean platelet volume and platelet count in patients with schizophrenia %D 2018 %J FAMILY PRACTICE AND PALLIATIVE CARE %P 2458-8865-2459-1505 %V 3 %N 2 %R doi: 10.22391/fppc.401101 %U 10.22391/fppc.401101
ISNAD Aydin, Memduha , Cetin Ilhan, Bilge , Elmas, Tuba Serife , Cokunlu, Yusuf , Eren, Ibrahim . "Şizofreni hastalarında ortalama trombosit hacminin değerlendirilmesi". FAMILY PRACTICE AND PALLIATIVE CARE 3 / 2 (Ağustos 2018): 102-107. http://dx.doi.org/10.22391/fppc.401101