Yıl 2018, Cilt 3, Sayı 3, Sayfalar 133 - 138 2018-10-04

İdiopatik ani işitme kaybı olan hastaların tiyol/disülfit homeostazisi üzerine hiperbarik oksijen tedavisinin etkisi
Effect of hyperbaric oxygen therapy on thiol/disulfide homeostasis in patients with idiopathic sudden sensorineural hearing loss

Ibrahim Solak [1] , Abdullah Arslan [2] , Ruhusen Kutlu [3] , Betul Kozanhan [4] , Salim Neselioglu [5] , Ozcan Erel [6] , Cigdem Damla Cetinkaya [7] , Mehmet Ali Eryilmaz [8]

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Giriş: İdyopatik ani sensorinöral işitme kaybı (ISSNHL) en önemli insan duyularından birinin işlev kaybına neden olabilen otolojik acil bir durumdur. Son zamanlarda ISSNHL’ nda hiperbarik oksijen tedavisi (HBOT), farmakoterapi ile birlikte popülerlik kazanmaktadır. Bu çalışmada ISSNHL olan hastalarda farmakoterapi ile HBOT’nin sistemik oksidatif stresin yeni bir göstergesi olan tiyol/disülfit homeostrazisinde (TDH) meydana getirdiği değişikliklerin tespiti amaçlandı.

Yöntem: Bu prospektif çalışmada ISSNHL olan hastalarda, çalışma başında ve standart tedaviyle birlikte HBOT uygulandıktan sonra albümin, total tiyol, native tiyol, disülfit düzeyleri ile disülfit /native tiyol, disülfit /total tiyol ve native tiyol/total tiyol oranları yeni bir kolorimetrik yöntem kullanılarak analiz edilmiştir.

Bulgular: Çalışmaya 14’ü (%34,1) kadın 27’si (%65,9) erkek olmak üzere 41 ISSNH’ li hasta katıldı. Hastaların yaş ortalaması 48,02±13,10 idi. Hastaların 24’ü (%58,5) sağ kulaktan 17’si (%41,5) sol kulaktan şikayeti vardı. Hastaların başlangıca göre tedavi sonrasında native tiyol (p<0,001), total tiyol (p<0,001), disülfit  (p<0,001) ve albümin (p<0,001) değerlerinde istatistiksel olarak anlamlı düşme olmuştur. Disülfit /native tiyol (p=0,148), disülfit /total tiyol (p=0,172) ve native tiyol/total tiyol (p=0,169) oranlarında tedavi sonrasında öncesine göre istatistiki olarak anlamlı fark bulunamamıştır.

Sonuç: Sonuç olarak bu çalışmada, ISSNHL hastalarda başlangıca göre HBOT ve medikal tedavi verildikten sonra tiyol-disülfit dengesinin oksidasyon yönüne doğru kayma eğiliminde olduğu ve tedavi sonrası oksidasyonun yüksek olduğu hastalarda tedaviye cevabın daha iyi olduğu görülmektedir.

Introduction: Idiopathic sudden sensorineural hearing loss (ISSNHL) is an otologic emergency that can lead to loss of function in one of the most important human senses. Recently, hyperbaric oxygen therapy (HBOT) has gained popularity with pharmacotherapy in ISSNHL. This study aimed to determine changes induced in thiol/disulfide homeostasis (TDH, a new biomarker of systemic oxidative stress) by pharmacotherapy and HBOT in patients with ISSNHL.

Methods: This prospective study analyzed the albumin, total thiol, native thiol, and disulfide levels and disulfide-native thiol, disulfide-total thiol, and native thiol-total thiol ratios before and after HBOT with standardizing pharmacotherapy using a new colorimetric method in patients with ISSNHL.

Results: 41 patients with ISSNHL including 14 (34.1%) women and 27 (65.9%) men participated in the study. The mean age of the patients was 48.02 ± 13.10 years. Of them, 24 (58.5%) had hearing loss in the right ear and 17 (41.5%) had hearing loss in the left ear. There was a statistically significant decrease in the albumin (p<0.001), total thiol (p<0.001), native thiol (p<0.001), and disulfide (p<0.001) levels after treatment compared to baseline. There was no statistically significant difference in the disulfide-native thiol (p=0.148), disulfide-total thiol (p=0.172), and native thiol-total thiol (p=0.169) ratios after treatment compared to baseline.

Conclusion: Consequently, this study demonstrated that the thiol-disulphide balance tended to shift towards the oxidative side after HBOT and pharmacotherapy compared to baseline in patients with ISSNHL and that patients with high oxidation level after treatment had better treatment response.

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Birincil Dil en
Konular Sağlık Bilimleri ve Hizmetleri
Yayımlanma Tarihi Dec 2018
Dergi Bölümü Araştırma Makalesi (Original Article)
Yazarlar

Orcid: 0000-0001-5311-0631
Yazar: Ibrahim Solak (Sorumlu Yazar)
Kurum: University of Health Sciences, Training and Research Hospital, Department of Family Medicine, Konya
Ülke: Turkey


Orcid: 0000-0001-5575-326X
Yazar: Abdullah Arslan
Kurum: University of Health Sciences, Training and Research Hospital, Department of Underwater and Hyperbaric, Konya
Ülke: Turkey


Orcid: 0000-0002-8502-0232
Yazar: Ruhusen Kutlu
Kurum: Necmettin Erbakan University, School of Medicine, Department of Family Medicine, Konya
Ülke: Turkey


Orcid: 0000-0002-5097-9291
Yazar: Betul Kozanhan
Kurum: University of Health Sciences, Training and Research Hospital, Department of Anesthesiology, Konya
Ülke: Turkey


Orcid: 0000-0001-7571-5949
Yazar: Salim Neselioglu
Kurum: Yildirim Beyazit University, Ankara Ataturk Training and Research Hospital, Department of Biochemistry, Ankara
Ülke: Turkey


Orcid: 0000-0002-2483-1939
Yazar: Ozcan Erel
Kurum: Yildirim Beyazit University, Ankara Ataturk Training and Research Hospital, Department of Biochemistry, Ankara
Ülke: Turkey


Orcid: 0000-0002-6052-4645
Yazar: Cigdem Damla Cetinkaya
Kurum: University of Health Sciences, Training and Research Hospital, Department of Biochemistry, Konya
Ülke: Turkey


Orcid: 0000-0002-5280-3943
Yazar: Mehmet Ali Eryilmaz
Kurum: University of Health Sciences, Training and Research Hospital, Department of General Surgery, Konya
Ülke: Turkey


Bibtex @araştırma makalesi { fppc470360, journal = {FAMILY PRACTICE AND PALLIATIVE CARE}, issn = {2458-8865}, eissn = {2459-1505}, address = {SERNEV}, year = {2018}, volume = {3}, pages = {133 - 138}, doi = {10.22391/fppc.470360}, title = {Effect of hyperbaric oxygen therapy on thiol/disulfide homeostasis in patients with idiopathic sudden sensorineural hearing loss}, key = {cite}, author = {Neselioglu, Salim and Kutlu, Ruhusen and Erel, Ozcan and Eryilmaz, Mehmet Ali and Solak, Ibrahim and Cetinkaya, Cigdem Damla and Kozanhan, Betul and Arslan, Abdullah} }
APA Solak, I , Arslan, A , Kutlu, R , Kozanhan, B , Neselioglu, S , Erel, O , Cetinkaya, C , Eryilmaz, M . (2018). Effect of hyperbaric oxygen therapy on thiol/disulfide homeostasis in patients with idiopathic sudden sensorineural hearing loss. FAMILY PRACTICE AND PALLIATIVE CARE, 3 (3), 133-138. DOI: 10.22391/fppc.470360
MLA Solak, I , Arslan, A , Kutlu, R , Kozanhan, B , Neselioglu, S , Erel, O , Cetinkaya, C , Eryilmaz, M . "Effect of hyperbaric oxygen therapy on thiol/disulfide homeostasis in patients with idiopathic sudden sensorineural hearing loss". FAMILY PRACTICE AND PALLIATIVE CARE 3 (2018): 133-138 <http://www.fppc.com.tr/issue/39527/470360>
Chicago Solak, I , Arslan, A , Kutlu, R , Kozanhan, B , Neselioglu, S , Erel, O , Cetinkaya, C , Eryilmaz, M . "Effect of hyperbaric oxygen therapy on thiol/disulfide homeostasis in patients with idiopathic sudden sensorineural hearing loss". FAMILY PRACTICE AND PALLIATIVE CARE 3 (2018): 133-138
RIS TY - JOUR T1 - Effect of hyperbaric oxygen therapy on thiol/disulfide homeostasis in patients with idiopathic sudden sensorineural hearing loss AU - Ibrahim Solak , Abdullah Arslan , Ruhusen Kutlu , Betul Kozanhan , Salim Neselioglu , Ozcan Erel , Cigdem Damla Cetinkaya , Mehmet Ali Eryilmaz Y1 - 2018 PY - 2018 N1 - doi: 10.22391/fppc.470360 DO - 10.22391/fppc.470360 T2 - FAMILY PRACTICE AND PALLIATIVE CARE JF - Journal JO - JOR SP - 133 EP - 138 VL - 3 IS - 3 SN - 2458-8865-2459-1505 M3 - doi: 10.22391/fppc.470360 UR - http://dx.doi.org/10.22391/fppc.470360 Y2 - 2018 ER -
EndNote %0 FAMILY PRACTICE AND PALLIATIVE CARE Effect of hyperbaric oxygen therapy on thiol/disulfide homeostasis in patients with idiopathic sudden sensorineural hearing loss %A Ibrahim Solak , Abdullah Arslan , Ruhusen Kutlu , Betul Kozanhan , Salim Neselioglu , Ozcan Erel , Cigdem Damla Cetinkaya , Mehmet Ali Eryilmaz %T Effect of hyperbaric oxygen therapy on thiol/disulfide homeostasis in patients with idiopathic sudden sensorineural hearing loss %D 2018 %J FAMILY PRACTICE AND PALLIATIVE CARE %P 2458-8865-2459-1505 %V 3 %N 3 %R doi: 10.22391/fppc.470360 %U 10.22391/fppc.470360
ISNAD Solak, Ibrahim , Arslan, Abdullah , Kutlu, Ruhusen , Kozanhan, Betul , Neselioglu, Salim , Erel, Ozcan , Cetinkaya, Cigdem Damla , Eryilmaz, Mehmet Ali . "İdiopatik ani işitme kaybı olan hastaların tiyol/disülfit homeostazisi üzerine hiperbarik oksijen tedavisinin etkisi". FAMILY PRACTICE AND PALLIATIVE CARE 3 / 3 (Ekim 2018): 133-138. http://dx.doi.org/10.22391/fppc.470360