Yıl 2018, Cilt 3, Sayı 3, Sayfalar 139 - 144 2018-10-04

Changes in systemic inflammatory and nasal mucociliary response following smoking cessation
Sigara bırakma sonrası sistemik inflamatuar ve nazal mukosilier yanıttaki değişiklikler

Ibrahim Solak [1] , Kamile Marakoglu [2] , Selma Pekgor [3] , Nisa Cetin Kargin [4] , Yavuz Turgut Gederet [5] , Necat Alatas [6] , Mehmet Ali Eryilmaz [7]

15 16

Introduction: This study aimed to evaluate the changes both in the systemic inflammation and in the mucociliary clearance following smoking cessation, and their associations with smoking characteristics.

Methods: A total of 30 cases admitted to Konya Training and Research Hospital, University of Health Sciences, Department of Smoking Cessation were recruited, and 27 of them completed the study. Tumor necrosis factor alpha (TNF-α), interleukin (IL) -4, IL-6, IL-8, IL-10 and saccharin transit time (STT) was measuredat the beginning and 2 months after smoking cessation.

Results: We found in this study that STT decreased significantly in 2 months after cessation (p<0.001). In our study, we found that serum TNF-α (p=0.035) and IL-8 (p=0.002) levels were decreased significantly at 2 months after quitting when compared with the basal levels. In our study, serum IL-6 (p=0.132) and IL-10 (p=0.657) levels did not change significantly in the 2nd month of quitting, when compared to basal levels.

Conclusion: In this study, two months after smoking cessation, nasal mucosal clearance and systemic inflammatory response especially plasma TNF- α and IL-8 levels were improved. We think that further studies with larger sample size and longer follow-up will provide more detailed data about the improvements in systemic inflammation.

Giriş: Bu çalışmada, sigara bırakma sonrası, hem sistemik inflamasyonda hem de nasal mukosilier klirensde meydana gelen değişiklikleri ve bunların sigara içme özellikleri ile ilişkilerinin değerlendirilmesi amaçlanmıştır.

Yöntem: Sağlık Bilimleri Üniversitesi Konya Eğitim Araştırma Hastanesi Sigara Bırakma Polikliniğine başvuran 30 vaka çalışmaya dahil edilip 27 vaka ile çalışma tamamlanmıştır. Tümör nekrozis faktör-alfa (TNF-α), interlökin (IL) -4, IL-6, IL-8, IL-10 ve sakarin geçiş süresi (STT), kayıt ve sigara bırakılmasından 2 ay sonra ölçüldü.

Bulgular: Bu çalışmada, STT’nin sigara bırakıldıktan 2 ay sonra anlamlı olarak kısaldığı görüldü (p <0,001). Serum TNF-α (p = 0,035) ve IL-8 (p = 0,002) düzeylerinin, bazal seviyelerle karşılaştırıldığında, sigara bıraktıktan sonraki 2. ayda anlamlı olarak azaldığını bulduk. Bazal seviyelerle karşılaştırıldığında, sigara bıraktıktan sonraki 2. ayda serum IL-6 (p = 0,132) ve IL-10 (p = 0,657) seviyelerinin değişiminin anlamlı olmadığı gözlendi.

Sonuç: Sigara bırakma işleminden iki ay sonra, nazal mukosiliyer klirens ve sistemik inflamatuar yanıtta, özellikle plazma TNF- α ve IL-8 düzeylerinde iyileşme görülmüştür. Daha büyük katılımlı ve daha uzun süreli sigara bırakma sonrası yapılan çalışmalarla, sistemik inflamasyondaki düzelmelerin daha ayrıntılı gösterilebileceği düşünülmektedir.

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Birincil Dil en
Konular Sağlık Bilimleri ve Hizmetleri
Yayımlanma Tarihi Dec 2018
Dergi Bölümü Araştırma Makalesi (Original Article)
Yazarlar

Orcid: 0000-0001-5311-0631
Yazar: Ibrahim Solak (Sorumlu Yazar)
Kurum: University of Health Sciences, Training and Research Hospital, Department of Family Medicine, Konya
Ülke: Turkey


Orcid: 0000-0002-6585-7019
Yazar: Kamile Marakoglu
Kurum: Selcuk University, School of Medicine, Department of Family Medicine, Konya
Ülke: Turkey


Orcid: 0000-0001-9907-1842
Yazar: Selma Pekgor
Kurum: University of Health Sciences, Training and Research Hospital, Department of Family Medicine, Konya
Ülke: Turkey


Orcid: 0000-0002-3819-2402
Yazar: Nisa Cetin Kargin
Kurum: Selcuk University, School of Medicine, Department of Family Medicine, Konya
Ülke: Turkey


Orcid: 0000-0002-6140-4581
Yazar: Yavuz Turgut Gederet
Kurum: University of Health Sciences, Training and Research Hospital, Department of Biochemistry, Konya
Ülke: Turkey


Orcid: 0000-0003-0894-2134
Yazar: Necat Alatas
Kurum: University of Health Sciences, Training and Research Hospital, Department of Otorhinolaryngology, Konya
Ülke: Turkey


Orcid: 0000-0002-5820-3943
Yazar: Mehmet Ali Eryilmaz
Kurum: University of Health Sciences, Training and Research Hospital, Department of General Surgery, Konya
Ülke: Turkey


Bibtex @araştırma makalesi { fppc474484, journal = {FAMILY PRACTICE AND PALLIATIVE CARE}, issn = {2458-8865}, eissn = {2459-1505}, address = {SERNEV}, year = {2018}, volume = {3}, pages = {139 - 144}, doi = {10.22391/fppc.474484}, title = {Changes in systemic inflammatory and nasal mucociliary response following smoking cessation}, key = {cite}, author = {Gederet, Yavuz Turgut and Pekgor, Selma and Kargin, Nisa Cetin and Alatas, Necat and Eryilmaz, Mehmet Ali and Marakoglu, Kamile and Solak, Ibrahim} }
APA Solak, I , Marakoglu, K , Pekgor, S , Kargin, N , Gederet, Y , Alatas, N , Eryilmaz, M . (2018). Changes in systemic inflammatory and nasal mucociliary response following smoking cessation. FAMILY PRACTICE AND PALLIATIVE CARE, 3 (3), 139-144. DOI: 10.22391/fppc.474484
MLA Solak, I , Marakoglu, K , Pekgor, S , Kargin, N , Gederet, Y , Alatas, N , Eryilmaz, M . "Changes in systemic inflammatory and nasal mucociliary response following smoking cessation". FAMILY PRACTICE AND PALLIATIVE CARE 3 (2018): 139-144 <http://www.fppc.com.tr/issue/39527/474484>
Chicago Solak, I , Marakoglu, K , Pekgor, S , Kargin, N , Gederet, Y , Alatas, N , Eryilmaz, M . "Changes in systemic inflammatory and nasal mucociliary response following smoking cessation". FAMILY PRACTICE AND PALLIATIVE CARE 3 (2018): 139-144
RIS TY - JOUR T1 - Changes in systemic inflammatory and nasal mucociliary response following smoking cessation AU - Ibrahim Solak , Kamile Marakoglu , Selma Pekgor , Nisa Cetin Kargin , Yavuz Turgut Gederet , Necat Alatas , Mehmet Ali Eryilmaz Y1 - 2018 PY - 2018 N1 - doi: 10.22391/fppc.474484 DO - 10.22391/fppc.474484 T2 - FAMILY PRACTICE AND PALLIATIVE CARE JF - Journal JO - JOR SP - 139 EP - 144 VL - 3 IS - 3 SN - 2458-8865-2459-1505 M3 - doi: 10.22391/fppc.474484 UR - http://dx.doi.org/10.22391/fppc.474484 Y2 - 2018 ER -
EndNote %0 FAMILY PRACTICE AND PALLIATIVE CARE Changes in systemic inflammatory and nasal mucociliary response following smoking cessation %A Ibrahim Solak , Kamile Marakoglu , Selma Pekgor , Nisa Cetin Kargin , Yavuz Turgut Gederet , Necat Alatas , Mehmet Ali Eryilmaz %T Changes in systemic inflammatory and nasal mucociliary response following smoking cessation %D 2018 %J FAMILY PRACTICE AND PALLIATIVE CARE %P 2458-8865-2459-1505 %V 3 %N 3 %R doi: 10.22391/fppc.474484 %U 10.22391/fppc.474484
ISNAD Solak, Ibrahim , Marakoglu, Kamile , Pekgor, Selma , Kargin, Nisa Cetin , Gederet, Yavuz Turgut , Alatas, Necat , Eryilmaz, Mehmet Ali . "Sigara bırakma sonrası sistemik inflamatuar ve nazal mukosilier yanıttaki değişiklikler". FAMILY PRACTICE AND PALLIATIVE CARE 3 / 3 (Ekim 2018): 139-144. http://dx.doi.org/10.22391/fppc.474484