Monosit Sayısının Yüksek Yoğunluklu Lipoproteine Oranı Akut İskemik İnmede İnflamasyon Belirteci Midir?
Öz
GİRİŞ ve AMAÇ: Bu çalışmanın amacı akut iskemik strok hastalarında monosit sayısının yüksek dansiteli lipoproteine (HDL) oranının bir belirteç olup olmadığını saptamak.
YÖNTEM ve GEREÇLER: Dahiliye yoğun bakım kliniğinde akut iskemik strok ile takip edilen elli hasta (Grup 1) ile dahiliye polikliniğine başvuran elli sağlıklı kişinin (Grup 2) dosya kayıtları retrospektif olarak taranarak çalışmaya dahil edildi. Her iki grupta hastaların demografik özellikleri ve laboratuvar sonuçları dosya kayıtlarından tarandı. Monosit sayısının HDL'ye oranı değerlendirildi. İstatistiksel olarak anlamlılık p<0.005 olarak kabul edildi.
BULGULAR: Ortalama yaş grub 1'de 78.45±12.55; grup 2'de 76.93±8.69 idi (p=0.306). Erkek cinsiyet %56 (n=28), %48 (n=24) ve (p=0.423) (sırasıyla grup1, grup 2). Lökosit sayısı, HDL düzeyi, monosit sayısının HDL'ye oranı grup 1'de grup 2'den yüksekti ve istatistiksel olarak anlamlılık saptandı (p=0.002, 0.002, 0.003, sırasıyla). Hastaların yoğun bakımda kalış gün sayısı 11.38±7.540 gün ve mortalite oranı %34 (n=17) olarak saptandı.
TARTIŞMA ve SONUÇ: Kardiyak iskemilerdeki gibi benzer patolojiye sahip olduğu düşünülen akut iskemik stroklarda monosit sayısının HDL oranı kronik inflamasyonun bir göstergesi olarak kullanılabilir.
Anahtar Kelimeler
Kaynakça
- Tanrıverdi B, Tetik ŞS, Aterosklerozun Patofizyolojisi ve Risk Faktörleri. Marmara Pharmaceutical Journal 2017; 21: 1-9.
- Serçelik A, Besnili AB, Increased monocyte to high-density lipoprotein cholesterol ratio is associated with TIMI risk score in patients with ST-segment elevation myocardial infarction. Rev Port Cardiol. 2018;37(3):217-23.
- Kızılgül M, Çalışkan M, Uçan B Monocyte to HDL Cholesterol Ratio and its association with cardio-metabolic risk factors in Primary Hyperparathyroidism. Medeniyet Medical Journal 2018;33(2):94-9.
- Barter PJ, Nicholls S, Rye KA, Antiinflammatory properties of HDL. Circ Res. 2004 Oct 15;95(8):764-72.
- E. Idzkowska, A. Eljaszewicz, P. Miklasz, The Role of Different Monocyte Subsets in the Pathogenesis of Atherosclerosis and Acute Coronary Syndromes. Scandinavian Journal of Immunology, 2015, 82, 163–73.
- Ganjali S, Ruscica M, Atkin SL, Monocyte‐to‐HDL‐cholesterol ratio as a prognostic marker in cardiovascular diseases. J Cell Physiol. 2018; 233(12):9237-46.
- Bolayir A, Gokce SF, Cigdem B, Monocyte/high-density lipoprotein ratio predicts the mortality in ischemic stroke patients. Neurol Neurochir Pol. 2018;52(2):150-5.
- Enhos A, Cosansu K, Huyut MA, Assessment of the Relationship between Monocyte to High-Density Lipoprotein Ratio and Myocardial Bridge. Arq Bras Cardiol. 2019; 112(1):12-7.
Is the Ratio of Monocyte Count to High Density Lipoprotein an Indicator of Inflammation In Acute Ischemic Stroke?
Öz
INTRODUCTION: The aim of this study is to determine whether the ratio of monocyte count to high density lipoprotein (HDL) is an indicator in acute ischemic stroke patients.
METHODS: Fifty patients (Group 1) followed by an acute ischemic stroke at the internal medicine care unit and fifty healthy individuals (Group 2) who applied to the internal medicine outptient clinic were retrospectively scanned and included in the study.The demographic characteristics and laboratory results of the patients in both groups were scanned from the file records. The ratio of monocyte count to HDL was evaluated. Statistical significance was accepted as p <0.005.
RESULTS: The mean age was 78.45 ± 12.55 in group 1; in group 2 it was 76.93 ± 8.69 (p = 0.306). Male gender 56% (n = 28), 48% (n = 24) and (p = 0.423) (group1, group 2, respectively). The leukocyte count, HDL level, and the ratio of monocyte count to HDL were higher in group 1 than in group 2 and statistically significant (p = 0.002, 0.002, 0.003, respectively). Length of stay in intensive care unit of patients was 11.38 ± 7.540 days and the mortality rate was 34% (n = 17).
DISCUSSION and CONCLUSION: In acute ischemic strokes, which are thought to have similar pathology, as in cardiac ischemia, the ratio of monocyte count to HDL can be used as a hall-mark of chronic inflammation.
Anahtar Kelimeler
Kaynakça
- Tanrıverdi B, Tetik ŞS, Aterosklerozun Patofizyolojisi ve Risk Faktörleri. Marmara Pharmaceutical Journal 2017; 21: 1-9.
- Serçelik A, Besnili AB, Increased monocyte to high-density lipoprotein cholesterol ratio is associated with TIMI risk score in patients with ST-segment elevation myocardial infarction. Rev Port Cardiol. 2018;37(3):217-23.
- Kızılgül M, Çalışkan M, Uçan B Monocyte to HDL Cholesterol Ratio and its association with cardio-metabolic risk factors in Primary Hyperparathyroidism. Medeniyet Medical Journal 2018;33(2):94-9.
- Barter PJ, Nicholls S, Rye KA, Antiinflammatory properties of HDL. Circ Res. 2004 Oct 15;95(8):764-72.
- E. Idzkowska, A. Eljaszewicz, P. Miklasz, The Role of Different Monocyte Subsets in the Pathogenesis of Atherosclerosis and Acute Coronary Syndromes. Scandinavian Journal of Immunology, 2015, 82, 163–73.
- Ganjali S, Ruscica M, Atkin SL, Monocyte‐to‐HDL‐cholesterol ratio as a prognostic marker in cardiovascular diseases. J Cell Physiol. 2018; 233(12):9237-46.
- Bolayir A, Gokce SF, Cigdem B, Monocyte/high-density lipoprotein ratio predicts the mortality in ischemic stroke patients. Neurol Neurochir Pol. 2018;52(2):150-5.
- Enhos A, Cosansu K, Huyut MA, Assessment of the Relationship between Monocyte to High-Density Lipoprotein Ratio and Myocardial Bridge. Arq Bras Cardiol. 2019; 112(1):12-7.
Ayrıntılar
| Birincil Dil | Türkçe |
|---|---|
| Konular | Klinik Tıp Bilimleri |
| Bölüm | Research Article |
| Yazarlar | |
| Yayımlanma Tarihi | 31 Ağustos 2020 |
| Gönderilme Tarihi | 9 Şubat 2020 |
| Yayımlandığı Sayı | Yıl 2020 Cilt: 9 Sayı: 2 |
