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Yıl 2021, Cilt: 8 Sayı: 1, 27 - 37, 30.06.2021
https://doi.org/10.48138/cjo.934158

Öz

Kaynakça

  • Borrell, L. N., & Samuel, L. (2014). Body mass index categories and mortality risk in US adults: the effect of overweight and obesity on advancing death. American Journal of Public Health, 104(3), 512–519. https://doi.org/10.2105/AJPH.2013.301597
  • Brown, C. D., Higgins, M., Donato, K. A., Rohde, F. C., Garrison, R., Obarzanek, E., Ernst, N. D., & Horan, M. (2000). Body mass index and the prevalence of hypertension and dyslipidemia. Obesity Research, 8(9), 605–619. https://doi.org/10.1038/oby.2000.79
  • Cantó, C., Houtkooper, R. H., Pirinen, E., Youn, D. Y., Oosterveer, M. H., Cen, Y., Fernandez-Marcos, P. J., Yamamoto, H., Andreux, P. A., Cettour-Rose, P., Gademann, K., Rinsch, C., Schoonjans, K., Sauve, A. A., & Auwerx, J. (2012). The NAD(+) precursor nicotinamide riboside enhances oxidative metabolism and protects against high-fat diet-induced obesity. Cell Metabolism, 15(6), 838–847. https://doi.org/10.1016/j.cmet.2012.04.022
  • Cantó, C., Menzies, K. J., & Auwerx, J. (2015). NAD(+) Metabolism and the Control of Energy Homeostasis: A Balancing Act between Mitochondria and the Nucleus. Cell Metabolism, 22(1), 31–53. https://doi.org/10.1016/j.cmet.2015.05.023
  • Cawley, J., & Meyerhoefer, C. (2012). The medical care costs of obesity: an instrumental variables approach. Journal of Health Economics, 31(1), 219–230. https://doi.org/10.1016/j.jhealeco.2011.10.003
  • Cohen, J. (1988). Statistical power analysis for the behavioral sciences. Academic press.
  • Fernández Vázquez, G., Reiter, R. J., & Agil, A. (2018). Melatonin increases brown adipose tissue mass and function in Zücker diabetic fatty rats: implications for obesity control. Journal of Pineal Research, 64(4), e12472. https://doi.org/10.1111/jpi.12472
  • Gronowska-Senger, A., Magdalena, G., & Katarzyna, K. (2009). Tocopherol acetate vs. oxidative stress induced by physical exercise in rats. Pol. J. Food Nutr. Sci., 59(3), 263–269. https://doi.org/10.2165/00128415-200510340-00041
  • Heo, J.-I., Yoon, D. W., Yu, J. H., Kim, N. H., Yoo, H. J., Seo, J. A., Kim, S. G., Choi, K. M., Baik, S. H., Choi, D. S., & Kim, N. H. (2018). Melatonin improves insulin resistance and hepatic steatosis through attenuation of alpha-2-HS-glycoprotein. Journal of Pineal Research, 65(2), e12493. https://doi.org/10.1111/jpi.12493
  • Jensen, M. D., Ryan, D. H., Apovian, C. M., Ard, J. D., Comuzzie, A. G., Donato, K. A., Hu, F. B., Hubbard, V. S., Jakicic, J. M., Kushner, R. F., Loria, C. M., Millen, B. E., Nonas, C. A., Pi-Sunyer, F. X., Stevens, J., Stevens, V. J., Wadden, T. A., Wolfe, B. M., & Yanovski, S. Z. (2014). 2013 AHA/ACC/TOS Guideline for the Management of Overweight and Obesity in Adults. Circulation, 129(25\_suppl\_2), S102–S138. https://doi.org/10.1161/01.cir.0000437739.71477.ee
  • Kwon, W. Y., Suh, G. J., Kim, K. S., Jung, Y. S., Kim, S. H., Lee, A. R., You, K. M., & Park, M. J. (2018). Niacin and Selenium Attenuate Brain Injury After Cardiac Arrest in Rats by Up-Regulating DJ-1-Akt Signaling. Critical Care Medicine, 46(8), e788–e796. https://doi.org/10.1097/CCM.0000000000003198
  • Lopez, J. (2013). Carl A. Burtis, Edward R. Ashwood and David E. Bruns (eds): Tietz Textbook of Clinical Chemistry and Molecular Diagnosis (5th edition). Indian Journal of Clinical Biochemistry, 28(1), 104–105. https://doi.org/10.1007/s12291-012-0287-7
  • Magkos, F., Fraterrigo, G., Yoshino, J., Luecking, C., Kirbach, K., Kelly, S. C., de Las Fuentes, L., He, S., Okunade, A. L., Patterson, B. W., & Klein, S. (2016). Effects of Moderate and Subsequent Progressive Weight Loss on Metabolic Function and Adipose Tissue Biology in Humans with Obesity. Cell Metabolism, 23(4), 591–601. https://doi.org/10.1016/j.cmet.2016.02.005
  • Mendes, C., Gomes, G., Belpiede, L. T., do Carmo Buonfiglio, D., Motta-Teixeira, L. C., Amaral, F. G., & Cipolla-Neto, J. (2021). The effects of melatonin daily supplementation to aged rats on the ability to withstand cold, thermoregulation and body weight. Life Sciences, 265, 118769.
  • Montalbano, G., Mania, M., Abbate, F., Navarra, M., Guerrera, M. C., Laura, R., Vega, J. A., Levanti, M., & Germanà, A. (2018). Melatonin treatment suppresses appetite genes and improves adipose tissue plasticity in diet-induced obese zebrafish. Endocrine, 62(2), 381–393. https://doi.org/10.1007/s12020-018-1653-x
  • Mostafavi, S.-A., Akhondzadeh, S., Reza Mohammadi, M., Keshtkar, A.-A., Hosseini, S., Reza Eshraghian, M., Ahmadi Motlagh, T., Alipour, R., & Ali Keshavarz, S. (2017). Role of melatonin in body weight: A systematic review and meta-analysis. Current Pharmaceutical Design, 23(23), 3445–3452.
  • Preuss, H. G., Bagchi, D., Bagchi, M., Rao, C. V. S., Dey, D. K., & Satyanarayana, S. (2004). Effects of a natural extract of (-)-hydroxycitric acid (HCA-SX) and a combination of HCA-SX plus niacin-bound chromium and Gymnema sylvestre extract on weight loss. Diabetes, Obesity & Metabolism, 6(3), 171–180. https://doi.org/10.1111/j.1462-8902.2004.00328.x
  • Reiter, R. J., Mayo, J. C., Tan, D.-X., Sainz, R. M., Alatorre-Jimenez, M., & Qin, L. (2016). Melatonin as an antioxidant: under promises but over delivers. Journal of Pineal Research, 61(3), 253–278. https://doi.org/10.1111/jpi.12360
  • Sasai, H., Sairenchi, T., Iso, H., Irie, F., Otaka, E., Tanaka, K., Ota, H., & Muto, T. (2010). Relationship between obesity and incident diabetes in middle-aged and older Japanese adults: the Ibaraki Prefectural Health Study. Mayo Clinic Proceedings, 85(1), 36–40. https://doi.org/10.4065/mcp.2009.0230
  • Sawilowsky, S. S. (2009). Very large and huge effect sizes. Journal of Modern Applied Statistical Methods, 8(2), 597–599. https://doi.org/10.22237/jmasm/1257035100 Spiegelman, B. M., & Flier, J. S. (2001). Obesity and the regulation of energy balance. Cell, 104(4), 531–543. https://doi.org/10.1016/s0092-8674(01)00240-9
  • Wang, W., Basinger, A., Neese, R. A., Shane, B., Myong, S.-A., Christiansen, M., & Hellerstein, M. K. (2001). Effect of nicotinic acid administration on hepatic very low density lipoprotein-triglyceride production. American Journal of Physiology-Endocrinology and Metabolism, 280(3), E540–E547. https://doi.org/10.1152/ajpendo.2001.280.3.E540
  • Ward, Z. J., Long, M. W., Resch, S. C., Gortmaker, S. L., Cradock, A. L., Giles, C., Hsiao, A., & Wang, Y. C. (2016). Redrawing the US Obesity Landscape: Bias-Corrected Estimates of State-Specific Adult Obesity Prevalence. PloS One, 11(3), e0150735. https://doi.org/10.1371/journal.pone.0150735
  • Wilson, P. W. F., Meigs, J. B., Sullivan, L., Fox, C. S., Nathan, D. M., & D’Agostino, R. B. S. (2007). Prediction of incident diabetes mellitus in middle-aged adults: the Framingham Offspring Study. Archives of Internal Medicine, 167(10), 1068–1074. https://doi.org/10.1001/archinte.167.10.1068
  • Wormser, D., Kaptoge, S., Di Angelantonio, E., Wood, A. M., Pennells, L., Thompson, A., Sarwar, N., Kizer, J. R., Lawlor, D. A., Nordestgaard, B. G., Ridker, P., Salomaa, V., Stevens, J., Woodward, M., Sattar, N., Collins, R., Thompson, S. G., Whitlock, G., & Danesh, J. (2011). Separate and combined associations of body-mass index and abdominal adiposity with cardiovascular disease: collaborative analysis of 58 prospective studies. Lancet (London, England), 377(9771), 1085–1095. https://doi.org/10.1016/S0140-6736(11)60105-0
  • Xiang, D., Zhang, Q., & Wang, Y.-T. (2020). Effectiveness of niacin supplementation for patients with type 2 diabetes: A meta-analysis of randomized controlled trials. Medicine, 99(29), e21235. https://doi.org/10.1097/MD.0000000000021235
  • Xu, P., Wang, J., Hong, F., Wang, S., Jin, X., Xue, T., Jia, L., & Zhai, Y. (2017). Melatonin prevents obesity through modulation of gut microbiota in mice. Journal of Pineal Research, 62(4). https://doi.org/10.1111/jpi.12399
  • Ye, L., Cao, Z., Lai, X., Wang, W., Guo, Z., Yan, L., Wang, Y., Shi, Y., & Zhou, N. (2019). Niacin fine-tunes energy homeostasis through canonical GPR109A signaling. The FASEB Journal, 33(4), 4765–4779. https://doi.org/https://doi.org/10.1096/fj.201801951R
  • Yin, J., Li, Y., Han, H., Chen, S., Gao, J., Liu, G., Wu, X., Deng, J., Yu, Q., & Huang, X. (2018). Melatonin reprogramming of gut microbiota improves lipid dysmetabolism in high‐fat diet‐fed mice. Journal of Pineal Research, 65(4), e12524.
  • Ying, W. (2008). NAD+/NADH and NADP+/NADPH in cellular functions and cell death: regulation and biological consequences. Antioxidants & Redox Signaling, 10(2), 179–206. https://doi.org/10.1089/ars.2007.1672

Physiological and Anti-obesity Effects of Melatonin and Niacin Supplements in Rat Models

Yıl 2021, Cilt: 8 Sayı: 1, 27 - 37, 30.06.2021
https://doi.org/10.48138/cjo.934158

Öz

In recent years, the increase in obesity in the world has led to the development of new strategies in combating obesity. In the present study, it was aimed to investigate the effect of niacin and melatonin supplements to combat obesity in rats as a model organism. Treadmill exercise was performed on rats after niacin and melatonin supplementation for 10 days. In each group, weight loss was observed at the end of the 10 days exercise. In this study, it was observed that niacin supplementation leading to weight loss in rats that had treadmill exercise when compared to the control group. In addition, it was found that the weight loss observed in melatonin+niacin supplement was higher than niacin supplement only. It was found that the weight loss observed in the group given melatonin+niacin supplement was higher than the weight loss observed in niacin supplement only. As a result, niacin and melatonin supplementation can be recommended before exercise to combat obesity.

Kaynakça

  • Borrell, L. N., & Samuel, L. (2014). Body mass index categories and mortality risk in US adults: the effect of overweight and obesity on advancing death. American Journal of Public Health, 104(3), 512–519. https://doi.org/10.2105/AJPH.2013.301597
  • Brown, C. D., Higgins, M., Donato, K. A., Rohde, F. C., Garrison, R., Obarzanek, E., Ernst, N. D., & Horan, M. (2000). Body mass index and the prevalence of hypertension and dyslipidemia. Obesity Research, 8(9), 605–619. https://doi.org/10.1038/oby.2000.79
  • Cantó, C., Houtkooper, R. H., Pirinen, E., Youn, D. Y., Oosterveer, M. H., Cen, Y., Fernandez-Marcos, P. J., Yamamoto, H., Andreux, P. A., Cettour-Rose, P., Gademann, K., Rinsch, C., Schoonjans, K., Sauve, A. A., & Auwerx, J. (2012). The NAD(+) precursor nicotinamide riboside enhances oxidative metabolism and protects against high-fat diet-induced obesity. Cell Metabolism, 15(6), 838–847. https://doi.org/10.1016/j.cmet.2012.04.022
  • Cantó, C., Menzies, K. J., & Auwerx, J. (2015). NAD(+) Metabolism and the Control of Energy Homeostasis: A Balancing Act between Mitochondria and the Nucleus. Cell Metabolism, 22(1), 31–53. https://doi.org/10.1016/j.cmet.2015.05.023
  • Cawley, J., & Meyerhoefer, C. (2012). The medical care costs of obesity: an instrumental variables approach. Journal of Health Economics, 31(1), 219–230. https://doi.org/10.1016/j.jhealeco.2011.10.003
  • Cohen, J. (1988). Statistical power analysis for the behavioral sciences. Academic press.
  • Fernández Vázquez, G., Reiter, R. J., & Agil, A. (2018). Melatonin increases brown adipose tissue mass and function in Zücker diabetic fatty rats: implications for obesity control. Journal of Pineal Research, 64(4), e12472. https://doi.org/10.1111/jpi.12472
  • Gronowska-Senger, A., Magdalena, G., & Katarzyna, K. (2009). Tocopherol acetate vs. oxidative stress induced by physical exercise in rats. Pol. J. Food Nutr. Sci., 59(3), 263–269. https://doi.org/10.2165/00128415-200510340-00041
  • Heo, J.-I., Yoon, D. W., Yu, J. H., Kim, N. H., Yoo, H. J., Seo, J. A., Kim, S. G., Choi, K. M., Baik, S. H., Choi, D. S., & Kim, N. H. (2018). Melatonin improves insulin resistance and hepatic steatosis through attenuation of alpha-2-HS-glycoprotein. Journal of Pineal Research, 65(2), e12493. https://doi.org/10.1111/jpi.12493
  • Jensen, M. D., Ryan, D. H., Apovian, C. M., Ard, J. D., Comuzzie, A. G., Donato, K. A., Hu, F. B., Hubbard, V. S., Jakicic, J. M., Kushner, R. F., Loria, C. M., Millen, B. E., Nonas, C. A., Pi-Sunyer, F. X., Stevens, J., Stevens, V. J., Wadden, T. A., Wolfe, B. M., & Yanovski, S. Z. (2014). 2013 AHA/ACC/TOS Guideline for the Management of Overweight and Obesity in Adults. Circulation, 129(25\_suppl\_2), S102–S138. https://doi.org/10.1161/01.cir.0000437739.71477.ee
  • Kwon, W. Y., Suh, G. J., Kim, K. S., Jung, Y. S., Kim, S. H., Lee, A. R., You, K. M., & Park, M. J. (2018). Niacin and Selenium Attenuate Brain Injury After Cardiac Arrest in Rats by Up-Regulating DJ-1-Akt Signaling. Critical Care Medicine, 46(8), e788–e796. https://doi.org/10.1097/CCM.0000000000003198
  • Lopez, J. (2013). Carl A. Burtis, Edward R. Ashwood and David E. Bruns (eds): Tietz Textbook of Clinical Chemistry and Molecular Diagnosis (5th edition). Indian Journal of Clinical Biochemistry, 28(1), 104–105. https://doi.org/10.1007/s12291-012-0287-7
  • Magkos, F., Fraterrigo, G., Yoshino, J., Luecking, C., Kirbach, K., Kelly, S. C., de Las Fuentes, L., He, S., Okunade, A. L., Patterson, B. W., & Klein, S. (2016). Effects of Moderate and Subsequent Progressive Weight Loss on Metabolic Function and Adipose Tissue Biology in Humans with Obesity. Cell Metabolism, 23(4), 591–601. https://doi.org/10.1016/j.cmet.2016.02.005
  • Mendes, C., Gomes, G., Belpiede, L. T., do Carmo Buonfiglio, D., Motta-Teixeira, L. C., Amaral, F. G., & Cipolla-Neto, J. (2021). The effects of melatonin daily supplementation to aged rats on the ability to withstand cold, thermoregulation and body weight. Life Sciences, 265, 118769.
  • Montalbano, G., Mania, M., Abbate, F., Navarra, M., Guerrera, M. C., Laura, R., Vega, J. A., Levanti, M., & Germanà, A. (2018). Melatonin treatment suppresses appetite genes and improves adipose tissue plasticity in diet-induced obese zebrafish. Endocrine, 62(2), 381–393. https://doi.org/10.1007/s12020-018-1653-x
  • Mostafavi, S.-A., Akhondzadeh, S., Reza Mohammadi, M., Keshtkar, A.-A., Hosseini, S., Reza Eshraghian, M., Ahmadi Motlagh, T., Alipour, R., & Ali Keshavarz, S. (2017). Role of melatonin in body weight: A systematic review and meta-analysis. Current Pharmaceutical Design, 23(23), 3445–3452.
  • Preuss, H. G., Bagchi, D., Bagchi, M., Rao, C. V. S., Dey, D. K., & Satyanarayana, S. (2004). Effects of a natural extract of (-)-hydroxycitric acid (HCA-SX) and a combination of HCA-SX plus niacin-bound chromium and Gymnema sylvestre extract on weight loss. Diabetes, Obesity & Metabolism, 6(3), 171–180. https://doi.org/10.1111/j.1462-8902.2004.00328.x
  • Reiter, R. J., Mayo, J. C., Tan, D.-X., Sainz, R. M., Alatorre-Jimenez, M., & Qin, L. (2016). Melatonin as an antioxidant: under promises but over delivers. Journal of Pineal Research, 61(3), 253–278. https://doi.org/10.1111/jpi.12360
  • Sasai, H., Sairenchi, T., Iso, H., Irie, F., Otaka, E., Tanaka, K., Ota, H., & Muto, T. (2010). Relationship between obesity and incident diabetes in middle-aged and older Japanese adults: the Ibaraki Prefectural Health Study. Mayo Clinic Proceedings, 85(1), 36–40. https://doi.org/10.4065/mcp.2009.0230
  • Sawilowsky, S. S. (2009). Very large and huge effect sizes. Journal of Modern Applied Statistical Methods, 8(2), 597–599. https://doi.org/10.22237/jmasm/1257035100 Spiegelman, B. M., & Flier, J. S. (2001). Obesity and the regulation of energy balance. Cell, 104(4), 531–543. https://doi.org/10.1016/s0092-8674(01)00240-9
  • Wang, W., Basinger, A., Neese, R. A., Shane, B., Myong, S.-A., Christiansen, M., & Hellerstein, M. K. (2001). Effect of nicotinic acid administration on hepatic very low density lipoprotein-triglyceride production. American Journal of Physiology-Endocrinology and Metabolism, 280(3), E540–E547. https://doi.org/10.1152/ajpendo.2001.280.3.E540
  • Ward, Z. J., Long, M. W., Resch, S. C., Gortmaker, S. L., Cradock, A. L., Giles, C., Hsiao, A., & Wang, Y. C. (2016). Redrawing the US Obesity Landscape: Bias-Corrected Estimates of State-Specific Adult Obesity Prevalence. PloS One, 11(3), e0150735. https://doi.org/10.1371/journal.pone.0150735
  • Wilson, P. W. F., Meigs, J. B., Sullivan, L., Fox, C. S., Nathan, D. M., & D’Agostino, R. B. S. (2007). Prediction of incident diabetes mellitus in middle-aged adults: the Framingham Offspring Study. Archives of Internal Medicine, 167(10), 1068–1074. https://doi.org/10.1001/archinte.167.10.1068
  • Wormser, D., Kaptoge, S., Di Angelantonio, E., Wood, A. M., Pennells, L., Thompson, A., Sarwar, N., Kizer, J. R., Lawlor, D. A., Nordestgaard, B. G., Ridker, P., Salomaa, V., Stevens, J., Woodward, M., Sattar, N., Collins, R., Thompson, S. G., Whitlock, G., & Danesh, J. (2011). Separate and combined associations of body-mass index and abdominal adiposity with cardiovascular disease: collaborative analysis of 58 prospective studies. Lancet (London, England), 377(9771), 1085–1095. https://doi.org/10.1016/S0140-6736(11)60105-0
  • Xiang, D., Zhang, Q., & Wang, Y.-T. (2020). Effectiveness of niacin supplementation for patients with type 2 diabetes: A meta-analysis of randomized controlled trials. Medicine, 99(29), e21235. https://doi.org/10.1097/MD.0000000000021235
  • Xu, P., Wang, J., Hong, F., Wang, S., Jin, X., Xue, T., Jia, L., & Zhai, Y. (2017). Melatonin prevents obesity through modulation of gut microbiota in mice. Journal of Pineal Research, 62(4). https://doi.org/10.1111/jpi.12399
  • Ye, L., Cao, Z., Lai, X., Wang, W., Guo, Z., Yan, L., Wang, Y., Shi, Y., & Zhou, N. (2019). Niacin fine-tunes energy homeostasis through canonical GPR109A signaling. The FASEB Journal, 33(4), 4765–4779. https://doi.org/https://doi.org/10.1096/fj.201801951R
  • Yin, J., Li, Y., Han, H., Chen, S., Gao, J., Liu, G., Wu, X., Deng, J., Yu, Q., & Huang, X. (2018). Melatonin reprogramming of gut microbiota improves lipid dysmetabolism in high‐fat diet‐fed mice. Journal of Pineal Research, 65(4), e12524.
  • Ying, W. (2008). NAD+/NADH and NADP+/NADPH in cellular functions and cell death: regulation and biological consequences. Antioxidants & Redox Signaling, 10(2), 179–206. https://doi.org/10.1089/ars.2007.1672
Toplam 29 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Çevre Bilimleri
Bölüm Caucasian Journal of Science
Yazarlar

Adem Keskin 0000-0003-1921-2583

Recai Aci 0000-0002-3332-6619

Utku Duran 0000-0002-0002-8893

Serkan Sugeçti 0000-0003-3412-2367

Yayımlanma Tarihi 30 Haziran 2021
Gönderilme Tarihi 7 Mayıs 2021
Kabul Tarihi 22 Haziran 2021
Yayımlandığı Sayı Yıl 2021 Cilt: 8 Sayı: 1

Kaynak Göster

APA Keskin, A., Aci, R., Duran, U., Sugeçti, S. (2021). Physiological and Anti-obesity Effects of Melatonin and Niacin Supplements in Rat Models. Caucasian Journal of Science, 8(1), 27-37. https://doi.org/10.48138/cjo.934158

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