Öz
Kaynakça
- Akçapınar, H., Atasoy, F., Yakan, A., & Uğurlu, M. (2008). Bafra koyunlarında bazı meme özellikleri ve kuzularda büyüme ile bu özelliklerin farklı süt kontrol yöntemleriyle tespit edilen süt verimi ve sağım özellikleriyle fenotipik korelasyonları. Ankara Üniversitesi Veteriner Fakültesi Dergisi, 55(2), 117–124.
- Findlay, J. K., Liew, S. H., Simpson, E. R., & Korach, K. S. (2010). Estrogen signaling in the regulation of female reproductive functions. Fertility Control, 29–35.
- Hui, Y., Zhang, Y., Wang, K., Pan, C., Chen, H., Qu, L., Song, X., & Lan, X. (2020). Goat DNMT3B: An indel mutation detection, association analysis with litter size and mRNA expression in gonads. Theriogenology, 147, 108–115.
- Jetten, A. M., & Cook, D. N. (2020). (Inverse) Agonists of retinoic acid–related orphan receptor γ: regulation of immune responses, inflammation, and autoimmune disease. Annual Review of Pharmacology and Toxicology, 60, 371–390.
- Jetten, A. M., & Ueda, E. (2001). The ROR nuclear orphan receptor subfamily: critical regulators of multiple biological processes.
- Lardone, M. C., Argandoña, F., Flórez, M., Parada‐Bustamante, A., Ebensperger, M., Palma, C., Piottante, A., & Castro, A. (2017). Overexpression of CYP19A1 aromatase in L eydig cells is associated with steroidogenic dysfunction in subjects with S ertoli cell‐only syndrome. Andrology, 5(1), 41–48.
- Marciano, D. P., Chang, M. R., Corzo, C. A., Goswami, D., Lam, V. Q., Pascal, B. D., & Griffin, P. R. (2014). The therapeutic potential of nuclear receptor modulators for treatment of metabolic disorders: PPARγ, RORs, and Rev-erbs. Cell Metabolism, 19(2), 193–208.
- Platten, J. D., Cobb, J. N., & Zantua, R. E. (2019). Criteria for evaluating molecular markers: Comprehensive quality metrics to improve marker-assisted selection. PloS One, 14(1), e0210529.
- Sarachana, T., & Hu, V. W. (2013). Differential recruitment of coregulators to the RORA promoter adds another layer of complexity to gene (dys) regulation by sex hormones in autism. Molecular Autism, 4(1), 1–17.
- Unlusoy, I., & Ertugrul, O. (2016). The effects of exon 2 of inhibin βB gene and exon 3 of FSHB gene on litter size in Akkaraman and Bafra sheep breeds. Kafkas Üniv. Vet. Fakültesi Derg, 22, 771–776.
- Wang, Z., Zhang, X., Jiang, E., Yan, H., Zhu, H., Chen, H., Liu, J., Qu, L., Pan, C., & Lan, X. (2020). InDels within caprine IGF 2 BP 1 intron 2 and the 3′‐untranslated regions are associated with goat growth traits. Animal Genetics, 51(1), 117–121.
- Yakan, A., & Ünal, N. (2010). Meat production traits of a new sheep breed called Bafra in Turkey 1. Fattening, slaughter, and carcass characteristics of lambs. Tropical Animal Health and Production, 42, 751–759.
- Yang, Y., Hu, H., Mao, C., Jiang, F., Lu, X., Han, X., Hao, K., Lan, X., Zhang, Q., & Pan, C. (2022). Detection of the 23-bp nucleotide sequence mutation in retinoid acid receptor related orphan receptor alpha (RORA) gene and its effect on sheep litter size. Animal Biotechnology, 33(1), 70–78.
- Yildiran, F., & Cakir, S. (2012). Analysis of genetic polymorphism with microsatellite method in Turkey local sheep breeds.
- Zhang, C. Y., Wu, C. J., Zeng, W. B., Huang, K. K., Li, X., Feng, J. H., Wang, D., Hua, G. H., Xu, D. Q., & Wen, Q. Y. (2011). Polymorphism in exon 3 of follicle stimulating hormone beta (FSHB) subunit gene and its association with litter traits and superovulation in the goat. Small Ruminant Research, 96(1), 53–57.
- Zhang, Y., Luo, X., Wu, D., & Xu, Y. (2015). ROR nuclear receptors: structures, related diseases, and drug discovery. Acta Pharmacologica Sinica, 36(1), 71–87.
The Role of Rora (Rar-Related Orphan Receptor Alpha) Receptors, One of The Candidate Genes Identified for Sheep Reproductive Traits, In Sheep Reproduction
Öz
RORA (RAR-Related Orphan Receptor Alpha) regulates estrogen synthesis by transcribing steroid related genes. Litter size is an important reproductive trait associated with estrogen synthesis. Therefore, it is critical to investigate the relationship between the RORA gene and sheep litter size. In this study, a 23 base pair nucleotide sequence mutation in a gene called RORA and the effect of this mutation on the productivity of sheep offspring were investigated. In this study, a 23 bp nucleotide sequence mutation was found in intron 1 of the RORA gene in 35 female Bafra ewes. Ten ml of milk was collected from each of the 35 samples. The litter size of the DD genotype was significantly higher than the ID genotype and the II genotype in the second born litter size (p> 0.05). The relationship between combined genotypes and average litter size showed that ewes with homozygous (DD) genotype had larger lambs than ewes with heterozygous (ID) genotype. Multiple pregnancy rates in the first and second litters were higher than the average stillbirth rate (p> 0.05). To summarize, this study provided theoretical references for further research on the function of RORA gene and breeding of Bafra sheep. The 23-bp indel variants can be used as molecular markers for the size of first and second born offspring of ewes in MAS (marker assisted selection) breeding.
Anahtar Kelimeler
RORA (RAR-Related Orphan Receptor Alpha) 23-bp nucleotide sequence mutation intron 1 Bafra sheep MAS (marker-assisted selection)
Kaynakça
- Akçapınar, H., Atasoy, F., Yakan, A., & Uğurlu, M. (2008). Bafra koyunlarında bazı meme özellikleri ve kuzularda büyüme ile bu özelliklerin farklı süt kontrol yöntemleriyle tespit edilen süt verimi ve sağım özellikleriyle fenotipik korelasyonları. Ankara Üniversitesi Veteriner Fakültesi Dergisi, 55(2), 117–124.
- Findlay, J. K., Liew, S. H., Simpson, E. R., & Korach, K. S. (2010). Estrogen signaling in the regulation of female reproductive functions. Fertility Control, 29–35.
- Hui, Y., Zhang, Y., Wang, K., Pan, C., Chen, H., Qu, L., Song, X., & Lan, X. (2020). Goat DNMT3B: An indel mutation detection, association analysis with litter size and mRNA expression in gonads. Theriogenology, 147, 108–115.
- Jetten, A. M., & Cook, D. N. (2020). (Inverse) Agonists of retinoic acid–related orphan receptor γ: regulation of immune responses, inflammation, and autoimmune disease. Annual Review of Pharmacology and Toxicology, 60, 371–390.
- Jetten, A. M., & Ueda, E. (2001). The ROR nuclear orphan receptor subfamily: critical regulators of multiple biological processes.
- Lardone, M. C., Argandoña, F., Flórez, M., Parada‐Bustamante, A., Ebensperger, M., Palma, C., Piottante, A., & Castro, A. (2017). Overexpression of CYP19A1 aromatase in L eydig cells is associated with steroidogenic dysfunction in subjects with S ertoli cell‐only syndrome. Andrology, 5(1), 41–48.
- Marciano, D. P., Chang, M. R., Corzo, C. A., Goswami, D., Lam, V. Q., Pascal, B. D., & Griffin, P. R. (2014). The therapeutic potential of nuclear receptor modulators for treatment of metabolic disorders: PPARγ, RORs, and Rev-erbs. Cell Metabolism, 19(2), 193–208.
- Platten, J. D., Cobb, J. N., & Zantua, R. E. (2019). Criteria for evaluating molecular markers: Comprehensive quality metrics to improve marker-assisted selection. PloS One, 14(1), e0210529.
- Sarachana, T., & Hu, V. W. (2013). Differential recruitment of coregulators to the RORA promoter adds another layer of complexity to gene (dys) regulation by sex hormones in autism. Molecular Autism, 4(1), 1–17.
- Unlusoy, I., & Ertugrul, O. (2016). The effects of exon 2 of inhibin βB gene and exon 3 of FSHB gene on litter size in Akkaraman and Bafra sheep breeds. Kafkas Üniv. Vet. Fakültesi Derg, 22, 771–776.
- Wang, Z., Zhang, X., Jiang, E., Yan, H., Zhu, H., Chen, H., Liu, J., Qu, L., Pan, C., & Lan, X. (2020). InDels within caprine IGF 2 BP 1 intron 2 and the 3′‐untranslated regions are associated with goat growth traits. Animal Genetics, 51(1), 117–121.
- Yakan, A., & Ünal, N. (2010). Meat production traits of a new sheep breed called Bafra in Turkey 1. Fattening, slaughter, and carcass characteristics of lambs. Tropical Animal Health and Production, 42, 751–759.
- Yang, Y., Hu, H., Mao, C., Jiang, F., Lu, X., Han, X., Hao, K., Lan, X., Zhang, Q., & Pan, C. (2022). Detection of the 23-bp nucleotide sequence mutation in retinoid acid receptor related orphan receptor alpha (RORA) gene and its effect on sheep litter size. Animal Biotechnology, 33(1), 70–78.
- Yildiran, F., & Cakir, S. (2012). Analysis of genetic polymorphism with microsatellite method in Turkey local sheep breeds.
- Zhang, C. Y., Wu, C. J., Zeng, W. B., Huang, K. K., Li, X., Feng, J. H., Wang, D., Hua, G. H., Xu, D. Q., & Wen, Q. Y. (2011). Polymorphism in exon 3 of follicle stimulating hormone beta (FSHB) subunit gene and its association with litter traits and superovulation in the goat. Small Ruminant Research, 96(1), 53–57.
- Zhang, Y., Luo, X., Wu, D., & Xu, Y. (2015). ROR nuclear receptors: structures, related diseases, and drug discovery. Acta Pharmacologica Sinica, 36(1), 71–87.
Ayrıntılar
| Birincil Dil | İngilizce |
|---|---|
| Konular | Biyokimya ve Hücre Biyolojisi (Diğer) |
| Bölüm | Caucasian Journal of Science |
| Yazarlar | |
| Yayımlanma Tarihi | 10 Temmuz 2023 |
| Gönderilme Tarihi | 8 Haziran 2023 |
| Kabul Tarihi | 27 Haziran 2023 |
| Yayımlandığı Sayı | Yıl 2023 Cilt: 10 Sayı: 1 |
