Serum kartonektin (CTRP-3) düzeyinin gestasyonel diyabetli ve sağlıklı gebelerde karşılaştırılması ve biyokimyasal parametreler ve insulin direnci ile ilişkisi
Öz
Amaç: Bu çalışmada gestasyonel diyabet mellitus (GDM) tanısı alan gebelerin serum kartonektin (CTRP-3) sevilerinin sağlıklı kontrol gebe grubu ile karşılaştırılması ve Kartonektin düzeyinin gebelerin biyokimyasal parametreleri ile ilişkisinin incelenmesi amaçlanmıştır.
Gereç ve Yöntem: Kesitsel tipte tasarlanan araştırma Haziran 2016 ile Ocak 2017 tarihleri arasında yürütülmüştür. Çalışmaya 24-32 haftalık 30 GDM ve 30 sağlıklı gebe dahil edildi. Tüm katılımcılardan 12 saat açlık sonrası kan şekeri, lipid paneli, insulin, c-peptid ve kartonektin düzeyleri elde edilmiştir.
Bulgular: Gestasyonel diyabeti olan katılımcıların Glikoz, HbA1C, İnsulin, C-peptid, HOMA-IR, Trigliserit, VLDL, HDL düzeyleri istatistiksel olarak kontrol grubundan yüksek saptandı. Kontrol grubunun kartonektin (CTRP-3) düzeyi 7.68±4.29 (ng/mL), GDM grubunun ortalama kartonektin düzeyi 6.95±4.02 (ng/mL) saptandı ve iki grup arasında istatistiksel anlamlı bir fark saptanmadı
Sonuç: GDM’lu hasta grubunda glikoz, HbA1c, insulin, HOMA-IR, C-peptid, trigliserit ve VLDL düzeylerinin yükseldiği saptanmıştır. Gestasyonel diyabetli hastalarda kartonektin ile glikoz ve insülin düzeyleri arasında negatif korelasyon saptanmıştır.
Anahtar Kelimeler
Kartonektin (CTRP-3) gestasyonel diyabet insülin direnci insülin gebelik
Kaynakça
- 1. Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus. Diabetes Care. 1997;20(7):1183-97. [PubMed] https://doi.org/10.2337/diacare.20.7.1183
- 2. Alfadhli EM. Gestational diabetes mellitus. Saudi Med J. 2015;36(4):399-406. https://doi.org/10.15537/smj.2015.4.10307
- 3. Gilmartin AB, Ural SH, Repke JT. Gestational diabetes mellitus. Rev Obstet Gynecol. 2008;1(3):129-34. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2582643/
- 4. Solomon CG, Willett WC, Carey VJ, Rich-Edwards J, Hunter DJ, Colditz GA, et al. A prospective study of pregravid determinants of gestational diabetes mellitus. JAMA. 1997;278(13):1078-83. https://www.ncbi.nlm.nih.gov/pubmed/9315766
- 5. Metzger BE, Lowe LP, Dyer AR, Trimble ER, Chaovarindr U, Coustan DR, et al. HAPO Study Cooperative Research Group. Hyperglycemia and adverse pregnancy outcomes. N Engl J Med. 2008;358(19):1991-2002. https://doi.org/10.1056/NEJMoa0707943
- 6. Ornoy A. Growth and neurodevelopmental outcome of children born to mothers with pregestational and gestational diabetes. Pediatr Endocrinol Rev. 2005;3(2):104-13. https://www.ncbi.nlm.nih.gov/pubmed/16361984
- 7. Barbour LA, McCurdy CE, Hernandez TL, Kirwan JP, Catalano PM, Friedman JE. Cellular mechanisms for insulin resistance in normal pregnancy and gestational diabetes. Diabetes Care. 2007;30 Suppl 2:S112-9. https://doi.org/10.2337/dc07-s202
- 8. Görkem Ü, Küçükler FK, Toğrul C, Güngör T. Are adipokines associated with gestational diabetes mellitus? J Turk Ger Gynecol Assoc. 2016;17(4):186-190. https://doi.org/10.5152/jtgga.2016.16112
- 9. Deng W, Li C, Zhang Y, Zhao J, Yang M, Tian M, et al. Serum C1q/TNF-related protein-3 (CTRP3) levels are decreased in obesity and hypertension and are negatively correlated with parameters of insulin resistance. Diabetol Metab Syndr. 2015; 7: 33. https://dx.doi.org/10.1186%2Fs13098-015-0029-0
- 10. Ban B, Bai B, Zhang M, Hu J, Ramanjaneya M, Tan BK, et al. Low serum cartonectin/CTRP3 concentrations in newly diagnosed type 2 diabetes mellitus: in vivo regulation of cartonectin by glucose. PLoS One. 2014;9(11):e112931. https://doi.org/10.1371/journal.pone.0112931
- 11. Li JY, Wu GM, Hou Z, Cao YM. Expression of C1q/TNF-related protein-3 (CTRP3) in serum of patients with gestational diabetes mellitus and its relationship with insulin resistance. Eur Rev Med Pharmacol Sci. 2017;21(24):5702-10. https://doi.org/10.26355/eurrev_201712_14016
- 12. American Diabetes Association. Management of Diabetes in Pregnancy: Standards of Medical Care in Diabetes-2018. Diabetes Care. 2018;41(Suppl 1):137-143. https://doi.org/10.2337/dc18-S013
- 13. Bhavadharini B, Uma R, Saravanan P, Mohancorresponding V. Screening and diagnosis of gestational diabetes mellitus – relevance to low and middle income countries. Clin Diabetes Endocrinol. 2016; 2: 13. https://dx.doi.org/10.1186%2Fs40842-016-0031-y
- 14. Shostrom DCV, Sun Y, Oleson JJ, Snetselaar LG, Bao W. History of Gestational Diabetes Mellitus in Relation to Cardiovascular Disease and Cardiovascular Risk Factors in US Women. Front Endocrinol (Lausanne). 2017;8:144. https://doi.org/10.3389/fendo.2017.00144
- 15. Maeda T, Abe M, Kurisu K, Jikko A, Furukawa S. Molecular cloning and characterization of a novel gene, CORS26, encoding a putative secretory protein and its possible involvement in skeletal development. J Biol Chem. 2001;276(5):3628-34. https://doi.org/10.1074/jbc.M007898200
- 16. Wurm S, Neumeier M, Weigert J, Schäffler A, Buechler C. Plasma levels of leptin, omentin, collagenous repeat-containing sequence of 26-kDa protein (CORS-26) and adiponectin before and after oral glucose uptake in slim adults. Cardiovasc Diabetol. 2007;6:7. https://doi.org/10.1186/1475-2840-6-7
- 17. Qu H, Deng M, Wang H, Wei H, Liu F, Wu J, Deng H. Plasma CTRP-3 concentrations in Chinese patients with obesity and type II diabetes negatively correlate with insulin resistance. J Clin Lipidol. 2015 May-Jun;9(3):289-94. https://doi.org/10.1016/j.jacl.2015.03.006
Comparison of serum cartonectin (CTRP-3) level in gestational diabetes patient and healthy pregnant women and its relationship with biochemical parameters and insulin resistance
Öz
Purpose: The aim of this study was to compare the serum cartonectin (CTRP-3) levels of patients with gestational diabetes mellitus with the healthy control pregnant group and to investigate the relationship of cartonectin with the biochemical parameters of pregnant women.
Material and Methods: The cross-sectional study was conducted between June 2016 and January 2017. A total of 30 patients with GDM and 30 healthy pregnant women were included in the study. Glucose, lipid, insulin, c-peptide and cartonectin levels were obtained from all participants after 12 hours of fasting.
Results: Participants with gestational diabetes glucose, HbA1C, insulin, C-peptide, HOMA-IR, triglyceride, VLDL, HDL levels were statistically higher than the control group. Cartonectin level of the control group was 7.68 ± 4.29, mean cartonectin level of the GDM group was 6.95 ± 4.02 (ng / mL) and there was no statistically significant difference between the two groups.
Conclusion: Glucose, HbA1c, insulin, HOMA-IR, C-peptide, triglyceride and VLDL levels were increased in patients with GDM. Negative correlation was found between cartonectin and glucose and insulin levels in patients with gestational diabetes.
Anahtar Kelimeler
Kaynakça
- 1. Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus. Diabetes Care. 1997;20(7):1183-97. [PubMed] https://doi.org/10.2337/diacare.20.7.1183
- 2. Alfadhli EM. Gestational diabetes mellitus. Saudi Med J. 2015;36(4):399-406. https://doi.org/10.15537/smj.2015.4.10307
- 3. Gilmartin AB, Ural SH, Repke JT. Gestational diabetes mellitus. Rev Obstet Gynecol. 2008;1(3):129-34. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2582643/
- 4. Solomon CG, Willett WC, Carey VJ, Rich-Edwards J, Hunter DJ, Colditz GA, et al. A prospective study of pregravid determinants of gestational diabetes mellitus. JAMA. 1997;278(13):1078-83. https://www.ncbi.nlm.nih.gov/pubmed/9315766
- 5. Metzger BE, Lowe LP, Dyer AR, Trimble ER, Chaovarindr U, Coustan DR, et al. HAPO Study Cooperative Research Group. Hyperglycemia and adverse pregnancy outcomes. N Engl J Med. 2008;358(19):1991-2002. https://doi.org/10.1056/NEJMoa0707943
- 6. Ornoy A. Growth and neurodevelopmental outcome of children born to mothers with pregestational and gestational diabetes. Pediatr Endocrinol Rev. 2005;3(2):104-13. https://www.ncbi.nlm.nih.gov/pubmed/16361984
- 7. Barbour LA, McCurdy CE, Hernandez TL, Kirwan JP, Catalano PM, Friedman JE. Cellular mechanisms for insulin resistance in normal pregnancy and gestational diabetes. Diabetes Care. 2007;30 Suppl 2:S112-9. https://doi.org/10.2337/dc07-s202
- 8. Görkem Ü, Küçükler FK, Toğrul C, Güngör T. Are adipokines associated with gestational diabetes mellitus? J Turk Ger Gynecol Assoc. 2016;17(4):186-190. https://doi.org/10.5152/jtgga.2016.16112
- 9. Deng W, Li C, Zhang Y, Zhao J, Yang M, Tian M, et al. Serum C1q/TNF-related protein-3 (CTRP3) levels are decreased in obesity and hypertension and are negatively correlated with parameters of insulin resistance. Diabetol Metab Syndr. 2015; 7: 33. https://dx.doi.org/10.1186%2Fs13098-015-0029-0
- 10. Ban B, Bai B, Zhang M, Hu J, Ramanjaneya M, Tan BK, et al. Low serum cartonectin/CTRP3 concentrations in newly diagnosed type 2 diabetes mellitus: in vivo regulation of cartonectin by glucose. PLoS One. 2014;9(11):e112931. https://doi.org/10.1371/journal.pone.0112931
- 11. Li JY, Wu GM, Hou Z, Cao YM. Expression of C1q/TNF-related protein-3 (CTRP3) in serum of patients with gestational diabetes mellitus and its relationship with insulin resistance. Eur Rev Med Pharmacol Sci. 2017;21(24):5702-10. https://doi.org/10.26355/eurrev_201712_14016
- 12. American Diabetes Association. Management of Diabetes in Pregnancy: Standards of Medical Care in Diabetes-2018. Diabetes Care. 2018;41(Suppl 1):137-143. https://doi.org/10.2337/dc18-S013
- 13. Bhavadharini B, Uma R, Saravanan P, Mohancorresponding V. Screening and diagnosis of gestational diabetes mellitus – relevance to low and middle income countries. Clin Diabetes Endocrinol. 2016; 2: 13. https://dx.doi.org/10.1186%2Fs40842-016-0031-y
- 14. Shostrom DCV, Sun Y, Oleson JJ, Snetselaar LG, Bao W. History of Gestational Diabetes Mellitus in Relation to Cardiovascular Disease and Cardiovascular Risk Factors in US Women. Front Endocrinol (Lausanne). 2017;8:144. https://doi.org/10.3389/fendo.2017.00144
- 15. Maeda T, Abe M, Kurisu K, Jikko A, Furukawa S. Molecular cloning and characterization of a novel gene, CORS26, encoding a putative secretory protein and its possible involvement in skeletal development. J Biol Chem. 2001;276(5):3628-34. https://doi.org/10.1074/jbc.M007898200
- 16. Wurm S, Neumeier M, Weigert J, Schäffler A, Buechler C. Plasma levels of leptin, omentin, collagenous repeat-containing sequence of 26-kDa protein (CORS-26) and adiponectin before and after oral glucose uptake in slim adults. Cardiovasc Diabetol. 2007;6:7. https://doi.org/10.1186/1475-2840-6-7
- 17. Qu H, Deng M, Wang H, Wei H, Liu F, Wu J, Deng H. Plasma CTRP-3 concentrations in Chinese patients with obesity and type II diabetes negatively correlate with insulin resistance. J Clin Lipidol. 2015 May-Jun;9(3):289-94. https://doi.org/10.1016/j.jacl.2015.03.006
Ayrıntılar
| Birincil Dil | Türkçe |
|---|---|
| Konular | Klinik Tıp Bilimleri |
| Bölüm | Araştırma |
| Yazarlar | |
| Yayımlanma Tarihi | 27 Aralık 2020 |
| Kabul Tarihi | 25 Ağustos 2020 |
| Yayımlandığı Sayı | Yıl 2020 Cilt: 45 Sayı: 4 |
