Öz
Destekleyen Kurum
Yok
Proje Numarası
-
Teşekkür
Editör ve hakemlere teşekkürlerimle..
Kaynakça
- Rosa, R.G. and L.Z. Goldani, Cohort study of the impact of time to antibiotic administration on mortality in patients with febrile neutropenia. Antimicrob Agents Chemother, 2014. 58(7): p. 3799-803.
- Kuderer, N.M., et al., Mortality, morbidity, and cost associated with febrile neutropenia in adult cancer patients. Cancer, 2006. 106(10): p. 2258-66.
- Kim, J.S., et al., Clinical outcomes and prognostic factors of empirical antifungal therapy with itraconazole in the patients with hematological malignancies: a prospective multicenter observation-al study in Korea. Yonsei Med J, 2014. 55(1): p. 9-18.
- Tumbarello, M., et al., Factors associated with mortality in bacteremic patients with hematologic malignancies. Diagn Microbiol Infect Dis, 2009. 64(3): p. 320-6.
- Mukoyama, N., et al., Retrospective survey and evaluation of first-line antibiotics for chemo-therapy-induced febrile neutropenia in patients with acute myeloid leukemia. Nagoya J Med Sci, 2017. 79(1): p. 17-26.
- Horasan, E.S., et al., Bloodstream infections and mortality-related factors in febrile neutropenic cancer patients. Med Sci Monit, 2011. 17(5): p. CR304-9.
- Gencer, S., T. Salepci, and S. Ozer, Evaluation of infectious etiology and prognostic risk factors of febrile episodes in neutropenic cancer patients. J Infect, 2003. 47(1): p. 65-72.
- Kanafani, Z.A., et al., Bloodstream infections in febrile neutropenic patients at a tertiary care cen-ter in Lebanon: a view of the past decade. Int J Infect Dis, 2007. 11(5): p. 450-3.
- Demiraslan, H., et al., Risk factors influencing mortality related to Stenotrophomonas maltophil-ia infection in hematology–oncology patients. International Journal of Hematology, 2013. 97(3): p. 414-420.
- Hii, I.M., et al., Changing epidemiology of candidemia in a medical center in middle Taiwan. J Microbiol Immunol Infect, 2015. 48(3): p. 306-15.
- Massaro, K.S., et al., Risk factor for death in hematopoietic stem cell transplantation: are bi-omarkers useful to foresee the prognosis in this population of patients? Infection, 2014. 42(6): p. 1023-32.
- Osmani, A.H., et al., Outcome of febrile neutropenic patients on granulocyte colony stimulating factor in a tertiary care hospital. Asian Pac J Cancer Prev, 2012. 13(6): p. 2523-6.
- Calik Basaran, N., et al., Prospective Evaluation of Infection Episodes in Cancer Patients in a Tertiary Care Academic Center: Microbiological Features and Risk Factors for Mortality. Turk J Haematol, 2016. 33(4): p. 311-319.
Öz
Objectives: Hematological malignancies presenting with febrile neutropenia constitute an important health issue all over the globe. In this study, we aimed to elucidate the prognostic factors of febrile neutropenic patients with hematological malignancies and to investigate the causes of mortality.
Method: This research had a retrospective nature. A total of 174 febrile neutropenia patients ≥ 18 years of age hospitalized have been enrolled in the study. Patients enrolled in the analysis were determined according to the American Society for Infectious Diseases 2010 Febrile Neutropenia Diagnosis and Treatment Guidelines. Accordingly, neutropenia was defined as an expected decrease in the absolute neutrophil count (ANS) to < 500 cells/mm³ or < 500 cells/mm³ over the next 48 hours and body temperature over ≥ 38°C.
Results: A total of 174 patients have been included in the analysis and 32 (18.5%) died while 142 (81.5%) did not develop mortality. When the statistically significant results are evaluated according to multivariate analysis; Age, Crp, MASCC, acute renal failure, and hypotension were similar in both groups. On the other hand, when univariate statistically highly significant results are evaluated according to multivariate analysis; the Presence of urinary catheter, diagnosis of bacterial pneumonia, and ANS not increasing after 1 week were found to be statistically significant in the mortality group.
Conclusion: The results of the study showed that in febrile neutropenic patients, mortality was increased by 6.7 times by a diagnosis of bacterial pneumonia, 245.6 times by the absence of ANS elevation, and 13.9 times by urinary catheterization.
Anahtar Kelimeler
Proje Numarası
-
Kaynakça
- Rosa, R.G. and L.Z. Goldani, Cohort study of the impact of time to antibiotic administration on mortality in patients with febrile neutropenia. Antimicrob Agents Chemother, 2014. 58(7): p. 3799-803.
- Kuderer, N.M., et al., Mortality, morbidity, and cost associated with febrile neutropenia in adult cancer patients. Cancer, 2006. 106(10): p. 2258-66.
- Kim, J.S., et al., Clinical outcomes and prognostic factors of empirical antifungal therapy with itraconazole in the patients with hematological malignancies: a prospective multicenter observation-al study in Korea. Yonsei Med J, 2014. 55(1): p. 9-18.
- Tumbarello, M., et al., Factors associated with mortality in bacteremic patients with hematologic malignancies. Diagn Microbiol Infect Dis, 2009. 64(3): p. 320-6.
- Mukoyama, N., et al., Retrospective survey and evaluation of first-line antibiotics for chemo-therapy-induced febrile neutropenia in patients with acute myeloid leukemia. Nagoya J Med Sci, 2017. 79(1): p. 17-26.
- Horasan, E.S., et al., Bloodstream infections and mortality-related factors in febrile neutropenic cancer patients. Med Sci Monit, 2011. 17(5): p. CR304-9.
- Gencer, S., T. Salepci, and S. Ozer, Evaluation of infectious etiology and prognostic risk factors of febrile episodes in neutropenic cancer patients. J Infect, 2003. 47(1): p. 65-72.
- Kanafani, Z.A., et al., Bloodstream infections in febrile neutropenic patients at a tertiary care cen-ter in Lebanon: a view of the past decade. Int J Infect Dis, 2007. 11(5): p. 450-3.
- Demiraslan, H., et al., Risk factors influencing mortality related to Stenotrophomonas maltophil-ia infection in hematology–oncology patients. International Journal of Hematology, 2013. 97(3): p. 414-420.
- Hii, I.M., et al., Changing epidemiology of candidemia in a medical center in middle Taiwan. J Microbiol Immunol Infect, 2015. 48(3): p. 306-15.
- Massaro, K.S., et al., Risk factor for death in hematopoietic stem cell transplantation: are bi-omarkers useful to foresee the prognosis in this population of patients? Infection, 2014. 42(6): p. 1023-32.
- Osmani, A.H., et al., Outcome of febrile neutropenic patients on granulocyte colony stimulating factor in a tertiary care hospital. Asian Pac J Cancer Prev, 2012. 13(6): p. 2523-6.
- Calik Basaran, N., et al., Prospective Evaluation of Infection Episodes in Cancer Patients in a Tertiary Care Academic Center: Microbiological Features and Risk Factors for Mortality. Turk J Haematol, 2016. 33(4): p. 311-319.
Ayrıntılar
| Birincil Dil | İngilizce |
|---|---|
| Konular | İç Hastalıkları |
| Bölüm | Research Articles |
| Yazarlar | |
| Proje Numarası | - |
| Yayımlanma Tarihi | 29 Ekim 2022 |
| Gönderilme Tarihi | 11 Ekim 2022 |
| Yayımlandığı Sayı | Yıl 2022 Cilt: 2 Sayı: 4 |
