Challenges, Prognosis and Outcomes of Surgical Resection for Hepatic Alveolar Echinococcosis: A Single Centre Experience
Öz
Objective: Alveolar echinococcosis (AE) is an aggressive and potentially fatal infection, which affects the liver
primarily and presents as a tumor-like lesion. Outcomes associated with surgical procedures for this infection have
been rarely reported. In the present study, we aimed to evaluate long-term surgical treatment outcomes associated
with hepatic AE.
Methods: Between 2001 and 2013, the management and outcomes of twelve consecutive hepatic AE patients who
were considered feasible for complete hepatic resection with/without metastasectomy were described. In all patients,
pre-operative diagnosis of AE was based on clinical findings, imaging studies, and serological tests. Antibodies against
antigens of Echinococcus multilocularis metacestodes were screened as specific markers for the serological diagnosis
of AE by Western blot. The oral albendazole protocol was administered for hepatic AE patients who had complete
resection.
Results: Twelve patients (F/M=7/5) underwent complete resection for pathologically confirmed hepatic AE during
the study period. Median follow-up was 82 (32-164) months. The most common initial symptom was abdominal pain
(n=9) followed by jaundice (n=4). Four patients had metastasis: Brain, surrenal, splenic and colon. One patient was
lost due to massive pulmonary emboli despite appropriate interventions. All other complications that emerged were
treated successfully.
Conclusion: Long-term favorable outcomes can be achieved by complete surgical resection followed by
chemotherapy with albendazole in advanced hepatic AE cases.
Anahtar Kelimeler
alveolar echinococcosis; hepatic resection; Echinococcus multilocularis
Kaynakça
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Ayrıntılar
| Bölüm | Araştırma Yazıları |
|---|---|
| Yazarlar | |
| Yayımlanma Tarihi | 7 Haziran 2017 |
| Gönderilme Tarihi | 7 Haziran 2017 |
| Yayımlandığı Sayı | Yıl 2017 Cilt: 44 Sayı: 2 |