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INH Direnç Mekanizmaları

Yıl 2017, Cilt: 44 Sayı: 3, 287 - 292, 20.09.2017
https://doi.org/10.5798/dicletip.339020

Öz



Her ne kadar izoniazid (INH) ın Mycobacterium tuberculosis üzerindeki etki mekanizması tam anlaşılamamış olsa da öncü ilaç olan INH sitoplazmaya
pasif difüzyon ile girmektedir. KatG geni tarafından kodlanan katalaz/peroksidaz
enzimi ile aktiflenmektedir.
INH
ın aktiflenmesi ile serbest metabolik radikaller oluşmakta, bunlar da mikolik asit
sentezi gibi pek çok hücresel fonksiyonu bozmaktarlar.
KatG mutasyonları INH direncinin ana sebebidir. INH 'a dirençli klinik izolatların % 50 'den fazlasında katG 315. pozisyonda serin yerine treonin 'in değiştiği bir mutasyon varr. İnhA, ndh ve pompa genleri gibi genler de INH direncine katkıda bulunabilirler. Bu derleme yası
Mycobacterium tuberculosis 'de INH etki mekanizmasını ve ilaç direncinin moleküler temellerini özetlemektedir.

Kaynakça

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Toplam 21 adet kaynakça vardır.

Ayrıntılar

Bölüm Derlemeler
Yazarlar

Tanseli Gönlügür Bu kişi benim 0000-0003-0751-6184

Ugur Gönlügür 0000-0001-8720-2788

Yayımlanma Tarihi 20 Eylül 2017
Gönderilme Tarihi 20 Eylül 2017
Yayımlandığı Sayı Yıl 2017 Cilt: 44 Sayı: 3

Kaynak Göster

APA Gönlügür, T., & Gönlügür, U. (2017). INH Direnç Mekanizmaları. Dicle Tıp Dergisi, 44(3), 287-292. https://doi.org/10.5798/dicletip.339020
AMA Gönlügür T, Gönlügür U. INH Direnç Mekanizmaları. diclemedj. Eylül 2017;44(3):287-292. doi:10.5798/dicletip.339020
Chicago Gönlügür, Tanseli, ve Ugur Gönlügür. “INH Direnç Mekanizmaları”. Dicle Tıp Dergisi 44, sy. 3 (Eylül 2017): 287-92. https://doi.org/10.5798/dicletip.339020.
EndNote Gönlügür T, Gönlügür U (01 Eylül 2017) INH Direnç Mekanizmaları. Dicle Tıp Dergisi 44 3 287–292.
IEEE T. Gönlügür ve U. Gönlügür, “INH Direnç Mekanizmaları”, diclemedj, c. 44, sy. 3, ss. 287–292, 2017, doi: 10.5798/dicletip.339020.
ISNAD Gönlügür, Tanseli - Gönlügür, Ugur. “INH Direnç Mekanizmaları”. Dicle Tıp Dergisi 44/3 (Eylül 2017), 287-292. https://doi.org/10.5798/dicletip.339020.
JAMA Gönlügür T, Gönlügür U. INH Direnç Mekanizmaları. diclemedj. 2017;44:287–292.
MLA Gönlügür, Tanseli ve Ugur Gönlügür. “INH Direnç Mekanizmaları”. Dicle Tıp Dergisi, c. 44, sy. 3, 2017, ss. 287-92, doi:10.5798/dicletip.339020.
Vancouver Gönlügür T, Gönlügür U. INH Direnç Mekanizmaları. diclemedj. 2017;44(3):287-92.