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Can Caspase 3 Activity Determine Stroke Duration?”

Yıl 2021, Cilt: 3 Sayı: 3, 105 - 108, 28.12.2021

Sibel Gafuroğulları Yeşim İşler Halil Kaya Melih Yüksel Zeynep Nazlı Sır Yasemin Nennicioglu

Öz

Background and Purpose: This study aims to investigate the relationship between the stroke duration and Caspase 3 levels, measured in patients presenting to the emergency department in whom the time of stroke onset is known, and to seek an answer to the question of whether thrombolytics can be applied through the Caspase 3 levels in patients whose onset time of stroke is unknown.
Methods: A total of 100 patients with ischemic stroke who applied to the emergency department in a six-month period and 50 healthy control groups were included in the study. Age, gender, comorbid diseases, stroke onset times, and ischemic brain tissue volume of the patients who underwent brain diffusion magnetic resonance (MR) were calculated and recorded. Caspase 3 levels were studied from the blood taken from the patient and control groups.
Results: The mean age of the patients was 68.57±13.25. 45% were male When Caspase 3 levels were considered in neurological examination findings, only the median of those without facial paralysis was higher (p=0.033). No significant and linear correlation was found between the Caspase 3 levels with the ischemic volume and National Institutes of Health Stroke Scale (NIHSS) scores of stroke patients (p=0.831 and p=0.949). Additionally, no significant correlation was found between stroke duration and Caspase 3 levels (p=0.733).
Conclusion: No significant relationship was found between the ischemic stroke patients and the control group in terms of Caspase 3 levels. We found that the Caspase 3 level is not a reliable biomarker in patients whose stroke onset is unknown.

Anahtar Kelimeler

emergency department stroke caspace 3 stroke onset

Kaynakça

  • References 1. Lo EH, Moskowitz MA, Jacobs TP. Exciting, radical, suicidal: how brain cells die after stroke. Stroke. 2005, s. 36;189-92.
  • References 2. Love, S. Apoptozis and Brain İschaemia. Prog. Neuropsychopharmacol. Biol. 2003, s. 267-282.
  • References 3. Manabat C, Han B.H, Wendlad M, Derugin N, Fox C.K, Choi J. et al. Reperfusion differentially İnduces Caspase-3 Activation in İschemic Core and Penumbra After Stroke in İmmature Brain., Stroke 34, 2003. s. 207-213.
  • References 4. Güleş Ö, Eren Ü. Apoptozisin Belirlenmesinde Kullanılan Yöntemler. Y.Y.Ü. Veteriner Fakültesi Dergisi, 2008. s. 73-78.
  • References 5. Li H, Colbourne F, Sun P, Zhao Z, Buchan A.M. Caspase Inhibitors Reduce Neuronal Injury After Focal but Not Global Cerebral Ischemia in Rats. 2000, Stroke, s. 31:176-182.
  • References 6. Ferrer I, Planas A.M. Signaling of Cell Death and Cell Survival Following Focal Cerebral Ischemia: Life and Death. Journal of Neuropathology and Experimental Neurology, 2003. s. 329-339.
  • References 7. Le D. A, Wu Y, Huang Z, Matsushita K, Plesnila N, Augustinack J. C. Caspase activation and neuroprotection in caspase-3-deficient mice after in vivo cerebral ischemia and in vitro oxygen glucose deprivation. 2018. 10.1073.
  • References 8. S. Love, R. Barber, A. Srinivasan, G.K. Wilcock Activation of caspase-3 in permanent and transient brain ischaemia in man. Neuroreport, 2000. s. 2495-2499.
  • References 9. Rosell A, Cuadrado E, Avarez-Sabin J, Hernandez-Guillamon M, Delgado P, Penalba A, et al. Caspase-3 is related to infarct growth after human ischemic stroke. Neuroscience Letters, 2008. s. 1-6.
  • References 10. Jesper K. Jensen, Søren R. Kristensen, Søren Bak, Dan Atar, Poul Flemming Høilund-Carlsen, at al American Journal of Cardiology, Jan 2007. s. 99:108-12.
  • References 11. Bustamante A, López-Cancio E, Pich S, Penalba A, Giralt D, García-Berrocoso T, et al. Blood Biomarkers for the Early Diagnosis of Stroke: The Stroke-Chip Study. Stroke, 2017. s. 2419-2425.
  • References 12. Montaner J, Perea-Gainza M, Delgado P, Ribó M, Chacón P, Rosell A, et al. Etiologic diagnosis of ischemic stroke subtypes with plasma biomarkers. Stroke, 2008. s. 39(8):2280-2287.
  • References 13. Koç F, Kekeç Z. Neurologic Evaluation of Geriatric Cases Admited to the Emergency Department. Turkish Journal of Geriatrics, Jan 2011, s. 14 (2) 117-121.
  • References 14. Kıyan S, Özsaraç M, Ersel M, Aksay E, Yürüktümen A, Musalar E, ve ark. Acil Servise Başvuran Akut İskemik İnmeli 124 Hastanın 1 Yıllık Geriye Dönük İncelenmesi Akademik Acil Tıp Dergisi, Cilt 8, 2009. s. 15-20.
  • References 15. Morita N, Harada M, Uno M, Matsubara S, Nagahiro S, Nishitani H. Evaluation of initial diffusion-weighted image findings in acute stroke patients using a semiquantitative score. Magn Reson Med, 2009. s. 8(2):47-53.
  • References 16. Youn CS, Choi SP, Kim SH, Oh SH, Jeong WJ, Kim HJ, et al. Serum highly selective C-reactive protein concentration is associated with the volume of ischemic tissue in acute ischemic stroke. Am J Emerg Med, 2012. s. 124-8.
  • References 17. Appelros P, Nydevik I, Viitanen M. Poor Outcome After First-Ever Stroke: Predictors for Death, Dependency and Recurrent Stroke Wihin the First Year. Stroke, 2003. s. 34:122-126.
  • References 18. Linfante I, Llinas RH, Schlaug G, Chaves C, Warach S, Caplan LR. Diffusion-weighted imaging and National Institutes of Health Stroke Scale in the acute phase of posterior-circulation stroke. 2001. Arch Neurol., s. 621-8.
  • References 19. Rami A, Sims J, Botez G, Winckler J. Spatial resolution of phospholipid scramblase 1 (PLSCR1), caspase-3 activation and DNA-fragmentation in the human hippocampus after cerebral ischemia. Neurochem Int., 2003. s. 43: 79-87.
  • References 20. J. Montaner M. Mendioroz M. Ribó P. Delgado M. Quintana A. Penalba P. et al. A panel of biomarkers including caspase‐3 and D‐dimer may differentiate acute stroke from stroke‐mimicking conditions in the emergency department. Journal of İnternal Med., Nov 2010. s. 270:166-174.
  • References 21. Qi JP, Wu AP, Wang DS, Wang LF, Li SX, Xu FL. Correlation between neuronal injury and Caspase-3 after focal ischemia in human hippocampus. 2004, s. 1507-12.
  • References 22. Lynch JR, Blessing R, White WD, Grocott HP, Newman MF, Laskowitz DT. Novel diagnostictest for acute stroke. 2004, Stroke, s. 57-63.
  • References 23. Montaner J, Mendioroz M, Ribo M, Delgado P, Quintana M, Penalba A, et al. A Panel of Biyomarkers İncluding Caspase 3 and D-Dimer to Differentiate Acute Stroke from Stroke-Mimicking Conditions in the Emergency Department. Journal of İnternal Medicine, 2011. s. 166-174.

Yıl 2021, Cilt: 3 Sayı: 3, 105 - 108, 28.12.2021

Sibel Gafuroğulları Yeşim İşler Halil Kaya Melih Yüksel Zeynep Nazlı Sır Yasemin Nennicioglu

Öz

Kaynakça

  • References 1. Lo EH, Moskowitz MA, Jacobs TP. Exciting, radical, suicidal: how brain cells die after stroke. Stroke. 2005, s. 36;189-92.
  • References 2. Love, S. Apoptozis and Brain İschaemia. Prog. Neuropsychopharmacol. Biol. 2003, s. 267-282.
  • References 3. Manabat C, Han B.H, Wendlad M, Derugin N, Fox C.K, Choi J. et al. Reperfusion differentially İnduces Caspase-3 Activation in İschemic Core and Penumbra After Stroke in İmmature Brain., Stroke 34, 2003. s. 207-213.
  • References 4. Güleş Ö, Eren Ü. Apoptozisin Belirlenmesinde Kullanılan Yöntemler. Y.Y.Ü. Veteriner Fakültesi Dergisi, 2008. s. 73-78.
  • References 5. Li H, Colbourne F, Sun P, Zhao Z, Buchan A.M. Caspase Inhibitors Reduce Neuronal Injury After Focal but Not Global Cerebral Ischemia in Rats. 2000, Stroke, s. 31:176-182.
  • References 6. Ferrer I, Planas A.M. Signaling of Cell Death and Cell Survival Following Focal Cerebral Ischemia: Life and Death. Journal of Neuropathology and Experimental Neurology, 2003. s. 329-339.
  • References 7. Le D. A, Wu Y, Huang Z, Matsushita K, Plesnila N, Augustinack J. C. Caspase activation and neuroprotection in caspase-3-deficient mice after in vivo cerebral ischemia and in vitro oxygen glucose deprivation. 2018. 10.1073.
  • References 8. S. Love, R. Barber, A. Srinivasan, G.K. Wilcock Activation of caspase-3 in permanent and transient brain ischaemia in man. Neuroreport, 2000. s. 2495-2499.
  • References 9. Rosell A, Cuadrado E, Avarez-Sabin J, Hernandez-Guillamon M, Delgado P, Penalba A, et al. Caspase-3 is related to infarct growth after human ischemic stroke. Neuroscience Letters, 2008. s. 1-6.
  • References 10. Jesper K. Jensen, Søren R. Kristensen, Søren Bak, Dan Atar, Poul Flemming Høilund-Carlsen, at al American Journal of Cardiology, Jan 2007. s. 99:108-12.
  • References 11. Bustamante A, López-Cancio E, Pich S, Penalba A, Giralt D, García-Berrocoso T, et al. Blood Biomarkers for the Early Diagnosis of Stroke: The Stroke-Chip Study. Stroke, 2017. s. 2419-2425.
  • References 12. Montaner J, Perea-Gainza M, Delgado P, Ribó M, Chacón P, Rosell A, et al. Etiologic diagnosis of ischemic stroke subtypes with plasma biomarkers. Stroke, 2008. s. 39(8):2280-2287.
  • References 13. Koç F, Kekeç Z. Neurologic Evaluation of Geriatric Cases Admited to the Emergency Department. Turkish Journal of Geriatrics, Jan 2011, s. 14 (2) 117-121.
  • References 14. Kıyan S, Özsaraç M, Ersel M, Aksay E, Yürüktümen A, Musalar E, ve ark. Acil Servise Başvuran Akut İskemik İnmeli 124 Hastanın 1 Yıllık Geriye Dönük İncelenmesi Akademik Acil Tıp Dergisi, Cilt 8, 2009. s. 15-20.
  • References 15. Morita N, Harada M, Uno M, Matsubara S, Nagahiro S, Nishitani H. Evaluation of initial diffusion-weighted image findings in acute stroke patients using a semiquantitative score. Magn Reson Med, 2009. s. 8(2):47-53.
  • References 16. Youn CS, Choi SP, Kim SH, Oh SH, Jeong WJ, Kim HJ, et al. Serum highly selective C-reactive protein concentration is associated with the volume of ischemic tissue in acute ischemic stroke. Am J Emerg Med, 2012. s. 124-8.
  • References 17. Appelros P, Nydevik I, Viitanen M. Poor Outcome After First-Ever Stroke: Predictors for Death, Dependency and Recurrent Stroke Wihin the First Year. Stroke, 2003. s. 34:122-126.
  • References 18. Linfante I, Llinas RH, Schlaug G, Chaves C, Warach S, Caplan LR. Diffusion-weighted imaging and National Institutes of Health Stroke Scale in the acute phase of posterior-circulation stroke. 2001. Arch Neurol., s. 621-8.
  • References 19. Rami A, Sims J, Botez G, Winckler J. Spatial resolution of phospholipid scramblase 1 (PLSCR1), caspase-3 activation and DNA-fragmentation in the human hippocampus after cerebral ischemia. Neurochem Int., 2003. s. 43: 79-87.
  • References 20. J. Montaner M. Mendioroz M. Ribó P. Delgado M. Quintana A. Penalba P. et al. A panel of biomarkers including caspase‐3 and D‐dimer may differentiate acute stroke from stroke‐mimicking conditions in the emergency department. Journal of İnternal Med., Nov 2010. s. 270:166-174.
  • References 21. Qi JP, Wu AP, Wang DS, Wang LF, Li SX, Xu FL. Correlation between neuronal injury and Caspase-3 after focal ischemia in human hippocampus. 2004, s. 1507-12.
  • References 22. Lynch JR, Blessing R, White WD, Grocott HP, Newman MF, Laskowitz DT. Novel diagnostictest for acute stroke. 2004, Stroke, s. 57-63.
  • References 23. Montaner J, Mendioroz M, Ribo M, Delgado P, Quintana M, Penalba A, et al. A Panel of Biyomarkers İncluding Caspase 3 and D-Dimer to Differentiate Acute Stroke from Stroke-Mimicking Conditions in the Emergency Department. Journal of İnternal Medicine, 2011. s. 166-174.
Toplam 23 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Acil Tıp
Bölüm Original Articles
Yazarlar

Sibel Gafuroğulları 0000-0002-9757-8997

Yeşim İşler 0000-0002-6389-5361

Halil Kaya 0000-0003-2005-6100

Melih Yüksel 0000-0002-0793-3693

Zeynep Nazlı Sır 0000-0002-3518-2671

Yasemin Nennicioglu 0000-0002-1661-1338

Yayımlanma Tarihi 28 Aralık 2021
Gönderilme Tarihi 20 Ekim 2021
Kabul Tarihi 6 Aralık 2021
Yayımlandığı Sayı Yıl 2021 Cilt: 3 Sayı: 3

Kaynak Göster

APA Gafuroğulları, S., İşler, Y., Kaya, H., Yüksel, M., vd. (2021). Can Caspase 3 Activity Determine Stroke Duration?”. Eurasian Journal of Critical Care, 3(3), 105-108.
AMA Gafuroğulları S, İşler Y, Kaya H, Yüksel M, Sır ZN, Nennicioglu Y. Can Caspase 3 Activity Determine Stroke Duration?”. Eurasian j Crit Care. Aralık 2021;3(3):105-108.
Chicago Gafuroğulları, Sibel, Yeşim İşler, Halil Kaya, Melih Yüksel, Zeynep Nazlı Sır, ve Yasemin Nennicioglu. “Can Caspase 3 Activity Determine Stroke Duration?””. Eurasian Journal of Critical Care 3, sy. 3 (Aralık 2021): 105-8.
EndNote Gafuroğulları S, İşler Y, Kaya H, Yüksel M, Sır ZN, Nennicioglu Y (01 Aralık 2021) Can Caspase 3 Activity Determine Stroke Duration?”. Eurasian Journal of Critical Care 3 3 105–108.
IEEE S. Gafuroğulları, Y. İşler, H. Kaya, M. Yüksel, Z. N. Sır, ve Y. Nennicioglu, “Can Caspase 3 Activity Determine Stroke Duration?””, Eurasian j Crit Care, c. 3, sy. 3, ss. 105–108, 2021.
ISNAD Gafuroğulları, Sibel vd. “Can Caspase 3 Activity Determine Stroke Duration?””. Eurasian Journal of Critical Care 3/3 (Aralık 2021), 105-108.
JAMA Gafuroğulları S, İşler Y, Kaya H, Yüksel M, Sır ZN, Nennicioglu Y. Can Caspase 3 Activity Determine Stroke Duration?”. Eurasian j Crit Care. 2021;3:105–108.
MLA Gafuroğulları, Sibel vd. “Can Caspase 3 Activity Determine Stroke Duration?””. Eurasian Journal of Critical Care, c. 3, sy. 3, 2021, ss. 105-8.
Vancouver Gafuroğulları S, İşler Y, Kaya H, Yüksel M, Sır ZN, Nennicioglu Y. Can Caspase 3 Activity Determine Stroke Duration?”. Eurasian j Crit Care. 2021;3(3):105-8.
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