IMMUNOGENOMIC APPROACH TO THE CLINICAL MANAGEMENT OF COVID-19 SYNDROME

Ümit Yavuz Malkan; Olgu Erkin Çınar; Can Türk; Seyhan Türk; İbrahim Celaleddin Haznedaroğlu

Derleme

COVID-19 SENDROMUNUN KLİNİK YÖNETİMİNDE İMMUNOGENOMİK YAKLAŞIM

Yıl 2023, Cilt: 4 Sayı: Ek Sayı, 266 - 279, 16.10.2023

Ümit Yavuz Malkan Olgu Erkin Çınar Can Türk Seyhan Türk İbrahim Celaleddin Haznedaroğlu

Öz

SARS-CoV-2 enfeksiyonu sonucu gelişen ve "COVID-19 sendromu" olarak tanımlanabilecek tablonun üç özel immünogenomik gelişim aşaması vardır; başlatıcı, ilerleyici ve komplikasyon fazları. Her COVID-19 fazı, farklı terapötik klinik müdahaleler gerektiren kritik patobiyolojik korelasyonlara sahiptir. Renin-anjiyotensin sistemi (RAS) genleri, koronavirüs ailesi üyelerinin neden olduğu enfeksiyonların başlaması için gereklidir ve SARS-CoV-2 enfeksiyonunu takiben kritik immün gen ürünleriyle, özellikle de IFN ailesinin üyeleri ile güçlü bir etkileşime sahiptir. Bu makale, COVID-19 immün sendromu olarak tanımlanabilecek multisistemiı tablonun klinikopatolojik seyrine ilişkin daha önce yayınladığımız üç aşamalı modelin kavramları çerçevesinde COVID-19 için tedavi protokollerini güncel bir yaklaşımla gözden geçirmeyi amaçlamaktadır. Mevcut tedavi seçeneklerinin RAS'ı etkileyen gelecekteki olası terapötik adayları da sendromun immünogenomik perspektifiyle ele alınmaktadır.

Anahtar Kelimeler

COVID-19, remdesivir, paxlovid, coronavirus, covid-19 tedavisi, covid-19 sendromu

Kaynakça

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IMMUNOGENOMIC APPROACH TO THE CLINICAL MANAGEMENT OF COVID-19 SYNDROME

Yıl 2023, Cilt: 4 Sayı: Ek Sayı, 266 - 279, 16.10.2023

Ümit Yavuz Malkan Olgu Erkin Çınar Can Türk Seyhan Türk İbrahim Celaleddin Haznedaroğlu

Öz

The COVID-19 syndrome following the SARS-CoV-2 infection has three unique immunogenomic disease development phases; initiating, propagating, and complicating. Each COVID-19 phase has critical pathobiological correlations requiring distinct therapeutic clinical interventions. Renin-angiotensin system (RAS) genes are essential for initiating infections caused by coronavirus family members and may have a strong association with the exchange of critical immune genes, particularly IFN-family, in due course following the SARS-CoV-2 infection. This paper aims to review therapeutic protocols for COVID-19 within the concepts of our previously published three-phase model regarding the clinicopathological course of COVID-19 immune syndrome. The current treatment options have been reviewed in this synopsis within our three-phase disease schedule. Possible future drug candidates affecting the RAS are also considered from the immunogenomical perspective of the syndrome.

Anahtar Kelimeler

covid-19, remdesivir, paxlovid, covid-19 treatment, covid-19 syndrome, coronavirus

Kaynakça

1. Goker H, Aladag Karakulak E, Demiroglu H, et al. The effects of blood group types on the risk of COVID-19 infection and its clinical outcome. Turk J Med Sci. 2020; 50: 679-83.
2. Yang L, Liu S, Liu J, et al. COVID-19: immunopathogenesis and Immunotherapeutics. Signal Transduct Target Ther. 2020; 5:128.
3. Zhou P, Yang XL, Wang XG, et al. A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature. 2020; 579: 270-3.
4. Ciftciler R, Ciftciler AE, Haznedaroglu IC. Local Bone Marrow Renin-Angiotensin System and COVID-19. UHOD. 2020; 30: 001-8.
5. Gupta A, Madhavan MV, Sehgal K, et al. Extrapulmonary manifestations of COVID-19. Nat Med. 2020; 26: 1017-32.
6. Turk C, Turk S, Temirci ES, Malkan UY, Haznedaroglu IC. In vitro analysis of the renin-angiotensin system and inflammatory gene transcripts in human bronchial epithelial cells after infection with severe acute respiratory syndrome coronavirus. JRAAS. 2020; 21: 1470320320928872.
7. Turk C, Turk S, Malkan UY, Haznedaroglu IC. Three critical clinicobiological phases of the human sars-associated coronavirus infections. Eur Rev Med Pharmacol Sci. 2020; 24: 8606-20.
8. Malkan UY, Haznedaroglu IC. Hematological aspects of the COVID-19 syndrome. Eur Rev Med Pharmacol Sci. 2022; 26: 4463-76.
9. Wiersinga WJ, Rhodes A, Cheng AC, Peacock SJ, Prescott HC. Pathophysiology, Transmission, Diagnosis, and Treatment of Coronavirus Disease 2019 (COVID-19): A Review. JAMA. 2020; 324: 782-93.
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Toplam 117 adet kaynakça vardır.

Ayrıntılar

Birincil Dil	İngilizce
Konular	Klinik Tıp Bilimleri
Bölüm	Derlemeler
Yazarlar	Ümit Yavuz Malkan 0000-0001-5444-4895 Olgu Erkin Çınar 0000-0003-1226-5797 Can Türk 0000-0003-1514-7294 Seyhan Türk 0000-0003-3843-4173 İbrahim Celaleddin Haznedaroğlu 0000-0001-8028-9462
Erken Görünüm Tarihi	16 Ekim 2023
Yayımlanma Tarihi	16 Ekim 2023
Yayımlandığı Sayı	Yıl 2023 Cilt: 4 Sayı: Ek Sayı

Kaynak Göster

APA	Malkan, Ü. Y., Çınar, O. E., Türk, C., Türk, S., vd. (2023). IMMUNOGENOMIC APPROACH TO THE CLINICAL MANAGEMENT OF COVID-19 SYNDROME. Eskisehir Medical Journal, 4(Ek Sayı), 266-279.
AMA	Malkan ÜY, Çınar OE, Türk C, Türk S, Haznedaroğlu İC. IMMUNOGENOMIC APPROACH TO THE CLINICAL MANAGEMENT OF COVID-19 SYNDROME. Eskisehir Med J. Ekim 2023;4(Ek Sayı):266-279.
Chicago	Malkan, Ümit Yavuz, Olgu Erkin Çınar, Can Türk, Seyhan Türk, ve İbrahim Celaleddin Haznedaroğlu. “IMMUNOGENOMIC APPROACH TO THE CLINICAL MANAGEMENT OF COVID-19 SYNDROME”. Eskisehir Medical Journal 4, sy. Ek Sayı (Ekim 2023): 266-79.
EndNote	Malkan ÜY, Çınar OE, Türk C, Türk S, Haznedaroğlu İC (01 Ekim 2023) IMMUNOGENOMIC APPROACH TO THE CLINICAL MANAGEMENT OF COVID-19 SYNDROME. Eskisehir Medical Journal 4 Ek Sayı 266–279.
IEEE	Ü. Y. Malkan, O. E. Çınar, C. Türk, S. Türk, ve İ. C. Haznedaroğlu, “IMMUNOGENOMIC APPROACH TO THE CLINICAL MANAGEMENT OF COVID-19 SYNDROME”, Eskisehir Med J, c. 4, sy. Ek Sayı, ss. 266–279, 2023.
ISNAD	Malkan, Ümit Yavuz vd. “IMMUNOGENOMIC APPROACH TO THE CLINICAL MANAGEMENT OF COVID-19 SYNDROME”. Eskisehir Medical Journal 4/Ek Sayı (Ekim 2023), 266-279.
JAMA	Malkan ÜY, Çınar OE, Türk C, Türk S, Haznedaroğlu İC. IMMUNOGENOMIC APPROACH TO THE CLINICAL MANAGEMENT OF COVID-19 SYNDROME. Eskisehir Med J. 2023;4:266–279.
MLA	Malkan, Ümit Yavuz vd. “IMMUNOGENOMIC APPROACH TO THE CLINICAL MANAGEMENT OF COVID-19 SYNDROME”. Eskisehir Medical Journal, c. 4, sy. Ek Sayı, 2023, ss. 266-79.
Vancouver	Malkan ÜY, Çınar OE, Türk C, Türk S, Haznedaroğlu İC. IMMUNOGENOMIC APPROACH TO THE CLINICAL MANAGEMENT OF COVID-19 SYNDROME. Eskisehir Med J. 2023;4(Ek Sayı):266-79.

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