Öz
Primary Sjögren syndrome (pSS) is a systemic autoimmune disorder characterized by the chronic inflammation and dysfunction of exocrine glands, mainly salivary glands, causing dryness of the eyes and the mouth. Patients present with a spectrum of clinical manifestations from sicca (dryness) symptoms to potentially severe extra glandular and/or systemic features, such as inflammatory arthritis, parotitis, interstitial lung disease, neurological dysfunction, cryoglobulinemia, and lymphomas. SS have autoantibodies such as anti-Ro/SSA, anti-La/SSB, antinuclear antibodies (ANA), and rheumatoid factors(RF). These autoantibodies are present in 45% to 75% of patients. Patients fulfilling SS criteria who do not express classic serum antibodies are called patients with seronegative SS. Seronegative SS varies in the literature, ranging from 8% to 37% of SS cohorts. Diagnosing seronegative pSS can be difficult. Without readily detectable serum biomarkers, patients with seronegative SS may be overlooked in the clinic. Here we present 3 cases of seronegative SS with different organ involvement.
Anahtar Kelimeler
Öz
Primary Sjögren syndrome (pSS) is a systemic autoimmune disorder characterized by the chronic inflammation and dysfunction of exocrine glands, mainly salivary glands, causing dryness of the eyes and the mouth. Patients present with a spectrum of clinical manifestations from sicca (dryness) symptoms to potentially severe extra glandular and/or systemic features, such as inflammatory arthritis, parotitis, interstitial lung disease, neurological dysfunction, cryoglobulinemia, and lymphomas. SS have autoantibodies such as anti-Ro/SSA, anti-La/SSB, antinuclear antibodies (ANA), and rheumatoid factors(RF). These autoantibodies are present in 45% to 75% of patients. Patients fulfilling SS criteria who do not express classic serum antibodies are called patients with seronegative SS. Seronegative SS varies in the literature, ranging from 8% to 37% of SS cohorts. Diagnosing seronegative pSS can be difficult. Without readily detectable serum biomarkers, patients with seronegative SS may be overlooked in the clinic. Here we present 3 cases of seronegative SS with different organ involvement.
Anahtar Kelimeler
Ayrıntılar
| Birincil Dil | İngilizce |
|---|---|
| Konular | Romatoloji ve Artrit |
| Bölüm | Editöre Mektup |
| Yazarlar | |
| Erken Görünüm Tarihi | 28 Mart 2024 |
| Yayımlanma Tarihi | 28 Mart 2024 |
| Gönderilme Tarihi | 30 Ocak 2024 |
| Kabul Tarihi | 22 Şubat 2024 |
| Yayımlandığı Sayı | Yıl 2024 Cilt: 5 Sayı: 1 |
Kaynak Göster
Bu eser Creative Commons Alıntı-GayriTicari-Türetilemez 4.0 Uluslararası Lisansı ile lisanslanmıştır.