Tip II Diyabetes Mellituslu Hastalarda Serum Ürik Asit Ve Gama Glutamil Transferaz Düzeyleri İle Koroner Arter Hastalığı Gelişimi Arasındaki İlişki
Öz
Amaç: Çalışmamızda koroner arter hastalığının (KAH) eşlik ettiği tip 2 diyabetesmellituslu (DM) hastalarla
tip 2 DM tanısıyla takip edilen hastalar serum ürik asit (SÜA) ve gama glutamiltransferaz (GGT) düzeyleri
diğer metabolik parametreler ile birlikte incelenerek prospektif olarak karşılaştırılmış; diyabetik hastalarda
bu parametreler ile KAH gelişimi arasındaki ilişki ortaya koymak amaçlanmıştır.
Gereç ve Yöntem: Kahramanmaraş Necip Fazıl Şehir Hastanesi\'nde gerçekleştirilen bu çalışmaya,
kardiyoloji polikliniğine başvuran tip II DM'lI 118 hasta, KAH\'nın eşlik ettiği 222 adet tip 2 DM\'li hasta
dahil edildi.
Bulgular: Guruplar arasında SÜA düzeylerinde anlamlı farkın olmadığı (5.37±1.48 vs 5.27±1.51 mg/dl;
p=0.194), GGT düzeyinin ise tip II DM'nin eşlik ettiği KAH olan grupta sadece tip II DM olan gruba göre
istatistiki olarak anlamlı olarak daha yüksek olduğunu tespit ettik(23,0 (16,0-32,50) vs 25 (18,0-39,0) U/L; P
< 0,0001).
Sonuç: Çalışmamızda serum GGTdüzeyinin diyabetli hastalarda kardiyovasküler riskin artışını gösteren bir
prediktör olabileceğini gözlemledik. Ancak SÜAseviyesiyle tip II DM'li hastalarda KAH riski arasında ilişki
saptanamamıştır
Anahtar Kelimeler
Ürik Asid Gama glutamil Transferaz Tip II Diyabetes Mellitus Koroner Arter Hastalığı
Kaynakça
- 1.Solberg LA, Enger SC, Hjermann I, et al. Risk factors for coronary and cerebral atherosclerosis in Oslo Study. In: Gotto AM, Smith LC, Allen B AD AL. Atherosclerosis V. New York, NY: Springer Verlag; 1980:57-62.
- 2.American Diabetes Association. Standards of medicalcare in diabetes-2008. Diabetes Care 2008;31 Suppl 1:12-54.
- 3.Stamler J, Caccaro O, Neaton JD, Wentworth D. Diabetes, other risk factors, and 12-year cardiovascular mortality for men screened in the Multiple Risk Factor Intervention Trial (MRFIT). Diabetes Care 1993;16:434-44.
- 4.Ruttmann E, Brant LJ, Concin H ve ark.Vorarlberg health monitoring and promotion program study group. Gamma-glutamyl transferase as a risk factor for cardiovascular disease mortality: an epidemiological investigation in a cohort of 163,944 Austrianadults. Circulation. 2005; 112: 2130-7.
- 5.Pompella A, Emdin M, Passino C et al. Thesignificance of serum gamma-glutamyl transferase in cardiovascular diseases. Clin Chem Lab Med. 2004; 42: 1085-91.
- 6.Meisinger C, Döring A, Schneider A. Serum gammaglutamyl transferase is a predictor of incident coronary events in apparently healthy men fromthe general population. Atherosclerosis 2006; 189: 297-302.
- 7.Turgut O, Yilmaz A, Yalta K ve ark. Gamma glutamyl transferase is a promising biomarker for cardiovascular risk. MedHypotheses 2006; 67: 1060-4.
- 8.Ndrepepa G, Braun S, Schunkert H, et al. Gammaglutamyl transferase and prognosis in patients with coronary artery disease. Clin Chim Acta. 2015 Nov 12;452:155-60.
- 9.Celik O, Cakmak HA, Satilmis S, Gungor B at al. The relationship between gamma-glutamyl transferase levels and coronary plaque burdens and plaque structures in young adults with coronary atherosclerosis. Clin Cardiol. 2014 Sep;37(9):552-7.
- 10.Many A, Hubel CA, Roberts JM. Hyperuricemia and xanthine oxidase in preeclampsia, revisited. Am J Obstet Gynecol 1996;174:288-91.
- 11.Kato M, Hisatome I, Tomikura Yet al. Status of endothelial dependent vasodilation in patients with hyperuricemia. Am J Cardiol 2005;96:1576-8.
- 12.Biscaglia S, Ceconi C, Malagù M, Pavasini R, Ferrari R. Uric acid and coronary artery disease: An elusive link deserving further attention. Int J Cardiol. 2015 (15)30315- 6.
- 13.Freedman DS, Williamson DF, Gunter EW, Byers T. Relation of serum uric acid tomortality and ischemic heart disease. The NHANES I Epidemiologic Follow-up Study. Am J Epidemiol 1995;141:637-44.
- 14.Culleton BF, Larson MG, Kannel WB, Levy D. Serum uric acid and risk for cardiovascular disease and death: the Framingham Heart Study. Ann Intern Med 1999; 131:7-13.
- 15.Erdoğan D, Güllü H, Çalışkan M, et al. Relationship of serum uric acid to measures of endothelial function and atherosclerosis in healthy adults. Int J Clin Pract 2005;59:1276-82.
- 16.Tavil Y, Kaya MG, Oktar SO et al. Uric acid level and its association with carotid intima-media thickness in patients with hypertension. Atherosclerosis 2008;197:159-63.
The Relationship Between Type 2 DM Patients With Serum Uric Acid And Gamma Glutamyl Transferase Levels and Development Coronary Artery Disease
Öz
Objective: In this study we prospectively compared the patients with coronary artery disease (CAD)
accompanied type 2 diabetes mellitus (DM) and patients followed with type 2 diabetes in view of the serum
uric acid (SUA) and glutamil gamma transferase (GGT) levels furthermore metabolic parameters; it is
targeted to reveal the relationship between these parameters and CAD development risk in diabetic patients.
Materials-Methods: 118 patients with type ll DM and 222 type 2 DM patients with CAD who were applied
to the cardiology output clinic enrolled to the study.
Results: No significant difference was established between groups for SUAlevels (5.37 ± 1,48 vs 5.27±1,51
mg/dl; p=0,194) , while the GGT levels in CAD with type ll DM detected statistically significent higher than type II DM group(23.0 (16,0-32,50) vs 25 (18,0-39,0)U/L; P< 0,001).
Conclusion: We observed serum GGTlevels in DM patients are a predictor of the raising cardiovascular risk.
However, SUAlevels in type II DM are not have a relation with the risk of CAD.
Anahtar Kelimeler
Uric Acid Gamma Glutamyl Transferase Type Ii Diabetes Mellitus Coronary Artery Disease
Kaynakça
- 1.Solberg LA, Enger SC, Hjermann I, et al. Risk factors for coronary and cerebral atherosclerosis in Oslo Study. In: Gotto AM, Smith LC, Allen B AD AL. Atherosclerosis V. New York, NY: Springer Verlag; 1980:57-62.
- 2.American Diabetes Association. Standards of medicalcare in diabetes-2008. Diabetes Care 2008;31 Suppl 1:12-54.
- 3.Stamler J, Caccaro O, Neaton JD, Wentworth D. Diabetes, other risk factors, and 12-year cardiovascular mortality for men screened in the Multiple Risk Factor Intervention Trial (MRFIT). Diabetes Care 1993;16:434-44.
- 4.Ruttmann E, Brant LJ, Concin H ve ark.Vorarlberg health monitoring and promotion program study group. Gamma-glutamyl transferase as a risk factor for cardiovascular disease mortality: an epidemiological investigation in a cohort of 163,944 Austrianadults. Circulation. 2005; 112: 2130-7.
- 5.Pompella A, Emdin M, Passino C et al. Thesignificance of serum gamma-glutamyl transferase in cardiovascular diseases. Clin Chem Lab Med. 2004; 42: 1085-91.
- 6.Meisinger C, Döring A, Schneider A. Serum gammaglutamyl transferase is a predictor of incident coronary events in apparently healthy men fromthe general population. Atherosclerosis 2006; 189: 297-302.
- 7.Turgut O, Yilmaz A, Yalta K ve ark. Gamma glutamyl transferase is a promising biomarker for cardiovascular risk. MedHypotheses 2006; 67: 1060-4.
- 8.Ndrepepa G, Braun S, Schunkert H, et al. Gammaglutamyl transferase and prognosis in patients with coronary artery disease. Clin Chim Acta. 2015 Nov 12;452:155-60.
- 9.Celik O, Cakmak HA, Satilmis S, Gungor B at al. The relationship between gamma-glutamyl transferase levels and coronary plaque burdens and plaque structures in young adults with coronary atherosclerosis. Clin Cardiol. 2014 Sep;37(9):552-7.
- 10.Many A, Hubel CA, Roberts JM. Hyperuricemia and xanthine oxidase in preeclampsia, revisited. Am J Obstet Gynecol 1996;174:288-91.
- 11.Kato M, Hisatome I, Tomikura Yet al. Status of endothelial dependent vasodilation in patients with hyperuricemia. Am J Cardiol 2005;96:1576-8.
- 12.Biscaglia S, Ceconi C, Malagù M, Pavasini R, Ferrari R. Uric acid and coronary artery disease: An elusive link deserving further attention. Int J Cardiol. 2015 (15)30315- 6.
- 13.Freedman DS, Williamson DF, Gunter EW, Byers T. Relation of serum uric acid tomortality and ischemic heart disease. The NHANES I Epidemiologic Follow-up Study. Am J Epidemiol 1995;141:637-44.
- 14.Culleton BF, Larson MG, Kannel WB, Levy D. Serum uric acid and risk for cardiovascular disease and death: the Framingham Heart Study. Ann Intern Med 1999; 131:7-13.
- 15.Erdoğan D, Güllü H, Çalışkan M, et al. Relationship of serum uric acid to measures of endothelial function and atherosclerosis in healthy adults. Int J Clin Pract 2005;59:1276-82.
- 16.Tavil Y, Kaya MG, Oktar SO et al. Uric acid level and its association with carotid intima-media thickness in patients with hypertension. Atherosclerosis 2008;197:159-63.
Ayrıntılar
| Birincil Dil | Türkçe |
|---|---|
| Konular | Klinik Tıp Bilimleri |
| Bölüm | Araştırma Makalesi |
| Yazarlar | |
| Yayımlanma Tarihi | 30 Aralık 2016 |
| Gönderilme Tarihi | 16 Nisan 2016 |
| Kabul Tarihi | 27 Nisan 2016 |
| Yayımlandığı Sayı | Yıl 2016 Cilt: 13 Sayı: 3 |
Harran Üniversitesi Tıp Fakültesi Dergisi / Journal of Harran University Medical Faculty