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Hungry Bone Syndrome in Patients with End-Stage Renal Disease Receiving Hemodialysis

Yıl 2021, Cilt: 13 Sayı: 2, 1 - 10, 21.12.2021

Öz

Objective: Hyperparathyroidism develops in the majority of patients with end-stage renal disease receiving hemodialysis. Parathyroidectomy can be performed in cases who cannot be managed with medical therapy and a portion of the patients develop hungry bone syndrome (HBS) in the postoperative period. In this study, we investigated the factors that influence the development of HBS and the hospitalization times in hemodialysis patients who underwent parathyroidectomy.
Method: This study included 49 patients. Demographic, clinical and laboratory parameters of these patients were retrospectively evaluated.
Results: Patients’ median age was 46 years (22-62). The parathyroid gland that showed hyperplasia the most frequently was the left inferior 79.6% (n=39), followed by the right inferior 77.6% (n=38) gland. Rate of four-gland hyperplasia was 32.7% (n=16). Of the 49 operated patients, 34 (69.4%) developed HBS. In patients with postoperative PTH <500 pg/ml, calcium < 7mg/dl during the first 24 hours after surgery and calcium infusion > 4 ampules during the first 24 hours, hospitalization times were prolonged and the need for parenteral calcium infusion was elevated.
Conclusion: The need for parenteral calcium replacement during the first 24 hours, postoperative PTH and calcium levels during the first 24 hours were determined to be factors indicating the severity of HBS in the postoperative period.

Destekleyen Kurum

yok

Proje Numarası

-

Teşekkür

-

Kaynakça

  • Filopanti F, Corbetta S, Barbieri AM, and Spada A, “Pharmacology of the calcium sensing receptor,” Clinical Cases in Mineral and Bone Metabolism, 2013; 10(3): 162–165.
  • Dunlay R. and Hruska K. PTH receptor coupling to phospholipase C is an alternate pathway of signal transduction in bone and kidney, The American Journal of Physiology—Renal Fluid and Electrolyte Physiology, 1990; 258(2): F223–F231.
  • Jofre R, Lopez Gomez JM, Menarguez J, et al. Parathyroidectomy: whom and when? Kidney Int Suppl. 2003;63:S97–S100.
  • Jamal SA, Miller PD. Secondary and tertiary hyperparathyroidism. J Clin Densitom. 2013;16(1):64–68.
  • Assadi F. Hypophosphatemia: An evidencebased problem-solving approach to clinical cases. Iran J Kidney Dis 2010;4:195-201.
  • Albright F, Reifenstein EC. The parathyroid glands and metabolic bone disease, Ulster Medical Journal, 1950; 19 (1):130–131.
  • Farese S. The hungry bone syndrome: An update. Ther Umsch 2007;64:277-80.
  • Kritmetapak K, Kongpetch S, Chotmongkol W, Raruenrom Y, Sangkhamanon S and Pongchaiyakul C. Incidence of and risk factors for post-parathyroidectomy hungry bone syndrome in patients with secondary hyperparathyroidism. RENAL FAILURE 2020;42(1): 1118–1126.
  • Jain N, Reilly RF. Hungry bone syndrome. Curr Opin Nephrol Hypertens. 2017;26(4):250–255.
  • Brasier AR, Nussbaum SR. “Hungry bone syndrome: clinical and biochemical predictors of its occurrence after parathyroid surgery,” The American Journal of Medicine, 1988; 84(4): 654–660.
  • Jofré R, López Gómez JM, Menárguez J. et al. Parathyroidectomy: whom and when? Kidney Int Suppl 2003; S97.
  • Witteveen JE, van Thiel S, Romijn JA, Hamdy NA. Hungry bone syndrome: still a challenge in the post-operative management of primary hyperparathyroidism: a systematic review of the literature. European Journal of Endocrinology/European Federation of Endocrine Societies. 2013;168(3):R45–R53.
  • Heath DA, Van't Hoff W, Barnes AD and Gray JG. Value of 1-α-hydroxy vitamin D3 in treatment of primary hyperparathyroidism before parathyroidectomy. BMJ 1979;1: 450–452.
  • Kebebew E, Duh QY, Clark OH. Tertiary hyperparathyroidism: histologic patterns of disease and results of parathyroidectomy. Arch Surg 2004; 139:974.
  • Vercauteren M, Boeckx E and Adriaensen H. Parathyroidectomy and postoperative hypocalcemia: a retrospective study. Acta Anaesthesiologica Belgica 1988;39: 59–63.
  • Benz RL, Schleifer CR, Teehan BP, et al. Successful treatment of postparathyroidectomy hypocalcemia using continuous ambulatory intraperitoneal calcium (CAIC) therapy. Perit Dial Int 1989; 9:285.
Yıl 2021, Cilt: 13 Sayı: 2, 1 - 10, 21.12.2021

Öz

Proje Numarası

-

Kaynakça

  • Filopanti F, Corbetta S, Barbieri AM, and Spada A, “Pharmacology of the calcium sensing receptor,” Clinical Cases in Mineral and Bone Metabolism, 2013; 10(3): 162–165.
  • Dunlay R. and Hruska K. PTH receptor coupling to phospholipase C is an alternate pathway of signal transduction in bone and kidney, The American Journal of Physiology—Renal Fluid and Electrolyte Physiology, 1990; 258(2): F223–F231.
  • Jofre R, Lopez Gomez JM, Menarguez J, et al. Parathyroidectomy: whom and when? Kidney Int Suppl. 2003;63:S97–S100.
  • Jamal SA, Miller PD. Secondary and tertiary hyperparathyroidism. J Clin Densitom. 2013;16(1):64–68.
  • Assadi F. Hypophosphatemia: An evidencebased problem-solving approach to clinical cases. Iran J Kidney Dis 2010;4:195-201.
  • Albright F, Reifenstein EC. The parathyroid glands and metabolic bone disease, Ulster Medical Journal, 1950; 19 (1):130–131.
  • Farese S. The hungry bone syndrome: An update. Ther Umsch 2007;64:277-80.
  • Kritmetapak K, Kongpetch S, Chotmongkol W, Raruenrom Y, Sangkhamanon S and Pongchaiyakul C. Incidence of and risk factors for post-parathyroidectomy hungry bone syndrome in patients with secondary hyperparathyroidism. RENAL FAILURE 2020;42(1): 1118–1126.
  • Jain N, Reilly RF. Hungry bone syndrome. Curr Opin Nephrol Hypertens. 2017;26(4):250–255.
  • Brasier AR, Nussbaum SR. “Hungry bone syndrome: clinical and biochemical predictors of its occurrence after parathyroid surgery,” The American Journal of Medicine, 1988; 84(4): 654–660.
  • Jofré R, López Gómez JM, Menárguez J. et al. Parathyroidectomy: whom and when? Kidney Int Suppl 2003; S97.
  • Witteveen JE, van Thiel S, Romijn JA, Hamdy NA. Hungry bone syndrome: still a challenge in the post-operative management of primary hyperparathyroidism: a systematic review of the literature. European Journal of Endocrinology/European Federation of Endocrine Societies. 2013;168(3):R45–R53.
  • Heath DA, Van't Hoff W, Barnes AD and Gray JG. Value of 1-α-hydroxy vitamin D3 in treatment of primary hyperparathyroidism before parathyroidectomy. BMJ 1979;1: 450–452.
  • Kebebew E, Duh QY, Clark OH. Tertiary hyperparathyroidism: histologic patterns of disease and results of parathyroidectomy. Arch Surg 2004; 139:974.
  • Vercauteren M, Boeckx E and Adriaensen H. Parathyroidectomy and postoperative hypocalcemia: a retrospective study. Acta Anaesthesiologica Belgica 1988;39: 59–63.
  • Benz RL, Schleifer CR, Teehan BP, et al. Successful treatment of postparathyroidectomy hypocalcemia using continuous ambulatory intraperitoneal calcium (CAIC) therapy. Perit Dial Int 1989; 9:285.
Toplam 16 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular İç Hastalıkları
Bölüm Original Research Paper
Yazarlar

Mehmet Erdem 0000-0001-5439-9473

Senar Ebinç 0000-0002-0878-6525

Azad Duman 0000-0002-3208-4929

İdris Oruç 0000-0003-0396-7498

Ümit Haluk İliklerden 0000-0003-3950-5535

Yasemin Soyoral 0000-0002-4394-3872

Proje Numarası -
Yayımlanma Tarihi 21 Aralık 2021
Yayımlandığı Sayı Yıl 2021 Cilt: 13 Sayı: 2

Kaynak Göster

APA Erdem, M., Ebinç, S., Duman, A., Oruç, İ., vd. (2021). Hungry Bone Syndrome in Patients with End-Stage Renal Disease Receiving Hemodialysis. International Archives of Medical Research, 13(2), 1-10.
AMA Erdem M, Ebinç S, Duman A, Oruç İ, İliklerden ÜH, Soyoral Y. Hungry Bone Syndrome in Patients with End-Stage Renal Disease Receiving Hemodialysis. IAMR. Aralık 2021;13(2):1-10.
Chicago Erdem, Mehmet, Senar Ebinç, Azad Duman, İdris Oruç, Ümit Haluk İliklerden, ve Yasemin Soyoral. “Hungry Bone Syndrome in Patients With End-Stage Renal Disease Receiving Hemodialysis”. International Archives of Medical Research 13, sy. 2 (Aralık 2021): 1-10.
EndNote Erdem M, Ebinç S, Duman A, Oruç İ, İliklerden ÜH, Soyoral Y (01 Aralık 2021) Hungry Bone Syndrome in Patients with End-Stage Renal Disease Receiving Hemodialysis. International Archives of Medical Research 13 2 1–10.
IEEE M. Erdem, S. Ebinç, A. Duman, İ. Oruç, Ü. H. İliklerden, ve Y. Soyoral, “Hungry Bone Syndrome in Patients with End-Stage Renal Disease Receiving Hemodialysis”, IAMR, c. 13, sy. 2, ss. 1–10, 2021.
ISNAD Erdem, Mehmet vd. “Hungry Bone Syndrome in Patients With End-Stage Renal Disease Receiving Hemodialysis”. International Archives of Medical Research 13/2 (Aralık 2021), 1-10.
JAMA Erdem M, Ebinç S, Duman A, Oruç İ, İliklerden ÜH, Soyoral Y. Hungry Bone Syndrome in Patients with End-Stage Renal Disease Receiving Hemodialysis. IAMR. 2021;13:1–10.
MLA Erdem, Mehmet vd. “Hungry Bone Syndrome in Patients With End-Stage Renal Disease Receiving Hemodialysis”. International Archives of Medical Research, c. 13, sy. 2, 2021, ss. 1-10.
Vancouver Erdem M, Ebinç S, Duman A, Oruç İ, İliklerden ÜH, Soyoral Y. Hungry Bone Syndrome in Patients with End-Stage Renal Disease Receiving Hemodialysis. IAMR. 2021;13(2):1-10.

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