Araştırma Makalesi
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Yıl 2017, Cilt: 8 Sayı: 3, 71 - 75, 30.09.2017

Nibal Abunahlah Aisha Abimbola Yildiz Okuturlar

https://doi.org/10.5799/jcei.343189

Öz

Kaynakça

  • 1. Greinacher A, Farner B, Kroll H, Kohlmann T, Warkentin TE, Eichler P. Clinical features of heparin-induced thrombocytopenia including risk factors for thrombosis. Thromb Haemost. 2005;94:132-5.
  • 2. Theodore E, Warkentin MD. Heparin-Induced Thrombocytopenia. Hematol/Oncol Clin North Am. 2007;21:589–607.
  • 3. Greinacher A. Heparin-Induced Thrombocytopenia. The New England Journal of Medicine. 2015:373:252–261.
  • 4. Arepally G, Cines DB. Pathogenesis of heparin-induced thrombocytopenia and thrombosis. 2002;1:125–132.
  • 5. Bakchoul T. An update on heparin-induced thrombocytopenia: diagnosis and management. Expert Opinion on Drug Safety. 2016;15:787–97.
  • 6. Bakchoul T, Greinacher A. Recent advances in the diagnosis and treatment of heparin-induced thrombocytopenia. Ther Adv Hematol. 2012;3:237–51.
  • 7. Solomon CG, Greinacher A. Heparin-Induced Thrombocytopenia. New Engl J Med. 2015;373:252–61.
  • 8. Gruel Y, Régina S, Pouplard C. Usefulness of pretest clinical score (4Ts) combined with immunoassay for the diagnosis of heparin-induced thrombocytopenia. Current Opinion in Pulmonary Medicine. 2008;14:397–402.
  • 9. Martel N, Lee J, Wells PS. Risk for heparin-induced thrombocytopenia with unfractionated and low- molecular-weight heparin thromboprophylaxis : a meta-analysis. Blood. 2016;106:2710–6.
  • 10. Yim JM, Frazier JL. Ranitidine and thrombocytopenia. Journal of Pharmacy Technology. 1995;11:263–6.

Use of Heparin and The Related Incidence of Heparin- Induced Thrombocytopenia in an Education and Research Hospital in Turkey

Yıl 2017, Cilt: 8 Sayı: 3, 71 - 75, 30.09.2017

Nibal Abunahlah Aisha Abimbola Yildiz Okuturlar

https://doi.org/10.5799/jcei.343189

Öz

Objective: We analyzed the incidence of heparin-induced thrombocytopenia in a group of
patients who received heparin (LMWH, UFH) in an education and research hospital using the 4T
test score as a diagnostic tool.
Patients and Methods: A retrospective descriptive study analyzing patients using heparin
preparations within the years 2015 and 2016. The risk for heparin-induced thrombocytopenia
was calculated using the 4T test score system and also the monitoring of platelet counts of each
patient.
Results: Of 19.257 patients who used either UFH or LMWH and were admitted to the hospital
within 2015 and 2016, 308 patients were suspected to have thrombocytopenia based on their
individual platelet counts by excluding only patients with thrombocytopenia. 100 patients were
determined to probably have heparin-induced thrombocytopenia and were further evaluated
using the 4t test score. Overall risk was calculated to be 0.5%. Incidence was calculated to be
0.15% (29 out of 19257). For patients with high-risk scores, the incidence was 0.01% (2 out of
19257). Patients who had a high 4T test score were using ranitidine. In 29 patients who had
intermediate and high-risk probability for HIT, mean starting day of HIT was 6.24±3.68 days;
mean withdrawal day of heparin was 9,55±5,86 days and mean delay of heparin withdrawal was
3.31±3.39 days.
Conclusion: Although the use of LMWH is being favored in the hospital when compared to
UFH, health care practitioners should still remain vigilant about the occurrence of HIT as a
complication of heparin therapy in hospitalized patients most especially within the first few
weeks following heparin administration.

Anahtar Kelimeler

Heparin thrombocytopenia hospital setting incidence

Kaynakça

  • 1. Greinacher A, Farner B, Kroll H, Kohlmann T, Warkentin TE, Eichler P. Clinical features of heparin-induced thrombocytopenia including risk factors for thrombosis. Thromb Haemost. 2005;94:132-5.
  • 2. Theodore E, Warkentin MD. Heparin-Induced Thrombocytopenia. Hematol/Oncol Clin North Am. 2007;21:589–607.
  • 3. Greinacher A. Heparin-Induced Thrombocytopenia. The New England Journal of Medicine. 2015:373:252–261.
  • 4. Arepally G, Cines DB. Pathogenesis of heparin-induced thrombocytopenia and thrombosis. 2002;1:125–132.
  • 5. Bakchoul T. An update on heparin-induced thrombocytopenia: diagnosis and management. Expert Opinion on Drug Safety. 2016;15:787–97.
  • 6. Bakchoul T, Greinacher A. Recent advances in the diagnosis and treatment of heparin-induced thrombocytopenia. Ther Adv Hematol. 2012;3:237–51.
  • 7. Solomon CG, Greinacher A. Heparin-Induced Thrombocytopenia. New Engl J Med. 2015;373:252–61.
  • 8. Gruel Y, Régina S, Pouplard C. Usefulness of pretest clinical score (4Ts) combined with immunoassay for the diagnosis of heparin-induced thrombocytopenia. Current Opinion in Pulmonary Medicine. 2008;14:397–402.
  • 9. Martel N, Lee J, Wells PS. Risk for heparin-induced thrombocytopenia with unfractionated and low- molecular-weight heparin thromboprophylaxis : a meta-analysis. Blood. 2016;106:2710–6.
  • 10. Yim JM, Frazier JL. Ranitidine and thrombocytopenia. Journal of Pharmacy Technology. 1995;11:263–6.
Toplam 10 adet kaynakça vardır.

Ayrıntılar

Bölüm Araştırma Yazısı
Yazarlar

Nibal Abunahlah Bu kişi benim

Aisha Abimbola Bu kişi benim

Yildiz Okuturlar

Yayımlanma Tarihi 30 Eylül 2017
Yayımlandığı Sayı Yıl 2017 Cilt: 8 Sayı: 3

Kaynak Göster

APA Abunahlah, N., Abimbola, A., & Okuturlar, Y. (2017). Use of Heparin and The Related Incidence of Heparin- Induced Thrombocytopenia in an Education and Research Hospital in Turkey. Journal of Clinical and Experimental Investigations, 8(3), 71-75. https://doi.org/10.5799/jcei.343189
AMA Abunahlah N, Abimbola A, Okuturlar Y. Use of Heparin and The Related Incidence of Heparin- Induced Thrombocytopenia in an Education and Research Hospital in Turkey. J Clin Exp Invest. Eylül 2017;8(3):71-75. doi:10.5799/jcei.343189
Chicago Abunahlah, Nibal, Aisha Abimbola, ve Yildiz Okuturlar. “Use of Heparin and The Related Incidence of Heparin- Induced Thrombocytopenia in an Education and Research Hospital in Turkey”. Journal of Clinical and Experimental Investigations 8, sy. 3 (Eylül 2017): 71-75. https://doi.org/10.5799/jcei.343189.
EndNote Abunahlah N, Abimbola A, Okuturlar Y (01 Eylül 2017) Use of Heparin and The Related Incidence of Heparin- Induced Thrombocytopenia in an Education and Research Hospital in Turkey. Journal of Clinical and Experimental Investigations 8 3 71–75.
IEEE N. Abunahlah, A. Abimbola, ve Y. Okuturlar, “Use of Heparin and The Related Incidence of Heparin- Induced Thrombocytopenia in an Education and Research Hospital in Turkey”, J Clin Exp Invest, c. 8, sy. 3, ss. 71–75, 2017, doi: 10.5799/jcei.343189.
ISNAD Abunahlah, Nibal vd. “Use of Heparin and The Related Incidence of Heparin- Induced Thrombocytopenia in an Education and Research Hospital in Turkey”. Journal of Clinical and Experimental Investigations 8/3 (Eylül 2017), 71-75. https://doi.org/10.5799/jcei.343189.
JAMA Abunahlah N, Abimbola A, Okuturlar Y. Use of Heparin and The Related Incidence of Heparin- Induced Thrombocytopenia in an Education and Research Hospital in Turkey. J Clin Exp Invest. 2017;8:71–75.
MLA Abunahlah, Nibal vd. “Use of Heparin and The Related Incidence of Heparin- Induced Thrombocytopenia in an Education and Research Hospital in Turkey”. Journal of Clinical and Experimental Investigations, c. 8, sy. 3, 2017, ss. 71-75, doi:10.5799/jcei.343189.
Vancouver Abunahlah N, Abimbola A, Okuturlar Y. Use of Heparin and The Related Incidence of Heparin- Induced Thrombocytopenia in an Education and Research Hospital in Turkey. J Clin Exp Invest. 2017;8(3):71-5.