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CASE SERİES WITH ATROPA BELLADONNA (DEADLY NIGHTSHADE) INTOXICATION AND EXPERIENCE OF PHYSOSTIGMIN

Yıl 2022, Cilt: 13 Sayı: 1, 25 - 28, 08.03.2022
https://doi.org/10.33706/jemcr.998002

Öz

Introduction: Atropa belladonna (deadly nightshade) is a poisonous herb that can be especially seen in Northern regions of our country and cause anticholinergic toxic syndrome (ATS) when consumed. ATS can be seen when consuming the plant which contains atropine or in overdose of psychoactive drugs containing atropine (such as antipsychotics, tricyclic antidepressants).
Case 1: A 65-year-old female patient was admitted to emergency service with the clinic of agitation, speech disorder and consciousness change. It was learned that she consumed atropa belladonna fruits about an hour ago. She was followed up with the diagnosis of ATS and treated with conservative approach.
Case 2: A 58-year-old male patient was admitted to the emergency servise due to impaired consciousness, agitation, difficulty in speaking, vomiting and fever. He also ate the same fruits with his relative, case 1. He also followed up with a diagnosis of ATS and treated with both conservative approach and physostigmine.
Conclusion: Consuming atropa belladonna fruits and leaves can lead to ATS and life-threatening consequences can be seen in severe toxicity. Early diagnosis and treatment are important in prognosis. Physostigmine must be kept in mind in cases who does not benefit from conservative approach.

Kaynakça

  • Referans1 Heindl S, Binder C, Desel H et al. Etiology of initially unexplained confusion of excitability in deadly nightshade poisoning with suicidal intent. Symptoms, differential diagnosis, toxicology and physostigmine therapy of anticholinergic syndrome. Dtsch Med Wochenschr 2000; 125: 1361-1365.
  • Referans2 Caksen H, Odabaş D, Akbayram S, Cesur Y, Arslan S,Uner A, Oner AF. Deadly nightshade (Atropa belladonna) intoxication: an analysis of 49 children. Hum Exp Toxicol. 22:665-8, 2003.
  • Referans3 Southgate HJ, Egerton M, Dauncey EA. Lessons to be learned: a case study approach. Unseasonal severe poisoning of two adults by deadly nightside (Atropa belladonna). J R Soc Promot Health 2000; 120: 127-30.
  • Referans4 Lange A, Toft P. Poisoning with nightside, Atropa belladona. Ugeskr Laeger. 152: 1096, 1990.
  • Referans5 Perlik-Gattner I. Atropa belladona poisoning suggesting severe post – traumatic brain damage. Przegl Lek 54: 464-65, 1997.
  • Referans6 Fidan Tulin, Kirpinar Ismet. Psychiatric Aspects of a Case with Deadly Nightshade Intoxication. Journal of academic emergency medicine. 10:86-88, 2011.
  • Referans7 Atropa Belladonna ile Gelişen Antikolinerjik Sendrom, Ali AHISKALIOĞLU, İlker İNCE, Ayşenur DOSTBİL, İbrahim Hakkı TÖR, Hüsnü KÜRŞAD ve ark. Ortadogu Medical Journal 8 (2): 118-120,2016.
  • Referans8 Atropa Belladonna (Güzel Avrat Otu) Yaprakları Pişirilirse Ne Olur? : Antikolinerjik Toksik Sendrom Olgusu, Ethemoglu ve ark: Anticholinergic Toxic Syndrome, Anestezi Dergisi 2017; 25 (2): 87 – 89.
  • Referans9 Schneider F, Lutun P, Kintz P, Astruc D, Flesch F, Tempe JD: Plasma and urine concentrations of atropine after the ingestion of cooked deadly nightshade berries. J Toxicol Clin Toxicol 34:113-17, 1996.
  • Referans10 Tekelioğlu, İsa Yıldız, Tanzer Korkmaz, Murat Bilgi, Akcan Akkaya, Hasan Koçoğlu. Atropa Belladonna (Güzel Avrat Otu) Meyvesi ile İlişkili Antikolinerjik Toksik Sendrom: Bir Olgu Sunumu. Abdullah Demirhan, Ümit Yaşar Turk J Anaesth Reanim. 41: 226-8, 2013.
  • Referans11 Joshi P, Wicks AC, Munshi SK. Recurrent autumnal psychosis. Postgrad Med J. 79:239-240, 2003.
  • Referans12 Cikla U, Turkmen S, Karaca Y, Ayaz AF, Turedi S, Gunduz A. An Atropa belladonna L poisoning with acute subdural hematoma. Hum Exp Toxicol. 30: 1998-2001, 2011.

ATROPA BELLADONNA (ÖLÜMCÜL İTÜZÜMÜ) ZEHİRLENMESİ OLAN OLGU SERİSİ VE FİZOSTİGMİN DENEYİMİ

Yıl 2022, Cilt: 13 Sayı: 1, 25 - 28, 08.03.2022
https://doi.org/10.33706/jemcr.998002

Öz

Giriş: Atropa belladonna (ölümcül itüzümü), ülkemizin özellikle kuzey bölgelerinde görülebilen ve tüketildiğinde antikolinerjik toksik sendroma (ATS) neden olabilen zehirli bir bitkidir. ATS; atropin içeren bitkilerin veya atropin içeren psikoaktif ilaçların (antipsikotikler, trisiklik antidepresanlar gibi) aşırı dozda alınmasında görülebilir.
Olgu 1: 65 yaşında kadın hasta ajitasyon, konuşma bozukluğu ve bilinç değişikliği kliniği ile acil servise başvurdu. Yaklaşık bir saat önce atropa belladonna meyvelerinden tükettiği öğrenildi. ATS tanısı ile takibe alındı ve konservatif yaklaşımla tedavi edildi.
Olgu 2: 58 yaşında erkek hasta bilinç bozukluğu, ajitasyon, konuşma güçlüğü, kusma ve ateş şikayetleri ile acil servise başvurdu. Akrabası olan olgu 1 ile aynı meyveleri yediği öğrenildi. ATS tanısı ile takibe alınan hasta konservatif yaklaşımlar ve fizostigmin ile tedavi edildi.
Sonuç: Atropa belladonna meyve ve yapraklarının tüketilmesi ATS' ye yol açabilmekte ve şiddetli toksisitede hayatı tehdit eden sonuçlar görülebilmektedir. Prognozda erken tanı ve tedavi önemlidir. Konservatif yaklaşımdan fayda görmeyen olgularda fizostigmin tedavisi akılda tutulmalıdır.

Teşekkür

Akademik yayın imkanı sunarak bilime katkı sağladığınız için teşekkür ediyoruz.

Kaynakça

  • Referans1 Heindl S, Binder C, Desel H et al. Etiology of initially unexplained confusion of excitability in deadly nightshade poisoning with suicidal intent. Symptoms, differential diagnosis, toxicology and physostigmine therapy of anticholinergic syndrome. Dtsch Med Wochenschr 2000; 125: 1361-1365.
  • Referans2 Caksen H, Odabaş D, Akbayram S, Cesur Y, Arslan S,Uner A, Oner AF. Deadly nightshade (Atropa belladonna) intoxication: an analysis of 49 children. Hum Exp Toxicol. 22:665-8, 2003.
  • Referans3 Southgate HJ, Egerton M, Dauncey EA. Lessons to be learned: a case study approach. Unseasonal severe poisoning of two adults by deadly nightside (Atropa belladonna). J R Soc Promot Health 2000; 120: 127-30.
  • Referans4 Lange A, Toft P. Poisoning with nightside, Atropa belladona. Ugeskr Laeger. 152: 1096, 1990.
  • Referans5 Perlik-Gattner I. Atropa belladona poisoning suggesting severe post – traumatic brain damage. Przegl Lek 54: 464-65, 1997.
  • Referans6 Fidan Tulin, Kirpinar Ismet. Psychiatric Aspects of a Case with Deadly Nightshade Intoxication. Journal of academic emergency medicine. 10:86-88, 2011.
  • Referans7 Atropa Belladonna ile Gelişen Antikolinerjik Sendrom, Ali AHISKALIOĞLU, İlker İNCE, Ayşenur DOSTBİL, İbrahim Hakkı TÖR, Hüsnü KÜRŞAD ve ark. Ortadogu Medical Journal 8 (2): 118-120,2016.
  • Referans8 Atropa Belladonna (Güzel Avrat Otu) Yaprakları Pişirilirse Ne Olur? : Antikolinerjik Toksik Sendrom Olgusu, Ethemoglu ve ark: Anticholinergic Toxic Syndrome, Anestezi Dergisi 2017; 25 (2): 87 – 89.
  • Referans9 Schneider F, Lutun P, Kintz P, Astruc D, Flesch F, Tempe JD: Plasma and urine concentrations of atropine after the ingestion of cooked deadly nightshade berries. J Toxicol Clin Toxicol 34:113-17, 1996.
  • Referans10 Tekelioğlu, İsa Yıldız, Tanzer Korkmaz, Murat Bilgi, Akcan Akkaya, Hasan Koçoğlu. Atropa Belladonna (Güzel Avrat Otu) Meyvesi ile İlişkili Antikolinerjik Toksik Sendrom: Bir Olgu Sunumu. Abdullah Demirhan, Ümit Yaşar Turk J Anaesth Reanim. 41: 226-8, 2013.
  • Referans11 Joshi P, Wicks AC, Munshi SK. Recurrent autumnal psychosis. Postgrad Med J. 79:239-240, 2003.
  • Referans12 Cikla U, Turkmen S, Karaca Y, Ayaz AF, Turedi S, Gunduz A. An Atropa belladonna L poisoning with acute subdural hematoma. Hum Exp Toxicol. 30: 1998-2001, 2011.
Toplam 12 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Klinik Tıp Bilimleri
Bölüm Case Report
Yazarlar

Burak Hasgül 0000-0001-6779-4843

Merve Çatak 0000-0003-2654-3911

Arif İsmet Çatak 0000-0002-3828-004X

Serhat Karaman 0000-0003-4554-1364

Erken Görünüm Tarihi 7 Mart 2022
Yayımlanma Tarihi 8 Mart 2022
Gönderilme Tarihi 21 Eylül 2021
Yayımlandığı Sayı Yıl 2022 Cilt: 13 Sayı: 1

Kaynak Göster

APA Hasgül, B., Çatak, M., Çatak, A. İ., Karaman, S. (2022). CASE SERİES WITH ATROPA BELLADONNA (DEADLY NIGHTSHADE) INTOXICATION AND EXPERIENCE OF PHYSOSTIGMIN. Journal of Emergency Medicine Case Reports, 13(1), 25-28. https://doi.org/10.33706/jemcr.998002
AMA Hasgül B, Çatak M, Çatak Aİ, Karaman S. CASE SERİES WITH ATROPA BELLADONNA (DEADLY NIGHTSHADE) INTOXICATION AND EXPERIENCE OF PHYSOSTIGMIN. Journal of Emergency Medicine Case Reports. Mart 2022;13(1):25-28. doi:10.33706/jemcr.998002
Chicago Hasgül, Burak, Merve Çatak, Arif İsmet Çatak, ve Serhat Karaman. “CASE SERİES WITH ATROPA BELLADONNA (DEADLY NIGHTSHADE) INTOXICATION AND EXPERIENCE OF PHYSOSTIGMIN”. Journal of Emergency Medicine Case Reports 13, sy. 1 (Mart 2022): 25-28. https://doi.org/10.33706/jemcr.998002.
EndNote Hasgül B, Çatak M, Çatak Aİ, Karaman S (01 Mart 2022) CASE SERİES WITH ATROPA BELLADONNA (DEADLY NIGHTSHADE) INTOXICATION AND EXPERIENCE OF PHYSOSTIGMIN. Journal of Emergency Medicine Case Reports 13 1 25–28.
IEEE B. Hasgül, M. Çatak, A. İ. Çatak, ve S. Karaman, “CASE SERİES WITH ATROPA BELLADONNA (DEADLY NIGHTSHADE) INTOXICATION AND EXPERIENCE OF PHYSOSTIGMIN”, Journal of Emergency Medicine Case Reports, c. 13, sy. 1, ss. 25–28, 2022, doi: 10.33706/jemcr.998002.
ISNAD Hasgül, Burak vd. “CASE SERİES WITH ATROPA BELLADONNA (DEADLY NIGHTSHADE) INTOXICATION AND EXPERIENCE OF PHYSOSTIGMIN”. Journal of Emergency Medicine Case Reports 13/1 (Mart 2022), 25-28. https://doi.org/10.33706/jemcr.998002.
JAMA Hasgül B, Çatak M, Çatak Aİ, Karaman S. CASE SERİES WITH ATROPA BELLADONNA (DEADLY NIGHTSHADE) INTOXICATION AND EXPERIENCE OF PHYSOSTIGMIN. Journal of Emergency Medicine Case Reports. 2022;13:25–28.
MLA Hasgül, Burak vd. “CASE SERİES WITH ATROPA BELLADONNA (DEADLY NIGHTSHADE) INTOXICATION AND EXPERIENCE OF PHYSOSTIGMIN”. Journal of Emergency Medicine Case Reports, c. 13, sy. 1, 2022, ss. 25-28, doi:10.33706/jemcr.998002.
Vancouver Hasgül B, Çatak M, Çatak Aİ, Karaman S. CASE SERİES WITH ATROPA BELLADONNA (DEADLY NIGHTSHADE) INTOXICATION AND EXPERIENCE OF PHYSOSTIGMIN. Journal of Emergency Medicine Case Reports. 2022;13(1):25-8.