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Role of Gut Microbiota in Cardiovascular Diseases

Yıl 2022, Cilt: 1 Sayı: 1, 91 - 100, 25.12.2022

Öz

The incidence and mortality of cardiovascular diseases are quite high worldwide. This situation causes the pathogenesis of the disease and the treatment methods to be constantly investigated. Studies conducted in recent years draw attention to the relationship between the intestinal microbiota and cardiovascular diseases, as well as many chronic diseases, and show that the microbiota is associated with various cardiovascular diseases. The gut microbiota is considered to be the body's largest endocrine organ. The diversity of the microbiota differs between individuals as it is affected by genetics and many environmental factors. It is thought that regulating the intestinal microbiota with various applications such as diet therapy, probiotic therapy, antibiotic therapy, fecal microbiota transplantation, and microbial enzyme inhibitors may also be a potential treatment for cardiovascular diseases. Therefore, understanding the role of the gut microbiota in the occurrence and development of cardiovascular diseases will help to understand the pathogenesis of the disease better and provide new ideas for treatment. In this review, the relationship between intestinal microbiota and its metabolites and cardiovascular diseases is explained.

Kaynakça

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Kardiyovasküler Hastalıklarda Bağırsak Mikrobiyotasının Rolü

Yıl 2022, Cilt: 1 Sayı: 1, 91 - 100, 25.12.2022

Öz

Dünya genelinde kardiyovasküler hastalıkların görülme sıklığı ve mortalitesi oldukça yüksektir. Bu durum hastalığın patogenezi ile tedavi yöntemlerinin sürekli araştırılmasına neden olmaktadır. Son yıllarda yapılan çalışmalar, pek çok kronik hastalığın yanı sıra bağırsak mikrobiyotasının kardiyovasküler hastalıklarla olan ilişkisine dikkat çekmekte, çeşitli kardiyovasküler hastalıklarla mikrobiyotanın ilişkili olduğunu göstermektedir. Bağırsak mikrobiyotası vücudun en büyük endokrin organı olarak kabul edilmektedir. Mikrobiyotanın çeşitliliği genetik ve pek çok çevresel faktörden etkilendiği için bireyler arasında farklılık göstermektedir. Bağırsak mikrobiyotasının, diyet tedavisi, probiyotik tedavi, antibiyotik tedavisi, fekal mikrobiyota transplantasyonu, mikrobiyal enzim inhibitörleri gibi çeşitli uygulamalarla düzenlenmesinin kardiyovasküler hastalıklar için de potansiyel bir tedavi olabileceği düşünülmektedir. Bu nedenle, bağırsak mikrobiyotasının kardiyovasküler hastalıkların oluşumunda ve gelişimindeki rolünü anlamak, hastalığın patogenezinin daha iyi anlaşılmasına ve tedavi için yeni fikirler sunulmasına yardımcı olacaktır. Bu derlemede, bağırsak mikrobiyotası ile metabolitlerinin kardiyovasküler hastalıklarla ilişkisi anlatılmıştır.

Kaynakça

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  • 2. ALBENBERG, L. G. & WU, G. D. 2014. Diet and the intestinal microbiome: associations, functions, and implications for health and disease. Gastroenterology, 146, 1564-1572.
  • 3. ANDRAWS, R., BERGER, J. S. & BROWN, D. L. 2005. Effects of antibiotic therapy on outcomes of patients with coronary artery disease: a meta-analysis of randomized controlled trials. Jama, 293, 2641-2647.
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  • 8. BROWN, J. M. & HAZEN, S. L. 2015. The gut microbial endocrine organ: bacterially derived signals driving cardiometabolic diseases. Annual review of medicine, 66, 343-359.
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  • 67. WANG, Z., ROBERTS, A. B., BUFFA, J. A., LEVISON, B. S., ZHU, W., ORG, E., GU, X., HUANG, Y., ZAMANIAN-DARYOUSH, M. & CULLEY, M. K. 2015. Non-lethal inhibition of gut microbial trimethylamine production for the treatment of atherosclerosis. Cell, 163, 1585-1595.
  • 68. WITKOWSKI, M., WEEKS, T. L. & HAZEN, S. L. 2020. Gut microbiota and cardiovascular disease. Circulation research, 127, 553-570.
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  • 70. YEŞIL, P. & ALTıOK, M. 2012. Kardiyovasküler hastalıkların önlenmesi ve kontrolünde fiziksel aktivitenin önemi. Türk Kardiyoloji Derneği Kardiyovasküler Hemşirelik Dergisi, 3, 39-48.
  • 71. ZABELL, A. & TANG, W. 2017. Targeting the microbiome in heart failure. Current treatment options in cardiovascular medicine, 19, 1-12.
  • 72. ZHANG, Y., WANG, X., VALES, C., LEE, F. Y., LEE, H., LUSIS, A. J. & EDWARDS, P. A. 2006. FXR deficiency causes reduced atherosclerosis in Ldlr−/− mice. Arteriosclerosis, thrombosis, and vascular biology, 26, 2316-2321.
  • 73. ZHU, W., GREGORY, J. C., ORG, E., BUFFA, J. A., GUPTA, N., WANG, Z., LI, L., FU, X., WU, Y. & MEHRABIAN, M. 2016. Gut microbial metabolite TMAO enhances platelet hyperreactivity and thrombosis risk. Cell, 165, 111-124.
Toplam 73 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Konular Beslenme ve Diyetetik
Bölüm Derlemeler
Yazarlar

Ebrar Kökcü

Üla Akil

Esma Asil 0000-0003-0809-4008

Yayımlanma Tarihi 25 Aralık 2022
Gönderilme Tarihi 5 Ağustos 2022
Yayımlandığı Sayı Yıl 2022 Cilt: 1 Sayı: 1

Kaynak Göster

APA Kökcü, E., Akil, Ü., & Asil, E. (2022). Kardiyovasküler Hastalıklarda Bağırsak Mikrobiyotasının Rolü. Toros University Journal of Food Nutrition and Gastronomy, 1(1), 91-100.
AMA Kökcü E, Akil Ü, Asil E. Kardiyovasküler Hastalıklarda Bağırsak Mikrobiyotasının Rolü. JFNG. Aralık 2022;1(1):91-100.
Chicago Kökcü, Ebrar, Üla Akil, ve Esma Asil. “Kardiyovasküler Hastalıklarda Bağırsak Mikrobiyotasının Rolü”. Toros University Journal of Food Nutrition and Gastronomy 1, sy. 1 (Aralık 2022): 91-100.
EndNote Kökcü E, Akil Ü, Asil E (01 Aralık 2022) Kardiyovasküler Hastalıklarda Bağırsak Mikrobiyotasının Rolü. Toros University Journal of Food Nutrition and Gastronomy 1 1 91–100.
IEEE E. Kökcü, Ü. Akil, ve E. Asil, “Kardiyovasküler Hastalıklarda Bağırsak Mikrobiyotasının Rolü”, JFNG, c. 1, sy. 1, ss. 91–100, 2022.
ISNAD Kökcü, Ebrar vd. “Kardiyovasküler Hastalıklarda Bağırsak Mikrobiyotasının Rolü”. Toros University Journal of Food Nutrition and Gastronomy 1/1 (Aralık 2022), 91-100.
JAMA Kökcü E, Akil Ü, Asil E. Kardiyovasküler Hastalıklarda Bağırsak Mikrobiyotasının Rolü. JFNG. 2022;1:91–100.
MLA Kökcü, Ebrar vd. “Kardiyovasküler Hastalıklarda Bağırsak Mikrobiyotasının Rolü”. Toros University Journal of Food Nutrition and Gastronomy, c. 1, sy. 1, 2022, ss. 91-100.
Vancouver Kökcü E, Akil Ü, Asil E. Kardiyovasküler Hastalıklarda Bağırsak Mikrobiyotasının Rolü. JFNG. 2022;1(1):91-100.