Araştırma Makalesi
BibTex RIS Kaynak Göster
Yıl 2021, Cilt: 4 Sayı: 3, 334 - 339, 21.05.2021
https://doi.org/10.32322/jhsm.904567

Öz

Kaynakça

  • Ye Y, Meyer HH, Rapoport TA. The AAA ATPase Cdc48/p97 and its partners transport proteins from the ER into the cytosol.Nature 2001; 414: 652-6.
  • Xue L, Blythe E, Freiberger E, Mamrosh  E, Hebert A, Reitsma J. Valosin-containing protein (VCP)–Adaptor Interactions are Exceptionally Dynamic and Subject to Differential Modulation by a VCP Inhibitor. Mol Cell Proteomics 2016; 15: 2970-86.
  • Ciechanover A. Intracellular protein degradation from a vague idea through the lysosome and the ubiquitin-proteasome system and on to human diseases and drug targeting: Nobel Lecture, December 8, 2004. Ann N Y Acad Sci 2007; 1116: 1–28.
  • Lord JM, Roberts LM, Stirling CJ. Quality control: another player joins the ERAD cast. Curr Biol 2005; 15: R963–R964.
  • Cao K, Nakajima R, Meyer HH, Zheng Y. The AAA-ATPase Cdc48/p97 regulates spindle disassembly at the end of mitosis. Cell 2003; 115: 355-67.
  • Voges D , Zwick P,  Baumeister W. The 26S proteasome: a molecular machine designed for controlled proteolysis. Annu Rev Biochem 1999; 68: 1015-68.
  • Song C, Wang O, Li H. ATPase Activity of p97-Valosin-containing Protein (VCP). J Biol Chem 2002; 278: 3648–55.
  • Maurizi M, Li C. AAA proteins: in search of a common molecular basis. EMBO Rep 2001; 2: 980–5.
  • Wang Y, Shirogane T, Liu D, Harper W, Elledge L. Exit from exit: resetting the cell cycle through Amn1 inhibition of G protein signaling. Cell 2003; 112: 697-709.
  • Kondo H, Rabouille C, Newman R, et al. p47 is a cofactor for p97-mediated membrane fusion. Nature 1997; 388: 75-8.
  • Dai RM, Li CC. Valosin-containing protein is a multi-ubiquitin chaintargeting factor required in ubiquitin-proteasome degradation. Nat Cell Biol 2001; 3: 740-4.
  • Meusser B, Hirsch C, Jarosch E, Sommer T. ERAD: the long road to destruction. Nat Cell Biol 2005; 7: 766-72.
  • Klein JB, Barati MT, Wu R, et al. Akt-mediated valosin-containing protein 97 phosphorylation regulates its association with ubiquitinated proteins. J Biol Chem 2005; 280: 31870-81.
  • Cayli S, Klug J, Chapiro J, et al. The COP9 signalosome interacts ATP-dependently with p97/VCP and controls the ubiquitination status of proteins bound to p97/VCP. J Biol Chem 2009; 284: 34944-953.
  • Ozsoy A, Cayli S, Sahin C, Ocakli S, Sanci T, İlhan D. Altered expression of p97/Valosin containing protein and impaired autophagy in preeclamptic human placenta. Placenta 2018; 67: 45-53
  • Cayli S, Erdemir F, Ocaklı S. Interaction between smad1 and p97/vcp in rat testis and epididymis during the postnatal development. Reprod Sci 2012; 19: 190–201.
  • Cayli S, Ocakli S, Erdemi F, et al. Developmental expression of p97/VCP (Valosincontaining protein) and Jab1/CSN5 in the rat testis and epididymis. Reprod Biol Endocrinol 2011; 9: 117.
  • Ortak H, Cayli S, Tas U, Ocakli S, Söğüt E, Demir HD. Expression of p97/VCP and ubiquitin during postnatal development of the degenerating rat retina. J Mol Hist 2012; 43: 17–25.
  • Donna H, David K, Peter W. p97: An emerging target for cancer, neurodegenerative diseases, and viral infections. J Med Chem 2020; 12: 1892-907.
  • Anelya A, Margarita R, Elena F, Alexey K, Olga D, Kseniya D. VCP expression decrease as a biomarker of preclinical and early clinical stages of Parkinson’s disease. Sci Rep 2020; 10: 827.
  • Hongyang S, Yizhong P, Weijian H, Ning Z, Dao W. Emerging role of VCP/p97 in cardiovascular diseases: novel insights and therapeutic opportunities. Biochem Soc Trans 2021; 49: 485-94.
  • Lan B , Chai S , Wang P , Wang K . VCP/p97/Cdc48, A linking of protein homeostasis and cancer therapy. Curr Mol Med 2017; 17: 608-18.
  • Nakkas H, Gumuskaya Ocal B, Kipel S, et al. Ubiquitin proteasome system and autophagy associated proteins in human testicular tumors. Tissue Cell 2021; 71: 101513.

Immunohistochemical examination of p97/VCP expression in developing mouse pancreas and liver

Yıl 2021, Cilt: 4 Sayı: 3, 334 - 339, 21.05.2021
https://doi.org/10.32322/jhsm.904567

Öz

Abstract
Aim: The 97-kDa Valosin-containing protein has important functions in proteolysis. Although the expression of p97 / VCP has been studied in many types of cells and tissues, the localization of p97 / VCP at cellular level in developing mouse pancreas and liver has not been determined. Therefore, the aim of our study was investigate the immuolocalization of p97/VCP in the rat fetal and postnatal liver and pancreas.
Material Methods: The liver and pancreas from fetal, postnatal (1, 5, 15, 35 days old ) and adult (50 days old) mice were examined by using immunohistochemistry in order to determine the expression of p97/VCP. Furthermore the development of mouse pancreas and liver were histomorphologically analyzed under light microscope.
Results: The histological structures of the mouse pancreas and liver were maintained in postnatal period. The histological differences between endocrine and exocrine pancreas were significantly observed from the postnatal 5th day. The expression of p97/VCP in Langerhans islets was determined from day 5. p97/VCP expression was also seen in the exocrine pancreas in all postnatal days. p97/VCP was expressed in developing pancreatic and liver tissues and its expression was increased with the development.
Conclusion: This study is the first to examine the distribution and the localization of p97/VCP in the fetal and postnatal rat liver and pancreas. This study forms the basis for clinical studies in order to determine the function of p97 / VCP in liver and pancreatic cells.

Kaynakça

  • Ye Y, Meyer HH, Rapoport TA. The AAA ATPase Cdc48/p97 and its partners transport proteins from the ER into the cytosol.Nature 2001; 414: 652-6.
  • Xue L, Blythe E, Freiberger E, Mamrosh  E, Hebert A, Reitsma J. Valosin-containing protein (VCP)–Adaptor Interactions are Exceptionally Dynamic and Subject to Differential Modulation by a VCP Inhibitor. Mol Cell Proteomics 2016; 15: 2970-86.
  • Ciechanover A. Intracellular protein degradation from a vague idea through the lysosome and the ubiquitin-proteasome system and on to human diseases and drug targeting: Nobel Lecture, December 8, 2004. Ann N Y Acad Sci 2007; 1116: 1–28.
  • Lord JM, Roberts LM, Stirling CJ. Quality control: another player joins the ERAD cast. Curr Biol 2005; 15: R963–R964.
  • Cao K, Nakajima R, Meyer HH, Zheng Y. The AAA-ATPase Cdc48/p97 regulates spindle disassembly at the end of mitosis. Cell 2003; 115: 355-67.
  • Voges D , Zwick P,  Baumeister W. The 26S proteasome: a molecular machine designed for controlled proteolysis. Annu Rev Biochem 1999; 68: 1015-68.
  • Song C, Wang O, Li H. ATPase Activity of p97-Valosin-containing Protein (VCP). J Biol Chem 2002; 278: 3648–55.
  • Maurizi M, Li C. AAA proteins: in search of a common molecular basis. EMBO Rep 2001; 2: 980–5.
  • Wang Y, Shirogane T, Liu D, Harper W, Elledge L. Exit from exit: resetting the cell cycle through Amn1 inhibition of G protein signaling. Cell 2003; 112: 697-709.
  • Kondo H, Rabouille C, Newman R, et al. p47 is a cofactor for p97-mediated membrane fusion. Nature 1997; 388: 75-8.
  • Dai RM, Li CC. Valosin-containing protein is a multi-ubiquitin chaintargeting factor required in ubiquitin-proteasome degradation. Nat Cell Biol 2001; 3: 740-4.
  • Meusser B, Hirsch C, Jarosch E, Sommer T. ERAD: the long road to destruction. Nat Cell Biol 2005; 7: 766-72.
  • Klein JB, Barati MT, Wu R, et al. Akt-mediated valosin-containing protein 97 phosphorylation regulates its association with ubiquitinated proteins. J Biol Chem 2005; 280: 31870-81.
  • Cayli S, Klug J, Chapiro J, et al. The COP9 signalosome interacts ATP-dependently with p97/VCP and controls the ubiquitination status of proteins bound to p97/VCP. J Biol Chem 2009; 284: 34944-953.
  • Ozsoy A, Cayli S, Sahin C, Ocakli S, Sanci T, İlhan D. Altered expression of p97/Valosin containing protein and impaired autophagy in preeclamptic human placenta. Placenta 2018; 67: 45-53
  • Cayli S, Erdemir F, Ocaklı S. Interaction between smad1 and p97/vcp in rat testis and epididymis during the postnatal development. Reprod Sci 2012; 19: 190–201.
  • Cayli S, Ocakli S, Erdemi F, et al. Developmental expression of p97/VCP (Valosincontaining protein) and Jab1/CSN5 in the rat testis and epididymis. Reprod Biol Endocrinol 2011; 9: 117.
  • Ortak H, Cayli S, Tas U, Ocakli S, Söğüt E, Demir HD. Expression of p97/VCP and ubiquitin during postnatal development of the degenerating rat retina. J Mol Hist 2012; 43: 17–25.
  • Donna H, David K, Peter W. p97: An emerging target for cancer, neurodegenerative diseases, and viral infections. J Med Chem 2020; 12: 1892-907.
  • Anelya A, Margarita R, Elena F, Alexey K, Olga D, Kseniya D. VCP expression decrease as a biomarker of preclinical and early clinical stages of Parkinson’s disease. Sci Rep 2020; 10: 827.
  • Hongyang S, Yizhong P, Weijian H, Ning Z, Dao W. Emerging role of VCP/p97 in cardiovascular diseases: novel insights and therapeutic opportunities. Biochem Soc Trans 2021; 49: 485-94.
  • Lan B , Chai S , Wang P , Wang K . VCP/p97/Cdc48, A linking of protein homeostasis and cancer therapy. Curr Mol Med 2017; 17: 608-18.
  • Nakkas H, Gumuskaya Ocal B, Kipel S, et al. Ubiquitin proteasome system and autophagy associated proteins in human testicular tumors. Tissue Cell 2021; 71: 101513.
Toplam 23 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Sağlık Kurumları Yönetimi
Bölüm Orijinal Makale
Yazarlar

Bahar Kartal 0000-0001-9558-4122

Ebru Alimoğulları 0000-0002-9557-3631

Gülben Akcan

Sevil Çaylı 0000-0003-2465-5389

Muaz Alperen Vergili Bu kişi benim 0000-0002-4110-1815

Yayımlanma Tarihi 21 Mayıs 2021
Yayımlandığı Sayı Yıl 2021 Cilt: 4 Sayı: 3

Kaynak Göster

AMA Kartal B, Alimoğulları E, Akcan G, Çaylı S, Vergili MA. Immunohistochemical examination of p97/VCP expression in developing mouse pancreas and liver. J Health Sci Med /JHSM /jhsm. Mayıs 2021;4(3):334-339. doi:10.32322/jhsm.904567

Üniversitelerarası Kurul (ÜAK) Eşdeğerliği:  Ulakbim TR Dizin'de olan dergilerde yayımlanan makale [10 PUAN] ve 1a, b, c hariç  uluslararası indekslerde (1d) olan dergilerde yayımlanan makale [5 PUAN]

Dahil olduğumuz İndeksler (Dizinler) ve Platformlar sayfanın en altındadır.

Not:
Dergimiz WOS indeksli değildir ve bu nedenle Q olarak sınıflandırılmamıştır.

Yüksek Öğretim Kurumu (YÖK) kriterlerine göre yağmacı/şüpheli dergiler hakkındaki kararları ile yazar aydınlatma metni ve dergi ücretlendirme politikasını tarayıcınızdan indirebilirsiniz. https://dergipark.org.tr/tr/journal/2316/file/4905/show 


Dergi Dizin ve Platformları

Dizinler; ULAKBİM TR Dizin, Index Copernicus, ICI World of Journals, DOAJ, Directory of Research Journals Indexing (DRJI), General Impact Factor, ASOS Index, WorldCat (OCLC), MIAR, EuroPub, OpenAIRE, Türkiye Citation Index, Türk Medline Index, InfoBase Index, Scilit, vs.

Platformlar; Google Scholar, CrossRef (DOI), ResearchBib, Open Access, COPE, ICMJE, NCBI, ORCID, Creative Commons vs.