Araştırma Makalesi
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Yıl 2022, Cilt: 5 Sayı: 3, 844 - 849, 30.05.2022
https://doi.org/10.32322/jhsm.1096501

Öz

Destekleyen Kurum

Çanakkale Onsekiz Mart Üniversitesi

Proje Numarası

THD-2020-3255

Kaynakça

  • Yadav D, Lowenfels AB. The epidemiology of pancreatitis and pancreatic cancer. Gastroenterology 2013; 144: 1252-61.
  • Gumaste VV. Diagnostic tests for acute pancreatitis. Gastroenterologist. 1994; 2: 119-30.
  • Foell D, Roth J. Proinflammatory S100 proteins in arthritis and autoimmune disease. Arthritis Rheum 2004; 50: 3762-71
  • Manolakis AC, Kapsoritakis AN, Georgoulias P, et al. Moderate performance of serum S100A12, in distinguishing inflammatory bowel disease from irritable bowel syndrome. BMC Gastroenterol 2010; 10: 118.
  • Liu K, Pichichero ME. Clinical significance of serum S100A12 in acute otitis media in young children. Pediatr Infect Dis J 2012; 3: e56-8.
  • Gohar F, Anink J, Moncrieffe H, et al. S100A12 Is Associated with Response to Therapy in Juvenile Idiopathic Arthritis. J Rheumatol 2018; 45: 547-54
  • Hinze CH, Foell D, Johnson AL, et al. Serum S100A8/A9 and S100A12 Levels in children with polyarticular forms of juvenile idiopathic arthritis: relationship to maintenance of clinically inactive disease during anti-tumor necrosis factor therapy and occurrence of disease flare after discontinuation of therapy. Arthritis Rheumatol 2019; 71: 451-9.
  • Prystupa A, Kiciński P, Luchowska-Kocot D, et al. Analysis of novel serum markers of fibrosis and angiogenesis in patients with alcoholic liver cirrhosis. Ann Agric Environ Med 2020; 27: 568-73.
  • Şumnu Ş, Mehtap Ö, Mersin S, et al. Serum calprotectin (S100A8/A9) levels as a new potential biomarker of treatment response in Hodgkin lymphoma. Int J Lab Hematol 202; 43: 638-44
  • Müller I, Vogl T, Kühl U, et al. Serum alarmin S100A8/S100A9 levels and its potential role as biomarker in myocarditis. ESC Heart Fail 2020; 7: 1442-51.
  • Banks PA, Bollen TL, Dervenis C, et al. Acute Pancreatitis Classification Working Group. Classification of acute pancreatitis--2012: revision of the Atlanta classification and definitions by international consensus. Gut 2013; 62: 102-11.
  • van Dijk SM, Hallensleben NDL, van Santvoort HC, et al. Acute pancreatitis: recent advances through randomised trials. Gut 2017; 66: 2024-32.
  • Vatansever S, Doğru R, Pakoz ZB, Genç H, Ünsal B. Evaluation of laboratory findings and mortality in elderly patients with acute biliary pancreatitis. Sisli Etfal Hastan Tip Bul 2018; 52: 274-8.
  • Ünal Çetin E, Kamiş F, Çetin AU, Beyazit Y, Kekilli M. Serum chitotriosidase and YKL-40 in acute pancreatitis: Reliability as prognostic marker for disease severity and correlation with inflammatory markers. Turk J Med Sci 2021; 51: 3038-46.
  • Gezer NS, Bengi G, Baran A, et al. Comparison of radiological scoring systems, clinical scores, neutrophil-lymphocyte ratio and serum C-reactive protein level for severity and mortality in acute pancreatitis. Rev Assoc Med Bras (1992) 2020; 66: 762-70.
  • Rasslan R, Novo FDCF, Bitran A, Utiyama EM, Rasslan S. Management of infected pancreatic necrosis: state of the art. Rev Col Bras Cir 2017; 44: 521-9.
  • Korkmaz H, Tabur S, Savaş E, et al. Evaluation of serum S100A8/S100A9 levels in patients with autoimmune thyroid diseases. Balkan Med J 2016; 33: 547-51.
  • van Bon L, Cossu M, Loof A, et al. Proteomic analysis of plasma identifies the Toll-like receptor agonists S100A8/A9 as a novel possible marker for systemic sclerosis phenotype. Ann Rheum Dis 2014 A; 73: 1585-9.
  • Kessel C, Lavric M, Weinhage T, et al. Serum biomarkers confirming stable remission in inflammatory bowel disease. Sci Rep 2021; 11: 6690.
  • Türkmenoğlu Y, Güney E, Bezen D, İrdem A, Ertürk B, Dursun H. Evaluation of S100A12 protein levels in children with familial Mediterranean fever. Turk J Med Sci 2021; 51: 1396-1405.
  • van den Bos C, Roth J, Koch HG, Hartmann M, Sorg C. Phosphorylation of MRP14, an S100 protein expressed during monocytic differentiation, modulates Ca(2+)-dependent translocation from cytoplasm to membranes and cytoskeleton. J Immunol. 1996; 156: 1247-54
  • Hu W, Lin C. S100a8 silencing attenuates inflammation, oxidative stress and apoptosis in BV2 cells induced by oxygen glucose deprivation and reoxygenation by upregulating GAB1 expression. Mol Med Rep 2021; 23: 64.
  • El Gammal AT, Sturm JH, Pinnschmidt HO, et al. Protein S100A8/A9: A potential new biomarker for pancreatic diseases. Int J Clin Endocrinol Metab 2017;3: 23-8.
  • Foell D, Roth J. Proinflammatory S100 proteins in arthritis and autoimmune disease. Arthritis Rheum 2004; 50:3762-71.
  • Cai J, Han T, Nie C, et al. Biomarkers of oxidation stress, inflammation, necrosis and apoptosis are associated with hepatitis B-related acute-on-chronic liver failure. Clin Res Hepatol Gastroenterol 2016; 40: 41-50.
  • Aljaberi N, Tronconi E, Schulert G, et al. The use of S100 proteins testing in juvenile idiopathic arthritis and autoinflammatory diseases in a pediatric clinical setting: a retrospective analysis. Pediatr Rheumatol Online J 2020; 18: 7
  • Feng Z, Yinchu Z, Yinsheng S, et al. Potential effects of calcium binding protein S100A12 on severity evaluation and curative effect of severe acute pancreatitis. Inflammation 2015; 38: 290-7.

The diagnostic value of calcium binding protein S100A8/A9 and S100A12 in acute pancreatitis

Yıl 2022, Cilt: 5 Sayı: 3, 844 - 849, 30.05.2022
https://doi.org/10.32322/jhsm.1096501

Öz

Background: S100A8/A9 and S100A12 which are the major calcium-binding proinflammatory proteins secreted by granulocytes, has been proposed to be related to distinct disease states of inflammatory origin. This study aims to explore the circulating levels of S100A8/A9 and S100A12 in acute pancreatitis (AP) and reveal their relationship with conventional inflammatory markers.
Material and Method: Serum S100A8/A9 and S100A12 were determined in AP patients (male/female: 17/13) by using a specific enzyme-linked immunosorbent assay (ELISA) method at both onset and remission and in 30 healthy controls (male/female: 17/13).
Results: Significantly higher S100A8/A9 and S100A12 levels were found in AP patients compared to healthy controls (p<0.001). Circulating levels of S100A8/9, S100A12 and C-reactive protein (CRP) were found to be elevated in AP patients at disease onset compared with remission. The correlation analysis demonstrated a significant association between S100A8/A9 and S100A12 (r=0.366, p=0.047). The cut-off level for S100A8/A9 for detecting AP was ≥54.4 ng/ml with a sensitivity and specificity of 96.7% and 73.3% (AUC: 0.958). The optimum cut-off level for S100A12 for detecting AP was ≥350.25 ng/ml with a sensitivity and specificity of 73.3% and 76.7% (AUC: 0.752) respectively.
Conclusion: Circulating S100A8/A9 and S100A12 levels were found to be elevated in AP patients. Both of these markers might serve as an additional tool in the diagnostic workup in AP since S100A8/A9 and S100A12 were significantly correlated with CRP.

Proje Numarası

THD-2020-3255

Kaynakça

  • Yadav D, Lowenfels AB. The epidemiology of pancreatitis and pancreatic cancer. Gastroenterology 2013; 144: 1252-61.
  • Gumaste VV. Diagnostic tests for acute pancreatitis. Gastroenterologist. 1994; 2: 119-30.
  • Foell D, Roth J. Proinflammatory S100 proteins in arthritis and autoimmune disease. Arthritis Rheum 2004; 50: 3762-71
  • Manolakis AC, Kapsoritakis AN, Georgoulias P, et al. Moderate performance of serum S100A12, in distinguishing inflammatory bowel disease from irritable bowel syndrome. BMC Gastroenterol 2010; 10: 118.
  • Liu K, Pichichero ME. Clinical significance of serum S100A12 in acute otitis media in young children. Pediatr Infect Dis J 2012; 3: e56-8.
  • Gohar F, Anink J, Moncrieffe H, et al. S100A12 Is Associated with Response to Therapy in Juvenile Idiopathic Arthritis. J Rheumatol 2018; 45: 547-54
  • Hinze CH, Foell D, Johnson AL, et al. Serum S100A8/A9 and S100A12 Levels in children with polyarticular forms of juvenile idiopathic arthritis: relationship to maintenance of clinically inactive disease during anti-tumor necrosis factor therapy and occurrence of disease flare after discontinuation of therapy. Arthritis Rheumatol 2019; 71: 451-9.
  • Prystupa A, Kiciński P, Luchowska-Kocot D, et al. Analysis of novel serum markers of fibrosis and angiogenesis in patients with alcoholic liver cirrhosis. Ann Agric Environ Med 2020; 27: 568-73.
  • Şumnu Ş, Mehtap Ö, Mersin S, et al. Serum calprotectin (S100A8/A9) levels as a new potential biomarker of treatment response in Hodgkin lymphoma. Int J Lab Hematol 202; 43: 638-44
  • Müller I, Vogl T, Kühl U, et al. Serum alarmin S100A8/S100A9 levels and its potential role as biomarker in myocarditis. ESC Heart Fail 2020; 7: 1442-51.
  • Banks PA, Bollen TL, Dervenis C, et al. Acute Pancreatitis Classification Working Group. Classification of acute pancreatitis--2012: revision of the Atlanta classification and definitions by international consensus. Gut 2013; 62: 102-11.
  • van Dijk SM, Hallensleben NDL, van Santvoort HC, et al. Acute pancreatitis: recent advances through randomised trials. Gut 2017; 66: 2024-32.
  • Vatansever S, Doğru R, Pakoz ZB, Genç H, Ünsal B. Evaluation of laboratory findings and mortality in elderly patients with acute biliary pancreatitis. Sisli Etfal Hastan Tip Bul 2018; 52: 274-8.
  • Ünal Çetin E, Kamiş F, Çetin AU, Beyazit Y, Kekilli M. Serum chitotriosidase and YKL-40 in acute pancreatitis: Reliability as prognostic marker for disease severity and correlation with inflammatory markers. Turk J Med Sci 2021; 51: 3038-46.
  • Gezer NS, Bengi G, Baran A, et al. Comparison of radiological scoring systems, clinical scores, neutrophil-lymphocyte ratio and serum C-reactive protein level for severity and mortality in acute pancreatitis. Rev Assoc Med Bras (1992) 2020; 66: 762-70.
  • Rasslan R, Novo FDCF, Bitran A, Utiyama EM, Rasslan S. Management of infected pancreatic necrosis: state of the art. Rev Col Bras Cir 2017; 44: 521-9.
  • Korkmaz H, Tabur S, Savaş E, et al. Evaluation of serum S100A8/S100A9 levels in patients with autoimmune thyroid diseases. Balkan Med J 2016; 33: 547-51.
  • van Bon L, Cossu M, Loof A, et al. Proteomic analysis of plasma identifies the Toll-like receptor agonists S100A8/A9 as a novel possible marker for systemic sclerosis phenotype. Ann Rheum Dis 2014 A; 73: 1585-9.
  • Kessel C, Lavric M, Weinhage T, et al. Serum biomarkers confirming stable remission in inflammatory bowel disease. Sci Rep 2021; 11: 6690.
  • Türkmenoğlu Y, Güney E, Bezen D, İrdem A, Ertürk B, Dursun H. Evaluation of S100A12 protein levels in children with familial Mediterranean fever. Turk J Med Sci 2021; 51: 1396-1405.
  • van den Bos C, Roth J, Koch HG, Hartmann M, Sorg C. Phosphorylation of MRP14, an S100 protein expressed during monocytic differentiation, modulates Ca(2+)-dependent translocation from cytoplasm to membranes and cytoskeleton. J Immunol. 1996; 156: 1247-54
  • Hu W, Lin C. S100a8 silencing attenuates inflammation, oxidative stress and apoptosis in BV2 cells induced by oxygen glucose deprivation and reoxygenation by upregulating GAB1 expression. Mol Med Rep 2021; 23: 64.
  • El Gammal AT, Sturm JH, Pinnschmidt HO, et al. Protein S100A8/A9: A potential new biomarker for pancreatic diseases. Int J Clin Endocrinol Metab 2017;3: 23-8.
  • Foell D, Roth J. Proinflammatory S100 proteins in arthritis and autoimmune disease. Arthritis Rheum 2004; 50:3762-71.
  • Cai J, Han T, Nie C, et al. Biomarkers of oxidation stress, inflammation, necrosis and apoptosis are associated with hepatitis B-related acute-on-chronic liver failure. Clin Res Hepatol Gastroenterol 2016; 40: 41-50.
  • Aljaberi N, Tronconi E, Schulert G, et al. The use of S100 proteins testing in juvenile idiopathic arthritis and autoinflammatory diseases in a pediatric clinical setting: a retrospective analysis. Pediatr Rheumatol Online J 2020; 18: 7
  • Feng Z, Yinchu Z, Yinsheng S, et al. Potential effects of calcium binding protein S100A12 on severity evaluation and curative effect of severe acute pancreatitis. Inflammation 2015; 38: 290-7.
Toplam 27 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Sağlık Kurumları Yönetimi
Bölüm Orijinal Makale
Yazarlar

Okan Bardakcı 0000-0001-6829-7435

Murat Daş 0000-0003-0893-6084

Hilal Şehitoğlu 0000-0003-4436-9160

Ece Ünal Çetin 0000-0002-0933-7764

Ünzile Atalay 0000-0001-7665-6514

Uğur Küçük 0000-0003-4669-7387

Fatih Kamış 0000-0003-2913-6166

Alpaslan Tanoğlu 0000-0002-7477-6640

Yavuz Beyazıt 0000-0001-6247-2714

Proje Numarası THD-2020-3255
Yayımlanma Tarihi 30 Mayıs 2022
Yayımlandığı Sayı Yıl 2022 Cilt: 5 Sayı: 3

Kaynak Göster

AMA Bardakcı O, Daş M, Şehitoğlu H, Ünal Çetin E, Atalay Ü, Küçük U, Kamış F, Tanoğlu A, Beyazıt Y. The diagnostic value of calcium binding protein S100A8/A9 and S100A12 in acute pancreatitis. J Health Sci Med /JHSM /jhsm. Mayıs 2022;5(3):844-849. doi:10.32322/jhsm.1096501

Üniversitelerarası Kurul (ÜAK) Eşdeğerliği:  Ulakbim TR Dizin'de olan dergilerde yayımlanan makale [10 PUAN] ve 1a, b, c hariç  uluslararası indekslerde (1d) olan dergilerde yayımlanan makale [5 PUAN]

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Not:
Dergimiz WOS indeksli değildir ve bu nedenle Q olarak sınıflandırılmamıştır.

Yüksek Öğretim Kurumu (YÖK) kriterlerine göre yağmacı/şüpheli dergiler hakkındaki kararları ile yazar aydınlatma metni ve dergi ücretlendirme politikasını tarayıcınızdan indirebilirsiniz. https://dergipark.org.tr/tr/journal/2316/file/4905/show 


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