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Yıl 2023, Cilt: 6 Sayı: 4, 852 - 859, 30.07.2023

Sude Topkaraoğlu Alpaslan Tanoğlu

https://doi.org/10.32322/jhsm.1325357

Öz

Kaynakça

  • Bhattacharya S, Patel KK, Dehari D, Agrawal AK, Singh S. Melatonin and its ubiquitous anticancer effects. Mol Cell Biochem. 2019;462(1-2):133-155.
  • Meng X, Li Y, Li S, et al. Dietary sources and bioactivities of melatonin. Nutrients. 2017;9:367.
  • Tan DX, Manchester LC, Hardeland R, Lopez-Burillo S, Mayo JC, Sainz RM. Melatonin: a hormone, a tissue factor, an autocoid, a paracoid, and an antioxi- dant vitamin. J Pineal Res. 2003;34:75-78.
  • Reiter RJ, Tan D, Sainz RM, Mayo JC, Lopez-Burillo S. Melatonin: reducing the toxicity and increasing the efficacy of drugs. Pharm Pharmacol. 2002;5410:1299-1321.
  • Qi W, Reiter RJ, Tan DX, Manchester LC, Kim SJ, Garcia JJ. Inhibitory effects of melatonin on ferric nitrilotriacetate-induced lipid peroxidation and oxidative DNA damage in the rat kidney. Toxicology. 1999;139:81-91.
  • Liu L, Chen H, Jin J, et al. Melatonin ameliorates cerebral ischemia/reperfusion injury through SIRT3 activation. Life Sci. 2019;239:117036.
  • Stacchiotti A, Favero G. Giugno L, et al. Mitochondrial and metabolic dysfunction in renal convoluted tubules of obese mice: protective role of melatonin. Plos One. 2014;910:111-141.
  • Tanoğlu EG, Tanoğlu A, Meriçöz Aydin MÇ, Esen MF. Melatonin has favorable preventive effects on experimental chronic pancreatitis rat model. Turk J Med Sci. 2021;51:2734-2740.
  • Özçelik F, Hacimustafaoğlu F, Tanoğlu A. Modulatory effect of resveratrol and melatonin on natural killer cell activity and adrenomedullin in diabetic rats. Turk J Med Sci. 2022;521:258-267.
  • Sapmaz T, Sevgin K, Topkaraoglu S, et al. Comparison of melatonin, oxytetracycline, and N-acetylcysteine pre-treatments in autologous intraperitoneal ovarian transplantation in rats. Biochem Biophysic Res Comm. 2022;606:49-54.
  • Li Y, Li S, Zhou Y, et al. Melatonin for the prevention and treatment of cancer. Oncotarget. 2017;824:39896-39921.
  • Sadeghi M, Dehnavi S, Asadirad A, et al. Curcumin and chemokines: mechanism of action and therapeutic potential in inflammatory diseases. Inflammopharmacol. 2023:1-25
  • Xu XY, Meng X, Li S, Gan RY, Li Y, Li HB. Bioactivity, health benefits, and related molecular mechanisms of curcumin: current progress, challenges, and perspectives. Nutrients. 2018;1010:15-53.
  • Trujillo J, Chirino YI, Molina-Jijón E, Andérica-Romero AC, Tapia E, Pedraza-Chaverrí J. Renoprotective effect of the antioxidant curcumin: Recent findings. Redox Biol. 2013;11:448-456.
  • Shoba G, Joy D. Joseph T, Majeed M, Rajendran R, Srinivas PS. Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers. Planta Medica. 1998;644:353–356.
  • Prodhan AHMSU, Cavestro C, Kamal MA, Islam MA. Melatonin and sleep disturbances in Alzheimer's disease. CNS & Neurological Disorders - Drug Targets. 2021;208:736-754.
  • Li Y, Zhang J, Wan J, Liu A, Sun J. Melatonin regulates Aβ production/clearance balance and Aβ neurotoxicity: A potential therapeutic molecule for Alzheimer's disease. Biomed Pharmacother. 2020;132:110887.
  • Gerenu G, Liu K, Chojnacki JE, et al. Curcumin/melatonin hybrid 5-4-hydroxy-phenyl-3-oxo-pentanoic acid 2-5-methoxy-1H-indol-3-yl-ethyl-amide ameliorates AD-like pathology in the APP/PS1 mouse model. ACS Chemical Neuroscience. 2015;68:1393-1399.
  • Chojnacki JE, Liu K, Yan X, et al. Discovery of 5-4-hydroxyphenyl-3-oxo-pentanoic acid 2-5-methoxy-1H-indol-3-yl-ethyl-amide as a neuroprotectant for Alzheimer's disease by hybridization of curcumin and melatonin. ACS Chemical Neuroscience. 2014;58:690-699.
  • Khondker A, Alsop RJ, Himbert S, et al. Membrane-modulating drugs can affect the size of amyloid-β25-35 aggregates in anionic membranes. Scientific Reports. 2018;81:123-167.
  • Espargaró A, Ginex T, Vadell MD, et al. Combined in vitro cell-based/in silico screening of naturally occurring flavonoids and phenolic compounds as potential anti-Alzheimer drugs. J Natural Products. 2017;802:278-289.
  • Khyati, Malik I, Agrawal N, Kumar V. Melatonin and curcumin reestablish disturbed circadian gene expressions and restore locomotion ability and eclosion behavior in Drosophila model of Huntington's disease. Chronobiol Int. 2021;381:61-78.
  • Da Silva Morrone M, Schnorr CE, Behr GA, et al. Oral administration of curcumin relieves behavioral alterations and oxidative stress in the frontal cortex, hippocampus, and striatum of ovariectomized Wistar rats. J Nutr Biochem. 2016;32:181–188.
  • Madhu LN, Kodali M, Attaluri S, et al. Melatonin improves brain function in a model of chronic Gulf War Illness with modulation of oxidative stress, NLRP3 inflammasomes, and BDNF-ERK-CREB pathway in the hippocampus. Redox Biol. 2021;43:101973.
  • Keskin-Aktan A, Akbulut KG, Yazici-Mutlu Ç, Sonugur G, Ocal M, Akbulut H. The effects of melatonin and curcumin on the expression of SIRT2, Bcl-2 and Bax in the hippocampus of adult rats. Brain Res Bull. 2018;137:306-310.
  • Moharrami Kasmaie F, Jahromi Z, Gazor R, Zaminy A. Comparison of melatonin and curcumin effect at the light and dark periods on regeneration of sciatic nerve crush injury in rats. EXCLI J. 2019;18:653-665.
  • Antonio AM, Druse MJ. Antioxidants prevent ethanol-associated apoptosis in fetal rhombencephalic neurons. Brain Res. 2008;1204:16-23.
  • Borre YE, Panagaki T, Koelink PJ, et al. Neuroprotective and cognitive enhancing effects of a multi-targeted food intervention in an animal model of neurodegeneration and depression. Neuropharmacology. 2014;79:738-749.
  • Köse Vuruşkan, A., Elagül, N., Sapmaz, T., Topkaraoğlu, S. Effects of melatonin and curcumin treatments on the ovarium in kidney ischemia-reperfusion injury: A histopathological investigation. Gevher Nesibe J Med Health Sci. 2022;615, 45–51.
  • Ali BH, Abdelrahman A, Al Suleimani Y, et al. Effect of concomitant treatment of curcumin and melatonin on cisplatin-induced nephrotoxicity in rats. Biomedicine & Pharmacotherapy, 2020;131:110761.
  • Mercantepe F, Mercantepe T, Topcu A, Yılmaz A, Tumkaya L. Protective effects of amifostine, curcumin, and melatonin against cisplatin-induced acute kidney injury. Naunyn Schmiedebergs Naunyn-Schmiedeberg's Arch Pharmacol. 2018;3919:915-931.
  • Eybl V, Kotyzová D, Cerná P, Koutensky J. Effect of melatonin, curcumin, quercetin, and resveratrol on acute ferric nitrilotriacetate Fe-NTA-induced renal oxidative damage in rats. Human Experime Toxicol. 2008;274:347-353.
  • Muratoğlu S, Akarca Dizakar OS, Keskin Aktan A, Ömeroğlu S, Akbulut KG. The protective role of melatonin and curcumin in the testis of young and aged rats. Andrologia. 2019;513:e13203.
  • Cesur MG, Gülle K, Şirin FB, et al. Effects of curcumin and melatonin on bone formation in orthopedically expanded suture in rats: A biochemical, histological and immunohistochemical study. Orthodontics & Craniofacial Research. 2018 Jun 21.
  • Dkhar P, Sharma R. Attenuation of age-related increase of protein carbonylation in the liver of mice by melatonin and curcumin. Mol Cell Biochem. 2013;3801-2:153-160.
  • Moussavian MR, Scheuer C, Schmidt M, et al. Multidrug donor preconditioning prevents cold liver preservation and reperfusion injury. Langenbeck's Arch Surg. 2011;3962:231-241.
  • Ganguly K, Kundu P, Banerjee A, Reiter RJ, Swarnakar S. Hydrogen peroxide-mediated downregulation of matrix metalloprotease-2 in indomethacin-induced acute gastric ulceration is blocked by melatonin and other antioxidants. Free Radical Biol Med. 2006;416:911-925.
  • Raza H, John A, Brown EM, Benedict S, Kambal A. Alterations in mitochondrial respiratory functions, redox metabolism and apoptosis by oxidant 4-hydroxynonenal and antioxidants curcumin and melatonin in PC12 cells. Toxicol Applied Pharmacol. 2008;2262:161-168.
  • Shrestha S, Zhu J, Wang Q, et al. Melatonin potentiates the antitumor effect of curcumin by inhibiting IKKβ/NF-κB/COX-2 signaling pathway. Int J Oncol. 2017;514:1249-1260.
  • Rodriguez-Garcia A, Hevia D, Mayo JC, et al, Sainz RM. Thioredoxin 1 modulates apoptosis induced by bioactive compounds in prostate cancer cells. Redox Biol. 2017;12:634-664.

Does melatonin as an antioxidant and anticancer agent potentiate the efficacy of curcumin?

Yıl 2023, Cilt: 6 Sayı: 4, 852 - 859, 30.07.2023

Sude Topkaraoğlu Alpaslan Tanoğlu

https://doi.org/10.32322/jhsm.1325357

Öz

Melatonin is a hormone that exhibits many bioactivities such as antioxidant, anti-inflammatory, anti-carcinogenic, anti-diabetic, neuroprotective, and anti-aging activity. In addition, melatonin has been used to strengthen the effect of drugs or agents used for treatment in many different disease models such as cancer, tumor, bacterial infection, autoimmune diseases, and gastrointestinal diseases. According to recent studies, curcumin is used as a pigment and powerful antioxidant and anti-inflammatory agent with therapeutic potential against various cancers. Melatonin and curcumin have been used in different models of disease or injury: such as Alzheimer's disease treatment, testicular tissue preservation, bladder cancer treatment, gastric mucosal damage, and prevention of nephrotoxicity. This review covers published literature studies on the effects of comparison or combined use of melatonin and curcumin as anticancer and antioxidant agents and it reveals whether melatonin potentiates the effect of curcumin when used together.

Anahtar Kelimeler

Melatonin curcumin antioxidant anticancer apoptosis

Kaynakça

  • Bhattacharya S, Patel KK, Dehari D, Agrawal AK, Singh S. Melatonin and its ubiquitous anticancer effects. Mol Cell Biochem. 2019;462(1-2):133-155.
  • Meng X, Li Y, Li S, et al. Dietary sources and bioactivities of melatonin. Nutrients. 2017;9:367.
  • Tan DX, Manchester LC, Hardeland R, Lopez-Burillo S, Mayo JC, Sainz RM. Melatonin: a hormone, a tissue factor, an autocoid, a paracoid, and an antioxi- dant vitamin. J Pineal Res. 2003;34:75-78.
  • Reiter RJ, Tan D, Sainz RM, Mayo JC, Lopez-Burillo S. Melatonin: reducing the toxicity and increasing the efficacy of drugs. Pharm Pharmacol. 2002;5410:1299-1321.
  • Qi W, Reiter RJ, Tan DX, Manchester LC, Kim SJ, Garcia JJ. Inhibitory effects of melatonin on ferric nitrilotriacetate-induced lipid peroxidation and oxidative DNA damage in the rat kidney. Toxicology. 1999;139:81-91.
  • Liu L, Chen H, Jin J, et al. Melatonin ameliorates cerebral ischemia/reperfusion injury through SIRT3 activation. Life Sci. 2019;239:117036.
  • Stacchiotti A, Favero G. Giugno L, et al. Mitochondrial and metabolic dysfunction in renal convoluted tubules of obese mice: protective role of melatonin. Plos One. 2014;910:111-141.
  • Tanoğlu EG, Tanoğlu A, Meriçöz Aydin MÇ, Esen MF. Melatonin has favorable preventive effects on experimental chronic pancreatitis rat model. Turk J Med Sci. 2021;51:2734-2740.
  • Özçelik F, Hacimustafaoğlu F, Tanoğlu A. Modulatory effect of resveratrol and melatonin on natural killer cell activity and adrenomedullin in diabetic rats. Turk J Med Sci. 2022;521:258-267.
  • Sapmaz T, Sevgin K, Topkaraoglu S, et al. Comparison of melatonin, oxytetracycline, and N-acetylcysteine pre-treatments in autologous intraperitoneal ovarian transplantation in rats. Biochem Biophysic Res Comm. 2022;606:49-54.
  • Li Y, Li S, Zhou Y, et al. Melatonin for the prevention and treatment of cancer. Oncotarget. 2017;824:39896-39921.
  • Sadeghi M, Dehnavi S, Asadirad A, et al. Curcumin and chemokines: mechanism of action and therapeutic potential in inflammatory diseases. Inflammopharmacol. 2023:1-25
  • Xu XY, Meng X, Li S, Gan RY, Li Y, Li HB. Bioactivity, health benefits, and related molecular mechanisms of curcumin: current progress, challenges, and perspectives. Nutrients. 2018;1010:15-53.
  • Trujillo J, Chirino YI, Molina-Jijón E, Andérica-Romero AC, Tapia E, Pedraza-Chaverrí J. Renoprotective effect of the antioxidant curcumin: Recent findings. Redox Biol. 2013;11:448-456.
  • Shoba G, Joy D. Joseph T, Majeed M, Rajendran R, Srinivas PS. Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers. Planta Medica. 1998;644:353–356.
  • Prodhan AHMSU, Cavestro C, Kamal MA, Islam MA. Melatonin and sleep disturbances in Alzheimer's disease. CNS & Neurological Disorders - Drug Targets. 2021;208:736-754.
  • Li Y, Zhang J, Wan J, Liu A, Sun J. Melatonin regulates Aβ production/clearance balance and Aβ neurotoxicity: A potential therapeutic molecule for Alzheimer's disease. Biomed Pharmacother. 2020;132:110887.
  • Gerenu G, Liu K, Chojnacki JE, et al. Curcumin/melatonin hybrid 5-4-hydroxy-phenyl-3-oxo-pentanoic acid 2-5-methoxy-1H-indol-3-yl-ethyl-amide ameliorates AD-like pathology in the APP/PS1 mouse model. ACS Chemical Neuroscience. 2015;68:1393-1399.
  • Chojnacki JE, Liu K, Yan X, et al. Discovery of 5-4-hydroxyphenyl-3-oxo-pentanoic acid 2-5-methoxy-1H-indol-3-yl-ethyl-amide as a neuroprotectant for Alzheimer's disease by hybridization of curcumin and melatonin. ACS Chemical Neuroscience. 2014;58:690-699.
  • Khondker A, Alsop RJ, Himbert S, et al. Membrane-modulating drugs can affect the size of amyloid-β25-35 aggregates in anionic membranes. Scientific Reports. 2018;81:123-167.
  • Espargaró A, Ginex T, Vadell MD, et al. Combined in vitro cell-based/in silico screening of naturally occurring flavonoids and phenolic compounds as potential anti-Alzheimer drugs. J Natural Products. 2017;802:278-289.
  • Khyati, Malik I, Agrawal N, Kumar V. Melatonin and curcumin reestablish disturbed circadian gene expressions and restore locomotion ability and eclosion behavior in Drosophila model of Huntington's disease. Chronobiol Int. 2021;381:61-78.
  • Da Silva Morrone M, Schnorr CE, Behr GA, et al. Oral administration of curcumin relieves behavioral alterations and oxidative stress in the frontal cortex, hippocampus, and striatum of ovariectomized Wistar rats. J Nutr Biochem. 2016;32:181–188.
  • Madhu LN, Kodali M, Attaluri S, et al. Melatonin improves brain function in a model of chronic Gulf War Illness with modulation of oxidative stress, NLRP3 inflammasomes, and BDNF-ERK-CREB pathway in the hippocampus. Redox Biol. 2021;43:101973.
  • Keskin-Aktan A, Akbulut KG, Yazici-Mutlu Ç, Sonugur G, Ocal M, Akbulut H. The effects of melatonin and curcumin on the expression of SIRT2, Bcl-2 and Bax in the hippocampus of adult rats. Brain Res Bull. 2018;137:306-310.
  • Moharrami Kasmaie F, Jahromi Z, Gazor R, Zaminy A. Comparison of melatonin and curcumin effect at the light and dark periods on regeneration of sciatic nerve crush injury in rats. EXCLI J. 2019;18:653-665.
  • Antonio AM, Druse MJ. Antioxidants prevent ethanol-associated apoptosis in fetal rhombencephalic neurons. Brain Res. 2008;1204:16-23.
  • Borre YE, Panagaki T, Koelink PJ, et al. Neuroprotective and cognitive enhancing effects of a multi-targeted food intervention in an animal model of neurodegeneration and depression. Neuropharmacology. 2014;79:738-749.
  • Köse Vuruşkan, A., Elagül, N., Sapmaz, T., Topkaraoğlu, S. Effects of melatonin and curcumin treatments on the ovarium in kidney ischemia-reperfusion injury: A histopathological investigation. Gevher Nesibe J Med Health Sci. 2022;615, 45–51.
  • Ali BH, Abdelrahman A, Al Suleimani Y, et al. Effect of concomitant treatment of curcumin and melatonin on cisplatin-induced nephrotoxicity in rats. Biomedicine & Pharmacotherapy, 2020;131:110761.
  • Mercantepe F, Mercantepe T, Topcu A, Yılmaz A, Tumkaya L. Protective effects of amifostine, curcumin, and melatonin against cisplatin-induced acute kidney injury. Naunyn Schmiedebergs Naunyn-Schmiedeberg's Arch Pharmacol. 2018;3919:915-931.
  • Eybl V, Kotyzová D, Cerná P, Koutensky J. Effect of melatonin, curcumin, quercetin, and resveratrol on acute ferric nitrilotriacetate Fe-NTA-induced renal oxidative damage in rats. Human Experime Toxicol. 2008;274:347-353.
  • Muratoğlu S, Akarca Dizakar OS, Keskin Aktan A, Ömeroğlu S, Akbulut KG. The protective role of melatonin and curcumin in the testis of young and aged rats. Andrologia. 2019;513:e13203.
  • Cesur MG, Gülle K, Şirin FB, et al. Effects of curcumin and melatonin on bone formation in orthopedically expanded suture in rats: A biochemical, histological and immunohistochemical study. Orthodontics & Craniofacial Research. 2018 Jun 21.
  • Dkhar P, Sharma R. Attenuation of age-related increase of protein carbonylation in the liver of mice by melatonin and curcumin. Mol Cell Biochem. 2013;3801-2:153-160.
  • Moussavian MR, Scheuer C, Schmidt M, et al. Multidrug donor preconditioning prevents cold liver preservation and reperfusion injury. Langenbeck's Arch Surg. 2011;3962:231-241.
  • Ganguly K, Kundu P, Banerjee A, Reiter RJ, Swarnakar S. Hydrogen peroxide-mediated downregulation of matrix metalloprotease-2 in indomethacin-induced acute gastric ulceration is blocked by melatonin and other antioxidants. Free Radical Biol Med. 2006;416:911-925.
  • Raza H, John A, Brown EM, Benedict S, Kambal A. Alterations in mitochondrial respiratory functions, redox metabolism and apoptosis by oxidant 4-hydroxynonenal and antioxidants curcumin and melatonin in PC12 cells. Toxicol Applied Pharmacol. 2008;2262:161-168.
  • Shrestha S, Zhu J, Wang Q, et al. Melatonin potentiates the antitumor effect of curcumin by inhibiting IKKβ/NF-κB/COX-2 signaling pathway. Int J Oncol. 2017;514:1249-1260.
  • Rodriguez-Garcia A, Hevia D, Mayo JC, et al, Sainz RM. Thioredoxin 1 modulates apoptosis induced by bioactive compounds in prostate cancer cells. Redox Biol. 2017;12:634-664.
Toplam 40 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Geleneksel, Tamamlayıcı ve Bütünleştirici Tıp (Diğer)
Bölüm Derleme
Yazarlar

Sude Topkaraoğlu 0000-0002-7680-7156

Alpaslan Tanoğlu 0000-0002-7477-6640

Erken Görünüm Tarihi 28 Temmuz 2023
Yayımlanma Tarihi 30 Temmuz 2023
Yayımlandığı Sayı Yıl 2023 Cilt: 6 Sayı: 4

Kaynak Göster

AMA Topkaraoğlu S, Tanoğlu A. Does melatonin as an antioxidant and anticancer agent potentiate the efficacy of curcumin?. J Health Sci Med /JHSM /jhsm. Temmuz 2023;6(4):852-859. doi:10.32322/jhsm.1325357
 Kapak Resmi İndir

Üniversitelerarası Kurul (ÜAK) Eşdeğerliği:  Ulakbim TR Dizin'de olan dergilerde yayımlanan makale [10 PUAN] ve 1a, b, c hariç  uluslararası indekslerde (1d) olan dergilerde yayımlanan makale [5 PUAN]

Dahil olduğumuz İndeksler (Dizinler) ve Platformlar sayfanın en altındadır.

Not: Dergimiz WOS indeksli değildir ve bu nedenle Q olarak sınıflandırılmamıştır.

Yüksek Öğretim Kurumu (YÖK) kriterlerine göre yağmacı/şüpheli dergiler hakkındaki kararları ile yazar aydınlatma metni ve dergi ücretlendirme politikasını tarayıcınızdan indirebilirsiniz. https://dergipark.org.tr/tr/journal/2316/file/4905/show 


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