Araştırma Makalesi
BibTex RIS Kaynak Göster

NSTEMI'da Erken Evrede HALP Skorunun Öngörü Değeri

Yıl 2024, Cilt: 7 Sayı: 1, 12 - 16, 11.03.2024
https://doi.org/10.36516/jocass.1396148

Öz

Giriş: Pek çok inflamatuar belirteç, koroner arter hastalığının ciddiyetiyle ve kötü kardiyovasküler sonuçlarla ilişkilidir. Hemoglobin, albumin, lenfosit ve platelet (HALP) skoru inflamasyon ve beslenme durumunun bir göstergesidir. Bu çalışmada ST elevasyonu olmayan miyokard enfarktüslü (NSTEMI) hastalarda HALP skorunun uygulanabilirliğini değerlendirmeyi amaçladık.
Gereç ve Yöntemler: Bu çalışma retrospektif kohort çalışması olarak tasarlandı. Akut koroner sendrom tanısı alan 18 yaş üstü hastalar hastane kayıtlarından geriye dönük olarak tarandı. Çalışma grupları koroner anjiyografi sonuçlarına göre oluşturuldu. Hastaların yaş, cinsiyet gibi demografik verileri, tam kan sayımı, albümin düzeyleri, troponin düzeyleri ve HALP skorları incelenerek gruplar arası karşılaştırmalar yapıldı.
Bulgular: Çalışmaya 201 hasta dahil edilmiş olup veriler hastane kayıtlarından retrospektif olarak elde edilmiştir. ST elevasyonlu miyokard enfarktüsü (STEMI) nedeniyle 79 hasta çalışma dışı bırakıldı. Araştırmanın evreni iki grup altında toplanmıştır; NSTEMI grubu (n=66) ve normal koroner arter (NKA) grubu (n=56). NSTEMI grubunun yaş ortalaması 62,3 ± 11,8 olup %71,2'si (n=47) erkekti. NKA grubunun yaş ortalaması 51,8 ± 9,2 olup %30,3'ü (n=17) erkekti. NSTEMI ve NKA grupları arasında yaş ve cinsiyet açısından istatistiksel olarak anlamlı fark saptandı (p<0,05). HALP skoru NSTEMI grubunda NKA grubuna göre istatistiksel olarak daha yüksek saptandı (p<0,001). Yaş ve HALP skoru NSTEMI hastaları üzerinde açıklayıcı güce sahip olarak saptandı (sırasıyla p=0,001 ve p=0,022).
Sonuç: HALP skoru klinik uygulamada kolay uygulanabilir ve ucuz bir yöntem olarak NSTEMI hastalarının erken tanısına katkı sağlayabilecek bir yöntem olarak kullanılabilir.

Kaynakça

  • 1.Blais C, Rochette L, Ouellet S, et al. Complex evolution of epidemiology of vascular diseases, including increased disease burden: from 2000 to 2015. Can J Cardiol. 2020;36(5):740-6. https://doi.org/10.1016/j.cjca.2019.10.021
  • 2.Reigle J. Coronary circulation disorders. In: Sorenson M, Quinn L, Klein D, editors. Pathophysiology: concepts of human disease. Hoboken (NJ): Pear-son; 2019. p. 572–611.
  • 3.D’Ascenzo F, Biondi-Zoccai G, Moretti C, et al. TIMI, GRACE and alterna-tive risk scores in acute coronary syndromes: a metaanalysis of 40 deri-vation studies on 216,552 patients and of 42 validation studies on 31,625 patients. Contemp Clin Trials. 2012;33:507-14. https://doi.org/10.1016/j.cct.2012.01.001
  • 4.Zhang DP, Mao XF, Wu TT, et al. The fibrinogen-to-albumin ratio is asso-ciated with outcomes in patients with coronary artery disease who un-derwent percutaneous coronary intervention. Clin Appl Thromb Hemost. 2020;26:1076029620933008. https://doi.org/10.1177/1076029620933008
  • 5.Zhou D, Wang G, Fan Y, et al. Platelet to lymphocyte ratio is associated with the severity of coronary artery disease and clinical outcomes of per-cutaneous coronary intervention in the Chinese Han population. Exp Ther Med 2017;13:731–8. https://doi.org/10.3892/etm.2016.3993
  • 6.Cagdas M, Rencuzoğullari I, Karakoyun S, et al. Assessment of relation-ship between C-reactive protein to albumin ratio and coronary artery disease severity in patients with acute coronary syndrome. Angiology 2017;70:361–8. https://doi.org/10.1177/0003319717743325
  • 7.Teng TH, Finn J, Hung J. Mild anaemia is associated with increased all-cause mortality in heart failure. Heart Lung Circ 2010;19: 31−7. https://doi.org/10.1016/j.hlc.2009.08.004
  • 8.Reininger AJ, Bernlochner I, Penz SM, et al. A 2-step mechanism of arteri-al thrombus formation induced by human atherosclerotic plaques. J Am Coll Cardiol 2010;55(11): 1147-58. https://doi.org/10.1016/j.jacc.2009.11.051
  • 9.Karakayali M, Omar T, Artac I, et al. The White Blood Cell Count to Mean Platelet Volume Ratio (WMR) is Associated With Syntax Score in Patients With ST-Segment Elevation Myocardial Infarction. Kafkas J Med Sci 2023; 13(2):173–8. https://doi.org/10.5505/kjms.2023.98512
  • 10.Xu SS, Li S, Xu HX, et al. Haemoglobin, albumin, lymphocyte and platelet predicts postoperative survival in pancreatic cancer. World J Gastroen-terol. 2020;26:828–38. https://doi.org/10.3748/wjg.v26.i8.828
  • 11.Guo Y, Shi D, Zhang J, et al. The hemoglobin, albumin, lymphocyte, and platelet (HALP) score is a novel significant prognostic factor for patients with metastatic prostate cancer undergoing cytoreductive radical prosta-tectomy. J Cancer. 2019;10:81– 91. https://doi.org/10.7150/jca.27210
  • 12.Kocaoğlu S, Alatlı T. The Efficiency of the HALP Score and the Modified HALP Score in Predicting Mortality in Patients with Acute Heart Failure Presenting to the Emergency Department. Journal of the College of Physi-cians and Surgeons Pakistan 2022, Vol. 32(06): 706-11.
  • 13.Tian M, Li Y, Wang X, et al. The hemoglobin, albumin, lymphocyte, and platelet (HALP) score is associated with poor outcome of acute ischemic stroke. Front Neurol 2021;11:610318. https://doi.org/10.3389/fneur. 2020.610318
  • 14.Karakayalı M, Omar T, Artac I, et al. The prognostic value of HALP score in predicting in-hospital mortality in patients with ST-elevation myocar-dial infarction undergoing primary percutaneous coronary intervention. Coron Artery Dis. 2023:1;34(7):483-8. https://doi.org/10.1097/MCA.0000000000001271
  • 15.Chen XL, Xue L, Wang W, et al. Prognostic significance of the combina-tion of preoperative hemoglobin, albumin, lymphocyte and platelet in patients with gastric carcinoma: A retrospective cohort study. Oncotarget 2015;6(38):41370-382. https://doi.org/10.18632/oncotarget.5629
  • 16.Cay F, Duran A. Predictive factors of success in sleeve gastrectomy: One-year follow-up and the significance of HALP score. J Coll Physicians Surg Pak 2021;31(12):1406-11. https://doi.org/10.29271/jcpsp.2021.12.1406
  • 17.Pang WW, Schrier SL. Anemia in the elderly. Curr Opin Hematol 2012;19: 133−40.
  • 18.Arques S. Human serum albumin in cardiovascular diseases. Eur J In-tern Med. 2018;52:8-12.
  • 19.Ommen SR, Gibbons RJ, Hodge DO, et al. Usefulness of the lymphocyte concentration as a prognostic marker in coronary artery disease. Am J Cardiol 1997;79(6):812-4. https://doi.org/10.1016/s0002-9149(96)00878-8
  • 20.Kurtul A, Ornek E. Platelet to lymphocyte ratio in cardiovascular dis-eases: a systematic review. Angiology. 2019;70(9):802-18.
  • 21.Shen Y, Huang X, Zhang W. Platelet-to-lymphocyte ratio as a prognostic predictor of mortality for sepsis: interaction effect with disease severity-a retrospective study. BMJ Open. 2019;9(1):e022896.
  • 22.Vanderschueren S, De Weerdt A, Malbrain M, et al. Thrombocytopenia and prognosis in intensive care. Crit Care Med 2000;28(6):1871-6. https://doi.org/10.1097/0000 3246-200006000-00031
  • 23.Yadav M, Généreux P, Giustino G, et al. Efect of baseline thrombocyto-penia on ischemic outcomes in patients with acute coronary syndromes who undergo percutaneous coronary intervention. Can J Cardiol 2016;32:226–33.
  • 24.Peng D, Zhang CJ, Tang Q, et al. Prognostic significance of the combina-tion of preoperative hemoglobin and albumin levels and lymphocyte and platelet counts (HALP) in patients with renal cell carcinoma after nephrec-tomy. BMC Urol. 2018;18:20. https://doi.org/10.1186/s12894-018-0333-8
  • 25.Shen XB, Zhang YX, Wang W, et al. The hemoglobin, albumin, lympho-cyte, and platelet (HALP) score in patients with small cell lung cancer be-fore first-line treatment with etoposide and progression-free survival. Med Sci Monit. 2019;25:5630–9. https://doi.org/10.12659/MSM.917968
  • 26.Kocaoğlu S, Alatlı T. The efficiency of HALP score, neutrophil-lymphocyte ratio, and platelet-lymphocyte ratio in predicting mortality in intensive care patients. J Health Sci Med 2022;5(1): 201-6.

Predictive Value of HALP Score in The Early Stage of NSTEMI

Yıl 2024, Cilt: 7 Sayı: 1, 12 - 16, 11.03.2024
https://doi.org/10.36516/jocass.1396148

Öz

Introduction: Several inflammatory markers are associated with coronary artery disease severity and worse cardiovascular outcomes. The haemoglobin, albumin, lymphocyte, and platelet (HALP) score is an indicator of inflammation and nutritional status. We aimed to evaluate the practicity of HALP score in non-ST elevation myocardial infarction (NSTEMI) patients.
Materials and Methods: This study was designed as a retrospective cohort study. Patients over the age of 18 who have been diagnosed with acute coronary syndrome were retrospectively searched from hospital records. The study groups were formed according to the results of the coronary angiography. Demographic data such as age, gender, total blood count, albümin levels, troponin levels and HALP scores of the patients were analyzed and comparisons between the groups were made decisively.
Results: 201 patients were enrolled in the study and the data was obtained from hospital records retrospectively. 79 patients were excluded from the study due to ST segment elevation myocardial infarction (STEMI). The study population was collected under two groups; the NSTEMI group (n=66) and normal coronary arteries (NCA) group (n=56). The mean age of NSTEMI group was 62.3 ± 11.8 and 71.2% (n=47) was male. The mean age of NCA group was 51.8 ± 9.2 and 30.3% (n=17) was male. There were statistically significant difference between NSTEMI and NCA groups in term of age and gender (p<0.05). The HALP score was statistically higher in NSTEMI group compared to NCA group (p<0.001). Age and HALP score have explanatory powers on NSTEMI patients (p=0.001 and p=0.022, in order of).
Conclusion: HALP score may be used as an easily applicable and inexpensive method in clinical practice that can contribute to the early diagnosis of NSTEMI patients.

Kaynakça

  • 1.Blais C, Rochette L, Ouellet S, et al. Complex evolution of epidemiology of vascular diseases, including increased disease burden: from 2000 to 2015. Can J Cardiol. 2020;36(5):740-6. https://doi.org/10.1016/j.cjca.2019.10.021
  • 2.Reigle J. Coronary circulation disorders. In: Sorenson M, Quinn L, Klein D, editors. Pathophysiology: concepts of human disease. Hoboken (NJ): Pear-son; 2019. p. 572–611.
  • 3.D’Ascenzo F, Biondi-Zoccai G, Moretti C, et al. TIMI, GRACE and alterna-tive risk scores in acute coronary syndromes: a metaanalysis of 40 deri-vation studies on 216,552 patients and of 42 validation studies on 31,625 patients. Contemp Clin Trials. 2012;33:507-14. https://doi.org/10.1016/j.cct.2012.01.001
  • 4.Zhang DP, Mao XF, Wu TT, et al. The fibrinogen-to-albumin ratio is asso-ciated with outcomes in patients with coronary artery disease who un-derwent percutaneous coronary intervention. Clin Appl Thromb Hemost. 2020;26:1076029620933008. https://doi.org/10.1177/1076029620933008
  • 5.Zhou D, Wang G, Fan Y, et al. Platelet to lymphocyte ratio is associated with the severity of coronary artery disease and clinical outcomes of per-cutaneous coronary intervention in the Chinese Han population. Exp Ther Med 2017;13:731–8. https://doi.org/10.3892/etm.2016.3993
  • 6.Cagdas M, Rencuzoğullari I, Karakoyun S, et al. Assessment of relation-ship between C-reactive protein to albumin ratio and coronary artery disease severity in patients with acute coronary syndrome. Angiology 2017;70:361–8. https://doi.org/10.1177/0003319717743325
  • 7.Teng TH, Finn J, Hung J. Mild anaemia is associated with increased all-cause mortality in heart failure. Heart Lung Circ 2010;19: 31−7. https://doi.org/10.1016/j.hlc.2009.08.004
  • 8.Reininger AJ, Bernlochner I, Penz SM, et al. A 2-step mechanism of arteri-al thrombus formation induced by human atherosclerotic plaques. J Am Coll Cardiol 2010;55(11): 1147-58. https://doi.org/10.1016/j.jacc.2009.11.051
  • 9.Karakayali M, Omar T, Artac I, et al. The White Blood Cell Count to Mean Platelet Volume Ratio (WMR) is Associated With Syntax Score in Patients With ST-Segment Elevation Myocardial Infarction. Kafkas J Med Sci 2023; 13(2):173–8. https://doi.org/10.5505/kjms.2023.98512
  • 10.Xu SS, Li S, Xu HX, et al. Haemoglobin, albumin, lymphocyte and platelet predicts postoperative survival in pancreatic cancer. World J Gastroen-terol. 2020;26:828–38. https://doi.org/10.3748/wjg.v26.i8.828
  • 11.Guo Y, Shi D, Zhang J, et al. The hemoglobin, albumin, lymphocyte, and platelet (HALP) score is a novel significant prognostic factor for patients with metastatic prostate cancer undergoing cytoreductive radical prosta-tectomy. J Cancer. 2019;10:81– 91. https://doi.org/10.7150/jca.27210
  • 12.Kocaoğlu S, Alatlı T. The Efficiency of the HALP Score and the Modified HALP Score in Predicting Mortality in Patients with Acute Heart Failure Presenting to the Emergency Department. Journal of the College of Physi-cians and Surgeons Pakistan 2022, Vol. 32(06): 706-11.
  • 13.Tian M, Li Y, Wang X, et al. The hemoglobin, albumin, lymphocyte, and platelet (HALP) score is associated with poor outcome of acute ischemic stroke. Front Neurol 2021;11:610318. https://doi.org/10.3389/fneur. 2020.610318
  • 14.Karakayalı M, Omar T, Artac I, et al. The prognostic value of HALP score in predicting in-hospital mortality in patients with ST-elevation myocar-dial infarction undergoing primary percutaneous coronary intervention. Coron Artery Dis. 2023:1;34(7):483-8. https://doi.org/10.1097/MCA.0000000000001271
  • 15.Chen XL, Xue L, Wang W, et al. Prognostic significance of the combina-tion of preoperative hemoglobin, albumin, lymphocyte and platelet in patients with gastric carcinoma: A retrospective cohort study. Oncotarget 2015;6(38):41370-382. https://doi.org/10.18632/oncotarget.5629
  • 16.Cay F, Duran A. Predictive factors of success in sleeve gastrectomy: One-year follow-up and the significance of HALP score. J Coll Physicians Surg Pak 2021;31(12):1406-11. https://doi.org/10.29271/jcpsp.2021.12.1406
  • 17.Pang WW, Schrier SL. Anemia in the elderly. Curr Opin Hematol 2012;19: 133−40.
  • 18.Arques S. Human serum albumin in cardiovascular diseases. Eur J In-tern Med. 2018;52:8-12.
  • 19.Ommen SR, Gibbons RJ, Hodge DO, et al. Usefulness of the lymphocyte concentration as a prognostic marker in coronary artery disease. Am J Cardiol 1997;79(6):812-4. https://doi.org/10.1016/s0002-9149(96)00878-8
  • 20.Kurtul A, Ornek E. Platelet to lymphocyte ratio in cardiovascular dis-eases: a systematic review. Angiology. 2019;70(9):802-18.
  • 21.Shen Y, Huang X, Zhang W. Platelet-to-lymphocyte ratio as a prognostic predictor of mortality for sepsis: interaction effect with disease severity-a retrospective study. BMJ Open. 2019;9(1):e022896.
  • 22.Vanderschueren S, De Weerdt A, Malbrain M, et al. Thrombocytopenia and prognosis in intensive care. Crit Care Med 2000;28(6):1871-6. https://doi.org/10.1097/0000 3246-200006000-00031
  • 23.Yadav M, Généreux P, Giustino G, et al. Efect of baseline thrombocyto-penia on ischemic outcomes in patients with acute coronary syndromes who undergo percutaneous coronary intervention. Can J Cardiol 2016;32:226–33.
  • 24.Peng D, Zhang CJ, Tang Q, et al. Prognostic significance of the combina-tion of preoperative hemoglobin and albumin levels and lymphocyte and platelet counts (HALP) in patients with renal cell carcinoma after nephrec-tomy. BMC Urol. 2018;18:20. https://doi.org/10.1186/s12894-018-0333-8
  • 25.Shen XB, Zhang YX, Wang W, et al. The hemoglobin, albumin, lympho-cyte, and platelet (HALP) score in patients with small cell lung cancer be-fore first-line treatment with etoposide and progression-free survival. Med Sci Monit. 2019;25:5630–9. https://doi.org/10.12659/MSM.917968
  • 26.Kocaoğlu S, Alatlı T. The efficiency of HALP score, neutrophil-lymphocyte ratio, and platelet-lymphocyte ratio in predicting mortality in intensive care patients. J Health Sci Med 2022;5(1): 201-6.
Toplam 26 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Kardiyoloji , Acil Tıp
Bölüm Makaleler
Yazarlar

Göknur Yıldız 0000-0002-2097-2531

Fatih Alper Ayyıldız 0000-0002-2502-1030

Özge Turgay Yıldırım 0000-0002-6731-4958

Yayımlanma Tarihi 11 Mart 2024
Gönderilme Tarihi 26 Kasım 2023
Kabul Tarihi 18 Ocak 2024
Yayımlandığı Sayı Yıl 2024 Cilt: 7 Sayı: 1

Kaynak Göster

APA Yıldız, G., Ayyıldız, F. A., & Turgay Yıldırım, Ö. (2024). Predictive Value of HALP Score in The Early Stage of NSTEMI. Journal of Cukurova Anesthesia and Surgical Sciences, 7(1), 12-16. https://doi.org/10.36516/jocass.1396148
https://dergipark.org.tr/tr/download/journal-file/11303