Araştırma Makalesi
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Suriyeli mülteciler arasında Hepatit B, Hepatit C ve HIV seroprevalansı: Türkiye'deki bir üçüncü basamak merkezinden kesitsel bir çalışma

Yıl 2019, Cilt: 3 Sayı: 12, 845 - 847, 03.12.2019

Ayhanım Tümtürk Bayram Yeşil

https://doi.org/10.28982/josam.650891
Cited By: 1

Öz

Amaç: Hepatit B (HBV), Hepatit C (HCV) ve İnsan İmmün Yetmezlik Virüsü (HIV) tüm dünyada ciddi sağlık sorunlarına neden olmaktadır. Suriye'deki son çatışmalar ve savaş nedeniyle, birçok göçmen kontrollü ve / veya kontrolsüz bir şekilde Türkiye'ye girmiştir. Bu çalışmada hastanemize başvuran Suriyeli göçmenlerde HBV, HCV ve HIV seroprevalansının belirlenmesi amaçlandı.

Yöntemler: Bu kesitsel çalışma 01.01.2015 - 14.05.2018 tarihleri arasında Ankara Yüksek İhtisas Eğitim ve Araştırma Hastanesi'nde yapıldı. Hastalardan alınan serum örnekleri ELISA (Enzim-Bağımlı İmmunosorbent Testi) yöntemiyle çalışılarak, HBV yüzey antijeni (HBsAg), anti-HBs, HCV antikoru (anti-HCV) ve anti-HIV titreleri araştırıldı.

Bulgular: Çalışmaya alınan 244 hastanın 154'u erkek (%63,11), 90'ı kadındı (%36,89). HBV seroprevalansı erkekler ve kadınlar arasında anlamlı farklılık göstermedi ve sırasıyla %5,84 ve %5,55 olarak bulundu (P>0,05). Anti-HCV pozitif bulunan hasta sayısı 6 (%2,46) 6 idi. HCV seroprevalansı erkeklerde %1,29, kadınlarda %4,44 olarak bulundu. Bu 244 hastanın hiçbirinde anti-HIV pozitifliği tespit edilmedi.

Sonuç: Çalışmamızda Suriyeli göçmenlerde HBV ve Anti-HIV seroprevalansının lokal verilere benzer olduğunu, ancak anti-HCV pozitifliğinin lokal verilere göre daha yüksek olduğu gözlenmiştir. Yaşa bağlı insidans oranları da farklı bulundu. Bu verilerin bilinmesinin, göçmenler için önleyici ve terapötik önlemlerin planlanması açısından önemli olduğuna inanıyoruz.

Anahtar Kelimeler

Hepatit B Hepatit C İnsan immün yetmezlik virüsü Suriyeli mülteciler

Kaynakça

  • 1. Castelli F, Sulis G. Migration and infectious diseases. Clin Microbiol Infect. 2017 May;23(5):283-9.
  • 2. Pottie K, Mayhew AD, Morton RL, Greenaway C, Akl EA, Rahman P, et al. Prevention and assessment of infectious diseases among children and adult migrants arriving to the European Union/European Economic Association: a protocol for a suite of systematic reviews for public health and health systems. BMJ Open. 2017 Sep 11;7(9):e014608.
  • 3. McCarthy AE, Weld LH, Barnett ED, So H, Coyle C, Greenaway C, et al. Spectrum of illness in international migrants seen at GeoSentinel clinics in 1997-2009, part 2: migrants resettled internationally and evaluated for specific health concerns. Clin Infect Dis. 2013 Apr;56(7):925-33.
  • 4. Sharma S, Carballo M, Feld JJ, Janssen HL. Immigration and viral hepatitis. J Hepatol. 2015 Aug;63(2):515-22.
  • 5. Yacoub R, Al Ali R, Moukeh G, Lahdo A, Mouhammad Y, Nasser M. Hepatitis B vaccination status and needlestick injuries among healthcare workers in syria. J Glob Infect Dis. 2010 Jan;2(1):28-34.
  • 6. Bashour H, Muhjazi G. Hepatitis B and C in the Syrian Arab Republic: a review. East Mediterr Health J. 2016 Jul 10;22(4):267-73.
  • 7. WHO, Syrian Arab Republic: Annual Report 2017. 2017.
  • 8. Chemaitelly H, Chaabna K, Abu-Raddad LJ. The Epidemiology of Hepatitis C Virus in the Fertile Crescent: Systematic Review and Meta-Analysis. PLoS One. 2015 Aug 21;10(8):e0135281.
  • 9. Yazaji W, Habbal W, Monem F. Seropositivity of Hepatitis B and C among Syrian Multi-transfused Patients with Hemoglobinopathy. Mediterr J Hematol Infect Dis. 2016 Sep 1;8(1):e2016046.
  • 10. Muselmani W, Habbal W, Monem F. Prevalence of "anti-HBc alone" among Syrian blood donors. J Infect Dev Ctries. 2014 Aug 13;8(8):1013-5.
  • 11. Antaki N, Haffar S, Ali Deeb S, Assaad F, Abou Harb R, Zeibane N, et al. High prevalence of HBV genotype D in Syria and the clinical characteristics of hepatitis B e antigen-negative chronic hepatitis B. Epidemiol Infect. 2010 Jan;138(1):40-4.
  • 12. Toy M, Önder FO, Wörmann T, Bozdayi AM, Schalm SW, Borsboom GJ, et al. Age- and region-specific hepatitis B prevalence in Turkey estimated using generalized linear mixed models: a systematic review. BMC Infect Dis. 2011;11:337.
  • 13. Tozun N, Ozdogan O, Cakaloglu Y, Idilman R, Karasu Z, Akarca U, et al. Seroprevalence of hepatitis B and C virus infections and risk factors in Turkey: a fieldwork TURHEP study. Clin Microbiol Infect. 2015;21:1020-6.
  • 14. Syrian Arab Republic - Global AIDS Response Progress Report 2012. Overview of the AIDS Epidemic in Syria. Country progress report Syrian Republic.
  • 15. İnci A, Sarıcı İŞ, Çalışkan G, Kalaycı MU. Investigation of Frequency of HbsAg, Anti Hbs, Anti HCV and Anti HIV in Refugee Patients from Syria who Admit to a Training and Research Hospital Department of Surgery. Acta Medica Mediterranea, 2017;33:59.
  • 16. Hussein NR, Abdullah IM, Younus OM, Taher AM, Salim AA, Shahab FI. Prevalence of HBV, HCV and HIV Infections Among Syrian Refugees in Kurdistan Region, Iraq. Int J Infect. 2017 April;4(2):e39420.
  • 17. Köse Ş, Ödemis İ, Çelik D, Tatar BG, Akbulut İ, Çiftdoğan DY. Hepatitis A, B, C and HIV seroprevalence among Syrian refugee children admitted to outpatient clinics. Le Infezioni in Medicina. 2017;4:339-43.
  • 18. Angeletti S, Ceccarelli G, Vita S, Dicuonzo G, Lopalco M, Dedej E, et al. Unusual microorganisms and antimicrobial resistances in a group of Syrian migrants: Sentinel surveillance data from an asylum seekers centre in Italy. Travel Med Infect Dis. 2016 Mar-Apr;14(2):115-22.
  • 19. Coppola N, Alessio L, Gualdieri L, Pisaturo M, Sagnelli C, Minichini C, et al. Hepatitis B virus infection in undocumented immigrants and refugees in Southern Italy: demographic, virological, and clinical features. Infect Dis Poverty. 2017 Feb 9;6(1):33.
  • 20. İnci A, Okay M, Güven D. HBsAg, Anti-HBs, Anti-HCV and Anti-HIV Seroprevalence of the Patients Applied to Artvin State Hospital. Viral Hepatitis Journal. 2013;19(1):41-4.
  • 21. Öner S, Yapıcı G, Şaşmaz CT, Kurt AÖ, Buğdaycı R. Hepatitis B, hepatitis C, HIV, and VDRL seroprevalence of blood donors in Mersin, Turkey. Turk J Med Sci. 2011;41(2):335-41.
  • 22. Denk A, Balin ŞÖ. Koroner Anjiyografi Yapılan Hastalarda HBsAg, Anti-HCV ve Anti-HIV Seropozitifliği. Firat Med J. 2016;21(3):125-8.
  • 23. Köse Ş, Ersan G, Liv F. Six-Year Analysis of the Seropositivity of HBV, HCV, HIV, and Syphilis in Volunteer Blood Donors Attending Our Blood Center. Viral Hepat J. 2015;21(1):28-30.
  • 24. Pehlivanoğlu F, Yaşar KK, ŞENGÖZ G. Seroprevalences of Hepatitis B and C in Patients undergoing an Operation. Viral Hepat J. 2011;17:32-6.
  • 25. Çoban M, Sertoğlu E. HBsAg, Anti-HBs, Anti-HBc Total and Anti-HCV Seroprevalence of the Patients Applied to Beytepe Military Hospital. Viral Hepat J. 2013;19(3):152-5.

Hepatitis B, Hepatitis C and HIV seroprevalence among Syrian refugees: A cross-sectional study from a tertiary referral center in Turkey

Yıl 2019, Cilt: 3 Sayı: 12, 845 - 847, 03.12.2019

Ayhanım Tümtürk Bayram Yeşil

https://doi.org/10.28982/josam.650891
Cited By: 1

Öz

Aim: Hepatitis B (HBV), Hepatitis C (HCV) and Human Immunodeficiency Virus (HIV) cause serious health problems all over the world. Due to the recent conflicts and war in Syria, many immigrants have entered Turkey in a controlled and / or uncontrolled manner. In this study, we aimed to determine HBV, HCV, and HIV seroprevalence among Syrian migrants who were referred to our hospital.

Methods: This cross-sectional study was performed between 01/01/2015 - 14/05/2018 in Ankara Yuksek Ihtisas Training and Research Hospital. Serum samples from patients were evaluated for positivity of HBV surface antigen (HBsAg), antibodies against HBV surface antigen (anti-HBs), HCV antibody (anti-HCV) and anti-HIV with the Enzyme-Linked Immunosorbent Assay (ELISA) method.

Results: Among 244 patients included in the study, 154 were male (63.11%) and 90 were female (36.89%). Seroprevalences of HBV were 5.84% and 5.55%, respectively, the difference between which was statistically insignificant (P>0.05). Anti-HCV was positive in 6 (2.46%) patients. HCV seroprevalence rates were 1.29% in men, and 4.44% in women. None of these 244 patients had anti-HIV positivity.

Conclusion: In our study, we found that the seroprevalences of HBV and Anti-HIV in Syrian migrants were similar to domestic values, but that of anti-HCV was higher. Age-related incidence rates also differed. We believe that the knowledge of these data is important in terms of planning preventive and therapeutic measures for migrants.

Anahtar Kelimeler

Hepatitis B Hepatitis C Human immunodeficiency virus Syrian refugees

Kaynakça

  • 1. Castelli F, Sulis G. Migration and infectious diseases. Clin Microbiol Infect. 2017 May;23(5):283-9.
  • 2. Pottie K, Mayhew AD, Morton RL, Greenaway C, Akl EA, Rahman P, et al. Prevention and assessment of infectious diseases among children and adult migrants arriving to the European Union/European Economic Association: a protocol for a suite of systematic reviews for public health and health systems. BMJ Open. 2017 Sep 11;7(9):e014608.
  • 3. McCarthy AE, Weld LH, Barnett ED, So H, Coyle C, Greenaway C, et al. Spectrum of illness in international migrants seen at GeoSentinel clinics in 1997-2009, part 2: migrants resettled internationally and evaluated for specific health concerns. Clin Infect Dis. 2013 Apr;56(7):925-33.
  • 4. Sharma S, Carballo M, Feld JJ, Janssen HL. Immigration and viral hepatitis. J Hepatol. 2015 Aug;63(2):515-22.
  • 5. Yacoub R, Al Ali R, Moukeh G, Lahdo A, Mouhammad Y, Nasser M. Hepatitis B vaccination status and needlestick injuries among healthcare workers in syria. J Glob Infect Dis. 2010 Jan;2(1):28-34.
  • 6. Bashour H, Muhjazi G. Hepatitis B and C in the Syrian Arab Republic: a review. East Mediterr Health J. 2016 Jul 10;22(4):267-73.
  • 7. WHO, Syrian Arab Republic: Annual Report 2017. 2017.
  • 8. Chemaitelly H, Chaabna K, Abu-Raddad LJ. The Epidemiology of Hepatitis C Virus in the Fertile Crescent: Systematic Review and Meta-Analysis. PLoS One. 2015 Aug 21;10(8):e0135281.
  • 9. Yazaji W, Habbal W, Monem F. Seropositivity of Hepatitis B and C among Syrian Multi-transfused Patients with Hemoglobinopathy. Mediterr J Hematol Infect Dis. 2016 Sep 1;8(1):e2016046.
  • 10. Muselmani W, Habbal W, Monem F. Prevalence of "anti-HBc alone" among Syrian blood donors. J Infect Dev Ctries. 2014 Aug 13;8(8):1013-5.
  • 11. Antaki N, Haffar S, Ali Deeb S, Assaad F, Abou Harb R, Zeibane N, et al. High prevalence of HBV genotype D in Syria and the clinical characteristics of hepatitis B e antigen-negative chronic hepatitis B. Epidemiol Infect. 2010 Jan;138(1):40-4.
  • 12. Toy M, Önder FO, Wörmann T, Bozdayi AM, Schalm SW, Borsboom GJ, et al. Age- and region-specific hepatitis B prevalence in Turkey estimated using generalized linear mixed models: a systematic review. BMC Infect Dis. 2011;11:337.
  • 13. Tozun N, Ozdogan O, Cakaloglu Y, Idilman R, Karasu Z, Akarca U, et al. Seroprevalence of hepatitis B and C virus infections and risk factors in Turkey: a fieldwork TURHEP study. Clin Microbiol Infect. 2015;21:1020-6.
  • 14. Syrian Arab Republic - Global AIDS Response Progress Report 2012. Overview of the AIDS Epidemic in Syria. Country progress report Syrian Republic.
  • 15. İnci A, Sarıcı İŞ, Çalışkan G, Kalaycı MU. Investigation of Frequency of HbsAg, Anti Hbs, Anti HCV and Anti HIV in Refugee Patients from Syria who Admit to a Training and Research Hospital Department of Surgery. Acta Medica Mediterranea, 2017;33:59.
  • 16. Hussein NR, Abdullah IM, Younus OM, Taher AM, Salim AA, Shahab FI. Prevalence of HBV, HCV and HIV Infections Among Syrian Refugees in Kurdistan Region, Iraq. Int J Infect. 2017 April;4(2):e39420.
  • 17. Köse Ş, Ödemis İ, Çelik D, Tatar BG, Akbulut İ, Çiftdoğan DY. Hepatitis A, B, C and HIV seroprevalence among Syrian refugee children admitted to outpatient clinics. Le Infezioni in Medicina. 2017;4:339-43.
  • 18. Angeletti S, Ceccarelli G, Vita S, Dicuonzo G, Lopalco M, Dedej E, et al. Unusual microorganisms and antimicrobial resistances in a group of Syrian migrants: Sentinel surveillance data from an asylum seekers centre in Italy. Travel Med Infect Dis. 2016 Mar-Apr;14(2):115-22.
  • 19. Coppola N, Alessio L, Gualdieri L, Pisaturo M, Sagnelli C, Minichini C, et al. Hepatitis B virus infection in undocumented immigrants and refugees in Southern Italy: demographic, virological, and clinical features. Infect Dis Poverty. 2017 Feb 9;6(1):33.
  • 20. İnci A, Okay M, Güven D. HBsAg, Anti-HBs, Anti-HCV and Anti-HIV Seroprevalence of the Patients Applied to Artvin State Hospital. Viral Hepatitis Journal. 2013;19(1):41-4.
  • 21. Öner S, Yapıcı G, Şaşmaz CT, Kurt AÖ, Buğdaycı R. Hepatitis B, hepatitis C, HIV, and VDRL seroprevalence of blood donors in Mersin, Turkey. Turk J Med Sci. 2011;41(2):335-41.
  • 22. Denk A, Balin ŞÖ. Koroner Anjiyografi Yapılan Hastalarda HBsAg, Anti-HCV ve Anti-HIV Seropozitifliği. Firat Med J. 2016;21(3):125-8.
  • 23. Köse Ş, Ersan G, Liv F. Six-Year Analysis of the Seropositivity of HBV, HCV, HIV, and Syphilis in Volunteer Blood Donors Attending Our Blood Center. Viral Hepat J. 2015;21(1):28-30.
  • 24. Pehlivanoğlu F, Yaşar KK, ŞENGÖZ G. Seroprevalences of Hepatitis B and C in Patients undergoing an Operation. Viral Hepat J. 2011;17:32-6.
  • 25. Çoban M, Sertoğlu E. HBsAg, Anti-HBs, Anti-HBc Total and Anti-HCV Seroprevalence of the Patients Applied to Beytepe Military Hospital. Viral Hepat J. 2013;19(3):152-5.
Toplam 25 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Bulaşıcı Hastalıklar
Bölüm Araştırma makalesi
Yazarlar

Ayhanım Tümtürk 0000-0002-0653-6725

Bayram Yeşil Bu kişi benim 0000-0002-9511-6836

Yayımlanma Tarihi 3 Aralık 2019
Yayımlandığı Sayı Yıl 2019 Cilt: 3 Sayı: 12

Kaynak Göster

APA Tümtürk, A., & Yeşil, B. (2019). Hepatitis B, Hepatitis C and HIV seroprevalence among Syrian refugees: A cross-sectional study from a tertiary referral center in Turkey. Journal of Surgery and Medicine, 3(12), 845-847. https://doi.org/10.28982/josam.650891
AMA Tümtürk A, Yeşil B. Hepatitis B, Hepatitis C and HIV seroprevalence among Syrian refugees: A cross-sectional study from a tertiary referral center in Turkey. J Surg Med. Aralık 2019;3(12):845-847. doi:10.28982/josam.650891
Chicago Tümtürk, Ayhanım, ve Bayram Yeşil. “Hepatitis B, Hepatitis C and HIV Seroprevalence Among Syrian Refugees: A Cross-Sectional Study from a Tertiary Referral Center in Turkey”. Journal of Surgery and Medicine 3, sy. 12 (Aralık 2019): 845-47. https://doi.org/10.28982/josam.650891.
EndNote Tümtürk A, Yeşil B (01 Aralık 2019) Hepatitis B, Hepatitis C and HIV seroprevalence among Syrian refugees: A cross-sectional study from a tertiary referral center in Turkey. Journal of Surgery and Medicine 3 12 845–847.
IEEE A. Tümtürk ve B. Yeşil, “Hepatitis B, Hepatitis C and HIV seroprevalence among Syrian refugees: A cross-sectional study from a tertiary referral center in Turkey”, J Surg Med, c. 3, sy. 12, ss. 845–847, 2019, doi: 10.28982/josam.650891.
ISNAD Tümtürk, Ayhanım - Yeşil, Bayram. “Hepatitis B, Hepatitis C and HIV Seroprevalence Among Syrian Refugees: A Cross-Sectional Study from a Tertiary Referral Center in Turkey”. Journal of Surgery and Medicine 3/12 (Aralık 2019), 845-847. https://doi.org/10.28982/josam.650891.
JAMA Tümtürk A, Yeşil B. Hepatitis B, Hepatitis C and HIV seroprevalence among Syrian refugees: A cross-sectional study from a tertiary referral center in Turkey. J Surg Med. 2019;3:845–847.
MLA Tümtürk, Ayhanım ve Bayram Yeşil. “Hepatitis B, Hepatitis C and HIV Seroprevalence Among Syrian Refugees: A Cross-Sectional Study from a Tertiary Referral Center in Turkey”. Journal of Surgery and Medicine, c. 3, sy. 12, 2019, ss. 845-7, doi:10.28982/josam.650891.
Vancouver Tümtürk A, Yeşil B. Hepatitis B, Hepatitis C and HIV seroprevalence among Syrian refugees: A cross-sectional study from a tertiary referral center in Turkey. J Surg Med. 2019;3(12):845-7.

Cited By

Comparison of Hepatitis B and Hepatitis C Seropositivity of the Syrian Immigrant and Turkish Local People
Viral Hepatitis Journal
https://doi.org/10.4274/vhd.galenos.2022.2020-12-5
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