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ANORMAL UTERİN KANAMALI KADINLARDA ENDOMETRİAL BİYOPSİ SONUÇLARININ MENOPOZ DURUMUNA GÖRE KARŞILAŞTIRILMASI

Yıl 2022, Cilt: 23 Sayı: 2, 213 - 218, 20.04.2022

Hülya Özberk Samiye Mete Fatma Gül Arı Selda Yetkin Mehmet Özeren Zekiye Şahin Gülden Diniz

https://doi.org/10.18229/kocatepetip.910017

Öz

AMAÇ: Anormal uterin kanamalar (AUK) kadınlarda, jinekoloji polikliniğine başvurunun en yaygın nedenlerinden biridir. Bu çalışmada, anormal uterin kanaması olan kadınlarda, kadınların AUK’u öz değerlendirmeleri ve endometriyal biyopsi sonuçlarını menopoz durumuna göre karşılaştırdık.
GEREÇ VE YÖNTEM: Çalışma, tanımlayıcı, kesitsel olarak tasarlanmış ve AUK'lı 650 kadın ile gerçekleştirilmiştir. Veriler tanımlayıcı bilgi formu ve endometriyal biyopsi sonuçları ile elde edilmiştir.
BULGULAR: Çalışmaya katılan kadınların %29.6'sı menopozda olup, %70.4'ü menopozda değildir. Endometrial biyopsi sonuçları, %3.4'ünün endometriyal kanser, %7.4'ünün yetersiz materyal ve %11.2'sinin atipik hiperplazi olduğunu gösterdi. Postmenopozal dönemde olan kadınlarda atipik hiperplazi daha yüksek bulundu (p<0.05).
SONUÇ: Kadınlarda atipik hiperplazi oranının yaş ve AUK özellikleri ile arttığı belirlendi. Atipik hiperplazi postmenopozal dönemdeki kadınları daha fazla etkilemektedir. Atipik hiperplazili kadınların düzenli ve periyodik takibi malignite riskinin teşhisi için önemlidir. Yetersiz materyal oranının yüksek olması da önemli bir endişe kaynağıdır. Bu prosedürleri uygulayan sağlık uzmanları, doğru teşhisi koyarken dikkatli olmalıdır. Geçtiğimiz yıl boyunca AUK özellikleri yaşayan kadınların hastaneye başvurularını geciktirdikleri belirlenmiştir. Bu nedenle, kadınların AUK hakkında bilgilendirilmesi çok önemlidir.

Anahtar Kelimeler

Uterin kanama Endometriyal kanser Menopoz

Destekleyen Kurum

Bulunmamaktadır.

Proje Numarası

Bulunmamaktadır.

Teşekkür

Bulunmamaktadır.

Kaynakça

  • 1. Munro MG, Critchley HO, Broder MS, et al. FIGO Working Group on Menstrual Disorders. FIGO classification system (PALM-COEIN) for causes of abnormal uterine bleeding in nongravid women of reproductive age. Int J Gynecol Obstet. 2011;113:3–13.
  • 2. Munro MG, Critchley HOD, Fraser IS, FIGO Menstrual Disorders Committee. The two FIGO systems for normal and abnormal uterine bleeding symptoms and classification of causes of abnormal uterine bleeding in the reproductive years: 2018 revisions. Int J Gynaecol Obstet. 2018;143(3):393-408.
  • 3. Sweet MG, Schmidt-Dalton TA, Weiss PM, et al. Evaluation and management of abnormal uterine bleeding in premenopausal women. Am Fam Physician. 2012;85(1):35-43.
  • 4. Seebacher V, Schmid M, Polterauer S, et al. The presence of postmenopausal bleeding as prognostic parameter in patients with endometrial cancer: A retrospective multicenter study. BMC Cancer. 2009;9:460.
  • 5. Van Hanegem N, Prins MM, Bongers MY, et al. The accuracy of endometrial sampling in women with postmenopausal bleeding: A systematic review and meta-analysis. Eur J Obstet Gynecol Reprod Biol. 2016;197:147-155.
  • 6. World Cancer Research Fund. Endometrial cancer statistics. https://www.wcrf.org/dietandcancer/cancer-trends/endometrial-cancer-statistics (Erişim 10.09.2020).
  • 7. Ministry of Health Public Health Agency of Turkey. Cancer Statistics 2014 Year of Turkey. http://kanser.gov.tr/Dosya/ca_istatistik/2014 (Erişim 15.09.2020).
  • 8. American College of Obstetricians and Gynaecologists. Committee on Practice Bulletins Gynecology. Practice bulletin no. 136: management of abnormal uterine bleeding associated with ovulatory dysfunction. Obstet Gynecol. 2013;122(1):176-85.
  • 9. Iqbal MB, Kambale T, Khandelwal A, et al. Spectrum of endometrial lesions in patients presenting with abnormal uterine bleeding. Indian Journal of Pathology and Oncology. 2018;5(4):587-591.
  • 10. Deeba F, Shaista, Khan B. Histological pattern of endometrial samples in postmenopausal women with abnormal uterine bleeding. J Ayub Med Coll Abbottabad. 2016; 28(4):721-724.
  • 11. Kucur SK, Sencan H, Yuksel KB, et al. Evaluation of endometrial biopsy results in our clinic; Analysis of 744 cases. Medical Bulletin of Zeynep Kamil. 2014;45(3):146-150.
  • 12. Yanıkkerem E, Ozdemir M, Bingol H, et al. Women’s attitudes and expectations regarding gynaecological examination. Midwifery. 2009;25(5):500–508.
  • 13. Tan DA, Haththotuwa R, Fraser IS. Cultural aspects and mythologies surrounding menstruation and abnormal uterine bleeding. Best Pract Res Clin Obstet Gynaecol. 2017;40:121-133.
  • 14. Sumbuloglu S, Sumbuloglu V. Biyoistatistik. 1nci baskı, Ankara: Hatiboğlu Yayınevi, 2010.
  • 15. Royal College of Obstetrics and Gynaecologists. Management of Endometrial Hyperplasia. https://www.rcog.org.uk/globalassets/documents/guidelines/green-top- guidelines/gtg_67_endometrial_hyperplasia.pdf (Erişim 10.09.2020).
  • 16. Pennant ME, Mehta R, Moody P, et al. Premenopausal abnormal uterine bleeding and risk of endometrial cancer. 2017;124(3):404–411.
  • 17. Andarieh MG, Delavar MA, Moslemi D, et al. Risk factors for endometrial cancer: Results from a hospital-based case-control study. Asian Pac J Cancer Prev. 2016;17(10):4791–4796.
  • 18. Saccardi C, Vitagliano A, Marchetti M, et al. Endometrial cancer risk prediction according to indication of diagnostic hysteroscopy in post-menopausal women. Diagnostics. 2020;10(5):1-11.
  • 19. Cintesun E, Incesu Cintesun FN, Karataş Aslan B, et al. Results of our endometrial samplings: Analysis of 655 cases. The Journal of Gynecology- Obstetrics and Neonatology. 2017;14(2):56–59.
  • 20. Vehid S, Aran S, Koksal S, et al. The prevalence and the age at the onset of menopause in Turkish women in rural area. Saudi Med. 2006;27(9):1381–1386.
  • 21. Inal ZO, Inal HA, Kucukosmanoglu I, et al. Assessment of endometrial sampling and histopathological results: Analysis of 4,247 cases. Eurasian J Med. 2017;49(1):44-77

COMPARISON OF ENDOMETRIAL BIOPSY RESULTS IN WOMEN WITH ABNORMAL UTERINE BLEEDING ACCORDING TO THE MENOPAUSAL STATUS

Yıl 2022, Cilt: 23 Sayı: 2, 213 - 218, 20.04.2022

Hülya Özberk Samiye Mete Fatma Gül Arı Selda Yetkin Mehmet Özeren Zekiye Şahin Gülden Diniz

https://doi.org/10.18229/kocatepetip.910017

Öz

OBJECTIVE: Abnormal uterine bleeding (AUB) is one of the most common reasons for women to present to the gynecology outpatient clinic. In this study, we compared abnormal uterine bleeding self-assessments and endometrial biopsy results in women with AUB according to the menopausal status.
MATERIAL AND METHODS: The study was designed as a descriptive, cross-sectional one and was conducted on 650 women with AUB. Data were obtained by descriptive information form and endometrial biopsy results.
RESULTS: It was determined that 29.6% of the study participants were in the postmenopausal period, while 70.4% were in the non-menopausal period. The endometrial biopsy results demonstrated that 3.4% were endometrial cancers, 7.4% were inadequate material, while 11.2% were atypical hyperplasia. Atypical hyperplasia was found to be higher in women who were in the postmenopausal period (p <0.05).
CONCLUSIONS: It was determined that the rate of atypical hyperplasia in women increased with age and AUB characteristics. Atypical hyperplasia was found to affect a greater number of women in the postmenopausal period. Regular and periodic follow-up of women with atypical hyperplasia is important in determining the risk of malignancy. The high rate of inadequate material is also of significant concern. The healthcare professionals who perform these procedures must be careful in making the correct diagnosis. It has been determined that women who have experienced AUB over the past year, have delayed their admission to the hospital.Therefore, it is crucial to inform women about AUB.

Anahtar Kelimeler

Uterine hemorrhage Endometrial cancer Menopause.

Proje Numarası

Bulunmamaktadır.

Kaynakça

  • 1. Munro MG, Critchley HO, Broder MS, et al. FIGO Working Group on Menstrual Disorders. FIGO classification system (PALM-COEIN) for causes of abnormal uterine bleeding in nongravid women of reproductive age. Int J Gynecol Obstet. 2011;113:3–13.
  • 2. Munro MG, Critchley HOD, Fraser IS, FIGO Menstrual Disorders Committee. The two FIGO systems for normal and abnormal uterine bleeding symptoms and classification of causes of abnormal uterine bleeding in the reproductive years: 2018 revisions. Int J Gynaecol Obstet. 2018;143(3):393-408.
  • 3. Sweet MG, Schmidt-Dalton TA, Weiss PM, et al. Evaluation and management of abnormal uterine bleeding in premenopausal women. Am Fam Physician. 2012;85(1):35-43.
  • 4. Seebacher V, Schmid M, Polterauer S, et al. The presence of postmenopausal bleeding as prognostic parameter in patients with endometrial cancer: A retrospective multicenter study. BMC Cancer. 2009;9:460.
  • 5. Van Hanegem N, Prins MM, Bongers MY, et al. The accuracy of endometrial sampling in women with postmenopausal bleeding: A systematic review and meta-analysis. Eur J Obstet Gynecol Reprod Biol. 2016;197:147-155.
  • 6. World Cancer Research Fund. Endometrial cancer statistics. https://www.wcrf.org/dietandcancer/cancer-trends/endometrial-cancer-statistics (Erişim 10.09.2020).
  • 7. Ministry of Health Public Health Agency of Turkey. Cancer Statistics 2014 Year of Turkey. http://kanser.gov.tr/Dosya/ca_istatistik/2014 (Erişim 15.09.2020).
  • 8. American College of Obstetricians and Gynaecologists. Committee on Practice Bulletins Gynecology. Practice bulletin no. 136: management of abnormal uterine bleeding associated with ovulatory dysfunction. Obstet Gynecol. 2013;122(1):176-85.
  • 9. Iqbal MB, Kambale T, Khandelwal A, et al. Spectrum of endometrial lesions in patients presenting with abnormal uterine bleeding. Indian Journal of Pathology and Oncology. 2018;5(4):587-591.
  • 10. Deeba F, Shaista, Khan B. Histological pattern of endometrial samples in postmenopausal women with abnormal uterine bleeding. J Ayub Med Coll Abbottabad. 2016; 28(4):721-724.
  • 11. Kucur SK, Sencan H, Yuksel KB, et al. Evaluation of endometrial biopsy results in our clinic; Analysis of 744 cases. Medical Bulletin of Zeynep Kamil. 2014;45(3):146-150.
  • 12. Yanıkkerem E, Ozdemir M, Bingol H, et al. Women’s attitudes and expectations regarding gynaecological examination. Midwifery. 2009;25(5):500–508.
  • 13. Tan DA, Haththotuwa R, Fraser IS. Cultural aspects and mythologies surrounding menstruation and abnormal uterine bleeding. Best Pract Res Clin Obstet Gynaecol. 2017;40:121-133.
  • 14. Sumbuloglu S, Sumbuloglu V. Biyoistatistik. 1nci baskı, Ankara: Hatiboğlu Yayınevi, 2010.
  • 15. Royal College of Obstetrics and Gynaecologists. Management of Endometrial Hyperplasia. https://www.rcog.org.uk/globalassets/documents/guidelines/green-top- guidelines/gtg_67_endometrial_hyperplasia.pdf (Erişim 10.09.2020).
  • 16. Pennant ME, Mehta R, Moody P, et al. Premenopausal abnormal uterine bleeding and risk of endometrial cancer. 2017;124(3):404–411.
  • 17. Andarieh MG, Delavar MA, Moslemi D, et al. Risk factors for endometrial cancer: Results from a hospital-based case-control study. Asian Pac J Cancer Prev. 2016;17(10):4791–4796.
  • 18. Saccardi C, Vitagliano A, Marchetti M, et al. Endometrial cancer risk prediction according to indication of diagnostic hysteroscopy in post-menopausal women. Diagnostics. 2020;10(5):1-11.
  • 19. Cintesun E, Incesu Cintesun FN, Karataş Aslan B, et al. Results of our endometrial samplings: Analysis of 655 cases. The Journal of Gynecology- Obstetrics and Neonatology. 2017;14(2):56–59.
  • 20. Vehid S, Aran S, Koksal S, et al. The prevalence and the age at the onset of menopause in Turkish women in rural area. Saudi Med. 2006;27(9):1381–1386.
  • 21. Inal ZO, Inal HA, Kucukosmanoglu I, et al. Assessment of endometrial sampling and histopathological results: Analysis of 4,247 cases. Eurasian J Med. 2017;49(1):44-77
Toplam 21 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Klinik Tıp Bilimleri
Bölüm Makaleler-Araştırma Yazıları
Yazarlar

Hülya Özberk 0000-0002-0902-7037

Samiye Mete 0000-0002-3777-2456

Fatma Gül Arı 0000-0001-6432-6702

Selda Yetkin 0000-0001-5733-6689

Mehmet Özeren 0000-0002-4552-9042

Zekiye Şahin 0000-0002-1912-2126

Gülden Diniz 0000-0003-1512-7584

Proje Numarası Bulunmamaktadır.
Yayımlanma Tarihi 20 Nisan 2022
Kabul Tarihi 28 Temmuz 2021
Yayımlandığı Sayı Yıl 2022 Cilt: 23 Sayı: 2

Kaynak Göster

APA Özberk, H., Mete, S., Arı, F. G., Yetkin, S., vd. (2022). COMPARISON OF ENDOMETRIAL BIOPSY RESULTS IN WOMEN WITH ABNORMAL UTERINE BLEEDING ACCORDING TO THE MENOPAUSAL STATUS. Kocatepe Tıp Dergisi, 23(2), 213-218. https://doi.org/10.18229/kocatepetip.910017
AMA Özberk H, Mete S, Arı FG, Yetkin S, Özeren M, Şahin Z, Diniz G. COMPARISON OF ENDOMETRIAL BIOPSY RESULTS IN WOMEN WITH ABNORMAL UTERINE BLEEDING ACCORDING TO THE MENOPAUSAL STATUS. KTD. Nisan 2022;23(2):213-218. doi:10.18229/kocatepetip.910017
Chicago Özberk, Hülya, Samiye Mete, Fatma Gül Arı, Selda Yetkin, Mehmet Özeren, Zekiye Şahin, ve Gülden Diniz. “COMPARISON OF ENDOMETRIAL BIOPSY RESULTS IN WOMEN WITH ABNORMAL UTERINE BLEEDING ACCORDING TO THE MENOPAUSAL STATUS”. Kocatepe Tıp Dergisi 23, sy. 2 (Nisan 2022): 213-18. https://doi.org/10.18229/kocatepetip.910017.
EndNote Özberk H, Mete S, Arı FG, Yetkin S, Özeren M, Şahin Z, Diniz G (01 Nisan 2022) COMPARISON OF ENDOMETRIAL BIOPSY RESULTS IN WOMEN WITH ABNORMAL UTERINE BLEEDING ACCORDING TO THE MENOPAUSAL STATUS. Kocatepe Tıp Dergisi 23 2 213–218.
IEEE H. Özberk, “COMPARISON OF ENDOMETRIAL BIOPSY RESULTS IN WOMEN WITH ABNORMAL UTERINE BLEEDING ACCORDING TO THE MENOPAUSAL STATUS”, KTD, c. 23, sy. 2, ss. 213–218, 2022, doi: 10.18229/kocatepetip.910017.
ISNAD Özberk, Hülya vd. “COMPARISON OF ENDOMETRIAL BIOPSY RESULTS IN WOMEN WITH ABNORMAL UTERINE BLEEDING ACCORDING TO THE MENOPAUSAL STATUS”. Kocatepe Tıp Dergisi 23/2 (Nisan 2022), 213-218. https://doi.org/10.18229/kocatepetip.910017.
JAMA Özberk H, Mete S, Arı FG, Yetkin S, Özeren M, Şahin Z, Diniz G. COMPARISON OF ENDOMETRIAL BIOPSY RESULTS IN WOMEN WITH ABNORMAL UTERINE BLEEDING ACCORDING TO THE MENOPAUSAL STATUS. KTD. 2022;23:213–218.
MLA Özberk, Hülya vd. “COMPARISON OF ENDOMETRIAL BIOPSY RESULTS IN WOMEN WITH ABNORMAL UTERINE BLEEDING ACCORDING TO THE MENOPAUSAL STATUS”. Kocatepe Tıp Dergisi, c. 23, sy. 2, 2022, ss. 213-8, doi:10.18229/kocatepetip.910017.
Vancouver Özberk H, Mete S, Arı FG, Yetkin S, Özeren M, Şahin Z, Diniz G. COMPARISON OF ENDOMETRIAL BIOPSY RESULTS IN WOMEN WITH ABNORMAL UTERINE BLEEDING ACCORDING TO THE MENOPAUSAL STATUS. KTD. 2022;23(2):213-8.
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