Araştırma Makalesi
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Acil Servise Başvuran Hipertansif Hastalarda Serum Ürik Asit Düzeyleri

Yıl 2022, Cilt: 17 Sayı: 1, 59 - 62, 21.03.2022
https://doi.org/10.17517/ksutfd.868934

Öz

Amaç: Hipertansif acil hastalarda serum ürik asit düzeylerinin önemi konusunda yapılan literatürde yeterli bilgi yoktur. Çalışmamız, yüksek tansiyon nedeniyle acil servise başvuran hastalarda serum ürik asit düzeylerinin rolünü araştırmayı amaçlamaktadır.
Gereç ve yöntemler: Kan basıncı 180/110 mmHg ve üzerinde akut hedef organ hasarı olan hipertansif acil (grup I), kan basıncı 180/110 mmHg ve üzerinde olan akut hedef organ hasarı olmayan hipertansif acil hastalar (grup II) ve 140-180 mmHg arasında sistolik kan basıncı ve 90-110 mmHg arasında diyastolik kan basıncı olan kontrolsüz hipertansiyonu olan hastalar (grup III).
Bulgular: Yüz yirmi dört hipertansif hasta (80 kadın, 44 erkek) dahil edildi. Grup I'de 33 (% 26.6), grup II'de 19 (% 15.3) ve grup III'te 72 (% 58.1) hasta yer aldı. Serum ürik asit düzeyi açısından karşılaştırıldığında gruplar arasında istatistiksel olarak anlamlı fark olduğu bulundu (p = 0,001). Grup I'deki hastaların ortalama serum ürik asit düzeyi diğer gruplara göre yüksekti (p <0.05).
Sonuç: Acil servise yüksek tansiyon ile başvuran hastalarda serum ürik asit düzeyleri hipertansif acil durumu ayırt etmede önemli olabilir.

Kaynakça

  • References Reference 1. Valleloonga F, Carbone F, Benedetto F, Airale L, Totaro S, Leone D, et al. Accuracy of a Symptom-Based Approach to Identify Hypertensive Emergencies in the Emergency Department. J. Clin. Med 2020, 9, 2201; doi:10.3390/jcm9072201.https://pubmed.ncbi.nlm.nih.gov/32664670/
  • Reference 2. Muiesan ML, Salvetti M, Amadoro V, di Somma S, Perlini S, Semplicini A, et al. An update on hypertensive emergencies and urgencies.J Cardiovasc Med (Hagerstown) 2015; 16: 372-382. https://pubmed.ncbi.nlm.nih.gov/25575271/
  • Reference 3. Wang Y, Hu J-W, Lv Y-B, Chu C, Wang K-K, Zheng W-L, et al. The Role of Uric Acid in Hypertension of Adolescents, Prehypertension and Salt Sensitivity of Blood PressureMed SciMonit 2017; 23: 790-795. https://pubmed.ncbi.nlm.nih.gov/28190873/
  • Reference 4. Gois PHF, Souza ERM. Pharmacotherapy for hyperuricemia in hypertensive patients. Cochrane Database Syst Rev 2017; 13; 4(4): CD008652. https://pubmed.ncbi.nlm.nih.gov/28406263/
  • Reference 5. Cho J, Kim C, Kang DR, Park JB. Hyperuricemia and uncontrolled hypertension in treated hypertensive patients. Medicine (Baltimore) 2016; 95(28): e4177. https://pubmed.ncbi.nlm.nih.gov/27428212/
  • Reference 6. Johnson RJ, Nakagawa T, Jalal D, Sánchez-Lozada LG, Kang DH, Ritz E. Uric acid and chronic kidney disease: which is chasing which? Nephrol Dial Transplant 2013 ;28(9): 2221-2228.https://pubmed.ncbi.nlm.nih.gov/23543594/
  • Reference 7. Gür M, Yılmaz R, Demirbağ R, Seyfeli E, Özdoğru İ, Altıparmak Hİ, et al. Relationship between elastic properties of the aorta and uric acid levels in newly diagnosed hypertensive patients. Turk SocCardiol 2006; 34: 223-229.
  • Reference 8. Mallat SG, Kattar SA, Tanios BY, Jurjus A. Hyperuricemia, Hypertension, and Chronic Kidney Disease: an Emerhing Association. CurrHypertens Rep 2016; 18(10): 74. https://pubmed.ncbi.nlm.nih.gov/27696189/
  • Reference 9. Davis JW, Almubarak M, Mukherjee A, McElwee SK, Leesar MA, Chartterjee A. Ischemic Evaluation in patients Presenting with Hypertensive Emergency / Urgency and Acute Systolic Heart Failure :Is Coronary Angiography Required for all? Cardiovascular Revascularization Medicine 2019; 20(6): 492-495.
  • Reference 10. Fushimi K, Shichiri M, Marumo F. Decreased fractional excretion of urate as an indicator of prerenal azotemia. Am j Nephrol 1990; 10(6) :489-494. https://pubmed.ncbi.nlm.nih.gov/2075907/
  • Reference 11. Macedo E, Mehta R. Prerenal azotemia in congestive heart failure. Contributions to Nephrology 2010; 164: 79-87. https://pubmed.ncbi.nlm.nih.gov/20427996/

Serum Uric Acid Levels in Hypertensive Patients Admitted to The Emergency Department

Yıl 2022, Cilt: 17 Sayı: 1, 59 - 62, 21.03.2022
https://doi.org/10.17517/ksutfd.868934

Öz

Objective: There is not enough information in the literature conducted about the importance of serum uric acid levels in hypertensive emergency patients. Our study aims to investigate the role of serum uric acid levels in patients admitted to the emergency department due to high blood pressure.
Materials and methods: Hypertensive emergency with acute target organ damage with blood pressure 180/110 mmHg and above (group I), hypertensive urgency patients without acute target organ damage with blood pressure of 180/110 mmHg and above (group II), and the patients with uncontrolled hypertension with systolic blood pressure between 140-180 mmHg and diastolic blood pressure between 90-110 mmHg (group III).
Results: One hundred twenty-four hypertensive patients (80 female, 44 male) were included. 33 patients (26.6%) were in group I, 19 (15.3%) in group II and 72 (58.1%) in group III. When compared in terms of serum uric acid level, it was found that there was a statistically significant difference between the groups (p = 0.001). The average serum uric acid level of patients in group I was higher compared to other groups (p <0.05).
Conclusion: Serum uric acid levels in patients admitted to the emergency department with high blood pressure may be important in distinguishing hypertensive emergency.

Kaynakça

  • References Reference 1. Valleloonga F, Carbone F, Benedetto F, Airale L, Totaro S, Leone D, et al. Accuracy of a Symptom-Based Approach to Identify Hypertensive Emergencies in the Emergency Department. J. Clin. Med 2020, 9, 2201; doi:10.3390/jcm9072201.https://pubmed.ncbi.nlm.nih.gov/32664670/
  • Reference 2. Muiesan ML, Salvetti M, Amadoro V, di Somma S, Perlini S, Semplicini A, et al. An update on hypertensive emergencies and urgencies.J Cardiovasc Med (Hagerstown) 2015; 16: 372-382. https://pubmed.ncbi.nlm.nih.gov/25575271/
  • Reference 3. Wang Y, Hu J-W, Lv Y-B, Chu C, Wang K-K, Zheng W-L, et al. The Role of Uric Acid in Hypertension of Adolescents, Prehypertension and Salt Sensitivity of Blood PressureMed SciMonit 2017; 23: 790-795. https://pubmed.ncbi.nlm.nih.gov/28190873/
  • Reference 4. Gois PHF, Souza ERM. Pharmacotherapy for hyperuricemia in hypertensive patients. Cochrane Database Syst Rev 2017; 13; 4(4): CD008652. https://pubmed.ncbi.nlm.nih.gov/28406263/
  • Reference 5. Cho J, Kim C, Kang DR, Park JB. Hyperuricemia and uncontrolled hypertension in treated hypertensive patients. Medicine (Baltimore) 2016; 95(28): e4177. https://pubmed.ncbi.nlm.nih.gov/27428212/
  • Reference 6. Johnson RJ, Nakagawa T, Jalal D, Sánchez-Lozada LG, Kang DH, Ritz E. Uric acid and chronic kidney disease: which is chasing which? Nephrol Dial Transplant 2013 ;28(9): 2221-2228.https://pubmed.ncbi.nlm.nih.gov/23543594/
  • Reference 7. Gür M, Yılmaz R, Demirbağ R, Seyfeli E, Özdoğru İ, Altıparmak Hİ, et al. Relationship between elastic properties of the aorta and uric acid levels in newly diagnosed hypertensive patients. Turk SocCardiol 2006; 34: 223-229.
  • Reference 8. Mallat SG, Kattar SA, Tanios BY, Jurjus A. Hyperuricemia, Hypertension, and Chronic Kidney Disease: an Emerhing Association. CurrHypertens Rep 2016; 18(10): 74. https://pubmed.ncbi.nlm.nih.gov/27696189/
  • Reference 9. Davis JW, Almubarak M, Mukherjee A, McElwee SK, Leesar MA, Chartterjee A. Ischemic Evaluation in patients Presenting with Hypertensive Emergency / Urgency and Acute Systolic Heart Failure :Is Coronary Angiography Required for all? Cardiovascular Revascularization Medicine 2019; 20(6): 492-495.
  • Reference 10. Fushimi K, Shichiri M, Marumo F. Decreased fractional excretion of urate as an indicator of prerenal azotemia. Am j Nephrol 1990; 10(6) :489-494. https://pubmed.ncbi.nlm.nih.gov/2075907/
  • Reference 11. Macedo E, Mehta R. Prerenal azotemia in congestive heart failure. Contributions to Nephrology 2010; 164: 79-87. https://pubmed.ncbi.nlm.nih.gov/20427996/
Toplam 11 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Sağlık Kurumları Yönetimi
Bölüm Araştırma Makaleleri
Yazarlar

Canan Akman 0000-0002-3427-5649

Serkan Bakirdogen 0000-0002-3448-0490

Yayımlanma Tarihi 21 Mart 2022
Gönderilme Tarihi 26 Ocak 2021
Kabul Tarihi 25 Şubat 2021
Yayımlandığı Sayı Yıl 2022 Cilt: 17 Sayı: 1

Kaynak Göster

AMA Akman C, Bakirdogen S. Serum Uric Acid Levels in Hypertensive Patients Admitted to The Emergency Department. KSÜ Tıp Fak Der. Mart 2022;17(1):59-62. doi:10.17517/ksutfd.868934