Gamma Delta T Cells and Organ Transplantation: A Review of Recent Studies

Rumeysa Yegin; Aeisha Ahmed; Gulam Hekimoğlu

doi:10.37990/medr.1293786

Derleme

Gamma Delta T Cells and Organ Transplantation: A Review of Recent Studies

Yıl 2023, Cilt: 5 Sayı: 3, 659 - 63, 18.09.2023

Rumeysa Yegin Aeisha Ahmed Gulam Hekimoğlu

https://doi.org/10.37990/medr.1293786

Öz

Gamma delta (γδ) T cells have gained a lot of attention in the field of cancer immunotherapy due to their unique innate and adaptive immune properties. However, until recently, their potential significance in organ transplantation went unnoticed. This review highlights the effector roles and potential advantages of γδ T cells in organ transplantation by examining recent studies examining the connection between T cells and organ transplantation. Recent studies have shown that high γδ T-cell immune reconstitution following organ transplantation is associated with a significantly greater overall survival rate and a lower incidence of acute graft-versus-host disease (GVHD), despite prior studies' contradictory findings. These results suggest that γδ T cells might be a useful addition to the current transplantation procedures. The effector activities of γδ T cells and their putative modes of action following organ transplantation will be covered in this review. We also provide a summary of the most recent research on the connection between γδ T cells and organ transplant outcomes, such as acute GVHD and graft survival. Finally, we point out the areas that still need to be studied in order to fully comprehend how γδ T cells function after organ donation.

Anahtar Kelimeler

Transplant İmmunology, gamma delta T cells, organ transplantation

Kaynakça

1. Wencker M, Turchinovich G, Di Marco Barros R, et al. Innate-like T cells straddle innate and adaptive immunity by altering antigen-receptor responsiveness. Nat Immunol. 2014;15:80-7.
2. Vantourout P, Hayday A. Six-of-the-best: unique contributions of γδ T cells to immunology. Nat Rev Immunol. 2013;13:88-100.
3. Minculescu L, Sengeløv H. The role of gamma delta T cells in haematopoietic stem cell transplantation. Scand J Immunol. 2015;81:459-68.
4. Kasiske BL, Snyder JJ, Gilbertson DT, Wang C. Cancer after kidney transplantation in the United States. Am J Transplant. 2004;4:905-13.
5. Thedrez A, Sabourin C, Gertner-Dardenne J, et al. Self/non-self discrimination by human γδ T cells: simple solutions for a complex issue? Immunol Rev. 2007;215:123-35.
6. Pauza CD, Liou ML, Lahusen T, et al. Gamma delta T cell therapy for cancer: it is good to be local. Front Immunol. 2018;9:1305.
7. Wencker M, Turchinovich G, Di Marco Barros R, et al. Innate-like T cells straddle innate and adaptive immunity by altering antigen-receptor responsiveness. Nat Immunol. 2014;15:80-7.
8. Carding SR, Egan PJ. Gammadelta T cells: functional plasticity and heterogeneity. Nat Rev Immunol. 2002;2:336-45.
9. Witherden DA, Rieder SE, Boismenu R, et al. A role for epithelial γδ T cells in tissue repair. Springer Semin Immunopathol. 2000;22:265–81.
10. Silva-Santos B, Serre K, Norell H. γδ T cells in cancer. Nat Rev Immunol. 2015;15:683–91.
11. Scotet E, Martinez LO, Grant E, et al. Tumor recognition following Vgamma9Vdelta2 T cell receptor interactions with a surface F1-ATPase-related structure and apolipoprotein A-I. Immunity. 2005;22:71-80.
12. Dieli F, Vermijlen D, Fulfaro F, et al. Targeting human γδ T cells with zoledronate and interleukin-2 for immunotherapy of hormone-refractory prostate cancer. Cancer Res. 2007; 67:74507.
13. Brandes M, Willimann K, Moser B. Professional antigen-presentation function by human gamma-delta T Cells. Science. 2005;309:264-8.
14. Sheridan BS, Lefrançois L. Regional and mucosal memory T cells. Nat Immunol. 2011;12:485-91.
15. Cai Y, Xue F, Fleming C, et al. Differential developmental requirement and peripheral regulation for dermal Vγ4 and Vγ6T17 cells in health and inflammation. Nature communications. 2014;5:3986.
16. Yu X, Liu Z, Wang Y, et al. Characteristics of Vδ1+ and Vδ2+ γδ T cell subsets in acute liver allograft rejection. Transpl Immunol. 2013;29:118-22.
17. McCallion O, Hester J, Issa F. Deciphering the contribution of γδ T cells to outcomes in transplantation. Transplantation. 2018;102:1983-93.
18. Minculescu L, Marquart HV, Ryder LP, et al. Improved overall survival, relapse-free-survival, and less graft-vs.-host-disease in patients with high immune reconstitution of TCR gamma delta cells 2 months after allogeneic stem cell transplantation. Front Immunol. 2019;10:1997.
19. Sur S, Ravoor A, San Juan SP, et al. Flow cytometric pattern of gamma delta TCR expression identifies outcomes in kidney transplantation. Transplantation. 2022;106: S312.
20. Martínez-Llordella M, Puig-Pey I, Orlando G, et al. Multiparameter immune profiling of operational tolerance in liver transplantation. Am J Transplant. 2007;7:309-19.
21. Xia Q, Duan L, Shi L, et al. High-mobility group box 1 accelerates early acute allograft rejection via enhancing IL-17+ γδ T-cell response. Transpl Int. 2014;27:399-407.
22. Born WK, Reardon CL, O’Brien RL. The function of γδ T cells in innate immunity. Curr Opin Immunol. 2006;18:31-8.
23. Puig-Pey I, Bohne F, Benítez C, et al. Characterization of γδ T cell subsets in organ transplantation. Transpl Int. 2010;23:1045-55.
24. Mao Y, Yin S, Zhang J, et al. A new effect of IL-4 on human γδ T cells: promoting regulatory Vδ1 T cells via IL-10 production and inhibiting function of Vδ2 T cells. Cell Mol Immunol. 2016;13:217–28.
25. Caccamo N, Battistini L, Bonneville M, et al. CXCR5 identifies a subset of Vγ9Vδ2 T cells which secrete IL-4 and IL-10 and help B cells for antibody production. J Immunol. 2006;177:5290-5.
26. Peterfalvi A, Gomori E, Magyarlaki T, et al. Invariant Valpha7.2-Jalpha33 TCR is expressed in human kidney and brain tumors indicating infiltration by mucosal-associated invariant T (MAIT) cells. Int Immunol. 2008;20:1517-25.
27. Cvetkovski F, Hexham JM, Berglund E. Strategies for Liver Transplantation Tolerance. International journal of molecular sciences. 2021;24:2253.
28. Sullivan LC, Shaw EM, Stankovic S, et al. The complex existence of γδ T cells following transplantation: the good, the bad and the simply confusing. Clinical & translational immunology. 2019;8,e1078.
29. Lee S, Affandi JS, Irish AB, et al. Cytomegalovirus infection alters phenotypes of different γδ T-cell subsets in renal transplant recipients with long-term stable graft function. J Med Virol. 2017;89:1442-52.
30. Girardi M. Immunosurveillance and immunoregulation by γδ T cells. J Invest Dermatol. 2006;126:25-31.
31. Zhou J, Appleton SE, Stadnyk, et al. CD8+ gammadelta T regulatory cells mediate kidney allograft prolongation after oral exposure to alloantigen. Transpl Int. 2008;21-679-87.
32. Hochegger K, Schätz T, Eller P, et al. Role of α/β and γ/δ T cells in renal ischemia-reperfusion injury. Am J Physiol Renal Physiol. 2007;293: F741-7.
33. Bian Z, Xu LP, Fu Q, et al. Homeostatic γδ T cell contents are preserved by granulocyte colony-stimulating factor priming and correlate with the early recovery of γδ T cell subsets after haploidentical hematopoietic stem cell transplantation. Biol Blood Marrow Transplant. 2018;24:252-9.
34. de Witte MA, Sarhan D, Davis Z, et al. Early reconstitution of NK and γδ T cells and its implication for the design of post-transplant immunotherapy. Biol Blood Marrow Transplant. 2018;24:1152-62.
35. Saura-Esteller J, de Jong M, King LA, et al. Gamma delta T-Cell based cancer immunotherapy: past-present-future. Front Immunol. 2022;13:915837.
36. Giri S, Lal G. Differentiation and functional plasticity of gamma-delta (γδ) T cells under homeostatic and disease conditions. Mol Immunol. 2021;136:138-49.
37. Lahn M. The role of γδ T cells in the airways. J Mol Med. 2000;78:409-25.
38. Sullivan L, Shaw E, Snell G, et al. A longitudinal study of γδ T cell subsets post lung transplant: potential players in CMV immunity. The Journal of Heart and Lung Transplantation. 2019;38:S253.

Yıl 2023, Cilt: 5 Sayı: 3, 659 - 63, 18.09.2023

Rumeysa Yegin Aeisha Ahmed Gulam Hekimoğlu

https://doi.org/10.37990/medr.1293786

Öz

Kaynakça

1. Wencker M, Turchinovich G, Di Marco Barros R, et al. Innate-like T cells straddle innate and adaptive immunity by altering antigen-receptor responsiveness. Nat Immunol. 2014;15:80-7.
2. Vantourout P, Hayday A. Six-of-the-best: unique contributions of γδ T cells to immunology. Nat Rev Immunol. 2013;13:88-100.
3. Minculescu L, Sengeløv H. The role of gamma delta T cells in haematopoietic stem cell transplantation. Scand J Immunol. 2015;81:459-68.
4. Kasiske BL, Snyder JJ, Gilbertson DT, Wang C. Cancer after kidney transplantation in the United States. Am J Transplant. 2004;4:905-13.
5. Thedrez A, Sabourin C, Gertner-Dardenne J, et al. Self/non-self discrimination by human γδ T cells: simple solutions for a complex issue? Immunol Rev. 2007;215:123-35.
6. Pauza CD, Liou ML, Lahusen T, et al. Gamma delta T cell therapy for cancer: it is good to be local. Front Immunol. 2018;9:1305.
7. Wencker M, Turchinovich G, Di Marco Barros R, et al. Innate-like T cells straddle innate and adaptive immunity by altering antigen-receptor responsiveness. Nat Immunol. 2014;15:80-7.
8. Carding SR, Egan PJ. Gammadelta T cells: functional plasticity and heterogeneity. Nat Rev Immunol. 2002;2:336-45.
9. Witherden DA, Rieder SE, Boismenu R, et al. A role for epithelial γδ T cells in tissue repair. Springer Semin Immunopathol. 2000;22:265–81.
10. Silva-Santos B, Serre K, Norell H. γδ T cells in cancer. Nat Rev Immunol. 2015;15:683–91.
11. Scotet E, Martinez LO, Grant E, et al. Tumor recognition following Vgamma9Vdelta2 T cell receptor interactions with a surface F1-ATPase-related structure and apolipoprotein A-I. Immunity. 2005;22:71-80.
12. Dieli F, Vermijlen D, Fulfaro F, et al. Targeting human γδ T cells with zoledronate and interleukin-2 for immunotherapy of hormone-refractory prostate cancer. Cancer Res. 2007; 67:74507.
13. Brandes M, Willimann K, Moser B. Professional antigen-presentation function by human gamma-delta T Cells. Science. 2005;309:264-8.
14. Sheridan BS, Lefrançois L. Regional and mucosal memory T cells. Nat Immunol. 2011;12:485-91.
15. Cai Y, Xue F, Fleming C, et al. Differential developmental requirement and peripheral regulation for dermal Vγ4 and Vγ6T17 cells in health and inflammation. Nature communications. 2014;5:3986.
16. Yu X, Liu Z, Wang Y, et al. Characteristics of Vδ1+ and Vδ2+ γδ T cell subsets in acute liver allograft rejection. Transpl Immunol. 2013;29:118-22.
17. McCallion O, Hester J, Issa F. Deciphering the contribution of γδ T cells to outcomes in transplantation. Transplantation. 2018;102:1983-93.
18. Minculescu L, Marquart HV, Ryder LP, et al. Improved overall survival, relapse-free-survival, and less graft-vs.-host-disease in patients with high immune reconstitution of TCR gamma delta cells 2 months after allogeneic stem cell transplantation. Front Immunol. 2019;10:1997.
19. Sur S, Ravoor A, San Juan SP, et al. Flow cytometric pattern of gamma delta TCR expression identifies outcomes in kidney transplantation. Transplantation. 2022;106: S312.
20. Martínez-Llordella M, Puig-Pey I, Orlando G, et al. Multiparameter immune profiling of operational tolerance in liver transplantation. Am J Transplant. 2007;7:309-19.
21. Xia Q, Duan L, Shi L, et al. High-mobility group box 1 accelerates early acute allograft rejection via enhancing IL-17+ γδ T-cell response. Transpl Int. 2014;27:399-407.
22. Born WK, Reardon CL, O’Brien RL. The function of γδ T cells in innate immunity. Curr Opin Immunol. 2006;18:31-8.
23. Puig-Pey I, Bohne F, Benítez C, et al. Characterization of γδ T cell subsets in organ transplantation. Transpl Int. 2010;23:1045-55.
24. Mao Y, Yin S, Zhang J, et al. A new effect of IL-4 on human γδ T cells: promoting regulatory Vδ1 T cells via IL-10 production and inhibiting function of Vδ2 T cells. Cell Mol Immunol. 2016;13:217–28.
25. Caccamo N, Battistini L, Bonneville M, et al. CXCR5 identifies a subset of Vγ9Vδ2 T cells which secrete IL-4 and IL-10 and help B cells for antibody production. J Immunol. 2006;177:5290-5.
26. Peterfalvi A, Gomori E, Magyarlaki T, et al. Invariant Valpha7.2-Jalpha33 TCR is expressed in human kidney and brain tumors indicating infiltration by mucosal-associated invariant T (MAIT) cells. Int Immunol. 2008;20:1517-25.
27. Cvetkovski F, Hexham JM, Berglund E. Strategies for Liver Transplantation Tolerance. International journal of molecular sciences. 2021;24:2253.
28. Sullivan LC, Shaw EM, Stankovic S, et al. The complex existence of γδ T cells following transplantation: the good, the bad and the simply confusing. Clinical & translational immunology. 2019;8,e1078.
29. Lee S, Affandi JS, Irish AB, et al. Cytomegalovirus infection alters phenotypes of different γδ T-cell subsets in renal transplant recipients with long-term stable graft function. J Med Virol. 2017;89:1442-52.
30. Girardi M. Immunosurveillance and immunoregulation by γδ T cells. J Invest Dermatol. 2006;126:25-31.
31. Zhou J, Appleton SE, Stadnyk, et al. CD8+ gammadelta T regulatory cells mediate kidney allograft prolongation after oral exposure to alloantigen. Transpl Int. 2008;21-679-87.
32. Hochegger K, Schätz T, Eller P, et al. Role of α/β and γ/δ T cells in renal ischemia-reperfusion injury. Am J Physiol Renal Physiol. 2007;293: F741-7.
33. Bian Z, Xu LP, Fu Q, et al. Homeostatic γδ T cell contents are preserved by granulocyte colony-stimulating factor priming and correlate with the early recovery of γδ T cell subsets after haploidentical hematopoietic stem cell transplantation. Biol Blood Marrow Transplant. 2018;24:252-9.
34. de Witte MA, Sarhan D, Davis Z, et al. Early reconstitution of NK and γδ T cells and its implication for the design of post-transplant immunotherapy. Biol Blood Marrow Transplant. 2018;24:1152-62.
35. Saura-Esteller J, de Jong M, King LA, et al. Gamma delta T-Cell based cancer immunotherapy: past-present-future. Front Immunol. 2022;13:915837.
36. Giri S, Lal G. Differentiation and functional plasticity of gamma-delta (γδ) T cells under homeostatic and disease conditions. Mol Immunol. 2021;136:138-49.
37. Lahn M. The role of γδ T cells in the airways. J Mol Med. 2000;78:409-25.
38. Sullivan L, Shaw E, Snell G, et al. A longitudinal study of γδ T cell subsets post lung transplant: potential players in CMV immunity. The Journal of Heart and Lung Transplantation. 2019;38:S253.

Toplam 38 adet kaynakça vardır.

Ayrıntılar

Birincil Dil	İngilizce
Konular	Klinik Tıp Bilimleri
Bölüm	Derleme
Yazarlar	Rumeysa Yegin Bu kişi benim 0009-0001-9479-0298 Aeisha Ahmed Bu kişi benim 0009-0009-3671-6952 Gulam Hekimoğlu 0000-0002-5027-6756
Erken Görünüm Tarihi	12 Temmuz 2023
Yayımlanma Tarihi	18 Eylül 2023
Kabul Tarihi	25 Haziran 2023
Yayımlandığı Sayı	Yıl 2023 Cilt: 5 Sayı: 3

Kaynak Göster

AMA	Yegin R, Ahmed A, Hekimoğlu G. Gamma Delta T Cells and Organ Transplantation: A Review of Recent Studies. Med Records. Eylül 2023;5(3):659-63. doi:10.37990/medr.1293786

Kapak Resmi İndir

Makale Dosyaları

Tam Metin

Chief Editors
Assoc. Prof. Zülal Öner
Address: İzmir Bakırçay University, Department of Anatomy, İzmir, Turkey

Assoc. Prof. Deniz Şenol
Address: Düzce University, Department of Anatomy, Düzce, Turkey

E-mail: medrecsjournal@gmail.com

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Medical Records Association (Tıbbi Kayıtlar Derneği)
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