Öz
Endometrial polyp (EP) is a condition that is often encountered in obstetrics and gynecology clinic practices. In our study, we aimed to reveal the relationship between prolidase enzyme activity (PEA) and Oxidative Stress (OS) in patients with endometrial polyps. Thirty-five patients who were histopathologically diagnosed with EP and 35 patients with abnormal uterine bleeding (AUB) without pathology as a result of endometrial sampling were included in the control group. Serum TOS, OSI, tissue PEA, and endometrial thickness values were found to be statistically significantly higher in the EP group compared to the control group. We believe that our study, when supported by studies with larger patient groups, may be a useful marker for a more detailed understanding of the pathogenesis and clinical follow-up of patients.
Anahtar Kelimeler
Endometrial Polyp Oxidative Stress Prolidase Enzyme Activity
Etik Beyan
I confirm that all methods were performed in accordance with the relevant guidelines. Ethical approval was obtained from the MSKU Faculty of Medicine Clinical Research Ethics Committee, Türkiye (Date: 06/01/2021, Decision no: 1/II).
Destekleyen Kurum
This work was supported by the Muğla Sıtkı Koçman University Scientific Research Projects (Nu: 22/136/02/3/3).
Proje Numarası
This work was supported by the Muğla Sıtkı Koçman University Scientific Research Projects (Nu: 22/136/02/3/3).
Teşekkür
None
Kaynakça
- 1. Wong M, Crnobrnja B, Liberale V, et al. The natural history of endometrial polyps. Hum Reprod. 2017;32(2):340-5.
- 2. Goldstein SR, Zeltser I, Horan CK, et al. Ultrasonography-based triage for perimenopausal patients with abnormal uterine bleeding. Am J Obstet Gynecol. 1997;177(1):102-8.
- 3. Pehlivan H, Güler AE, Çakmak B, et al. The comparison of two endometrial biopsy techniques in detection of endometrial pathologies. Ege Tıp Bilim Derg. 2019;2(1):26-30.
- 4. Nappi L, Indraccolo U, Sardo ADS, et al. Are diabetes, hypertension, and obesity independent risk factors for endometrial polyps? J Minim Invasive Gynecol. 2009;16(2):157-62.
- 5. Savelli L, De Iaco P, Santini D, et al. Histopathologic features and risk factors for benignity, hyperplasia, and cancer in endometrial polyps. Am J Obstet Gynecol. 2003;188(4):927-31.
- 6. DeWaay DJ, Syrop CH, Nygaard IE, et al. Natural history of uterine polyps and leiomyomata. Obstet Gynecol. 2002;100(1):3-7.
- 7. Sezgin B, Kinci MF, Pirinççi F, et al. Thiol‐disulfide status of patients with cervical cancer. J Obstet Gynaecol Res. 2020;46(11):2423-9.
- 8. Donnez J, Binda MM, Donnez O, et al. Oxidative stress in the pelvic cavity and its role in the pathogenesis of endometriosis. Fertil Steril. 2016;106(5):1011-7.
- 9. Çınar M, Eryılmaz ÖG, Özel Ş, et al. The role of oxidative stress markers in development of endometrial polyp. J Exp Ther Oncol. 2016;11:269-73.
- 10. Vural M, Toy H, Camuzcuoglu H, et al. Comparison of prolidase enzyme activities of maternal serum and placental tissue in patients with early pregnancy failure. Arch Gynecol Obstet. 2011;283(5):953-8.
- 11. Dural MD, Bıldırcın FD, Karlı P, et al. The importance of serum prolidase activity in endometriosis. J Clin Trials Exp Investig. 2019;10(4):em00729.
- 12. Erel O. A novel automated direct measurement method for total antioxidant capacity using a new generation, more stable ABTS radical cation. Clin Biochem. 2004;37(4):277-85.
- 13. Erel O. A new automated colorimetric method for measuring total oxidant status. Clin Biochem. 2005;38(12):1103-11.
- 14. Yumru M, Savas HA, Kalenderoglu A, et al. Oxidative imbalance in bipolar disorder subtypes: a comparative study. Prog Neuropsychopharmacol Biol Psychiatry. 2009;33(6):1070-4.
- 15. Nijkang NP, Anderson L, Markham R, et al. Endometrial polyps: Pathogenesis, sequelae and treatment. SAGE Open Med. 2019;7:2050312119848247.
- 16. Erdemoglu E, Güney M, Karahan N, et al. Expression of cyclooxygenase-2, matrix metalloproteinase-2 and matrix metalloproteinase-9 in premenopausal and postmenopausal endometrial polyps. Maturitas. 2008;59(3):268-74.
- 17. Özgen E. Endometriyal polip olgularında total oksidan, antioksidan ve tiyol-disülfid homeostazının incelenmesi. Ankara Yıldırım Beyazıt Üniversitesi Tıp Fakültesi; 2020.
- 18. Nayki C, Nayki U, Gunay M, et al. Oxidative and antioxidative status in the endometrium of patients with benign gynecological disorders. J Gynecol Obstet Hum Reprod. 2017;46(3):243-7.
- 19. Çınar M, Eryılmaz ÖG, Özel Ş, et al. The role of oxidative stress markers in development of endometrial polyp. J Exp Ther Oncol. 2016;11(4):269-73.
- 20. Camuzcuoglu H, Arioz DT, Toy H, et al. Serum paraoxonase and arylesterase activities in patients with epithelial ovarian cancer. Gynecol Oncol. 2009;112(3):481-5.
- 21. Toy H, Camuzcuoglu H, Camuzcuoglu A, et al. Decreased serum prolidase activity and increased oxidative stress in early pregnancy loss. Gynecol Obstet Invest. 2010;69(2):122-7.
- 22. Hilali N, Vural M, Camuzcuoglu H, et al. Increased prolidase activity and oxidative stress in PCOS. Clin Endocrinol (Oxf). 2013;79(1):105-10.
Öz
Endometrial polip (EP) kadın hastalıkları ve doğum kliniği pratiğinde sıklıkla karşılaşılan bir durumdur. Biz çalışmamızda endometrial polip tanısı olan hastaların prolidaz enzim aktivitesi ve oksidatif stres (OS) ile ilişkisini ortaya çıkarmayı amaçladık. Araştırmaya dahil edilme kriterlerini karşılayan histopatolojik olarak EP tanısı konan 35 hasta ile endometrial örnekleme sonucunda patoloji tespit edilmeyen 35 anormal uterin kanaması (AUK) olan kontrol grubu hastası dahil edilmiştir. EP ve kontrol grupları arasında TAS, TOS, OSI, prolidaz ve endometrium kalınlığı değerleri karşılaştırıldığında EP grubunda, kontrol grubuna göre TOS, OSI, prolidaz ve endometrial kalınlık değerleri istatistiksel olarak anlamlı düzeyde yüksek bulunmuştur. Çalışmamız, daha geniş hasta grupları ile yapılan çalışmalarla desteklendiğinde patogenezin daha ayrıntılı anlaşılması ve klinik olarak hasta takibinde yararlı bir belirteç olabileceği görüşündeyiz.
Anahtar Kelimeler
Endometrial Polip Oksidatif Stress Prolidaz Enzim Aktivitesi
Proje Numarası
This work was supported by the Muğla Sıtkı Koçman University Scientific Research Projects (Nu: 22/136/02/3/3).
Kaynakça
- 1. Wong M, Crnobrnja B, Liberale V, et al. The natural history of endometrial polyps. Hum Reprod. 2017;32(2):340-5.
- 2. Goldstein SR, Zeltser I, Horan CK, et al. Ultrasonography-based triage for perimenopausal patients with abnormal uterine bleeding. Am J Obstet Gynecol. 1997;177(1):102-8.
- 3. Pehlivan H, Güler AE, Çakmak B, et al. The comparison of two endometrial biopsy techniques in detection of endometrial pathologies. Ege Tıp Bilim Derg. 2019;2(1):26-30.
- 4. Nappi L, Indraccolo U, Sardo ADS, et al. Are diabetes, hypertension, and obesity independent risk factors for endometrial polyps? J Minim Invasive Gynecol. 2009;16(2):157-62.
- 5. Savelli L, De Iaco P, Santini D, et al. Histopathologic features and risk factors for benignity, hyperplasia, and cancer in endometrial polyps. Am J Obstet Gynecol. 2003;188(4):927-31.
- 6. DeWaay DJ, Syrop CH, Nygaard IE, et al. Natural history of uterine polyps and leiomyomata. Obstet Gynecol. 2002;100(1):3-7.
- 7. Sezgin B, Kinci MF, Pirinççi F, et al. Thiol‐disulfide status of patients with cervical cancer. J Obstet Gynaecol Res. 2020;46(11):2423-9.
- 8. Donnez J, Binda MM, Donnez O, et al. Oxidative stress in the pelvic cavity and its role in the pathogenesis of endometriosis. Fertil Steril. 2016;106(5):1011-7.
- 9. Çınar M, Eryılmaz ÖG, Özel Ş, et al. The role of oxidative stress markers in development of endometrial polyp. J Exp Ther Oncol. 2016;11:269-73.
- 10. Vural M, Toy H, Camuzcuoglu H, et al. Comparison of prolidase enzyme activities of maternal serum and placental tissue in patients with early pregnancy failure. Arch Gynecol Obstet. 2011;283(5):953-8.
- 11. Dural MD, Bıldırcın FD, Karlı P, et al. The importance of serum prolidase activity in endometriosis. J Clin Trials Exp Investig. 2019;10(4):em00729.
- 12. Erel O. A novel automated direct measurement method for total antioxidant capacity using a new generation, more stable ABTS radical cation. Clin Biochem. 2004;37(4):277-85.
- 13. Erel O. A new automated colorimetric method for measuring total oxidant status. Clin Biochem. 2005;38(12):1103-11.
- 14. Yumru M, Savas HA, Kalenderoglu A, et al. Oxidative imbalance in bipolar disorder subtypes: a comparative study. Prog Neuropsychopharmacol Biol Psychiatry. 2009;33(6):1070-4.
- 15. Nijkang NP, Anderson L, Markham R, et al. Endometrial polyps: Pathogenesis, sequelae and treatment. SAGE Open Med. 2019;7:2050312119848247.
- 16. Erdemoglu E, Güney M, Karahan N, et al. Expression of cyclooxygenase-2, matrix metalloproteinase-2 and matrix metalloproteinase-9 in premenopausal and postmenopausal endometrial polyps. Maturitas. 2008;59(3):268-74.
- 17. Özgen E. Endometriyal polip olgularında total oksidan, antioksidan ve tiyol-disülfid homeostazının incelenmesi. Ankara Yıldırım Beyazıt Üniversitesi Tıp Fakültesi; 2020.
- 18. Nayki C, Nayki U, Gunay M, et al. Oxidative and antioxidative status in the endometrium of patients with benign gynecological disorders. J Gynecol Obstet Hum Reprod. 2017;46(3):243-7.
- 19. Çınar M, Eryılmaz ÖG, Özel Ş, et al. The role of oxidative stress markers in development of endometrial polyp. J Exp Ther Oncol. 2016;11(4):269-73.
- 20. Camuzcuoglu H, Arioz DT, Toy H, et al. Serum paraoxonase and arylesterase activities in patients with epithelial ovarian cancer. Gynecol Oncol. 2009;112(3):481-5.
- 21. Toy H, Camuzcuoglu H, Camuzcuoglu A, et al. Decreased serum prolidase activity and increased oxidative stress in early pregnancy loss. Gynecol Obstet Invest. 2010;69(2):122-7.
- 22. Hilali N, Vural M, Camuzcuoglu H, et al. Increased prolidase activity and oxidative stress in PCOS. Clin Endocrinol (Oxf). 2013;79(1):105-10.
Ayrıntılar
| Birincil Dil | İngilizce |
|---|---|
| Konular | Klinik Tıp Bilimleri (Diğer) |
| Bölüm | Araştırma Makalesi |
| Yazarlar | |
| Proje Numarası | This work was supported by the Muğla Sıtkı Koçman University Scientific Research Projects (Nu: 22/136/02/3/3). |
| Yayımlanma Tarihi | 30 Nisan 2024 |
| Gönderilme Tarihi | 11 Ekim 2023 |
| Kabul Tarihi | 13 Mart 2024 |
| Yayımlandığı Sayı | Yıl 2024 Cilt: 11 Sayı: 1 |
