Öz
Kaynakça
- 1. Kinuta K, Tanaka H, Moriwake T, Aya K, Kato S, Seino Y. Vitamin D is an important factor in estrogen biosynthesis of both female and male gonads. Endocrinology. 2000;141(4):1317–1324.
- 2. Elhusseini H, Lizneva D, Gavrilova-jordan L, Eziba N, Abdelaziz M, Brakta S, et al. Vitamin D and female reproduction. In: A critical evaluation of vitamin D-Basic overview. IntechOpen; 2017, p. 298–321.
- 3. Grundmann M, von Versen-Höynck F. Vitamin D - roles in women’s reproductive health? Reprod Biol Endocrinol. 2011;9(1):146.
- 4. Marca A La, Argento C, Sighinolfi G, Grisendi V, Carbone M, Ippolito GD, et al. Possibilities and limits of ovarian reserve testing in ART. Curr Pharm Biotechnol. 2012;13(3):398–408.
- 5. Lima ML, Martins WP, Neto MAC, Nastri CO, Rui A. The assessment of ovarian reserve by antral follicle count in ovaries with endometrioma. Ultrasound Obstet Gynecol. 2015;546(2):239–242.
- 6. Arslan S and Akdevelioğlu Y. The Relationship Between Female Reproductive Functions and Vitamin D. J Am Coll Nutr [Internet]. 2018;37(6):546–551.
- 7. Dennis NA, Houghton LA, Jones GT, Rij AM Van, Morgan K, Mclennan IS. The level of serum Anti-Müllerian hormone correlates with vitamin D status. J Clin Endocrinol Metab. 2012;97(7):2450–2455.
- 8. Pearce K, Gleeson K, Tremellen K. Serum anti-Mullerian hormone production is not correlated with seasonal fluctuations of vitamin D status in ovulatory or PCOS women. Hum Reprod. 2015;30(9):2171–2177.
- 9. Holick MF, Binkley NC, Bischoff-ferrari HA, Gordon CM, Hanley DA, Heaney RP, et al. Evaluation , treatment , and prevention of vitamin D deficiency : an Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab. 2011;96(7):1911–1930.
- 10. Drakopoulos P, Vijver A Van De, Schutyser V, Milatovic S, Anckaert E, Schiettecatte J, et al. The effect of serum vitamin D levels on ovarian reserve markers : a prospective cross-sectional study. Hum Reprod. 2017;32(1):208–214.
- 11. Alavi N, Ebrahimi M, Akbari-asbagh F. The effect of vitamin D status on ovarian reserve markers in infertile women : A prospective cross-sectional study. Int J Reprod Biomed. 2020;18(2):85–92.
- 12. Irani M, Minkoff H, Seifer DB, Merhi Z. Vitamin D increases serum levels of the soluble receptor for advanced glycation end products in women with PCOS. J Clin Endocrinol Metab. 2014;99(5):886–890.
- 13. Merhi Z, Seifer D, Weedon J, Adeyemi O, Holman S, Anastos K, et al. Circulating vitamin D correlates with serum Anti-Mullerian hormone levels in late reproductive-aged women: Women’s interagency HIV study. Fertil Steril. 2012;98(1):228–234.
- 14. Naderi Z, Kashanian M, Chenari L, Sheikhansari N. Evaluating the effects of administration of 25- hydroxyvitamin D supplement on serum anti- mullerian hormone ( AMH ) levels in infertile women. Gynecol Endocrinol. 2017;34(5):409–412.
- 15. Arefi S, Khalili G, Iranmanesh H, Farifteh F, Hosseini A, Fatemi HM, et al. Is the ovarian reserve influenced by vitamin D deficiency and the dress code in an infertile Iranian population ? J Ovarian Res. 2018;11(62):1–6.
- 16. Wheeler MJ. The Measurement of Anti-Müllerian Hormone ( AMH ). Methods Mol Biol. 2013;1065:141–146.
Is there a relation between serum vitamin D and ovarian reserve markers in infertile women?: A retrospective cohort study
Öz
Vitamin D is an essential molecule for reproductive health. There are studies in the literature showing contradictory results regarding te relationship between serum 25(OH) vitamin D levels and ovarian reserve markers. The aim of this retrospective cohort study was to investigate the relationship between ovarian reserve markers; follicle stimulating hormone (FSH), antral follicle count (AFC), and anti-Müllerian hormone (AMH), and serum 25(OH) vitamin D levels. 195 infertil women aged between 18-45 years were included in the study. After the participants were divided into 2 groups according to their 25 (OH) D levels (those with < 20ng/ml (vitamin D deficiency) and those with ≥ 20ng/ml (vitamin D insufficiency)), the age, body mass index (BMI), AFC, AMH, FSH levels of the groups were compared. The mean age of the 25(OH) vitamin D deficient group was significantly younger (p=0.025) than the other group. There was no statistically significant difference in BMI (p=0.47) or season of blood sampling (p=0.62) between groups. The levels of the ovarian reserve markers AFC, AMH, and FSH were not significantly different between groups (p=0.95,0.18,0.86, respectively). Multiple linear regression and logistic regression analysis after adjusting potential confounders showed no significant relationship between vitamin D and AMH (p=0.628) and AFC(p=0.107). In conclusion, we found no correlation between 25(OH) vitamin D concentrations and markers of ovarian reserve. We cannot, however, ignore the critical role of vitamin D in the female reproductivity. To determine the optimal 25(OH)D3 levels during the reproductive period and the amount of vitamin D supplementation required to achieve those levels for the numerous actions of vitamin D throughout reproductivity process, high-quality, large-scale randomized clinical trials are required.
Anahtar Kelimeler
Vitamin D infertility anti-Müllerian hormone antral follicle count
Kaynakça
- 1. Kinuta K, Tanaka H, Moriwake T, Aya K, Kato S, Seino Y. Vitamin D is an important factor in estrogen biosynthesis of both female and male gonads. Endocrinology. 2000;141(4):1317–1324.
- 2. Elhusseini H, Lizneva D, Gavrilova-jordan L, Eziba N, Abdelaziz M, Brakta S, et al. Vitamin D and female reproduction. In: A critical evaluation of vitamin D-Basic overview. IntechOpen; 2017, p. 298–321.
- 3. Grundmann M, von Versen-Höynck F. Vitamin D - roles in women’s reproductive health? Reprod Biol Endocrinol. 2011;9(1):146.
- 4. Marca A La, Argento C, Sighinolfi G, Grisendi V, Carbone M, Ippolito GD, et al. Possibilities and limits of ovarian reserve testing in ART. Curr Pharm Biotechnol. 2012;13(3):398–408.
- 5. Lima ML, Martins WP, Neto MAC, Nastri CO, Rui A. The assessment of ovarian reserve by antral follicle count in ovaries with endometrioma. Ultrasound Obstet Gynecol. 2015;546(2):239–242.
- 6. Arslan S and Akdevelioğlu Y. The Relationship Between Female Reproductive Functions and Vitamin D. J Am Coll Nutr [Internet]. 2018;37(6):546–551.
- 7. Dennis NA, Houghton LA, Jones GT, Rij AM Van, Morgan K, Mclennan IS. The level of serum Anti-Müllerian hormone correlates with vitamin D status. J Clin Endocrinol Metab. 2012;97(7):2450–2455.
- 8. Pearce K, Gleeson K, Tremellen K. Serum anti-Mullerian hormone production is not correlated with seasonal fluctuations of vitamin D status in ovulatory or PCOS women. Hum Reprod. 2015;30(9):2171–2177.
- 9. Holick MF, Binkley NC, Bischoff-ferrari HA, Gordon CM, Hanley DA, Heaney RP, et al. Evaluation , treatment , and prevention of vitamin D deficiency : an Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab. 2011;96(7):1911–1930.
- 10. Drakopoulos P, Vijver A Van De, Schutyser V, Milatovic S, Anckaert E, Schiettecatte J, et al. The effect of serum vitamin D levels on ovarian reserve markers : a prospective cross-sectional study. Hum Reprod. 2017;32(1):208–214.
- 11. Alavi N, Ebrahimi M, Akbari-asbagh F. The effect of vitamin D status on ovarian reserve markers in infertile women : A prospective cross-sectional study. Int J Reprod Biomed. 2020;18(2):85–92.
- 12. Irani M, Minkoff H, Seifer DB, Merhi Z. Vitamin D increases serum levels of the soluble receptor for advanced glycation end products in women with PCOS. J Clin Endocrinol Metab. 2014;99(5):886–890.
- 13. Merhi Z, Seifer D, Weedon J, Adeyemi O, Holman S, Anastos K, et al. Circulating vitamin D correlates with serum Anti-Mullerian hormone levels in late reproductive-aged women: Women’s interagency HIV study. Fertil Steril. 2012;98(1):228–234.
- 14. Naderi Z, Kashanian M, Chenari L, Sheikhansari N. Evaluating the effects of administration of 25- hydroxyvitamin D supplement on serum anti- mullerian hormone ( AMH ) levels in infertile women. Gynecol Endocrinol. 2017;34(5):409–412.
- 15. Arefi S, Khalili G, Iranmanesh H, Farifteh F, Hosseini A, Fatemi HM, et al. Is the ovarian reserve influenced by vitamin D deficiency and the dress code in an infertile Iranian population ? J Ovarian Res. 2018;11(62):1–6.
- 16. Wheeler MJ. The Measurement of Anti-Müllerian Hormone ( AMH ). Methods Mol Biol. 2013;1065:141–146.
Ayrıntılar
| Birincil Dil | İngilizce |
|---|---|
| Konular | Sağlık Kurumları Yönetimi |
| Bölüm | Clinical Research |
| Yazarlar | |
| Erken Görünüm Tarihi | 3 Ocak 2022 |
| Yayımlanma Tarihi | 1 Ocak 2022 |
| Gönderilme Tarihi | 16 Haziran 2021 |
| Kabul Tarihi | 26 Temmuz 2021 |
| Yayımlandığı Sayı | Yıl 2022 Cilt: 39 Sayı: 1 |
Kaynak Göster
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.