Öz
Kolorektal kanser dünya çapında en sık
görülen malignitelerden biridir. Genellikle adenomatöz polip zemini üzerinde
gelişir. İnsan papilloma virüsü (HPV), anogenital enfeksiyonlara neden olur ve
serviks kanseri ile iyi bilinen bir ilişkiye sahiptir. Bununla birlikte, HPV ve
kolorektal polip ve kanser arasındaki ilişkiyi araştıran çalışmalarda çelişkili
sonuçlar vardır. Bu nedenle, kanser potansiyeli yüksek olan kolorektal
adenomatöz poliplerde HPV varlığını değerlendirdik. Çalışmaya, alt
gastrointestinal semptomların taranması veya değerlendirilmesi için total
kolonoskopi uygulanan hastadan ≥1 cm boyutundaki polip alındı. Numuneler,
real-time PCR kullanılarak 25 genotip için tarandı. Real-time PCR kullanılarak
DNA izolasyon analizinde hiçbir örnekte HPV DNA saptanmadı. Sonuç: HPV ile
adenomatöz kolorektal polipler arasında bir ilişkinin olamadığına inanıyoruz. Bu konuyu açıklığa kavuşturmak
için daha fazla çalışmaya ihtiyaç vardır.
Anahtar Kelimeler
Kaynakça
- Brenner H, Altenhofen L, Katalinic A, Lansdorp-Vogelaar I, Hoffmeister M. Sojourn time of preclinical colorectal cancer by sex and age: estimates from the German national screening colonoscopy database. Am J Epidemiol. 2011; 174(10): 1140-1146.
- Atkin WS, Morson BC, Cuzick J. Long-term risk of colorectal cancer after excision of rectosigmoid adenomas. N Engl J Med. 1992; 326(10): 658-662.
- Gazzaz F, Mosli MH, Jawa H, Sibiany A. Detection of human papillomavirus infection by molecular tests and its relation to colonic polyps and colorectal cancer. Saudi Med J. 2016;37(3):256.
- Chen TH, Huang CC, Yeh KT, et al. Human papilloma virus 16 E6 oncoprotein associated with p53 inactivation in colorectal cancer. World J Gastroenterol. 2012; 18(30): 4051.
- Gornick MC, Castellsague X, Sanchez G, et al. Human papillomavirus is not associated with colorectal cancer in a large international study. Cancer Causes Control. 2010; 21(5): 737-743.
- Hixson LJ, Fennerty MB, Sampliner RE, Garewal HS. Prospective blinded trial of the colonoscopic miss-rate of large colorectal polyps. Gastrointest Endosc. 1991;37(2):125-127.
- Burd EM. Human papillomavirus and cervical cancer. Clin Microbiol Rev. 2003; 16(1): 1-17.
- D’Ambrogio A, Yearly S, Sahli R, et al. Human papilloma virus type and recurrence rate after surgical clearance of anal condylomata acuminata. Sex Transm Dis. 2009;36(9):536-540.
- Jelihovschi I, Bidescu AC, Tucaliuc SE, Iancu LS. Detection of human papilloma virus in head and neck squamous cell carcinomas: a literature review. Rev Med Chir a Soc Med si Nat Iasi. 2014; 119(2): 502-509.
- Mohiuddin MK, Chava S, Upendrum P, et al. Role of human papilloma virus infection and altered methylation of specific genes in esophageal cancer. Asian Pac J Cancer Prev. 2013;14(7):4187-4193.
- Ritchie JM, Smith EM, Summersgill KF, et al. Human papillomavirus infection as a prognostic factor in carcinomas of the oral cavity and oropharynx. Int J Cancer. 2003;104(3): 336-344.
- Muto T, Bussey HJR, Morson BC. The evolution of cancer of the colon and rectum. Cancer. 1975;36(6):2251-2270.
- Cappell MS. From colonic polyps to colon cancer: pathophysiology, clinical presentation, screening and colonoscopic therapy. Minerva Gastroenterol Dietol. 2007; 53(4): 351-373.
- Młynarczyk B, Malejczyk M, Muszyński J, Majewski S. The occurrence of human papillomavirus--HPV in the biopsies from colon polyps and cancer. Med Dosw mikrobiol. 2009;61(2):191-196.
- Erol D, Bulut Y, Yüce H, Ozercan IH. Investigation of the presence of human papillomavirus DNA in various gastrointestinal carcinoma samples. Mikrobiyol Bul. 2009; 43(2):259-268.
- Yavuzer D, Karadayi N, Salepci T, Baloglu H, Dabak R, Bayramicli OU. Investigation of human papillomavirus DNA in colorectal carcinomas and adenomas. Med Oncol. 2011;28(1):127-132.
- Burnett-Hartman AN, Newcomb PA, Mandelson M, et al. No evidence for human papillomavirus in the etiology of colorectal polyps. Cancer Epidemiol Biomarkers Prev 2011; 20:2288-2297.
- Shroyer KR, Kim JG, Manos MM, Greer CE, Pearlman NW, Franklin WA. Papillomavirus found in anorectal squamous carcinoma, not in colon adenocarcinoma. Arch Surg. 1992 127(6):741-744.
Öz
Colorectal cancer is one of the most
common malignancies worldwide. It often develops on grounds of adenomatous
polyp. Human papilloma virus (HPV) causes anogenital infections and has
well-known association with cervix cancer. However, there are conflicting
results in the studies investigating relationship between HPV and colorectal
polyps and cancer. Thus, we evaluated presence of HPV in colorectal adenomatous
polyps with high potential for cancer. The study included polyps ≥1 cm in size
from patient who underwent total colonoscopy for screening or evaluation of
lower gastrointestinal symptoms. Samples were screened for 25 genotypes by
using real-time PCR. No HPV DNA was detected in any of samples in DNA isolation
assay by using real-time PCR. We believe that there is no association of
colorectal adenomatous polyps with HPV. Further studies are needed to clarify
this issue.
Anahtar Kelimeler
Kaynakça
- Brenner H, Altenhofen L, Katalinic A, Lansdorp-Vogelaar I, Hoffmeister M. Sojourn time of preclinical colorectal cancer by sex and age: estimates from the German national screening colonoscopy database. Am J Epidemiol. 2011; 174(10): 1140-1146.
- Atkin WS, Morson BC, Cuzick J. Long-term risk of colorectal cancer after excision of rectosigmoid adenomas. N Engl J Med. 1992; 326(10): 658-662.
- Gazzaz F, Mosli MH, Jawa H, Sibiany A. Detection of human papillomavirus infection by molecular tests and its relation to colonic polyps and colorectal cancer. Saudi Med J. 2016;37(3):256.
- Chen TH, Huang CC, Yeh KT, et al. Human papilloma virus 16 E6 oncoprotein associated with p53 inactivation in colorectal cancer. World J Gastroenterol. 2012; 18(30): 4051.
- Gornick MC, Castellsague X, Sanchez G, et al. Human papillomavirus is not associated with colorectal cancer in a large international study. Cancer Causes Control. 2010; 21(5): 737-743.
- Hixson LJ, Fennerty MB, Sampliner RE, Garewal HS. Prospective blinded trial of the colonoscopic miss-rate of large colorectal polyps. Gastrointest Endosc. 1991;37(2):125-127.
- Burd EM. Human papillomavirus and cervical cancer. Clin Microbiol Rev. 2003; 16(1): 1-17.
- D’Ambrogio A, Yearly S, Sahli R, et al. Human papilloma virus type and recurrence rate after surgical clearance of anal condylomata acuminata. Sex Transm Dis. 2009;36(9):536-540.
- Jelihovschi I, Bidescu AC, Tucaliuc SE, Iancu LS. Detection of human papilloma virus in head and neck squamous cell carcinomas: a literature review. Rev Med Chir a Soc Med si Nat Iasi. 2014; 119(2): 502-509.
- Mohiuddin MK, Chava S, Upendrum P, et al. Role of human papilloma virus infection and altered methylation of specific genes in esophageal cancer. Asian Pac J Cancer Prev. 2013;14(7):4187-4193.
- Ritchie JM, Smith EM, Summersgill KF, et al. Human papillomavirus infection as a prognostic factor in carcinomas of the oral cavity and oropharynx. Int J Cancer. 2003;104(3): 336-344.
- Muto T, Bussey HJR, Morson BC. The evolution of cancer of the colon and rectum. Cancer. 1975;36(6):2251-2270.
- Cappell MS. From colonic polyps to colon cancer: pathophysiology, clinical presentation, screening and colonoscopic therapy. Minerva Gastroenterol Dietol. 2007; 53(4): 351-373.
- Młynarczyk B, Malejczyk M, Muszyński J, Majewski S. The occurrence of human papillomavirus--HPV in the biopsies from colon polyps and cancer. Med Dosw mikrobiol. 2009;61(2):191-196.
- Erol D, Bulut Y, Yüce H, Ozercan IH. Investigation of the presence of human papillomavirus DNA in various gastrointestinal carcinoma samples. Mikrobiyol Bul. 2009; 43(2):259-268.
- Yavuzer D, Karadayi N, Salepci T, Baloglu H, Dabak R, Bayramicli OU. Investigation of human papillomavirus DNA in colorectal carcinomas and adenomas. Med Oncol. 2011;28(1):127-132.
- Burnett-Hartman AN, Newcomb PA, Mandelson M, et al. No evidence for human papillomavirus in the etiology of colorectal polyps. Cancer Epidemiol Biomarkers Prev 2011; 20:2288-2297.
- Shroyer KR, Kim JG, Manos MM, Greer CE, Pearlman NW, Franklin WA. Papillomavirus found in anorectal squamous carcinoma, not in colon adenocarcinoma. Arch Surg. 1992 127(6):741-744.
Ayrıntılar
| Birincil Dil | İngilizce |
|---|---|
| Konular | Sağlık Kurumları Yönetimi |
| Bölüm | Araştırma Makalesi |
| Yazarlar | |
| Yayımlanma Tarihi | 30 Eylül 2018 |
| Gönderilme Tarihi | 17 Ağustos 2018 |
| Kabul Tarihi | 18 Ağustos 2018 |
| Yayımlandığı Sayı | Yıl 2018 Cilt: 3 Sayı: 3 |
