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Screening of hepatitis and HIV infections in an alcohol and drug addiction treatment center

Yıl 2020, Cilt: 13 Sayı: 1, 177 - 186, 21.01.2020

Ozgur Dagli

https://doi.org/10.31362/patd.644886

Öz

Purpose: Positivity of HBsAg, anti HCV, and
anti HIV can expected to be higher in patients treated in an Alcohol and Drug Addiction Treatment Center (ADATC)
as they have many risk factors. In this study, screening of these serologic
markers in hospitalised patients was aimed.

Material
and Methods: A
total of 434 patients with a history of alcohol, injecting or noninjecting drug
abuse who received treatment in Bursa ADATC unit in 2016 were included in the
study. Patient’s files were retrospectively screened for  HBsAg, anti HCV,  anti HIV positivity and demographic features.

Results: Of the 434 patients included in the
study  with a mean age of 31.95 ± 11.42
years. HbsAg and anti HCV positivity were 2.8%, and 1.4% respectively. None of
the patients had HIV positivity. 59.2% of the patients had a family history of
drug use.







Conclusion:
It was found that the prevalence of
hepatitis B or hepatitis C was higher in the patients who had begun drug use in
9-12 age range, or in the patients who were homeless, who had no social support
and living alone. Screening of these infections in ADATC is important for
public health which will provide prevention and treatment of these diseases.

Anahtar Kelimeler

Addiction HBV HCV HIV

Kaynakça

  • 1. Basu D, Sharma AK, Gupta S, Nebhinani N, Kumar V. Hepatitis C virus (HCV) infection & risk factors for HCV positivity in injecting & non-injecting drug users attending a de-addiction centre in northern India. The Indian journal of medical research 2015;142:311. https://doi.org/10.4103/0971-5916.166596
  • 2. Mutlu EA, Altıntoprak AE and Tokuçoğlu L. Seroprevalence of hepatitits B, hepatitits C, HIV and syphilis infections among non-injecting drug users. Anadolu Psikiyatri Derg 2015;16:65-68. https://doi.org/10.5455/apd.152522
  • 3. Ruiseñor-Escudero H, Wirtz AL, Berry M, et al. Risky behavior and correlates of HIV and Hepatitis C Virus infection among people who inject drugs in three cities in Afghanistan. Drug & Alcohol Dependence 2014; 143: 127-133. https://doi.org/10.1016/j.drugalcdep.2014.07.022
  • 4. Ott J, Stevens G, Groeger J, Wiersma S. Global epidemiology of hepatitis B virus infection: new estimates of age-specific HBsAg seroprevalence and endemicity. Vaccine 2012; 30:2212-2219. https://doi.org/10.1016/j.vaccine.2011.12.116
  • 5. Gurol E, Saban C, Oral O, Cigdem A, Armagan A. Trends in hepatitis B and hepatitis C virus among blood donors over 16 years in Turkey. European journal of epidemiology 2006; 21:299-305. https://doi.org/10.1007/s10654-006-0001-2
  • 6. Evren C, Bilici R, Üçbilek E, İnan D. Türkiye'de damar içi madde kullanan kişilerde hepatit C enfeksiyonunu önlemeye yönelik eylem çağrısı. Dusunen Adam 2017;30:271-277. https://doi.org/10.5350/dajpn20173004001
  • 7. Alaei A, Alaei K, Waye K, et al. Hepatitis C infection and other drug‐related harms among inpatients who injected drugs in Turkey. Journal of viral hepatitis 2017;24:496-505. https://doi.org/10.1111/jvh.12662
  • 8. Mutlu E, Alaei A, Tracy M, Waye K, Cetin MK, Alaei K. Correlates of injection drug use among individuals admitted to public and private drug treatment facilities in Turkey. Drug & Alcohol Dependence 2016;164:71-81. https://doi.org/10.1016/j.drugalcdep.2016.04.032
  • 9. Fuster D, Sanvisens A, Bolao F, Rivas I, Tor J, Muga R. Alcohol use disorder and its impact on chronic hepatitis C virus and human immunodeficiency virus infections. World journal of hepatology 2016;8:1295. https://doi.org/10.4254/wjh.v8.i31.1295
  • 10. Singal AK, Anand BS. Mechanisms of synergy between alcohol and hepatitis C virus. Journal of clinical gastroenterology 2007;41:761-772. https://doi.org/10.1097/mcg.0b013e3180381584
  • 11. Nolan S, Walley AY, Heeren TC, et al. HIV-infected individuals who use alcohol and other drugs and virologic suppression. AIDS care 2017;29:1129-1136. https://doi.org/10.1080/09540121.2017.1327646
  • 12. Mirsal H, Kalyoncu A, Pektas O, Tan D, Beyazyurek M. The prevalance of hepatitis B, C and HIV seropositivity among iv heroin users. J Depend 2003; 4:10-14.
  • 13. Cicek IE, Cicek E, Kayhan F, et al. The roles of BDNF, S100B, and oxidative stress in interferon-induced depression and the effect of antidepressant treatment in patients with chronic viral hepatitis: a prospective study. J Psychosom Res 2014;76:227-232. https://doi.org/10.1016/j.jpsychores.2014.01.003
  • 14. Tang LS, Covert E, Wilson E, Kottilil S. Chronic hepatitis B infection: a review. Jama 2018; 319: 1802-1813. https://doi.org/10.1001/jama.2018.3795
  • 15. Sterling RK, Dharel N. Treatment of hepatitis C, then, now and tomorrow. BMJ Evidence-Based Medicine 2015;20:23-23. https://doi.org/10.1136/ebmed-2014-110103
  • 16. Kohli A, Shaffer A, Sherman A, Kottilil S. Treatment of hepatitis C: a systematic review. Jama 2014;312:631-640. https://doi.org/10.1001/jama.2014.7085
  • 17. Gu W-G. Newly approved integrase inhibitors for clinical treatment of AIDS. Biomedicine & Pharmacotherapy 2014; 68:917-921. https://doi.org/10.1016/j.biopha.2014.09.013
  • 18. Aktaş EÖ, Koçak A, Şenol E, ve ark. Ege Bölgesinde ele geçirilen narkotik maddeler ve madde bağımlılarının incelenmesi. Turkiye Klinikleri Journal of Forensic Medicine and Forensic Sciences 2006;3:13-24.
  • 19. Avşar G, Koç F, Aslan G. Madde bağımlısı hastalarda sosyal destek ve benlik saygısı ACU Sağlık Bil Derg 2016(1):44-49.
  • 20. Yüncü Z, Basay BK, Özbaran B, Aydin C, Tamar M. Madde kullanim bozuklugu olan ergenlerde HBV: Yayginlik, riskler, asilama/Hepatitis B virus among adolescents with substance use disorder: Prevalence, risks, vaccinization. Anadolu Psikiyatri Dergisi 2008;9:208.
  • 21. Yüncü Z, Saatçioğlu H, Aydın C, Özbaran B, Altıntoprak E, Köse S. Bir şehir efsanesi: madde kullanmaya başlama yaşı düşüyor mu. Literatür Sempozyum 2014;1 (4): 43.2014;50.
  • 22. Karakukcu C, Ciraci MZ, Kocer D, Erturk Zararsiz G, Reyhancan M , Altintop I. Regional drug abuse prevalence depending on laboratory based urine illicit drug screening results. Anadolu Psikiyatri Derg 2018;19:169-176. https://doi.org/10.5455/apd.264474
  • 23. Tekin K. Gençlere yönelik güncel tehdit: bonzai Bağımlılığı. Turkiye Klinikleri Journal of Psychiatric Nursing-Special Topics 2015;1:1-5.
  • 24. Karaaziz M, Keskindağ B. Gençler arasındaki popüler psikoaktif madde; sentetik kannabinoid (bonzai): bir gözden geçirme. Klinik Psikiyatri Dergisi 2016;19:137-144. https://doi.org/10.5505/kpd.2016.03522
  • 25. Tozun N, Ozdogan O, Cakaloglu Y, et al. Seroprevalence of hepatitis B and C virus infections and risk factors in Turkey: a fieldwork TURHEP study. Clinical Microbiology and Infection 2015;21:1020-1026. https://doi.org/10.1016/j.cmi.2015.06.028
  • 26. Stasi C, Silvestri C, Voller F, Cipriani F. The epidemiological changes of HCV and HBV infections in the era of new antiviral therapies and the anti-HBV vaccine. Journal of infection and public health 2016;9:389-395. https://doi.org/10.1016/j.jiph.2015.05.004
  • 27. Lanini S, Easterbrook PJ, Zumla A, Ippolito G. Hepatitis C: global epidemiology and strategies for control. Clinical Microbiology and Infection 2016;22:833-838. https://doi.org/10.1016/j.cmi.2016.07.035
  • 28. Gökengin D. Türkiye’de HIV infeksiyonu: hedefe ne kadar yakınız? Klimik Dergisi 2018;31:4-10. https://doi.org/10.5152/kd.2018.04
  • 29. Kandemir Ö, Gültekin O. Kronik hepatit C enfeksiyonlu damar içi uyusturucu madde kullanicilarinda hepatit C virüs genotiplerinin dagilimi/distribution of hepatitis C virus genotypes in injection drug users with chronic hepatitis C. Türkiye Klinikleri. Tip Bilimleri Dergisi 2017;37:21. https://doi.org/10.5336/medsci.2016-54118
  • 30. Duffell EF, Hedrich D, Mardh O, Mozalevskis A. Towards elimination of hepatitis B and C in european union and european economic area countries: monitoring the World Health Organization’s global health sector strategy core indicators and scaling up key interventions. Eurosurveillance 2017;22:30476 https://doi.org/10.2807/1560-7917.es.2017.22.9.30476

Alkol ve uyuşturucu madde bağımlıları tedavi merkezinde hepatit ve HIV enfeksiyonlarının taranması

Yıl 2020, Cilt: 13 Sayı: 1, 177 - 186, 21.01.2020

Ozgur Dagli

https://doi.org/10.31362/patd.644886

Öz

Amaç: HBsAg, anti HCV ve anti HIV
pozitifliğinin, bir Alkol ve Uyuşturucu Madde Bağımlıları Tedavi Merkezi'nde
(AMATEM) tedavi edilen hastalarda, bir çok risk faktörüne sahip olmaları
nedeniyle daha yüksek olması beklenebilir. Bu çalışmada, hastanede yatan
hastalarda bu serolojik belirteçlerin taranması amaçlandı.

Gereç ve Yöntem: Çalışmaya 2016 yılında Bursa AMATEM
ünitesinde yatarak tedavi gören alkol, intravenöz veya intravenöz olmayan  madde bağımlılığı öyküsü olan toplam 434
hasta dahil edildi. Hasta dosyaları geriye dönük olarak HBsAg, anti HCV, anti
HIV pozitifliği ve demografik özellikler açısından tarandı

Bulgular: Çalışmaya alınan 434 hastanın
ortalama yaşları 31,95 ± 11,42 yıl, HbsAg ve anti HCV pozitifliği ise sırasıyla
% 2,8 ve % 1,4 idi. Hastaların hiçbirinde HIV pozitifliği saptanmadı.
Hastaların% 59,2'sinde ailede uyuşturucu kullanımı öyküsü vardı.







Sonuç: Hepatit B veya hepatit C
prevalansının, 9-12 yaş aralığında madde kullanmaya başlayanlarda veya  evsiz, sosyal destek almayan ve yalnız
yaşayan hastalarda yüksek olduğu bulundu. Bu enfeksiyonların AMATEM’de
taranması halk sağlığı açısından önemli olup bu hastalıkların önlenmesini ve
tedavisini sağlayacaktır.

Anahtar Kelimeler

Bağımlılık HBV HCV HIV

Kaynakça

  • 1. Basu D, Sharma AK, Gupta S, Nebhinani N, Kumar V. Hepatitis C virus (HCV) infection & risk factors for HCV positivity in injecting & non-injecting drug users attending a de-addiction centre in northern India. The Indian journal of medical research 2015;142:311. https://doi.org/10.4103/0971-5916.166596
  • 2. Mutlu EA, Altıntoprak AE and Tokuçoğlu L. Seroprevalence of hepatitits B, hepatitits C, HIV and syphilis infections among non-injecting drug users. Anadolu Psikiyatri Derg 2015;16:65-68. https://doi.org/10.5455/apd.152522
  • 3. Ruiseñor-Escudero H, Wirtz AL, Berry M, et al. Risky behavior and correlates of HIV and Hepatitis C Virus infection among people who inject drugs in three cities in Afghanistan. Drug & Alcohol Dependence 2014; 143: 127-133. https://doi.org/10.1016/j.drugalcdep.2014.07.022
  • 4. Ott J, Stevens G, Groeger J, Wiersma S. Global epidemiology of hepatitis B virus infection: new estimates of age-specific HBsAg seroprevalence and endemicity. Vaccine 2012; 30:2212-2219. https://doi.org/10.1016/j.vaccine.2011.12.116
  • 5. Gurol E, Saban C, Oral O, Cigdem A, Armagan A. Trends in hepatitis B and hepatitis C virus among blood donors over 16 years in Turkey. European journal of epidemiology 2006; 21:299-305. https://doi.org/10.1007/s10654-006-0001-2
  • 6. Evren C, Bilici R, Üçbilek E, İnan D. Türkiye'de damar içi madde kullanan kişilerde hepatit C enfeksiyonunu önlemeye yönelik eylem çağrısı. Dusunen Adam 2017;30:271-277. https://doi.org/10.5350/dajpn20173004001
  • 7. Alaei A, Alaei K, Waye K, et al. Hepatitis C infection and other drug‐related harms among inpatients who injected drugs in Turkey. Journal of viral hepatitis 2017;24:496-505. https://doi.org/10.1111/jvh.12662
  • 8. Mutlu E, Alaei A, Tracy M, Waye K, Cetin MK, Alaei K. Correlates of injection drug use among individuals admitted to public and private drug treatment facilities in Turkey. Drug & Alcohol Dependence 2016;164:71-81. https://doi.org/10.1016/j.drugalcdep.2016.04.032
  • 9. Fuster D, Sanvisens A, Bolao F, Rivas I, Tor J, Muga R. Alcohol use disorder and its impact on chronic hepatitis C virus and human immunodeficiency virus infections. World journal of hepatology 2016;8:1295. https://doi.org/10.4254/wjh.v8.i31.1295
  • 10. Singal AK, Anand BS. Mechanisms of synergy between alcohol and hepatitis C virus. Journal of clinical gastroenterology 2007;41:761-772. https://doi.org/10.1097/mcg.0b013e3180381584
  • 11. Nolan S, Walley AY, Heeren TC, et al. HIV-infected individuals who use alcohol and other drugs and virologic suppression. AIDS care 2017;29:1129-1136. https://doi.org/10.1080/09540121.2017.1327646
  • 12. Mirsal H, Kalyoncu A, Pektas O, Tan D, Beyazyurek M. The prevalance of hepatitis B, C and HIV seropositivity among iv heroin users. J Depend 2003; 4:10-14.
  • 13. Cicek IE, Cicek E, Kayhan F, et al. The roles of BDNF, S100B, and oxidative stress in interferon-induced depression and the effect of antidepressant treatment in patients with chronic viral hepatitis: a prospective study. J Psychosom Res 2014;76:227-232. https://doi.org/10.1016/j.jpsychores.2014.01.003
  • 14. Tang LS, Covert E, Wilson E, Kottilil S. Chronic hepatitis B infection: a review. Jama 2018; 319: 1802-1813. https://doi.org/10.1001/jama.2018.3795
  • 15. Sterling RK, Dharel N. Treatment of hepatitis C, then, now and tomorrow. BMJ Evidence-Based Medicine 2015;20:23-23. https://doi.org/10.1136/ebmed-2014-110103
  • 16. Kohli A, Shaffer A, Sherman A, Kottilil S. Treatment of hepatitis C: a systematic review. Jama 2014;312:631-640. https://doi.org/10.1001/jama.2014.7085
  • 17. Gu W-G. Newly approved integrase inhibitors for clinical treatment of AIDS. Biomedicine & Pharmacotherapy 2014; 68:917-921. https://doi.org/10.1016/j.biopha.2014.09.013
  • 18. Aktaş EÖ, Koçak A, Şenol E, ve ark. Ege Bölgesinde ele geçirilen narkotik maddeler ve madde bağımlılarının incelenmesi. Turkiye Klinikleri Journal of Forensic Medicine and Forensic Sciences 2006;3:13-24.
  • 19. Avşar G, Koç F, Aslan G. Madde bağımlısı hastalarda sosyal destek ve benlik saygısı ACU Sağlık Bil Derg 2016(1):44-49.
  • 20. Yüncü Z, Basay BK, Özbaran B, Aydin C, Tamar M. Madde kullanim bozuklugu olan ergenlerde HBV: Yayginlik, riskler, asilama/Hepatitis B virus among adolescents with substance use disorder: Prevalence, risks, vaccinization. Anadolu Psikiyatri Dergisi 2008;9:208.
  • 21. Yüncü Z, Saatçioğlu H, Aydın C, Özbaran B, Altıntoprak E, Köse S. Bir şehir efsanesi: madde kullanmaya başlama yaşı düşüyor mu. Literatür Sempozyum 2014;1 (4): 43.2014;50.
  • 22. Karakukcu C, Ciraci MZ, Kocer D, Erturk Zararsiz G, Reyhancan M , Altintop I. Regional drug abuse prevalence depending on laboratory based urine illicit drug screening results. Anadolu Psikiyatri Derg 2018;19:169-176. https://doi.org/10.5455/apd.264474
  • 23. Tekin K. Gençlere yönelik güncel tehdit: bonzai Bağımlılığı. Turkiye Klinikleri Journal of Psychiatric Nursing-Special Topics 2015;1:1-5.
  • 24. Karaaziz M, Keskindağ B. Gençler arasındaki popüler psikoaktif madde; sentetik kannabinoid (bonzai): bir gözden geçirme. Klinik Psikiyatri Dergisi 2016;19:137-144. https://doi.org/10.5505/kpd.2016.03522
  • 25. Tozun N, Ozdogan O, Cakaloglu Y, et al. Seroprevalence of hepatitis B and C virus infections and risk factors in Turkey: a fieldwork TURHEP study. Clinical Microbiology and Infection 2015;21:1020-1026. https://doi.org/10.1016/j.cmi.2015.06.028
  • 26. Stasi C, Silvestri C, Voller F, Cipriani F. The epidemiological changes of HCV and HBV infections in the era of new antiviral therapies and the anti-HBV vaccine. Journal of infection and public health 2016;9:389-395. https://doi.org/10.1016/j.jiph.2015.05.004
  • 27. Lanini S, Easterbrook PJ, Zumla A, Ippolito G. Hepatitis C: global epidemiology and strategies for control. Clinical Microbiology and Infection 2016;22:833-838. https://doi.org/10.1016/j.cmi.2016.07.035
  • 28. Gökengin D. Türkiye’de HIV infeksiyonu: hedefe ne kadar yakınız? Klimik Dergisi 2018;31:4-10. https://doi.org/10.5152/kd.2018.04
  • 29. Kandemir Ö, Gültekin O. Kronik hepatit C enfeksiyonlu damar içi uyusturucu madde kullanicilarinda hepatit C virüs genotiplerinin dagilimi/distribution of hepatitis C virus genotypes in injection drug users with chronic hepatitis C. Türkiye Klinikleri. Tip Bilimleri Dergisi 2017;37:21. https://doi.org/10.5336/medsci.2016-54118
  • 30. Duffell EF, Hedrich D, Mardh O, Mozalevskis A. Towards elimination of hepatitis B and C in european union and european economic area countries: monitoring the World Health Organization’s global health sector strategy core indicators and scaling up key interventions. Eurosurveillance 2017;22:30476 https://doi.org/10.2807/1560-7917.es.2017.22.9.30476
Toplam 30 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Bulaşıcı Hastalıklar
Bölüm Araştırma Makalesi
Yazarlar

Ozgur Dagli 0000-0002-6978-8671

Yayımlanma Tarihi 21 Ocak 2020
Gönderilme Tarihi 10 Kasım 2019
Kabul Tarihi 30 Aralık 2019
Yayımlandığı Sayı Yıl 2020 Cilt: 13 Sayı: 1

Kaynak Göster

APA Dagli, O. (2020). Screening of hepatitis and HIV infections in an alcohol and drug addiction treatment center. Pamukkale Medical Journal, 13(1), 177-186. https://doi.org/10.31362/patd.644886
AMA Dagli O. Screening of hepatitis and HIV infections in an alcohol and drug addiction treatment center. Pam Tıp Derg. Ocak 2020;13(1):177-186. doi:10.31362/patd.644886
Chicago Dagli, Ozgur. “Screening of Hepatitis and HIV Infections in an Alcohol and Drug Addiction Treatment Center”. Pamukkale Medical Journal 13, sy. 1 (Ocak 2020): 177-86. https://doi.org/10.31362/patd.644886.
EndNote Dagli O (01 Ocak 2020) Screening of hepatitis and HIV infections in an alcohol and drug addiction treatment center. Pamukkale Medical Journal 13 1 177–186.
IEEE O. Dagli, “Screening of hepatitis and HIV infections in an alcohol and drug addiction treatment center”, Pam Tıp Derg, c. 13, sy. 1, ss. 177–186, 2020, doi: 10.31362/patd.644886.
ISNAD Dagli, Ozgur. “Screening of Hepatitis and HIV Infections in an Alcohol and Drug Addiction Treatment Center”. Pamukkale Medical Journal 13/1 (Ocak 2020), 177-186. https://doi.org/10.31362/patd.644886.
JAMA Dagli O. Screening of hepatitis and HIV infections in an alcohol and drug addiction treatment center. Pam Tıp Derg. 2020;13:177–186.
MLA Dagli, Ozgur. “Screening of Hepatitis and HIV Infections in an Alcohol and Drug Addiction Treatment Center”. Pamukkale Medical Journal, c. 13, sy. 1, 2020, ss. 177-86, doi:10.31362/patd.644886.
Vancouver Dagli O. Screening of hepatitis and HIV infections in an alcohol and drug addiction treatment center. Pam Tıp Derg. 2020;13(1):177-86.
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