Toplantı Özeti
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DIETARY-BASED MOLECULAR TARGETS AND THERAPEUTIC OPPORTUNITIES IN CANCER

Yıl 2022, Cilt: 5 Sayı: S-1, 32 - 32, 09.08.2022
https://doi.org/10.26650/JARHS2021-1135830

Öz

Diet influence human health in different ways. But it is well known that diet can adversely affect various human pathologies, like obesity, diabetes, hypertension, and cancer. The relationship between diet, obesity and cancer has been studied for different types of cancer such as breast, colorectal and gastric cancers. High fat diet induced obesity is an established risk factor for cancer in many tissues. In the mammalian intestine, tumorigenesis is facilitated by a pro-obesity high-fat diet (HFD) by enhancing PPAR (peroxisome proliferator-activated receptor) nuclear receptor activation. PPARs induced fatty acid oxidation increased stem cell number and tumorigenesis. The rate controlling enzyme of fatty acid oxidation, CPT1A, dampens the pro-tumorigenic phenotype by blunting HFD effect in ISCs. High-fat ketogenic diet also elevates ISC function and regeneration capacity through βOHB-mediated Notch signaling, but a glucose-supplemented diet has the opposite effects. High glucose diet also presents an indirect link between sugar and cancer. The relationship dietary supplements used in addition to the diet and cancer is frequently studied. In literature, there is strong evidence on the anticancer effects of anthocyanins, curcumin, vitamin D, and their mechanisms.

Kaynakça

  • Wellek S, Blettner M. On the proper use of the crossover design in clinical trials: part 18 of a series on evaluation of scientific publications. Dtsch Arztebl Int. 2012;109(15):276-81

DIETARY-BASED MOLECULAR TARGETS AND THERAPEUTIC OPPORTUNITIES IN CANCER

Yıl 2022, Cilt: 5 Sayı: S-1, 32 - 32, 09.08.2022
https://doi.org/10.26650/JARHS2021-1135830

Öz

Diet influence human health in different ways. But it is well known that diet can adversely affect various human pathologies, like obesity, diabetes,
hypertension, and cancer. The relationship between diet, obesity and cancer has been studied for different types of cancer such as breast, colorectal and
gastric cancers. High fat diet induced obesity is an established risk factor for cancer in many tissues. In the mammalian intestine, tumorigenesis is facilitated
by a pro-obesity high-fat diet (HFD) by enhancing PPAR (peroxisome proliferator-activated receptor) nuclear receptor activation. PPARs induced fatty acid
oxidation increased stem cell number and tumorigenesis. The rate controlling enzyme of fatty acid oxidation, CPT1A, dampens the pro-tumorigenic
phenotype by blunting HFD effect in ISCs. High-fat ketogenic diet also elevates ISC function and regeneration capacity through βOHB-mediated Notch
signaling, but a glucose-supplemented diet has the opposite effects. High glucose diet also presents an indirect link between sugar and cancer. The
relationship dietary supplements used in addition to the diet and cancer is frequently studied. In literature, there is strong evidence on the anticancer
effects of anthocyanins, curcumin, vitamin D, and their mechanisms.

Kaynakça

  • Wellek S, Blettner M. On the proper use of the crossover design in clinical trials: part 18 of a series on evaluation of scientific publications. Dtsch Arztebl Int. 2012;109(15):276-81
Toplam 1 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Klinik Tıp Bilimleri
Bölüm Toplantı Özeti
Yazarlar

Gizem Çalıbaşı Koçal 0000-0002-3201-4752

Yayımlanma Tarihi 9 Ağustos 2022
Gönderilme Tarihi 25 Haziran 2022
Yayımlandığı Sayı Yıl 2022 Cilt: 5 Sayı: S-1

Kaynak Göster

MLA Çalıbaşı Koçal, Gizem. “DIETARY-BASED MOLECULAR TARGETS AND THERAPEUTIC OPPORTUNITIES IN CANCER”. Sağlık Bilimlerinde İleri Araştırmalar Dergisi, c. 5, sy. S-1, 2022, ss. 32-32, doi:10.26650/JARHS2021-1135830.