Araştırma Makalesi
BibTex RIS Kaynak Göster
Yıl 2019, Cilt: 1 Sayı: 1, 35 - 41, 18.03.2019

Öz

Kaynakça

  • 1. Marur S, Forastiere AA. Head and neck squamous cell carcinoma: Update on epidemiology, diagnosis, and treatment. Mayo Clin Proc 2016;91:386-96.
  • 2. Siegel R, Naishadham D, Jemal A. Cancer statistics, 2012. CA Cancer J Clin 2012;62:10-29.
  • 3. Mor N, Blitzer A. Functional anatomy and oncologic barriers of the larynx. Otolaryngol Clin North Am 2015;48:533-45.
  • 4. Hirvikoski P, Virtaniemi J, Kumpulainen E, Johansson R, Kosma VM. Supraglottic and glottic carcinomas. Clinically and biologically distinct entities? Eur J Cancer 2002;38:1717-23.
  • 5. Groome PA, O'Sullivan B, Irish JC, Rothwell DM, Schulze K, Warde PR, et al. Management and outcome differences in supraglottic cancer between ontario, canada, and the surveillance, epidemiology, and end results areas of the united states. J Clin Oncol 2003;21:496-505.
  • 6. Mendenhall WM, Werning JW, Hinerman RW, Amdur RJ, Villaret DB. Management of t1-t2 glottic carcinomas. Cancer 2004;100:1786-92.
  • 7. Luscher MS, Pedersen U, Johansen LV. Treatment outcome after laser excision of early glottic squamous cell carcinoma--a literature survey. Acta Oncol 2001;40:796-800.
  • 8. Ermis E, Teo M, Dyker KE, Fosker C, Sen M, Prestwich RJ. Definitive hypofractionated radiotherapy for early glottic carcinoma: Experience of 55gy in 20 fractions. Radiat Oncol 2015;10:203.
  • 9. Steuer CE, El-Deiry M, Parks JR, Higgins KA, Saba NF. An update on larynx cancer. CA Cancer J Clin 2017;67:31-50.
  • 10. Hartl DM, Ferlito A, Brasnu DF, Langendijk JA, Rinaldo A, Silver CE, et al. Evidence-based review of treatment options for patients with glottic cancer. Head Neck 2011;33:1638-48.
  • 11. Yamazaki H, Nishiyama K, Tanaka E, Koizumi M, Chatani M. Radiotherapy for early glottic carcinoma (t1n0m0): Results of prospective randomized study of radiation fraction size and overall treatment time. Int J Radiat Oncol Biol Phys 2006;64:77-82.
  • 12. Gultekin M, Ozyar E, Cengiz M, Ozyigit G, Hayran M, Hosal S, et al. High daily fraction dose external radiotherapy for t1 glottic carcinoma: Treatment results and prognostic factors. Head Neck 2012;34:1009-14.
  • 13. Le QT, Fu KK, Kroll S, Ryu JK, Quivey JM, Meyler TS, et al. Influence of fraction size, total dose, and overall time on local control of t1-t2 glottic carcinoma. Int J Radiat Oncol Biol Phys 1997;39:115-26.
  • 14. Chera BS, Amdur RJ, Morris CG, Kirwan JM, Mendenhall WM. T1n0 to t2n0 squamous cell carcinoma of the glottic larynx treated with definitive radiotherapy. Int J Radiat Oncol Biol Phys 2010;78:461-6.
  • 15. Warde P, O'Sullivan B, Bristow RG, Panzarella T, Keane TJ, Gullane PJ, et al. T1/t2 glottic cancer managed by external beam radiotherapy: The influence of pretreatment hemoglobin on local control. Int J Radiat Oncol Biol Phys 1998;41:347-53.
  • 16. Larson JT, Adams GL, Fattah HA. Survival statistics for multiple primaries in head and neck cancer. Otolaryngol Head Neck Surg 1990;103:14-24.
  • 17. Hong WK, Lippman SM, Itri LM, Karp DD, Lee JS, Byers RM, et al. Prevention of second primary tumors with isotretinoin in squamous-cell carcinoma of the head and neck. N Engl J Med 1990;323:795-801.
  • 18. Chuang SC, Scelo G, Tonita JM, Tamaro S, Jonasson JG, Kliewer EV, et al. Risk of second primary cancer among patients with head and neck cancers: A pooled analysis of 13 cancer registries. Int J Cancer 2008;123:2390-6.
  • 19. Holland JM, Arsanjani A, Liem BJ, Hoffelt SC, Cohen JI, Stevens KR, Jr. Second malignancies in early stage laryngeal carcinoma patients treated with radiotherapy. J Laryngol Otol 2002;116:190-3.
  • 20. Chu PY, Chang SY, Huang JL, Tai SK. Different patterns of second primary malignancy in patients with squamous cell carcinoma of larynx and hypopharynx. Am J Otolaryngol 2010;31:168-74.
  • 21. Laskar SG, Baijal G, Murthy V, Chilukuri S, Budrukkar A, Gupta T, et al. Hypofractionated radiotherapy for t1n0m0 glottic cancer: Retrospective analysis of two different cohorts of dose-fractionation schedules from a single institution. Clin Oncol (R Coll Radiol) 2012;24:e180-6.
  • 22. Dagli AS, Mahieu HF, Festen JM. Quantitative analysis of voice quality in early glottic laryngeal carcinomas treated with radiotherapy. Eur Arch Otorhinolaryngol 1997;254:78-80.
  • 23. Aaltonen LM, Rautiainen N, Sellman J, Saarilahti K, Makitie A, Rihkanen H, et al. Voice quality after treatment of early vocal cord cancer: A randomized trial comparing laser surgery with radiation therapy. Int J Radiat Oncol Biol Phys 2014;90:255-60.
  • 24. Llewellyn-Thomas HA, Sutherland HJ, Hogg SA, Ciampi A, Harwood AR, Keane TJ, et al. Linear analogue self-assessment of voice quality in laryngeal cancer. J Chronic Dis 1984;37:917-24.
  • 25. Gomez D, Cahlon O, Mechalakos J, Lee N. An investigation of intensity-modulated radiation therapy versus conventional two-dimensional and 3d-conformal radiation therapy for early stage larynx cancer. Radiat Oncol 2010;5:74.
  • 26. Chang YJ, Chang TC, Lee TH, Ryu SJ. Predictors of carotid artery stenosis after radiotherapy for head and neck cancers. J Vasc Surg 2009;50:280-5.
  • 27. Cheng SW, Ting AC, Ho P, Wu LL. Accelerated progression of carotid stenosis in patients with previous external neck irradiation. J Vasc Surg 2004;39:409-15.

The Outcomes of Patients with T1n0m0 Glottic Laryngeal Carcinoma Undergoing Radical Radiotherapy

Yıl 2019, Cilt: 1 Sayı: 1, 35 - 41, 18.03.2019

Öz

Amaç: T1N0M0 glottik larenks kanseri (GLK) nedeniyle radyoterapi almış hastalarda sağkalım ve uzun dönem toksisite sonuçlarımız ve ilişkili faktörlerin araştırılması.

Gereç ve Yöntem: Ocak 2007-Mayıs 2017 arasında 64,4 Gy (2,3 Gy/fx) radyoterapi alan 90 hasta geriye dönük olarak analiz edilmiştir. Sağkalım analizleri radyoterapi son günü ve son kontrol/olay tarihi temel alınarak Kaplan Meire yöntemiyle hesaplanmış olup geç yan etkiler Radiation Therapy Oncology Group’un (RTOG) kriterlerine göre değerlendirilmiştir.

Bulgular: Ortanca takip süresi 57 ay (0-129 ay) olup 12 (%13,3) hastada relaps gelişmiştir: %11,1 lokal, %1,1 lokal-bölgesel ve %1,1 lokal-bölgesel-uzak şeklindedir. Takipte 14 hasta ölmüş ve ölüm nedenleri 7 (%50) larenks kanser (LK), 5 (%35,7) ikinci primer kanser (İPK) ve 2 (%14,3) kanser dışı sebeplerdir. Relaps gelişen 12 hastanın 7’si (%58,3) LK, 1’i (%8,3) İPK ve 1’i (%8,3) kanser dışı sebeplerden kaybedilmiştir. Genel, hastalığa özgü ve lokal relapssız 5-yıllık sağkalımlar sırasıyla %88,7, %94 ve %83,6’dır. İPK 11 (%12,2) hastada gelişmiş olup %81,8’i akciğer kanseridir. İPK’ya kadar geçen ortanca süres 44,5 aydır (aralık: 23-105). İPK’lı hastaların ortanca sağkalımları İPK’sı olmayanlara göre daha kötü olup (66 ay vs. ortanca değere ulaşılamamıştır; p=0,005), 5 yıllık sağkalım sonuçları (%72,7 vs. %91,3) şeklinde bulunmuştur. Toplam 1 hastada (%1,1) geçici trakeostomi gerektiren grad 3 larenks ödemi ve 1 (%1,1) hastada sol karotis arter darlığı gelişmiştir.

Sonuç: Erken evre GLK’lı hastalarda İPK ölüm sebebi açsından ana hastalıkla yarışır niteliktedir. Radyoterapiye bağlı gelişebilen karotis arter darlığının takip sürelerinin uzamasıyla daha ön plana çıkabileceği ön görülmektedir.

Kaynakça

  • 1. Marur S, Forastiere AA. Head and neck squamous cell carcinoma: Update on epidemiology, diagnosis, and treatment. Mayo Clin Proc 2016;91:386-96.
  • 2. Siegel R, Naishadham D, Jemal A. Cancer statistics, 2012. CA Cancer J Clin 2012;62:10-29.
  • 3. Mor N, Blitzer A. Functional anatomy and oncologic barriers of the larynx. Otolaryngol Clin North Am 2015;48:533-45.
  • 4. Hirvikoski P, Virtaniemi J, Kumpulainen E, Johansson R, Kosma VM. Supraglottic and glottic carcinomas. Clinically and biologically distinct entities? Eur J Cancer 2002;38:1717-23.
  • 5. Groome PA, O'Sullivan B, Irish JC, Rothwell DM, Schulze K, Warde PR, et al. Management and outcome differences in supraglottic cancer between ontario, canada, and the surveillance, epidemiology, and end results areas of the united states. J Clin Oncol 2003;21:496-505.
  • 6. Mendenhall WM, Werning JW, Hinerman RW, Amdur RJ, Villaret DB. Management of t1-t2 glottic carcinomas. Cancer 2004;100:1786-92.
  • 7. Luscher MS, Pedersen U, Johansen LV. Treatment outcome after laser excision of early glottic squamous cell carcinoma--a literature survey. Acta Oncol 2001;40:796-800.
  • 8. Ermis E, Teo M, Dyker KE, Fosker C, Sen M, Prestwich RJ. Definitive hypofractionated radiotherapy for early glottic carcinoma: Experience of 55gy in 20 fractions. Radiat Oncol 2015;10:203.
  • 9. Steuer CE, El-Deiry M, Parks JR, Higgins KA, Saba NF. An update on larynx cancer. CA Cancer J Clin 2017;67:31-50.
  • 10. Hartl DM, Ferlito A, Brasnu DF, Langendijk JA, Rinaldo A, Silver CE, et al. Evidence-based review of treatment options for patients with glottic cancer. Head Neck 2011;33:1638-48.
  • 11. Yamazaki H, Nishiyama K, Tanaka E, Koizumi M, Chatani M. Radiotherapy for early glottic carcinoma (t1n0m0): Results of prospective randomized study of radiation fraction size and overall treatment time. Int J Radiat Oncol Biol Phys 2006;64:77-82.
  • 12. Gultekin M, Ozyar E, Cengiz M, Ozyigit G, Hayran M, Hosal S, et al. High daily fraction dose external radiotherapy for t1 glottic carcinoma: Treatment results and prognostic factors. Head Neck 2012;34:1009-14.
  • 13. Le QT, Fu KK, Kroll S, Ryu JK, Quivey JM, Meyler TS, et al. Influence of fraction size, total dose, and overall time on local control of t1-t2 glottic carcinoma. Int J Radiat Oncol Biol Phys 1997;39:115-26.
  • 14. Chera BS, Amdur RJ, Morris CG, Kirwan JM, Mendenhall WM. T1n0 to t2n0 squamous cell carcinoma of the glottic larynx treated with definitive radiotherapy. Int J Radiat Oncol Biol Phys 2010;78:461-6.
  • 15. Warde P, O'Sullivan B, Bristow RG, Panzarella T, Keane TJ, Gullane PJ, et al. T1/t2 glottic cancer managed by external beam radiotherapy: The influence of pretreatment hemoglobin on local control. Int J Radiat Oncol Biol Phys 1998;41:347-53.
  • 16. Larson JT, Adams GL, Fattah HA. Survival statistics for multiple primaries in head and neck cancer. Otolaryngol Head Neck Surg 1990;103:14-24.
  • 17. Hong WK, Lippman SM, Itri LM, Karp DD, Lee JS, Byers RM, et al. Prevention of second primary tumors with isotretinoin in squamous-cell carcinoma of the head and neck. N Engl J Med 1990;323:795-801.
  • 18. Chuang SC, Scelo G, Tonita JM, Tamaro S, Jonasson JG, Kliewer EV, et al. Risk of second primary cancer among patients with head and neck cancers: A pooled analysis of 13 cancer registries. Int J Cancer 2008;123:2390-6.
  • 19. Holland JM, Arsanjani A, Liem BJ, Hoffelt SC, Cohen JI, Stevens KR, Jr. Second malignancies in early stage laryngeal carcinoma patients treated with radiotherapy. J Laryngol Otol 2002;116:190-3.
  • 20. Chu PY, Chang SY, Huang JL, Tai SK. Different patterns of second primary malignancy in patients with squamous cell carcinoma of larynx and hypopharynx. Am J Otolaryngol 2010;31:168-74.
  • 21. Laskar SG, Baijal G, Murthy V, Chilukuri S, Budrukkar A, Gupta T, et al. Hypofractionated radiotherapy for t1n0m0 glottic cancer: Retrospective analysis of two different cohorts of dose-fractionation schedules from a single institution. Clin Oncol (R Coll Radiol) 2012;24:e180-6.
  • 22. Dagli AS, Mahieu HF, Festen JM. Quantitative analysis of voice quality in early glottic laryngeal carcinomas treated with radiotherapy. Eur Arch Otorhinolaryngol 1997;254:78-80.
  • 23. Aaltonen LM, Rautiainen N, Sellman J, Saarilahti K, Makitie A, Rihkanen H, et al. Voice quality after treatment of early vocal cord cancer: A randomized trial comparing laser surgery with radiation therapy. Int J Radiat Oncol Biol Phys 2014;90:255-60.
  • 24. Llewellyn-Thomas HA, Sutherland HJ, Hogg SA, Ciampi A, Harwood AR, Keane TJ, et al. Linear analogue self-assessment of voice quality in laryngeal cancer. J Chronic Dis 1984;37:917-24.
  • 25. Gomez D, Cahlon O, Mechalakos J, Lee N. An investigation of intensity-modulated radiation therapy versus conventional two-dimensional and 3d-conformal radiation therapy for early stage larynx cancer. Radiat Oncol 2010;5:74.
  • 26. Chang YJ, Chang TC, Lee TH, Ryu SJ. Predictors of carotid artery stenosis after radiotherapy for head and neck cancers. J Vasc Surg 2009;50:280-5.
  • 27. Cheng SW, Ting AC, Ho P, Wu LL. Accelerated progression of carotid stenosis in patients with previous external neck irradiation. J Vasc Surg 2004;39:409-15.
Toplam 27 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Konular Sağlık Kurumları Yönetimi
Bölüm Makaleler
Yazarlar

Yurday Ozdemir 0000-0002-2218-2074

Erkan Topkan 0000-0001-8120-7123

Yayımlanma Tarihi 18 Mart 2019
Gönderilme Tarihi 8 Ocak 2019
Yayımlandığı Sayı Yıl 2019 Cilt: 1 Sayı: 1

Kaynak Göster

APA Ozdemir, Y., & Topkan, E. (2019). The Outcomes of Patients with T1n0m0 Glottic Laryngeal Carcinoma Undergoing Radical Radiotherapy. Troia Medical Journal, 1(1), 35-41.
AMA Ozdemir Y, Topkan E. The Outcomes of Patients with T1n0m0 Glottic Laryngeal Carcinoma Undergoing Radical Radiotherapy. Troia Med J. Mart 2019;1(1):35-41.
Chicago Ozdemir, Yurday, ve Erkan Topkan. “The Outcomes of Patients With T1n0m0 Glottic Laryngeal Carcinoma Undergoing Radical Radiotherapy”. Troia Medical Journal 1, sy. 1 (Mart 2019): 35-41.
EndNote Ozdemir Y, Topkan E (01 Mart 2019) The Outcomes of Patients with T1n0m0 Glottic Laryngeal Carcinoma Undergoing Radical Radiotherapy. Troia Medical Journal 1 1 35–41.
IEEE Y. Ozdemir ve E. Topkan, “The Outcomes of Patients with T1n0m0 Glottic Laryngeal Carcinoma Undergoing Radical Radiotherapy”, Troia Med J, c. 1, sy. 1, ss. 35–41, 2019.
ISNAD Ozdemir, Yurday - Topkan, Erkan. “The Outcomes of Patients With T1n0m0 Glottic Laryngeal Carcinoma Undergoing Radical Radiotherapy”. Troia Medical Journal 1/1 (Mart 2019), 35-41.
JAMA Ozdemir Y, Topkan E. The Outcomes of Patients with T1n0m0 Glottic Laryngeal Carcinoma Undergoing Radical Radiotherapy. Troia Med J. 2019;1:35–41.
MLA Ozdemir, Yurday ve Erkan Topkan. “The Outcomes of Patients With T1n0m0 Glottic Laryngeal Carcinoma Undergoing Radical Radiotherapy”. Troia Medical Journal, c. 1, sy. 1, 2019, ss. 35-41.
Vancouver Ozdemir Y, Topkan E. The Outcomes of Patients with T1n0m0 Glottic Laryngeal Carcinoma Undergoing Radical Radiotherapy. Troia Med J. 2019;1(1):35-41.