Araştırma Makalesi
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Kanser Hastalarında Kemoterapi İlişkili Maninin Değerlendirilmesi

Yıl 2024, Cilt: 4 Sayı: 1, 623 - 631, 25.04.2024

Öz

Amaç: Bu çalışmanın amacı kanser hastalarında kemoterapiye bağlı maniyi değerlendirmektir. Gereç ve Yöntem: Kemoterapi alan 153 kanser hastasının mani durumu, kemoterapiye başlamadan önce ve bir seans kemoterapi rejimi sonrasında Young Mani Derecelendirme Ölçeği uygulanarak karşılaştırıldı. Bulgular: Kemoterapötik ajanlara göre tedavi öncesi ve tedavi sonrası mani toplam puanları karşılaştırıldığında, Fluorourasil-Folinik Asit-Oksaliplatin Folfox (p= 0,014) ve Paklitaksel (p=0,036) kemoterapi rejimi kullananlarda tedavi sonrası mani toplam puanlarının arttığı görüldü. Folfox rejimi alan 8 (%5,2) hastada mani skoru 20 puanın üzerine çıktı. Sonuçlar: Kan-beyin bariyeri merkezi sinir sistemini birçok ilacın toksisitesinden korusa da kanser tanısı stresi ve tedavide kullanılan bazı kemoterapötikler akut konfüzyon, depresyon ve mani gibi bozukluklara neden olabilir. Çalışmamızda, literatürdeki olgu bazlı yayınlarda olduğu gibi, 5-florourasil'in kan-beyin bariyerini kolaylıkla geçebilmesi nedeniyle Folfox rejiminde toplam mani skorunda istatistiksel olarak anlamlı bir artış tespit edildi. Literatürde yayınlanmış olgu sunumlarına göre ilaçların kümülatif veya gecikmiş yan etkileri nedeniyle ikinci, üçüncü ve bazen daha sonraki seanslarda mani belirtilerinin ortaya çıkma ihtimali dikkate alınmalıdır.

Etik Beyan

Bu çalışma için Karabük Üniversitesi Girişimsel Olmayan Etik kuruldan etik onay alındı (Onay No: 2021/726).

Destekleyen Kurum

yok

Teşekkür

yok

Kaynakça

  • Ahmed, N., Usmani, S., Jabbour, N., & Hegde, U. (2011). Acute psychosis after paclitaxel infusion. Conn Med., 75(8), 465-466. Retrieved from https://pubmed.ncbi.nlm.nih.gov/21980675/.
  • Bellman, V., Russell, N., Depala, K., Dellenbaugh, A., … Srinivas, S. (2021). Challenges in Treating Cancer Patients With Unstable Psychiatric Disorder. World J Oncol., 12(5), 137-148. http://dx.doi.org/10.14740/wjon1402.
  • Bond, S. M., Neelon, V. J., & Belyea, M. J. (2006). Delirium in hospitalized older patients with cancer. Oncol Nurs Forum, 33(6), 1075-1083. http://dx.doi.org/10.1188/06.ONF.1075-1083.
  • Cerullo, M. A. (2006). Corticosteroid-induced mania: Prepare for the unpredictable. Current Psychiatry, 5(6), 43.
  • Choi, S. M., Lee, S. H., Yang, Y. S., Kim, B. C., Kim, M. K., & Cho, K. H. (2001). 5-fluorouracil-induced leukoencephalopathy in patients with breast cancer. J Korean Med Sci., 16(3), 328-334. http://dx.doi.org/ 10.3346/jkms.2001.16.3.328.
  • Craddock, N., & Sklar P. (2013). Genetics of bipolar disorder. Lancet. 381(9878), 1654-1662. http://dx.doi.org/ 10.1016/S0140-6736(13)60855-7.
  • Elboga, G., Gizem Aksoy, P., Kus, T., Karayagmurlu, E., Aktas, G., Sahin, S., & Altindag, A. (2021). 5-fluorouracil-induced manic episode in patients with colon cancer: A case report and literature review. Annals of Medical Research, 26(6), 1123-1125.
  • Fellner, S., Bauer, B., Miller, DS., Schaffrik, M., … Fricker G. (2002). Transport of paclitaxel (Taxol) across the blood-brain barrier in vitro and in vivo. J Clin Invest., 110(9), 1309-1318. http://dx.doi.org/ 10.1172/JCI15451.
  • Fora, A., Alabsi, E., & Fakih, M. (2009). A case of 5-fluorouracil-induced acute psychosis. Clin Colorectal Cancer. 8(3), 166-168. http://dx.doi.org/ 10.3816/CCC.2009.n.027.
  • Garg, H., Prakash, S., Deb, KS., & Chadda, RK. (2018). Secondary mania following cancer chemotherapy with capecitabine. BMJ Case Rep. 2018 Mar 28;2018:bcr2017220995. http://dx.doi.org/ 10.1136/bcr-2017-220995.
  • Goodwin, F. K., & Jamison, K. R. (2007). Manic-depressive illness: bipolar disorders and recurrent depression. Oxford University Press.
  • Ha, J. H., Hwang, D. Y., Yu, J., Park, D. H., & Ryu, S. H. (2011). Onset of Manic Episode during Chemotherapy with 5-Fluorouracil. Psychiatry Investig., 8(1), 71-73. http://dx.doi.org/ 10.4306/pi.2011.8.1.71.
  • Hamer, M., Chida, Y., & Molloy, G. J. (2009). Psychological distress and cancer mortality. J Psychosom Res., 66(3), 255-258. http://dx.doi.org/ 10.1016/j.jpsychores.2008.11.002.
  • Hirschfeld, R. M., Calabrese, J. R., Weissman, M. M., Reed, M., … Wagner, KD. (2003). Screening for bipolar disorder in the community. J Clin Psychiatry, 64(1), 53-59. http://dx.doi.org/ 10.4088/jcp.v64n0111.
  • Jann, M. W. (2014). Diagnosis and treatment of bipolar disorders in adults: a review of the evidence on pharmacologic treatments. Am Health Drug Benefits, 7(9), 489-499.Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4296286/.
  • Merikangas, K. R., Akiskal, H. S., Angst, J., Greenberg, P. E., Hirschfeld, R. M., Petukhova, M., & Kessler, R. C. (2007). Lifetime and 12-month prevalence of bipolar spectrum disorder in the National Comorbidity Survey replication. Arch Gen Psychiatry, 64(5), 543-552. http://dx.doi.org/ 10.1001/archpsyc.64.5.543.
  • Niemann, B., Rochlitz, C., Herrmann, R., & Pless, M. (2004). Toxic encephalopathy induced by capecitabine. Oncology, 66(4), 331-335. http://dx.doi.org/ 10.1159/000078335.
  • Pacchiarotti, I., Mazzarini, L., Pellegrini, P., Venturelli, V., … Girardi, P. (2007). A case of manic episode during treatment with 5-fluorouracil, epirubicin and cyclophosphamide for breast cancer. Gen Hosp Psychiatry, 29(5), 461-463. http://dx.doi.org/ 10.1016/j.genhosppsych.2007.04.007.
  • Park, Yoo-Mi, Kwon, Hye-Young, Kım, Hoo-Won, & Kım, Dong-Kwon. (1995). A case of diffuse leukoencephalopathy caused by 5-Fluorouracil. Journal of the Korean Neurological Association, 1007-1010. Pavlova, O., & Weinrebe, W. (2020). Chemotherapy-induced fulminant, severe hyperactive delirium in a patient with a new diagnosed multiple myeloma. Archives of Clinical and Medical Case Reports, 4(3), 312-328. Retrieved from https://www.fortunejournals.com/articles/chemotherapyinduced-fulminant-severe-hyperactive-delirium-in-a-patient-with-a-new-diagnosed-multiple-myeloma.html.
  • Porcello Marrone, L. C., Marrone, B. F., Pascoal, T. A., Schilling, L.P., … da Costa, J. C. (2013). Posterior Reversible Encephalopathy Syndrome Associated with FOLFOX Chemotherapy. Case Rep Oncol Med., 2013, 306983. http://dx.doi.org/ 10.1155/2013/306983.
  • Puangthong, U., & Pongpirul, K. (2015). Chemotherapy-induced acute psychosis in a patient with malignant germ cell tumour. BMJ Case Rep., 2015, bcr2014208982. http://dx.doi.org/ 10.1136/bcr-2014-208982.
  • Shen, C. C., Hu, L. Y., Hu, Y. W., Chang, W. H., … Su, T. P. (2016). The Risk of Cancer in Patients With Obsessive-Compulsive Disorder: A Nationwide Population-Based Retrospective Cohort Study. Medicine (Baltimore). 95(9), e2989. http://dx.doi.org/ 10.1097/MD.0000000000002989.
  • Warren, K. N., Katakam, J., & Espiridion, E. D. (2019). Acute-onset Mania in a Patient with Non-small Cell Lung Cancer. Cureus., 11(8), e5436. http://dx.doi.org/ 10.7759/cureus.5436.
  • Ziske, C. G., Schöttker, B., Gorschlüter, M., Mey, U., … Schmidt-Wolf, I. G. (2002). Acute transient encephalopathy after paclitaxel infusion: report of three cases. Ann Oncol., 13(4), 629-631. http://dx.doi.org/ 10.1093/annonc/mdf025.

Evaluation of Chemotherapy Related Mania in Cancer Patients

Yıl 2024, Cilt: 4 Sayı: 1, 623 - 631, 25.04.2024

Öz

Objective: This study aims to evaluate chemotherapy-related mania in cancer patients. Methods: The mania status of 153 cancer patients who received chemotherapy was compared by applying the Young Mania Rating Scale before starting chemotherapy and after one session of the chemotherapy regimen. Results: When the mania total scores before and after treatment were compared according to the chemotherapeutic agents, it was seen that the post-treatment mania total scores increased in those using Fluorouracil-Folinic Acid-Oxaliplatin (Folfox) (p=0.014) and paclitaxel (p=0.036) chemotherapy regimens. In 8 (5.2%) patients who received the Folfox regimen, the mild mania score exceeded 20 points. Conclusions: Although the blood-brain barrier protects the central nervous system from the toxicity of many drugs, it is known that the stress of cancer diagnosis and some chemotherapeutics used in treatment cause disorders such as acute confusion, depression, and mania. In our study, as in case-based publications in the literature, a statistically significant increase in the total mania score was found in the Folfox regimen due to 5-fluorouracil's ability to cross the blood-brain barrier easily. According to published case reports in the literature, the possibility of mania symptoms appearing in the second, third, and sometimes subsequent sessions should be taken into consideration due to cumulative or delayed side effects of the drugs.

Kaynakça

  • Ahmed, N., Usmani, S., Jabbour, N., & Hegde, U. (2011). Acute psychosis after paclitaxel infusion. Conn Med., 75(8), 465-466. Retrieved from https://pubmed.ncbi.nlm.nih.gov/21980675/.
  • Bellman, V., Russell, N., Depala, K., Dellenbaugh, A., … Srinivas, S. (2021). Challenges in Treating Cancer Patients With Unstable Psychiatric Disorder. World J Oncol., 12(5), 137-148. http://dx.doi.org/10.14740/wjon1402.
  • Bond, S. M., Neelon, V. J., & Belyea, M. J. (2006). Delirium in hospitalized older patients with cancer. Oncol Nurs Forum, 33(6), 1075-1083. http://dx.doi.org/10.1188/06.ONF.1075-1083.
  • Cerullo, M. A. (2006). Corticosteroid-induced mania: Prepare for the unpredictable. Current Psychiatry, 5(6), 43.
  • Choi, S. M., Lee, S. H., Yang, Y. S., Kim, B. C., Kim, M. K., & Cho, K. H. (2001). 5-fluorouracil-induced leukoencephalopathy in patients with breast cancer. J Korean Med Sci., 16(3), 328-334. http://dx.doi.org/ 10.3346/jkms.2001.16.3.328.
  • Craddock, N., & Sklar P. (2013). Genetics of bipolar disorder. Lancet. 381(9878), 1654-1662. http://dx.doi.org/ 10.1016/S0140-6736(13)60855-7.
  • Elboga, G., Gizem Aksoy, P., Kus, T., Karayagmurlu, E., Aktas, G., Sahin, S., & Altindag, A. (2021). 5-fluorouracil-induced manic episode in patients with colon cancer: A case report and literature review. Annals of Medical Research, 26(6), 1123-1125.
  • Fellner, S., Bauer, B., Miller, DS., Schaffrik, M., … Fricker G. (2002). Transport of paclitaxel (Taxol) across the blood-brain barrier in vitro and in vivo. J Clin Invest., 110(9), 1309-1318. http://dx.doi.org/ 10.1172/JCI15451.
  • Fora, A., Alabsi, E., & Fakih, M. (2009). A case of 5-fluorouracil-induced acute psychosis. Clin Colorectal Cancer. 8(3), 166-168. http://dx.doi.org/ 10.3816/CCC.2009.n.027.
  • Garg, H., Prakash, S., Deb, KS., & Chadda, RK. (2018). Secondary mania following cancer chemotherapy with capecitabine. BMJ Case Rep. 2018 Mar 28;2018:bcr2017220995. http://dx.doi.org/ 10.1136/bcr-2017-220995.
  • Goodwin, F. K., & Jamison, K. R. (2007). Manic-depressive illness: bipolar disorders and recurrent depression. Oxford University Press.
  • Ha, J. H., Hwang, D. Y., Yu, J., Park, D. H., & Ryu, S. H. (2011). Onset of Manic Episode during Chemotherapy with 5-Fluorouracil. Psychiatry Investig., 8(1), 71-73. http://dx.doi.org/ 10.4306/pi.2011.8.1.71.
  • Hamer, M., Chida, Y., & Molloy, G. J. (2009). Psychological distress and cancer mortality. J Psychosom Res., 66(3), 255-258. http://dx.doi.org/ 10.1016/j.jpsychores.2008.11.002.
  • Hirschfeld, R. M., Calabrese, J. R., Weissman, M. M., Reed, M., … Wagner, KD. (2003). Screening for bipolar disorder in the community. J Clin Psychiatry, 64(1), 53-59. http://dx.doi.org/ 10.4088/jcp.v64n0111.
  • Jann, M. W. (2014). Diagnosis and treatment of bipolar disorders in adults: a review of the evidence on pharmacologic treatments. Am Health Drug Benefits, 7(9), 489-499.Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4296286/.
  • Merikangas, K. R., Akiskal, H. S., Angst, J., Greenberg, P. E., Hirschfeld, R. M., Petukhova, M., & Kessler, R. C. (2007). Lifetime and 12-month prevalence of bipolar spectrum disorder in the National Comorbidity Survey replication. Arch Gen Psychiatry, 64(5), 543-552. http://dx.doi.org/ 10.1001/archpsyc.64.5.543.
  • Niemann, B., Rochlitz, C., Herrmann, R., & Pless, M. (2004). Toxic encephalopathy induced by capecitabine. Oncology, 66(4), 331-335. http://dx.doi.org/ 10.1159/000078335.
  • Pacchiarotti, I., Mazzarini, L., Pellegrini, P., Venturelli, V., … Girardi, P. (2007). A case of manic episode during treatment with 5-fluorouracil, epirubicin and cyclophosphamide for breast cancer. Gen Hosp Psychiatry, 29(5), 461-463. http://dx.doi.org/ 10.1016/j.genhosppsych.2007.04.007.
  • Park, Yoo-Mi, Kwon, Hye-Young, Kım, Hoo-Won, & Kım, Dong-Kwon. (1995). A case of diffuse leukoencephalopathy caused by 5-Fluorouracil. Journal of the Korean Neurological Association, 1007-1010. Pavlova, O., & Weinrebe, W. (2020). Chemotherapy-induced fulminant, severe hyperactive delirium in a patient with a new diagnosed multiple myeloma. Archives of Clinical and Medical Case Reports, 4(3), 312-328. Retrieved from https://www.fortunejournals.com/articles/chemotherapyinduced-fulminant-severe-hyperactive-delirium-in-a-patient-with-a-new-diagnosed-multiple-myeloma.html.
  • Porcello Marrone, L. C., Marrone, B. F., Pascoal, T. A., Schilling, L.P., … da Costa, J. C. (2013). Posterior Reversible Encephalopathy Syndrome Associated with FOLFOX Chemotherapy. Case Rep Oncol Med., 2013, 306983. http://dx.doi.org/ 10.1155/2013/306983.
  • Puangthong, U., & Pongpirul, K. (2015). Chemotherapy-induced acute psychosis in a patient with malignant germ cell tumour. BMJ Case Rep., 2015, bcr2014208982. http://dx.doi.org/ 10.1136/bcr-2014-208982.
  • Shen, C. C., Hu, L. Y., Hu, Y. W., Chang, W. H., … Su, T. P. (2016). The Risk of Cancer in Patients With Obsessive-Compulsive Disorder: A Nationwide Population-Based Retrospective Cohort Study. Medicine (Baltimore). 95(9), e2989. http://dx.doi.org/ 10.1097/MD.0000000000002989.
  • Warren, K. N., Katakam, J., & Espiridion, E. D. (2019). Acute-onset Mania in a Patient with Non-small Cell Lung Cancer. Cureus., 11(8), e5436. http://dx.doi.org/ 10.7759/cureus.5436.
  • Ziske, C. G., Schöttker, B., Gorschlüter, M., Mey, U., … Schmidt-Wolf, I. G. (2002). Acute transient encephalopathy after paclitaxel infusion: report of three cases. Ann Oncol., 13(4), 629-631. http://dx.doi.org/ 10.1093/annonc/mdf025.
Toplam 24 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Sağlık Hizmetleri ve Sistemleri (Diğer)
Bölüm Araştırma Makalesi
Yazarlar

Fatih İnci 0000-0002-7590-7630

Habibe İnci 0000-0003-2883-259X

Yayımlanma Tarihi 25 Nisan 2024
Gönderilme Tarihi 2 Kasım 2023
Kabul Tarihi 11 Mart 2024
Yayımlandığı Sayı Yıl 2024 Cilt: 4 Sayı: 1

Kaynak Göster

APA İnci, F., & İnci, H. (2024). Evaluation of Chemotherapy Related Mania in Cancer Patients. Unika Sağlık Bilimleri Dergisi, 4(1), 623-631.