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A case of metoclopramide-induced oculogyric crisis in a schizophrenic patient under anticholinergic therapy

Year 2022, Volume: 7 Issue: 5, 142 - 144, 30.12.2022

Hülya Ertekin Begüm Aygen Gümüş

https://doi.org/10.22391/fppc.1031963

Abstract

Introduction: Oculogyric crisis (OGC) is a dystonic reaction characterized as conjugate and typically upward deviation of the eyes lasting from seconds to hours which is seen as an uncommon neurologic manifestation. Metoclopramide is a prokinetic agent that is frequently prescribed in the treatment of nausea, vomiting prophylaxis, and vomiting. One of the side effects after metoclopramide treatment is acute dystonic reactions.

Case Presentation: We report a case of metoclopramide-induced OGC despite the anticholinergic treatment in patient diagnosed with schizophrenia.

Conclusions: Metoclopramide-induced OGC and other acute dystonic reactions may be more frequent than expected. Therefore, clinicians should monitor patients closely during treatment with metoclopramide and necessary precautions should be taken for these reactions.

Keywords: Metoclopramide, oculogyric crisis, side effect, schizophrenia

Keywords

metoclopramide Oculogyric crisis side effect schizophrenia

References

  • 1. Barow E, Schneider S, Bhatia K, et al. Oculogyric crises: Etiology, pathophysiology and therapeutic approaches. Parkinsonism Relat Disord. 2016;36:3-9 https://doi.org/10.1016/j.parkreldis.2016.11.012
  • 2. Van der Padt A, Van Schaik RH, Sonneveld P. Acute dystonic reaction to metoclopramide in patients carrying homozygous cytochrome P450 2D6 genetic polymorphisms. Neth J Med. 2006;64(5):160–2. http://hdl.handle.net/1765/10407 (Access Date: July 22, 2022)
  • 3. Bateman DN, Rawlins MD, Simpson JM. Extrapyramidal reactions with metoclopramide. Br Med J.1985;291(6500):930–2. https://doi.org/10.1136/bmj.291.6500.930
  • 4. Albibi R, McCallum RW. Metoclopramide: pharmacology and clinical application. Ann Intern Med. 1983;98:86-95. https://doi.org/10.7326/0003-4819-98-1-86
  • 5. Koban Y, Ekinci M, Cagatay H, et al. Oculogyric crisis in a patient taking metoclopramide. Clin Ophthalmol. 2014;8:567–9. https://doi.org/10.2147/OPTH.S60041
  • 6. Slow E, Lang A. Oculogyric crises: A review of phenomenology, etiology, pathogenesis and treatment. Mov Disord.2017;32(2):193-202. https://doi.org/10.1002/mds.26910
  • 7. Nebhinani N, Suthar N. Oculogyric crisis with atypical antipsychotics: A case series. Indian J Psychiatry.2017;59(4):495-9. https://doi.org/10.4103/psychiatry.IndianJPsychiatry_211_17
  • 8. Mendhekar DN, Lohia D, Kataria P. Tardive oculogyric crisis associated with amisulpride monotherapy. J Postgrad Med. 2010;56:305–6. . https://doi.org/10.4103/0022-3859.70947
  • 9. Sandyck R. Oculogyric crisis induced by lithium carbonate. Eur Neurol. 1984;23(2):92-4. https://doi.org/10.1159/000115684
  • 10. O'Neill JR, Stephenson C. Antipsychotic-induced laryngeal dystonia. Psychopharmacol Bull. 2022;52(1):61-7. https://pubmed.ncbi.nlm.nih.gov/35342202/
  • 11. Hood S, Orr K, Bennett L, et al. Severe laryngeal dystonia in a patient receiving zuclopenthixol "Acuphase" and fluoxetine. Australas Psychiatry 2010;18(2):174-6. https://doi.org/10.3109/10398560903473686
  • 12. Blackman G, Oloyede E, Horowitz M, et al. Reducing the Risk of Withdrawal Symptoms and Relapse Following Clozapine Discontinuation-Is It Feasible to Develop Evidence-Based Guidelines? Schizophr Bull. 2022;48(1):176-189. https://academic.oup.com/schizophreniabulletin/article/48/1/176/6397220?login=true
  • 13. Nebhinani N, Avasthi A, Modi M. Oculogyric Crisis with Clozapine: A Case Report and Review of Similar Case Reports in the Literature. Indian J Psychol Med. 2015 Jul-Sep;37(3):342-4. https://journals.sagepub.com/doi/10.4103/0253-7176.162946
  • 14. Lin M, Robinson P, Flank J, et al. The safety of metoclopramide in children: A systematic review and meta-analysis. Drug Saf. 2016;39(7): 675–87 https://doi.org/10.1007/s40264-016-0418-9
  • 15. Arumugam J, Vijayalakshmi AM. Metoclopramide induced oculogyric crisis presenting as encephalitis in a young girl. Indian J Pharmacol. 2012;44(2):266-7. https://doi.org/10.4103/0253-7613.93867
  • 16. Karagoz G, Kadanali A, Dede B, et al. Metoclopramide induced acute dystonic reaction: A case report. Eurasian J Med. 2013;45(1):58-9. https://doi.org/10.5152/eajm.2013.10
  • 17. Tunay K, Tunay H, Oruc S, et al. Metoclopramide connected oculogyric crisis in pregnancy: Case report. Kocatepe Med J. 2016;17(1):19-21. https://doi.org/10.18229/ktd.93280
  • 18. Tianyi FL, Agbor VN, Njim T. Metoclopramide induced acute dystonic reaction: A case report. BMC Res Notes. 2017;10(1):32. https://doi.org/10.1186/s13104-016-2342-6
  • 19. Silfeler I, Arica S, and Dogan M. Development of acute dystonia in three brothers due to metoclopramide. J Res Med Sci.; 17(3):308–9. http://www.ncbi.nlm.nih.gov/pmc/articles/pmc3527052/

Antikolinerjik tedavi altındaki bir şizofreni hastasında metoklopramidle indüklenmiş bir okülojirik kriz vakası

Year 2022, Volume: 7 Issue: 5, 142 - 144, 30.12.2022

Hülya Ertekin Begüm Aygen Gümüş

https://doi.org/10.22391/fppc.1031963

Abstract

Giriş: Okülojirik kriz (OJK), gözlerin konjuge ve tipik olarak saniyelerden saatlere kadar süren yukarı doğru sapması olarak nitelendirilen ve nadir bir nörolojik tablo olarak görülen distonik bir reaksiyondur. Metoklopramid, bulantı, kusma profilaksisi ve kusma tedavisinde sıklıkla reçete edilen prokinetik bir ajandır. Metoklopramid tedavi sonrası oluşan yan etkilerden biri de akut distonik reaksiyonlardır.

Vaka Sunumu: Şizofreni tanılı bir hastaya uygulanan antikolinerjik tedaviye rağmen metoklopramidin indüklediği OJK olgusunu sunuyoruz.

Sonuç: Metoklopramid kaynaklı OJK ve diğer akut distonik reaksiyonlar beklenenden daha sık olabilir. Bu nedenle klinisyenler metoklopramid tedavisi sırasında hastaları yakından izlemeli ve bu reaksiyonlar için gerekli önlemler alınmalıdır.

Anahtar Kelimeler: Metoklopramid, okülojirik kriz, yan etki, şizofreni

Keywords

metoklopramid okülojirik kriz yan etki şizofreni

References

  • 1. Barow E, Schneider S, Bhatia K, et al. Oculogyric crises: Etiology, pathophysiology and therapeutic approaches. Parkinsonism Relat Disord. 2016;36:3-9 https://doi.org/10.1016/j.parkreldis.2016.11.012
  • 2. Van der Padt A, Van Schaik RH, Sonneveld P. Acute dystonic reaction to metoclopramide in patients carrying homozygous cytochrome P450 2D6 genetic polymorphisms. Neth J Med. 2006;64(5):160–2. http://hdl.handle.net/1765/10407 (Access Date: July 22, 2022)
  • 3. Bateman DN, Rawlins MD, Simpson JM. Extrapyramidal reactions with metoclopramide. Br Med J.1985;291(6500):930–2. https://doi.org/10.1136/bmj.291.6500.930
  • 4. Albibi R, McCallum RW. Metoclopramide: pharmacology and clinical application. Ann Intern Med. 1983;98:86-95. https://doi.org/10.7326/0003-4819-98-1-86
  • 5. Koban Y, Ekinci M, Cagatay H, et al. Oculogyric crisis in a patient taking metoclopramide. Clin Ophthalmol. 2014;8:567–9. https://doi.org/10.2147/OPTH.S60041
  • 6. Slow E, Lang A. Oculogyric crises: A review of phenomenology, etiology, pathogenesis and treatment. Mov Disord.2017;32(2):193-202. https://doi.org/10.1002/mds.26910
  • 7. Nebhinani N, Suthar N. Oculogyric crisis with atypical antipsychotics: A case series. Indian J Psychiatry.2017;59(4):495-9. https://doi.org/10.4103/psychiatry.IndianJPsychiatry_211_17
  • 8. Mendhekar DN, Lohia D, Kataria P. Tardive oculogyric crisis associated with amisulpride monotherapy. J Postgrad Med. 2010;56:305–6. . https://doi.org/10.4103/0022-3859.70947
  • 9. Sandyck R. Oculogyric crisis induced by lithium carbonate. Eur Neurol. 1984;23(2):92-4. https://doi.org/10.1159/000115684
  • 10. O'Neill JR, Stephenson C. Antipsychotic-induced laryngeal dystonia. Psychopharmacol Bull. 2022;52(1):61-7. https://pubmed.ncbi.nlm.nih.gov/35342202/
  • 11. Hood S, Orr K, Bennett L, et al. Severe laryngeal dystonia in a patient receiving zuclopenthixol "Acuphase" and fluoxetine. Australas Psychiatry 2010;18(2):174-6. https://doi.org/10.3109/10398560903473686
  • 12. Blackman G, Oloyede E, Horowitz M, et al. Reducing the Risk of Withdrawal Symptoms and Relapse Following Clozapine Discontinuation-Is It Feasible to Develop Evidence-Based Guidelines? Schizophr Bull. 2022;48(1):176-189. https://academic.oup.com/schizophreniabulletin/article/48/1/176/6397220?login=true
  • 13. Nebhinani N, Avasthi A, Modi M. Oculogyric Crisis with Clozapine: A Case Report and Review of Similar Case Reports in the Literature. Indian J Psychol Med. 2015 Jul-Sep;37(3):342-4. https://journals.sagepub.com/doi/10.4103/0253-7176.162946
  • 14. Lin M, Robinson P, Flank J, et al. The safety of metoclopramide in children: A systematic review and meta-analysis. Drug Saf. 2016;39(7): 675–87 https://doi.org/10.1007/s40264-016-0418-9
  • 15. Arumugam J, Vijayalakshmi AM. Metoclopramide induced oculogyric crisis presenting as encephalitis in a young girl. Indian J Pharmacol. 2012;44(2):266-7. https://doi.org/10.4103/0253-7613.93867
  • 16. Karagoz G, Kadanali A, Dede B, et al. Metoclopramide induced acute dystonic reaction: A case report. Eurasian J Med. 2013;45(1):58-9. https://doi.org/10.5152/eajm.2013.10
  • 17. Tunay K, Tunay H, Oruc S, et al. Metoclopramide connected oculogyric crisis in pregnancy: Case report. Kocatepe Med J. 2016;17(1):19-21. https://doi.org/10.18229/ktd.93280
  • 18. Tianyi FL, Agbor VN, Njim T. Metoclopramide induced acute dystonic reaction: A case report. BMC Res Notes. 2017;10(1):32. https://doi.org/10.1186/s13104-016-2342-6
  • 19. Silfeler I, Arica S, and Dogan M. Development of acute dystonia in three brothers due to metoclopramide. J Res Med Sci.; 17(3):308–9. http://www.ncbi.nlm.nih.gov/pmc/articles/pmc3527052/
There are 19 citations in total.

Details

Primary Language English
Subjects Clinical Sciences
Journal Section Case Report
Authors

Hülya Ertekin 0000-0003-4787-5333

Begüm Aygen Gümüş 0000-0002-4845-5106

Publication Date December 30, 2022
Submission Date December 3, 2021
Acceptance Date December 7, 2022
Published in Issue Year 2022Volume: 7 Issue: 5

Cite

APA Ertekin, H., & Gümüş, B. A. (2022). A case of metoclopramide-induced oculogyric crisis in a schizophrenic patient under anticholinergic therapy. Family Practice and Palliative Care, 7(5), 142-144. https://doi.org/10.22391/fppc.1031963
AMA Ertekin H, Gümüş BA. A case of metoclopramide-induced oculogyric crisis in a schizophrenic patient under anticholinergic therapy. Fam Pract Palliat Care. December 2022;7(5):142-144. doi:10.22391/fppc.1031963
Chicago Ertekin, Hülya, and Begüm Aygen Gümüş. “A Case of Metoclopramide-Induced Oculogyric Crisis in a Schizophrenic Patient under Anticholinergic Therapy”. Family Practice and Palliative Care 7, no. 5 (December 2022): 142-44. https://doi.org/10.22391/fppc.1031963.
EndNote Ertekin H, Gümüş BA (December 1, 2022) A case of metoclopramide-induced oculogyric crisis in a schizophrenic patient under anticholinergic therapy. Family Practice and Palliative Care 7 5 142–144.
IEEE H. Ertekin and B. A. Gümüş, “A case of metoclopramide-induced oculogyric crisis in a schizophrenic patient under anticholinergic therapy”, Fam Pract Palliat Care, vol. 7, no. 5, pp. 142–144, 2022, doi: 10.22391/fppc.1031963.
ISNAD Ertekin, Hülya - Gümüş, Begüm Aygen. “A Case of Metoclopramide-Induced Oculogyric Crisis in a Schizophrenic Patient under Anticholinergic Therapy”. Family Practice and Palliative Care 7/5 (December 2022), 142-144. https://doi.org/10.22391/fppc.1031963.
JAMA Ertekin H, Gümüş BA. A case of metoclopramide-induced oculogyric crisis in a schizophrenic patient under anticholinergic therapy. Fam Pract Palliat Care. 2022;7:142–144.
MLA Ertekin, Hülya and Begüm Aygen Gümüş. “A Case of Metoclopramide-Induced Oculogyric Crisis in a Schizophrenic Patient under Anticholinergic Therapy”. Family Practice and Palliative Care, vol. 7, no. 5, 2022, pp. 142-4, doi:10.22391/fppc.1031963.
Vancouver Ertekin H, Gümüş BA. A case of metoclopramide-induced oculogyric crisis in a schizophrenic patient under anticholinergic therapy. Fam Pract Palliat Care. 2022;7(5):142-4.
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Family Practice and Palliative Care       ISSN 2458-8865       E-ISSN 2459-1505