Yıl 2018, Cilt 3, Sayı 2, Sayfalar 85 - 91 2018-08-30

Effects of Saint John’s wort on the fetus in pregnant rats
Gebe sıçanlarda kantaron otunun fetüse etkisi

Basak Buyuk [1] , Mehmet Yuncu [2] , Ayhan Eralp [3] , Serap Inaloz Demir [4]

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Introduction: Because of the toxic and teratologic side effects that might develop into the fetus, the number of drugs that can be used in the treatment of depression seen in pregnancy is very limited. In this study, we investigated whether the Saint John’s wort used during pregnancy has side effects on the liver of fetus.

Methods: Thirteen Wistar albino female rats were used in this study. The animals divided into two groups as 8 rats for the experimental group and 5 rats for the control group.  The animals detected for pregnancy in the experimental group were fed with the Saint John’s wort extract as 100 mg/kg/day through orogastric probe from the first day of the pregnancy. The animals in the control group were fed with 2 ml distiled water through an orogastric probe every day begining from the first day of the pregnancy. The newborn pups were taken. Their liver tissues were harvested and investigated after the tissue processing and staining procedure.

Results: Microvesicular lipidosis and hydropic degeneration were observed in histopathological evaluation of the harvested tissues of experimental group.

Conclusion: As a result, there is not enough data in the literature in order to claim that Saint John’s worth is reliable for the pregnant women or fetus. It is important for the physician to evaluate the complaints related to the use of pregnancy and to raise the awareness of the physicians in the first stage of the pregnancy follow-up. For the usage of this herb as an alternative or addition to antidepressive drugs more preclinical (basic) and clinical studies need to be performed.

Giriş: Fetüste gelişebilecek toksik ve teratolojik yan etkilerinden dolayı, gebelikte görülen depresyonun tedavisinde kullanılabilecek ilaç sayısı oldukça sınırlıdır. Çalışmamızda, gebelik sırasında depresyon tedavisi için halk arasında sık kullanılan kantaron otunun fetüs karaciğeri üzerine yan etkilerini araştırdık.

Yöntem: Çalışmada kullanılan 13 adet dişi Wistar albino sıçan, 8 adet deney grubu,  5 adet de kontrol grubu olmak üzere ayrıldı. Gebe kalmaları sağlanan deney grubundaki hayvanlara, gebeliğin ilk gününden itibaren, gebelik süresince 100 mg/kg/gün kantaron otu ekstresi orogastrik sonda yardımıyla verildi. Kontrol grubundaki sıçanlara ise gebeliğin ilk gününden itibaren her gün 2 ml distile su orogastrik sonda yardımıyla verildi. Doğan yavruların karaciğer dokuları çıkarıldı, %10 nötral formalin ile fiksasyonu yapıldı, alkol takibinden sonra parafin blokları hazırlandı, alınan kesitler hematoksilen ve eosin ile boyanarak incelendi.

Bulgular: Deney grubuna ait karaciğer dokularının histopatolojik değerlendirmesinde mikroveziküler yağlanma ve hidropik dejenerasyon gözlendi.

Sonuç: Kantaron otunun gebe kadınlar veya fetus açısından güvenilir olduğunu iddia etmek için yeterli bilgi bulunmadığı sonucuna varıldı. Bu otun gebelik kullanımıyla ilgili sakıncaların hekimler tarafından değerlendirilmesi ve özellikle birinci basamakta hekimlerin, gebe takiplerinde hastaları bu konuda bilinçlendirmesi önem arz etmektedir. Kantaron otunun gebelikte kullanımı ve gerek anne gerek fetüste tüm vücuttaki etkilerinin ortaya konması için daha ileri çalışmalar yapılması gerekmektedir.

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Birincil Dil en
Konular Sağlık Bilimleri
Yayımlanma Tarihi Aug 2018
Dergi Bölümü Araştırma Makalesi (Original Article)
Yazarlar

Orcid: 0000-0003-1817-2241
Yazar: Basak Buyuk (Sorumlu Yazar)
Kurum: Canakkale Onsekiz Mart University, School of Medicine, Department of Histology and Embryology, Canakkale, Turkey
Ülke: Turkey


Orcid: 0000-0002-2519-6834
Yazar: Mehmet Yuncu
Kurum: University of Gaziantep, School of Medicine, Department of Histology and Embryology, Gaziantep, Turkey
Ülke: Turkey


Orcid: 0000-0002-0224-6173
Yazar: Ayhan Eralp
Kurum: University of Gaziantep, School of Medicine, Department of Histology and Embryology, Gaziantep, Turkey
Ülke: Turkey


Orcid: 0000-0001-9684-255X
Yazar: Serap Inaloz Demir
Kurum: University of Gaziantep, School of Medicine, Department of Histology and Embryology, Gaziantep, Turkey
Ülke: Turkey


Bibtex @araştırma makalesi { fppc406844, journal = {FAMILY PRACTICE AND PALLIATIVE CARE}, issn = {2458-8865}, eissn = {2459-1505}, address = {SERNEV}, year = {2018}, volume = {3}, pages = {85 - 91}, doi = {10.22391/fppc.406844}, title = {Effects of Saint John’s wort on the fetus in pregnant rats}, key = {cite}, author = {Inaloz Demir, Serap and Yuncu, Mehmet and Buyuk, Basak and Eralp, Ayhan} }
APA Buyuk, B , Yuncu, M , Eralp, A , Inaloz Demir, S . (2018). Effects of Saint John’s wort on the fetus in pregnant rats. FAMILY PRACTICE AND PALLIATIVE CARE, 3 (2), 85-91. DOI: 10.22391/fppc.406844
MLA Buyuk, B , Yuncu, M , Eralp, A , Inaloz Demir, S . "Effects of Saint John’s wort on the fetus in pregnant rats". FAMILY PRACTICE AND PALLIATIVE CARE 3 (2018): 85-91 <http://www.fppc.com.tr/issue/39137/406844>
Chicago Buyuk, B , Yuncu, M , Eralp, A , Inaloz Demir, S . "Effects of Saint John’s wort on the fetus in pregnant rats". FAMILY PRACTICE AND PALLIATIVE CARE 3 (2018): 85-91
RIS TY - JOUR T1 - Effects of Saint John’s wort on the fetus in pregnant rats AU - Basak Buyuk , Mehmet Yuncu , Ayhan Eralp , Serap Inaloz Demir Y1 - 2018 PY - 2018 N1 - doi: 10.22391/fppc.406844 DO - 10.22391/fppc.406844 T2 - FAMILY PRACTICE AND PALLIATIVE CARE JF - Journal JO - JOR SP - 85 EP - 91 VL - 3 IS - 2 SN - 2458-8865-2459-1505 M3 - doi: 10.22391/fppc.406844 UR - http://dx.doi.org/10.22391/fppc.406844 Y2 - 2018 ER -
EndNote %0 FAMILY PRACTICE AND PALLIATIVE CARE Effects of Saint John’s wort on the fetus in pregnant rats %A Basak Buyuk , Mehmet Yuncu , Ayhan Eralp , Serap Inaloz Demir %T Effects of Saint John’s wort on the fetus in pregnant rats %D 2018 %J FAMILY PRACTICE AND PALLIATIVE CARE %P 2458-8865-2459-1505 %V 3 %N 2 %R doi: 10.22391/fppc.406844 %U 10.22391/fppc.406844
ISNAD Buyuk, Basak , Yuncu, Mehmet , Eralp, Ayhan , Inaloz Demir, Serap . "Gebe sıçanlarda kantaron otunun fetüse etkisi". FAMILY PRACTICE AND PALLIATIVE CARE 3 / 2 (Ağustos 2018): 85-91. http://dx.doi.org/10.22391/fppc.406844