Yıl 2018, Cilt 3, Sayı 2, Sayfalar 92 - 97 2018-08-30

A relationship between subclinical hypothyroidism and hematologic parameters in patients with Down Syndrome
Down Sendromlu hastalarda subklinik hipotiroidizm ve hematolojik parametreler arasındaki ilişki

Abdullah Yazar [1] , Alaaddin Yorulmaz [2] , Esra Ture [3] , Fatih Akin [4] , Ahmet Sert [5]

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Introduction: Down syndrome (DS) which is defined as trisomy 21 is the most common chromosomal defect characterized by mental retardation, hypotonia, dysmorphic facial features, and other distinctive phenotypic characteristics. The prevalence of thyroid disorders in DS is 3% and is significantly higher than in the normal population. In this study we aimed to investigate hematologic parameters of children with DS who had and hadn’t subclinical hypothyroidism and compare them with healthy controls.  

Methods: This study included 184 patients who were followed up with genetically diagnosed DS. Complete blood count, levels of serum electrolytes, glucose, urea, liver function tests, thyroid function tests were reviewed.

Results: 102 (55.4%) of the patients with DS were male and 82 (44.6%) were female. Mean age was 6.2 ± 4.0 years. Control group was constituted of outpatient healthy children. White blood cell count, hemoglobin, hematocrit, and neutrophil counts were found to be significantly lower in patients with DS. Platelet count and plateletcrit levels were found to be higher and platelet distribution width was lower in patients with DS than in the control group.

Conclusion: We found significant differences among hematological parameters in patients with DS. Subclinical hypothyroidism influences red blood cell distribution width, platelet count and MPV. Knowing the incidence and severity of hematologic abnormalities in patients with DS will be beneficial during follow-up in clinical practice.

Giriş: Trizomi 21 olarak tanımlanan Down sendromu (DS) mental retardasyon, hipotoni, dismorfik yüz özellikleri ve diğer ayırt edici fenotipik özellikleri ile karakterize en sık görülen kromozomal defekttir. DS'de görülen tiroid bozukluğu prevalansı % 3'dür ve normal popülasyona göre anlamlı derecede yüksektir. Bu çalışmada, subklinik hipotiroidisi olan ve olmayan DS'lu çocukların hematolojik parametrelerini araştırmayı ve bunları sağlıklı kontrollerle karşılaştırmayı amaçladık.

Yöntem: Çalışmaya genetik olarak tanısı konan ve takip edilen DS’li 184 hasta dahil edildi. Hastaların tam kan sayımı, serum elektrolit seviyeleri, glikoz, üre, karaciğer fonksiyon testleri ve tiroid fonksiyon testleri gözden geçirildi.

Bulgular: DS'lu hastaların 102'si (% 55,4) erkek, 82'si (% 44,6) kadındı. Yaş ortalaması 6,2 ± 4 yıl idi. Kontrol grubu, polikliniğimize başvuran sağlıklı çocuklardan oluşturuldu. DS'lu hastalarda kan sayımı, hemoglobin, hematokrit ve nötrofil sayıları anlamlı olarak düşük bulundu. Yine DS'li hastalarda kontrol grubuna göre trombosit sayısı ve trombosit düzeyleri daha yüksek bulunurken  trombosit dağılım genişliği daha düşük bulundu.

Sonuç: DS'li hastalarda hematolojik parametreler arasında anlamlı farklar bulduk. Subklinik hipotiroidizm, eritrosit dağılım genişliğini, trombosit sayısını ve MPV'yi etkiler. DS'li hastalarda hematolojik anormalliklerin sıklığını ve şiddetini bilmek, klinik uygulamada takip sırasında yararlı olacaktır.

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Birincil Dil en
Konular Sağlık Bilimleri
Yayımlanma Tarihi Aug 2018
Dergi Bölümü Araştırma Makalesi (Original Article)
Yazarlar

Orcid: 0000-0003-0733-3943
Yazar: Abdullah Yazar (Sorumlu Yazar)
Kurum: Necmettin Erbakan University, School of Medicine, Department of Pediatrics, Konya, Turkey
Ülke: Turkey


Orcid: 0000-0001-5478-1197
Yazar: Alaaddin Yorulmaz
Kurum: Selcuk University, School of Medicine, Department of Pediatrics, Konya, Turkey
Ülke: Turkey


Orcid: 0000-0002-1015-1764
Yazar: Esra Ture
Kurum: Necmettin Erbakan University, School of Medicine, Department of Pediatrics, Konya, Turkey
Ülke: Turkey


Orcid: 0000-0001-5725-3867
Yazar: Fatih Akin
Kurum: Necmettin Erbakan University, School of Medicine, Department of Pediatrics, Konya, Turkey
Ülke: Turkey


Orcid: 0000-0002-1607-7569
Yazar: Ahmet Sert
Kurum: Selcuk University, School of Medicine, Department of Pediatrics, Konya, Turkey
Ülke: Turkey


Bibtex @araştırma makalesi { fppc422181, journal = {FAMILY PRACTICE AND PALLIATIVE CARE}, issn = {2458-8865}, eissn = {2459-1505}, address = {SERNEV}, year = {2018}, volume = {3}, pages = {92 - 97}, doi = {10.22391/fppc.422181}, title = {A relationship between subclinical hypothyroidism and hematologic parameters in patients with Down Syndrome}, key = {cite}, author = {Akin, Fatih and Ture, Esra and Yorulmaz, Alaaddin and Sert, Ahmet and Yazar, Abdullah} }
APA Yazar, A , Yorulmaz, A , Ture, E , Akin, F , Sert, A . (2018). A relationship between subclinical hypothyroidism and hematologic parameters in patients with Down Syndrome. FAMILY PRACTICE AND PALLIATIVE CARE, 3 (2), 92-97. DOI: 10.22391/fppc.422181
MLA Yazar, A , Yorulmaz, A , Ture, E , Akin, F , Sert, A . "A relationship between subclinical hypothyroidism and hematologic parameters in patients with Down Syndrome". FAMILY PRACTICE AND PALLIATIVE CARE 3 (2018): 92-97 <http://www.fppc.com.tr/issue/39137/422181>
Chicago Yazar, A , Yorulmaz, A , Ture, E , Akin, F , Sert, A . "A relationship between subclinical hypothyroidism and hematologic parameters in patients with Down Syndrome". FAMILY PRACTICE AND PALLIATIVE CARE 3 (2018): 92-97
RIS TY - JOUR T1 - A relationship between subclinical hypothyroidism and hematologic parameters in patients with Down Syndrome AU - Abdullah Yazar , Alaaddin Yorulmaz , Esra Ture , Fatih Akin , Ahmet Sert Y1 - 2018 PY - 2018 N1 - doi: 10.22391/fppc.422181 DO - 10.22391/fppc.422181 T2 - FAMILY PRACTICE AND PALLIATIVE CARE JF - Journal JO - JOR SP - 92 EP - 97 VL - 3 IS - 2 SN - 2458-8865-2459-1505 M3 - doi: 10.22391/fppc.422181 UR - http://dx.doi.org/10.22391/fppc.422181 Y2 - 2018 ER -
EndNote %0 FAMILY PRACTICE AND PALLIATIVE CARE A relationship between subclinical hypothyroidism and hematologic parameters in patients with Down Syndrome %A Abdullah Yazar , Alaaddin Yorulmaz , Esra Ture , Fatih Akin , Ahmet Sert %T A relationship between subclinical hypothyroidism and hematologic parameters in patients with Down Syndrome %D 2018 %J FAMILY PRACTICE AND PALLIATIVE CARE %P 2458-8865-2459-1505 %V 3 %N 2 %R doi: 10.22391/fppc.422181 %U 10.22391/fppc.422181
ISNAD Yazar, Abdullah , Yorulmaz, Alaaddin , Ture, Esra , Akin, Fatih , Sert, Ahmet . "Down Sendromlu hastalarda subklinik hipotiroidizm ve hematolojik parametreler arasındaki ilişki". FAMILY PRACTICE AND PALLIATIVE CARE 3 / 2 (Ağustos 2018): 92-97. http://dx.doi.org/10.22391/fppc.422181