Yıl 2018, Cilt 3, Sayı 3, Sayfalar 123 - 126 2018-10-04

Relationship of serum netrin-1 levels with breast masses
Serum netrin-1 seviyesinin meme kitleleriyle ilişkisi

Ibrahim Solak [1] , Duygu Ilke Yildirim [2] , Mustafa Solak [3] , Cigdem Damla Cetinkaya [4] , Ayse Boyaci [5] , Mehmet Ali Eryilmaz [6]

22 31

Introduction: Netrin-1 has been shown to induce angiogenesis and is considered to function as a proto-oncogene. We aimed to evaluate the relationship of serum netrin-1 level with the presence of breast mass and the nature of mass.

Methods: A total of 84 patients, including 27 patients with benign mass, 31 patients with malignant mass and 26 healthy controls, were enrolled in the study.

Results: In our study, the mean serum netrin-1 level was 479±325 pg/ml in the patients with malignant mass, 336.9±178.2 pg/ml in the patients with benign mass and 264.7±112.4 pg/ml in the healthy controls, respectively. There was a statistically significant difference in mean serum netrin-1 level between these three groups (p=0.007). When the patients participating in the study were divided in to two groups as those with (the benign and malign groups) and without (the control group) mass, the mean serum netrin-1 level was 264.7±112.4 pg/ml in those without mass and 412.8±274.2 pg/ml in those with mass, respectively. It was seen that the mean serum netrin-1 level of those with mass was statistically significantly higher than that of those without mass (p=0.016).

Conclusion: The mean serum netrin-1 level was found to be significantly higher in the patients with breast mass, especially those with malignant mass.

Giriş: Netrin-1'in anjiyogenezi indüklediği ve proto-onkogen olarak işlev gördüğü gösterilmiştir. Serum netrin-1 düzeyinin meme kitlesi varlığı ve kitlenin yapısı ile ilişkisini değerlendirmeyi amaçladık.

Yöntem: Çalışmaya 27 benign kitlesi olan, 31 hasta malign kitlesi olan ve 26 sağlıklı kontrol olmak üzere toplam 84 hasta alındı.

Bulgular: Çalışmamızda malign kitlesi olan hastalarda ortalama netrin-1 düzeyi 479 ± 325 pg / ml, benign kitlesi olanlarda 336.9 ± 178.2 pg / ml ve sağlıklı kontrollerde 264.7 ± 112.4 pg / ml bulundu. Bu üç grup arasında ortalama serum netrin-1 seviyesinde istatistiksel olarak anlamlı bir fark vardı (p = 0.007). Çalışmaya katılan hastalar (benign ve malign gruplar) ve kontrol grubu olmak üzere iki gruba ayrıldığında, ortalama netrin-1 düzeyi kitlesi olmayanlarda ortalama 264.7 ± 112.4 pg / ml ve kitlesi olanlarda 412.8 ± 274.2 pg / ml. Kitle saptananların ortalama netrin-1 düzeyi kitle olmayanlara göre istatistiksel olarak anlamlı yüksek olduğu görüldü (p = 0.016).

Sonuç: Ortalama serum netrin-1 düzeyi, meme kitlesi olan, özellikle de malign kitle olan hastalarda anlamlı olarak daha yüksek bulundu.

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Birincil Dil en
Konular Sağlık Bilimleri ve Hizmetleri
Yayımlanma Tarihi Dec 2018
Dergi Bölümü Araştırma Makalesi (Original Article)
Yazarlar

Orcid: 0000-0001-5311-0631
Yazar: Ibrahim Solak (Sorumlu Yazar)
Kurum: University of Health Sciences, Training and Research Hospital, Department of Family Medicine, Konya
Ülke: Turkey


Orcid: 0000-0002-3893-5173
Yazar: Duygu Ilke Yildirim
Kurum: University of Health Sciences, Training and Research Hospital, Department of Family Medicine, Konya
Ülke: Turkey


Orcid: 0000-0001-7939-7781
Yazar: Mustafa Solak
Kurum: Hisar Intercontinental Hospital, Department of Oncology, Istanbul
Ülke: Turkey


Orcid: 0000-0002-6052-4645
Yazar: Cigdem Damla Cetinkaya
Kurum: University of Health Sciences, Training and Research Hospital, Department of Biochemistry, Konya
Ülke: Turkey


Orcid: 0000-0002-9191-7687
Yazar: Ayse Boyaci
Kurum: University of Health Sciences, Training and Research Hospital, Department of General Surgery, Konya
Ülke: Turkey


Orcid: 0000-0002-5280-3943
Yazar: Mehmet Ali Eryilmaz
Kurum: University of Health Sciences, Training and Research Hospital, Department of General Surgery, Konya
Ülke: Turkey


Bibtex @araştırma makalesi { fppc467700, journal = {FAMILY PRACTICE AND PALLIATIVE CARE}, issn = {2458-8865}, eissn = {2459-1505}, address = {SERNEV}, year = {2018}, volume = {3}, pages = {123 - 126}, doi = {10.22391/fppc.467700}, title = {Relationship of serum netrin-1 levels with breast masses}, key = {cite}, author = {Solak, Mustafa and Eryilmaz, Mehmet Ali and Solak, Ibrahim and Yildirim, Duygu Ilke and Cetinkaya, Cigdem Damla and Boyaci, Ayse} }
APA Solak, I , Yildirim, D , Solak, M , Cetinkaya, C , Boyaci, A , Eryilmaz, M . (2018). Relationship of serum netrin-1 levels with breast masses. FAMILY PRACTICE AND PALLIATIVE CARE, 3 (3), 123-126. DOI: 10.22391/fppc.467700
MLA Solak, I , Yildirim, D , Solak, M , Cetinkaya, C , Boyaci, A , Eryilmaz, M . "Relationship of serum netrin-1 levels with breast masses". FAMILY PRACTICE AND PALLIATIVE CARE 3 (2018): 123-126 <http://www.fppc.com.tr/issue/39527/467700>
Chicago Solak, I , Yildirim, D , Solak, M , Cetinkaya, C , Boyaci, A , Eryilmaz, M . "Relationship of serum netrin-1 levels with breast masses". FAMILY PRACTICE AND PALLIATIVE CARE 3 (2018): 123-126
RIS TY - JOUR T1 - Relationship of serum netrin-1 levels with breast masses AU - Ibrahim Solak , Duygu Ilke Yildirim , Mustafa Solak , Cigdem Damla Cetinkaya , Ayse Boyaci , Mehmet Ali Eryilmaz Y1 - 2018 PY - 2018 N1 - doi: 10.22391/fppc.467700 DO - 10.22391/fppc.467700 T2 - FAMILY PRACTICE AND PALLIATIVE CARE JF - Journal JO - JOR SP - 123 EP - 126 VL - 3 IS - 3 SN - 2458-8865-2459-1505 M3 - doi: 10.22391/fppc.467700 UR - http://dx.doi.org/10.22391/fppc.467700 Y2 - 2018 ER -
EndNote %0 FAMILY PRACTICE AND PALLIATIVE CARE Relationship of serum netrin-1 levels with breast masses %A Ibrahim Solak , Duygu Ilke Yildirim , Mustafa Solak , Cigdem Damla Cetinkaya , Ayse Boyaci , Mehmet Ali Eryilmaz %T Relationship of serum netrin-1 levels with breast masses %D 2018 %J FAMILY PRACTICE AND PALLIATIVE CARE %P 2458-8865-2459-1505 %V 3 %N 3 %R doi: 10.22391/fppc.467700 %U 10.22391/fppc.467700
ISNAD Solak, Ibrahim , Yildirim, Duygu Ilke , Solak, Mustafa , Cetinkaya, Cigdem Damla , Boyaci, Ayse , Eryilmaz, Mehmet Ali . "Serum netrin-1 seviyesinin meme kitleleriyle ilişkisi". FAMILY PRACTICE AND PALLIATIVE CARE 3 / 3 (Ekim 2018): 123-126. http://dx.doi.org/10.22391/fppc.467700